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All Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal teknologi Kesehatan Borneo Eureka Herba Indonesia Journal of Economics and Public Health Journal of World Future Medicine, Health and Nursing Journal of Pharmacopoeia Dirya : Journal of Economic Management
Khrisna Agung Cendekiawan, Khrisna Agung
Fakultas Farmasi Universitas Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Effervescent Powder Activity of the God’s Crown Fruit Extract (Phaleria macrocapa) (Scheff) Boerl) in Rats Model of Alloxan-Induced Balb/C Diabetes Mellitus Cendekiawan, Khrisna Agung; Lia Fitriyaningrum
Eureka Herba Indonesia Vol. 4 No. 2 (2023): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v4i2.69

Abstract

God's crown fruit (Phaleria macrocarpa (Scheff) Boerl) is one of the ingredients that can be used as a natural anti-diabetic because of the presence of flavonoids which have activity as antioxidants. This study aimed to determine the anti-diabetic activity of the powder-effervescent God's crown fruit extract in various doses in test animals and to determine the effective dose of the powder-effervescent God's crown fruit extract as an anti-diabetic. This study is an in vivo experimental study. This study used 25 rats (Mus musculus) Balb/c, which were grouped into 5 groups (negative control, positive, and 3 treatment groups). Rats were induced diabetes mellitus with alloxan, then blood glucose levels were assessed. Data analysis was carried out using SPSS software version 25 in univariate and bivariate. There was no significant effect on reducing blood glucose levels in mice treated with effervescent powder of God's crown fruit extract.
The Influence of Community Knowledge Levels on the use of Amoxicillin in X Apotek Cendekiawan, Khrisna Agung; Wulandari, Hilwiyah Septi
Journal of Economics and Public Health Vol 1 No 4 (2022): Journal of Economics and Public Health: December 2022
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jeph.v1i4.1352

Abstract

Antibiotics are substances produced by bacteria or synthetic which aim to kill or inhibit the growth of other bacteria, and are substances produced by microorganisms which in low concentrations are capable of inhibiting the growth or killing of other microorganisms. The use of antibiotics is a widely used therapy and is commonly used by health workers as first-line therapy, so that its use is widely found in society. The use of antibiotics must be done appropriately because the side effect that arise due to inappropriate use of antibiotics is the resistance of a disease to antibiotics. There are several factors that influence community knowledge regarding the use of antibiotics including education, occupation, age, experience, information, environment, and culture. The purpose of this study was to determine the effect of the community knowledge level about the use of amoxicillin antibiotics.
Application of Voice Recognition Technology for Early Detection of Respiratory Disorders in Premature Babies Setyorini, Dhiana; Zani, Benny Novico; Rasmita, Dina; Cendekiawan, Khrisna Agung; Vandika, Arnes Yuli
Journal of World Future Medicine, Health and Nursing Vol. 2 No. 2 (2024)
Publisher : Yayasan Pendidikan Islam Daarut Thufulah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v2i2.758

Abstract

Bayi prematur memiliki risiko tinggi mengalami gangguan pernafasan yang berpotensi mengancam nyawa yang dapat berujung pada komplikasi atau permasalahan yang serius atau bahkan kematian jika tidak dideteksi secara tepat waktu. Untuk itu diterapkanlah sebuah teknologi pengenalan suara dagar dapat mengidentifikasi gangguan pernapsan yang terjadi pada bayi premature. Tujuan dari penelitian ini adalah untuk mengembangkan sistem yang dapat mengenali pola suara khas yang terkait dengan gangguan pernafasan pada bayi prematur. Dengan memanfaatkan teknologi ini, diharapkan dapat meningkatkan kemampuan deteksi dini gangguan pernafasan pada bayi prematur, sehingga memungkinkan intervensi medis yang lebih cepat dan tepat. Metode penelitian melibatkan pengumpulan data suara respirasi dari bayi prematur menggunakan mikrofon yang dipasang di sekitar inkubator mereka, diikuti oleh analisis menggunakan teknik pengolahan sinyal digital dan algoritma pembelajaran mesin. Hasil penelitian menunjukkan bahwa sistem yang dikembangkan mampu mengidentifikasi pola suara yang menunjukkan tanda-tanda gangguan pernafasan dengan tingkat akurasi yang tinggi yang di alami oleh bayi permatur. Hal ini didukung oleh data validasi yang menunjukkan bahwa sistem berhasil mendeteksi sebagian besar kasus gangguan pernafasan pada bayi permatur.Kesimpulan dari penelitian ini adalah bahwa teknologi pengenalan suara memiliki potensi besar sebagai alat deteksi dini gangguan pernafasan pada bayi prematur, yang dapat membantu tenaga medis dalam memberikan perawatan yang tepat waktu dan mengurangi risiko komplikasi serius. Dengan demikian, penerapan teknologi ini di lingkungan klinis dapat meningkatkan prognosis dan kelangsungan hidup bayi prematur yang rentan.
The Effect of Structured Physical Exercise on the Quality of Life of Patients with Multiple Sclerosis Minarti, Minarti; Sulistijono, Heru; Mukholid, Agus; Cendekiawan, Khrisna Agung; Runtu, Andro Ruben
Journal of World Future Medicine, Health and Nursing Vol. 2 No. 2 (2024)
Publisher : Yayasan Pendidikan Islam Daarut Thufulah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v2i2.759

