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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Al-Kimia Majalah Farmaseutik Pharmacology and Clinical Pharmacy Research Pharmaceutical Journal of Indonesia Jurnal Mandala Pharmacon Indonesia JURNAL FARMASIMED (JFM) Jurnal Ilmiah Farmako Bahari BERNAS: Jurnal Pengabdian Kepada Masyarakat Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Pengabdian UNDIKMA Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Eureka Herba Indonesia Natural Sciences Engineering and Technology Journal Jurnal Pengabdian Masyarakat Madani Jurnal Pengabdian Masyarakat Journal of Agropharmacy Dirya : Journal of Economic Management Halal Science Biodiversitas Journal of Biological Diversity
Wardhani, Firdha Aprillia
Department Of Clinical And Community Pharmacy, Faculty Of Pharmacy, Universitas Jember, Jember, Indonesia
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Association of Antiplatelet Type on Length of Stay and Neurological Outcomes in Ischemic Stroke Aprillia Wardhani, Firdha
Pharmaceutical Journal of Indonesia Vol. 10 No. 2 (2025)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2025.010.02.7

Abstract

Antiplatelet therapy plays an important role in preventing the progression of ischemic stroke. However, the effectiveness of different types of antiplatelet agents in improving clinical outcomes still requires further investigation. This study aimed to analyze the relationship between the type of antiplatelet used and the clinical outcomes of hospitalized ischemic stroke patients, based on changes in the National Institutes of Health Stroke Scale (NIHSS) score and length of stay (LoS). This research was a retrospective cross-sectional observational study involving 92 hospitalized patients with ischemic stroke. Patients were grouped based on the antiplatelet therapy received: Clopidogrel (CPG) (n=58), Aspirin (n=17), and dual antiplatelet therapy (DAPT) with Clopidogrel + Aspirin (n=17). Of the total patients, 43 (46.7%) showed improvement in NIHSS score, while 49 (53.2%) did not. The mean LoS was 7.033 days. The proportion of patients with NIHSS improvement by treatment group showed that the CPG group had the highest percentage of improvement, with 30 out of 58 patients (51.72%), compared to Aspirin 7/17 (41.2%) and DAPT 6/17 (35.3%). However, statistical analysis revealed no significant association between the type of antiplatelet and NIHSS improvement (p = 0.431). In addition, Kruskal-Wallis analysis revealed no significant association between LoS and antiplatelet type (p = 0.429). These findings suggest that other factors may play a more substantial role in determining the clinical outcomes of ischemic stroke patients. Keywords: antiplatelet, clinical outcome, NIHSS, ischemic stroke, LoS
The Role of Information Technology and Product Innovation on the Competitive Advantage of Companies at Jember East Java Cendekiawan, Khrisna Agung; Wardhani, Firdha Aprillia
JAKI : Jurnal Akuntansi Vol 2 No 1 (2025): Dirya : Journal of Economic Management
Publisher : Pascasarjana STIE Miftahul Huda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70283/dirya.v2i1.76

Abstract

This study aims to analyze the role of information technology and product innovation in creating a competitive advantage for companies in Jember, East Java. Competitive advantage is a critical factor in determining the survival and success of companies in an increasingly competitive market. Using a qualitative research method, this study explores the perspectives of key stakeholders within companies regarding the implementation of information technology and product innovation. In-depth interviews with company leaders, along with secondary data analysis, were employed to gain insights into how these two factors contribute to the company’s strategy. The findings of this study reveal that information technology plays a crucial role in enhancing operational efficiency, internal communication, and facilitating access to global markets. Additionally, product innovation proves to be a key differentiator for companies, enabling them to meet the ever-evolving needs of consumers. The research also highlights that companies successfully integrating both elements are able to build and sustain a competitive advantage. Overall, the findings demonstrate the importance of adapting to new technologies and continuously innovating in order to maintain a company’s competitiveness in the digital era.
Penyuluhan Interaktif Tentang Pubertas dan Kesehatan Reproduksi Remaja bagi Siswa SMP Negeri 14 Jember Eryani, Mikhania Christiningtyas; Winarti, Lina; Wardhani, Firdha Aprilia
Jurnal Pengabdian UNDIKMA Vol. 5 No. 4 (2024): November
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v5i4.12879

Abstract

This community service activity aims to increase the knowledge of students of SMP Negeri 14 Jember regarding puberty and reproductive health in order to realize healthy adolescents for Indonesia Emas 2045. The method used in this activity is the interactive counseling method. The evaluation instrument for this community service is a questionnaire and is analyzed descriptively qualitatively and quantitatively. The results of the community service show that there is an increase in student knowledge which initially had a score of 41.4 before the counseling to 84.1 after the counseling. So that the increase in participant scores after the community service process was carried out was 42.7 or 103%. Through this community service activity, adolescents at SMP Negeri 14 Jember increased their knowledge, especially regarding puberty and reproductive health.
Baricitinib for the treatment of COVID-19 Firdha Aprillia Wardhani; Syafika, Devina Sarah; Kusumaningrum, Yunita Dyah; Adelia Firandi
Journal of Agropharmacy Vol. 1 No. 2 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i2.1422

Abstract

Baricitinib which is one of the therapies for rheumatoid arthritis is a JAK inhibitor. WHO recommended therapy with the combination of baricitinib and corticosteroids in COVID-19 patients with severe or critical condition. Effectivity and safety assessment of Baricitinib use were carried out by reviewing the literature published between December 2019 – February 2022, and showed that the use of Baricitinib in COVID-19 patients resulted in an improvement of lung function, improvement of oxygen saturation, higher recovery rate, and lower mortality, with similar adverse event incidence. A loading dose or a higher dose can be recommended for patient with caution and consideration of higher possibility in the incidence of adverse events
Evaluasi Perencanaan dan Pengadaan Obat dengan Dana JKN di Puskesmas Rambipuji Jember Norcahyanti, Ika; Firandi, Adelia; Ramadhani, Nuril Izzati Farihatur; Rachmawati, Sinta; Rachmawati, Ema; Aryani, Dhita Evi; Wardhani, Firdha Aprillia; Kusumaningrum , Yunita Dyah
Journal of Agropharmacy Vol. 1 No. 3 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i3.1811

Abstract

Public Health Center is a health facility that organizes drug management activities, including planning and procurement activities. Evaluation needs to assess the success of achieving the objectives and results of the action. Indicators that can use are efficiency indicators published by the Ministry of Health of the Republic of Indonesia and efficiency indicators developed by Pudjaningsih. Rambipuji Public Health Center with spending funds for the most significant drug procurement in Jember Regency in 2020. Therefore, it is necessary to evaluate the results that can improve the quality of service in the next period. This research aims to determine the results of the evaluation of drug planning and procurement with JKN funds at Rambipuji Public Health Center for 2020. This research is descriptive, primary data through interview results. Secondary data includes total funds available, drug procurement funds, Drug Usage Reports, and Drug Demand Sheets for drugs purchased through JKN funds and stock cards. The data is analyzed descriptively, presented in the form of tables supported by interview results. The results showed that the Government of Indonesia had governed drug planning and procurement activities with JKN funds. The percentage indicator of available funds compared to the general funds needed is 114.26%. The percentage indicator of drug procurement fund allocation is 3.46%. Results on percentage indicator procurement conformity with the reality of the use of each drug item amounted to 133.33% and on the procurement frequency indicator of each drug item once a year. Through this research, it can be concluded that the evaluation results on indicators of the efficiency of drug planning and procurement activities at Rambipuji Public Health Center have not been by established standards. This matter was influenced by several factors, including a decrease in the number of patient visits due to the COVID-19 pandemic, changes in the organizational structure in the Jember Health Office that resulted in the frequency of procurement activities only once throughout 2020, and the absence of government regulations that regulate in more detail about the percentage of JKN funds allowed for drug procurement activities.
Peningkatan Edukasi Stroke Masyarakat dengan Video Edukasi Stroke – “CHERIE” (Cerebral Hemorrhage and Ischemic Educational Video) Wardhani, Firdha Aprillia; Amalia Wardatul Firdaus; Shinta Mayasari
Jurnal Pengabdian Masyarakat (JUDIMAS) Vol. 1 No. 2 (2023)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat STIKes Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/judimas.v1i2.163

Abstract

Berdasarkan data Kementerian Kesehatan, stroke merupakan penyebab kematian pertama untuk semua umur dengan persentase 15,4 persen, dan stroke juga menempati urutan pertama penyakit tidak menular yang mematikan. Time window yang ditujukan untuk pengobatan stroke adalah tiga jam, sehingga pengenalan gejala stroke sedini mungkin kepada masyarakat sangat penting. Tujuan Pengabdian masyarakat ini adalah untuk mengedukasi masyarakat dengan video edukasi stroke CHERIE (Cerebral Hemorrhage and Ischemic Educational Video) bagi masyarakat untuk lebih memahami penyakit stroke, mulai dari gejala hingga petunjuk penggunaan obat. Sasaran kegiatan ini adalah masyarakat umum di wilayah kabupaten Jember. Metode yang digunakan adalah memberikan edukasi dan mengukur tingkat pengetahuan melalui pretest dan post-test untuk mengetahui perubahan tingkat pengetahuan. Hasil dari kegiatan ini, sasaran mengalami peningkatan pengetahuan dengan rata-rata 42,8%, dengan nilai rata-rata pretest sebesar 68, dan rata-rata nilai post-test sebesar 95,3. Sehingga dapat disimpulkan bahwa kegiatan Pengabdian masyarakat dalam Upaya peningkatan edukasi masyarakat mengenai stroke melalui video CHERIE cukup efektif dalam meningkatkan pengetahuan masyarakat.
Ethnopharmacology, LC-MS profiling, and molecular docking of diarrheal-healing plants by the Osing tribe Cendekiawan, Khrisna Agung; Kintoko; Yuliani, Sapto; Wardhani, Firdha Aprillia
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.31315