Abstract

neurologis kronis yang seringkali menimbulkan penurunan fungsi fisik dan psikologis. Multiple Sclerosis (MS) adalah penyakit autoimun yang memengaruhi sistem saraf pusat, sering menyebabkan penurunan fungsi fisik dan psikologis. Gejala seperti kelemahan otot, kelelahan, dan gangguan kognitif dapat mengganggu aktivitas sehari-hari dan kualitas hidup pasien secara signifikan. Tujuan penelitian ini adalah untuk mengevaluasi apakah latihan fisik terstruktur dapat memperbaiki QoL pada pasien dengan MS. Metode penelitian yang digunakan adalah sebuah studi klinis acak terkontrol. Sejumlah pasien dengan Multiple Sclerosis dibagi secara acak menjadi dua kelompok: kelompok intervensi yang menjalani program latihan fisik terstruktur dan kelompok kontrol yang tidak menjalani program tersebut. Intervensi dilakukan dengan mengawasi dan menyesuaikan latihan fisik sesuai dengan kebutuhan individu pasien, dengan fokus pada peningkatan kekuatan, keseimbangan, dan mobilitas. Hasil penelitian menunjukkan bahwa pasien yang menjalani latihan fisik terstruktur mengalami peningkatan dalam QoL mereka dibandingkan dengan kelompok kontrol. Para peserta menunjukkan peningkatan dalam aspek-aspek seperti kemandirian, mobilitas, kualitas tidur, dan kesejahteraan psikologis. Selain itu, mereka melaporkan pengurangan dalam gejala kelelahan dan depresi. Kesimpulan dari penelitian ini yaitu latihan fisik terstruktur memiliki dampak positif pada QoL pasien dengan Multiple Sclerosis. Intervensi ini tidak hanya meningkatkan fungsi fisik, tetapi juga memberikan manfaat psikologis yang signifikan, meningkatkan rasa percaya diri dan kesejahteraan emosional. Implikasi dari temuan ini adalah pentingnya memasukkan latihan fisik terstruktur sebagai bagian integral dari manajemen MS, membantu pasien untuk mengelola gejala mereka secara efektif dan meningkatkan kualitas hidup mereka secara keseluruhan.
Pharmacological Effects of Curcumin in Chronic Inflammatory Therapy Muntasir, Muntasir; Faradina, Anggia; Wuryandari, Tutik; Cendekiawan, Khrisna Agung
Journal of Pharmacopoeia Vol. 2 No. 1 (2025): MARCH-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/r1y2wm33

Abstract

Herbal plants Herbal plants in Indonesia have an important role in traditional medicine and public health. The study aims to evaluate the effectiveness and mechanism of action of curcumin in chronic inflammatory therapy. This study employs the Systematic Literature Review (SLR) methodology.. This study uses a database from Scopus of 9 Scopus articles from the range of 2020 to 2025. There are three stages carried out in mapping the effectiveness and mechanism of action of curcumin in chronic inflammatory therapy, namely data harvesting, screening data and Data Analysis and Visualization. The results obtained are that curcumin is effective in chronic inflammatory therapy by inhibiting the main inflammatory pathways (NF-ƙB and JAK/STAT), has antioxidant effects, accelerates tissue regeneration, and functions as an immunomodulator. However, the limited bioavailability of curcumin presents a significant challenge in its application. Nanoformulation technology and its combination with compounds like CMPs can enhance its effectiveness in clinical therapy.The implications of this research are directed to researchers, the community and the government
Effectiveness of Antibiotic Use in the Prevention and Treatment of Respiratory Tract Infections Alfiansyah, Andika; Fadli, Fadli; Anggraeni, Lutvi; Cendekiawan, Khrisna Agung
Journal of Pharmacopoeia Vol. 2 No. 1 (2025): MARCH-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/6tqjqh98

Abstract

This study aims to analyze the effectiveness of the use of antibiotics in the prevention and treatment of respiratory tract infections. This study uses the Systematic Literature Review (SLR) method. There are three stages carried out in mapping the effectiveness of antibiotic use in the prevention and treatment of respiratory tract infections, namely: 1) harvesting data, 2) screening data, and 3) Data Analysis and Visualization. This study uses a database from Scopus with scientific journals as many as 9 articles from the range of 2021 to 2024. The effectiveness of antibiotic use in the prevention and treatment of respiratory tract infections is influenced by a variety of factors, including patient adherence, duration of therapy, and vaccine availability and use. Excessive or improper use of antibiotics can increase bacterial resistance, so more sustainable strategies, such as vaccination and stricter antibiotic use policies, are needed to improve the effectiveness of prevention and treatment of respiratory tract infections. The implications of this study are expected to be useful for future researchers and can be used in clinical applications
Antibiotics And Bacterial Resistance: A Global Challenge That Needs To Be Addressed Sugiah, Sugiah; Fadli, Fadli; Hariati , Fitria; Cendekiawan, Khrisna Agung
Journal of Pharmacopoeia Vol. 2 No. 1 (2025): MARCH-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/mwb7an91

Abstract

This study aims to explore the global challenges faced in addressing bacterial resistance to antibiotics, which are now one of the most serious health threats in the world. This study was conducted through the Systematic Literature Review (SLR) method by searching scientific articles from various databases such as PubMed, Scopus, and Google Scholar using the keywords "antibiotic resistance", "global health", "treatment failure", and "resistance mechanisms". The articles analyzed are publications in the last 10 years, focusing on the causes of resistance, their impact on global health, and countermeasures that have been carried out. The results of the study show that antibiotic resistance is mainly caused by the inappropriate use of antibiotics in the medical and non-medical sectors, lack of distribution supervision, and lack of development of new antibiotics. To overcome this, a comprehensive approach is needed, including increasing public education and health workers, strengthening regulations, and developing alternative therapies such as phagotherapy and vaccines. Without proper treatment, antibiotic resistance can lead to infection treatment failure, increased mortality rates, and burden the global health system
Peningkatan Pengetahuan Pemanfaatan Tanaman Berkhasiat Obat Daun Jambu Biji (Psidium guajava) Pada Masyarakat Suku Osing Kabupaten Banyuwangi Cendekiawan, Khrisna Agung; Isnawati, Nafisah; Anggraeni, Lutvi; Pangesti, Yuli; Mayasari, Shinta
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 2 (2025)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v6i2.13089