Abstract

Indonesia has a long history of using medicinal plants, but much of this knowledge, especially among groups like the Osing people in East Java, is not well-documented. This study looks at the plants used by the Osing community to treat diarrhea. This research was conducted through interviews with residents of Banjar and Licin Villages in Banyuwangi Regency. The significance and perceived efficacy of each medicinal plant were evaluated using the ethnobotanical indices Use Value (UV) and Fidelity Level (FL). They also did tests to find the active chemicals in the plants. The most common plants for treating diarrhea were Psidium guajava (UV = 2.44) and Piper betle (UV = 1.11). Psidium guajava had the highest FL value (64.7%). Tests have shown that these plants contain essential chemicals. Further analysis confirmed the presence of quercetin and kaempferol, which are known to help alleviate stomach problems. To support these findings, computer-based tests were done, including Lipinski rule prediction, ADMET profiling, and molecular docking. The results showed quercetin binds well (ΔG = -9.72) and has a good RMSD value (1.83 Å). This suggests quercetin could be a good starting point for making antidiarrheal drugs. Overall, the study underscores the significance of traditional knowledge and recommends further research on plant-based treatments for stomach issues.
In Silico Study of Compounds Bioactive Guava (Psidium guajava) as Antidiarrheal Assisted Liquid Chromatography-Mass Spectroscopy Cendekiawan, Khrisna Agung; Kintoko, Kintoko; Yuliani, Sapto; Anggraeni, Linda Suci; Ningrum, Lailatul Fitria; Hasana, Siti Nur; Wardhani, Firdha Aprillia
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.876

Abstract

Guava leaves seeds (Psidium guajava) are known contain various compound potential bioactives? as antidiarrheal, such as quercetin and tannins, which work with method hinder intestinal contractions and disrupts permeability membrane cell bacteria. Research This aim for explore potential antidiarrheal from compound in leaf guava seed through identification compound using LC-MS and simulation molecular docking to six human protein target receptors, namely Cytochrome P450 1A1, Ephrin Type-B Receptor 4, Multidrug Resistance Protein 1, Dihydrofolate Reductase, Extracellular Calcium-Sensing Receptor, and Rap Guanine Nucleotide Exchange Factor 4. Extraction done with method maceration use solvent methanol, then compound analyzed using Liquid Chromatography–Mass Spectrometry (LC-MS). A total of eleven compound main chosen foranalyzed in silico using device soft AutoDockTools, PyRx, and Discovery Studio. Validation was performed through redocking of native ligands with RMSD value ? 2 Å. The results show some ligands such as Kaempferol, Cathecin, and Quercetin own affinity strong bond, with? Kaempferol show lowest binding energy of -9.72 kcal /mol against BHF receptor. Drug-likeness test based on Lipinski's rule also shows that part big compound fullfil criteria compound drug analysis? interaction amino acids show existence bond hydrogen and hydrophobic support? stability bond. This result show that compound leaf guava seeds, especially Kaempferol and Cathecin, potentially as candidate agent antidiarrheal natural. Further studies in vitro and in vivo are recommended for support findings.
Peningkatan Pengetahuan Pemanfaatan Tanaman Obat Daun Sirih (Piper Betle) Pada Masyarakat Suku Osing Kabupaten Banyuwangi Khrisna Agung Cendekiawan; Nafisah Isnawati; Shinta Mayasari; Neny Poerwahyuningrum; Firdha Aprillia Wardhani; Dea Maulidi Saputri
Jurnal Pengabdian Masyarakat Madani Vol 6 No 1 (2026): Jurnal Pengabdian Masyarakat Madani (JPMM)
Publisher : Sekolah Tinggi Ekonomi Bisnis Syariah Bina Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51805/jpmm.v6i1.218