Abstract

Pulau Jawa merupakan pulau yang kaya keanekaragaman hayati. Obat tradisional pada etnis Suku Osing umumnya masih dalam bentuk yang sederhana. Bahan baku yang diambil dari alam setelah dibersihkan biasanya langsung digunakan dalam bentuk segar dengan cara direndam atau direbus kemudian diminum, diolah dengan cara dihaluskan dan ditumbuk/dipanaskan dalam bungkusan daun. Pengetahuan dan pemanfaatan tanaman obat masih minim terutama dalam pengolahannya menjadi sediaan yang efektif dan efisien agar mudah digunakan. Jambu Biji (Psidium guajava) merupakan tumbuhan yang dapat dimanfaatkan sebagai obat tradisional terutama pada bagian daunnya. Tujuan dari kegiatan ini untuk meningkatkan pengetahuan warga tentang khasiat tanaman Jambu Biji sekaligus mendorong warga memanfaatkan lahan pekarangan rumah untuk menanam tanaman tersebut sebagai tanaman obat keluarga serta dapat mengolah simplisia Jambu Biji sebagai teh herbal untuk digunakan menjadi minuman berkhasiat obat. Metode yang digunakan adalah sosialisasi, edukasi materi tentang Daun Jambu Biji dan pelatihan pembuatan teh herbal. Edukasi dilakukan dengan mengukur tingkat pengetahuan menggunakan kuesioner yang dibagikan sebelum (pretest) dan sesudah (post-test) pemberian materi. Hasil pretest menunjukkan bahwa pengetahuan dan minat warga untuk membudidayakan tanaman Jambu Biji masih kurang. Namun pada hasil post-test menujukkan pengetahuan mereka menjadi meningkat. Kesimpulan dari kegiatan ini terdapat peningkatan pengetahuan warga tentang tanaman berkhasiat obat Daun Jambu Biji (Psidium guajava)
Evaluation of Digital Maturity Level of Citra Husada Jember Hospital as a Strategy to Support Health Transformation Putra, Dewa Ngakan Gde Wahyu Mahatma; Cendekiawan, Khrisna Agung; Anggraeni, Lutvi Anggraeni
Jurnal teknologi Kesehatan Borneo Vol 6 No 1 (2025): Jurnal teknologi Kesehatan Borneo
Publisher : POLTEKKES KEMENKES PONTIANAK

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jtkb.v6i1.406

Abstract

The digital transformation of healthcare services demands hospital readiness in adopting integrated information systems. This study aimed to assess the digital maturity level of RS Citra Husada Jember using the Digital Maturity Instrument version 1.1 from the Ministry of Health of the Republic of Indonesia which includes seven main components: information systems and infrastructure, standards and interoperability, management and governance, data analysis, human resources, information security, and utilisation of electronic medical records and patient-centred services. This study used a descriptive cross-sectional design involving six internal hospital stakeholders through structured discussions. Results showed good digital maturity, with the highest scores in management and governance (4.5) and EMR (4.3), while the lowest scores were found in external interoperability (1.7) and data analytics. These findings emphasise the importance of strengthening digital infrastructure, improving digital literacy of health workers, and system integration to support the national OneHealth policy.
The Role of Information Technology and Product Innovation on the Competitive Advantage of Companies at Jember East Java Cendekiawan, Khrisna Agung; Wardhani, Firdha Aprillia
JAKI : Jurnal Akuntansi Vol 2 No 1 (2025): Dirya : Journal of Economic Management
Publisher : Pascasarjana STIE Miftahul Huda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70283/dirya.v2i1.76

Abstract

This study aims to analyze the role of information technology and product innovation in creating a competitive advantage for companies in Jember, East Java. Competitive advantage is a critical factor in determining the survival and success of companies in an increasingly competitive market. Using a qualitative research method, this study explores the perspectives of key stakeholders within companies regarding the implementation of information technology and product innovation. In-depth interviews with company leaders, along with secondary data analysis, were employed to gain insights into how these two factors contribute to the company’s strategy. The findings of this study reveal that information technology plays a crucial role in enhancing operational efficiency, internal communication, and facilitating access to global markets. Additionally, product innovation proves to be a key differentiator for companies, enabling them to meet the ever-evolving needs of consumers. The research also highlights that companies successfully integrating both elements are able to build and sustain a competitive advantage. Overall, the findings demonstrate the importance of adapting to new technologies and continuously innovating in order to maintain a company’s competitiveness in the digital era.
Co-Authors Agus Mukholid Alfiansyah, Andika Anggraeni, Linda Suci Anggraeni, Lutvi Anggraeni, Lutvi Anggraeni Arnes Yuli Vandika Fadli Fadli Faradina, Anggia Hariati , Fitria Heru Sulistijono Kintoko Kintoko Lia Fitriyaningrum Minarti Minarti Muntasir, Muntasir nafisah isnawati Pangesti, Yuli Putra, Dewa Ngakan Gde Wahyu Mahatma Rasmita, Dina Runtu, Andro Ruben Sapto Yuliani Setyorini, Dhiana Shinta Mayasari Sugiah, Sugiah Wardhani, Firdha Aprillia Wulandari, Hilwiyah Septi Wuryandari, Tutik Zani, Benny Novico