Abstract

Pulau Jawa merupakan “pulau yang kaya keanekaragaman hayati. Obat tradisional pada etnis Suku Osing umumnya masih dalam bentuk yang sederhana. Bahan baku yang diambil dari alam setelah dibersihkan biasanya langsung digunakan dalam bentuk segar dengan cara direndam atau direbus, kemudian diminum, diolah dengan cara dihaluskan dan ditumbuk/dipanaskan dalam bungkusan daun. Pengetahuan dan pemanfaatan tanaman obat masih minim, terutama dalam pengolahannya menjadi sediaan yang efektif dan efisien agar mudah digunakan. Sirih hijau (Piper betle) merupakan tumbuhan yang dapat dimanfaatkan sebagai obat tradisional terutama pada bagian daunnya. Tujuan dari kegiatan ini adalah untuk meningkatkan pengetahuan warga tentang khasiat tanaman sirih hijau sekaligus mendorong warga memanfaatkan lahan pekarangan rumah untuk menanam tanaman tersebut sebagai tanaman obat keluarga serta dapat mengolah simplisia sirih hijau sebagai teh herbal untuk digunakan sebagai minuman berkhasiat obat. Metode yang digunakan adalah sosialisasi, edukasi materi tentang daun sirih hijau, dan pelatihan pembuatan teh herbal. Edukasi dilakukan dengan mengukur tingkat pengetahuan menggunakan kuesioner yang dibagikan sebelum (pretest) dan sesudah (post-test) pemberian materi. Hasil pretest menunjukkan bahwa pengetahuan dan minat warga untuk membudidayakan tanaman sirih hijau masih kurang. Namun, hasil post-test menunjukkan bahwa pengetahuan mereka menjadi meningkat. Kesimpulan dari kegiatan ini adalah terdapat peningkatan pengetahuan warga tentang tanaman berkhasiat obat daun sirih hijau (Piper betle).”
The Role of Pharmacy Personnel in Ensuring Appropriate Diarrhea Self-Medication in an Agro-Coastal Community in Jember, Indonesia Wardhani, Firdha Aprillia; Nur Sepdianto, Bagas; Rachmawati, Ema; Pontanar, Mae Quenie; Afifah Machlaurin
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44285

Abstract

Background: Self-medication for diarrhea is a common self-care practice because diarrhea is often perceived as a mild, self-limiting condition. However, its high prevalence in Indonesia, particularly in Jember Regency, raises concerns about inappropriate medicine selection and use, including the unsupervised use of prescription-only drugs such as loperamide and antibiotics. Pharmacists and pharmacy personnel play a key role in promoting safe and rational self-medication. Method: This cross-sectional study was conducted in 15 pharmacies in Agro-Coastal Jember from August 2025 to January 2026. Using purposive sampling, 200 eligible respondents were recruited. Data were collected using a structured questionnaire and analyzed using univariate analysis and Chi-square analysis with the contingency coefficient test to assess the significance and strength of the relationship between variables. Result: Most respondents were female (67%), aged 26–35 years (46.5%), had a senior high school education (71%), and had a monthly income of < IDR 2,500,000 (86%). Loperamide was the most frequently used medication (46.36%), and more than half of the medications used were prescription-only (53.18%). The appropriateness of diarrhea self-medication remained low for both medicine selection (46.8% appropriate) and medicine use (28.2% appropriate). A significant association was found between the role of pharmacists/pharmaceutical staff and the appropriateness of diarrhea self-medication (p < 0.05), although the strength of the relationship was weak (r = 0.233 and r = 0.184). Conclusion: In conclusion, diarrhea self-medication in the Agro-Coastal Jember community was still dominated by inappropriate medication practices. Strengthening pharmacy-based counseling in community pharmacy and service quality is essential to improve the safety and rational use of medicines in diarrhea self-medication.
Co-Authors Adelia Firandi Amalia Wardatul Firdaus Amalia Wardatul Firdaus Anggraeni, Linda Suci Anggraeni, Lutvi Aryani, Dhita Aryani, Dhita Evi Dea Maulidi Saputri Dian Agung Pangaribowo Didik Hasmono Dwi Koko Pratoko Dyan Wigati Ema Rachmawati Eryani, Mikhania Christiningtyas Fifteen Aprila Fajrin Firandi, Adelia Hasana, Siti Nur Ika Norcahyanti Khrisna Agung Cendekiawan Kintoko Kintoko Kintoko Kintoko Kintoko Kintoko KINTOKO KINTOKO Kintoko, Kintoko Kusumaningrum , Yunita Dyah Lina Winarti Linda Suci Anggraeni Linda Suci Anggraeni Machlaurin, Afifah Nafisah Isnawati NANANG MUNIF YASIN Neny Poerwahyuningrum Neny Poerwahyuningrum Nia Kristiningrum Ningrum, Lailatul Fitria Nur Sepdianto, Bagas Pontanar, Mae Quenie Ramadhani, Nuril Izzati Farihatur Rina Fitriana RR. Ella Evrita Hestiandari Sapto Yuliani Sapto Yuliani Sapto Yuliani SAPTO YULIANI Shinta Mayasari Shinta Mayasari Sinta Rachmawati Siti Nur Hasana Syafika, Devina Sarah Zulkarnain Permana ZULLIES IKAWATI