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All Journal Pendas : Jurnah Ilmiah Pendidikan Dasar Nusantara Hasana Journal IJF (Indonesia Jurnal Farmasi) Jurnal Ilmiah Kesehatan Keperawatan Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Eko Retnowati
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Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Other

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Hubungan Profil Pasien Gagal Jantung terhadap Efektivitas Terapi Kombinasi Antihipertensi di Rawat Inap RSUD dr. Loekmono Hadi Kudus Zulia Tri Rahayu; Eko Retnowati; Galih Kurniawan
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 3 (2025): September: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i3.4838

Abstract

As one of the cardiovascular diseases, heart failure is a condition in which the heart loses its ability to pump blood adequately to deliver oxygen throughout the body's tissues. According to a WHO survey in 2016, non-communicable diseases such as cardiovascular problems accounted for 38 million out of 56 million total global deaths. Of these, 17.5 million deaths were specifically caused by circulatory system disorders. In Indonesia, heart failure ranks as a leading cause of mortality. Based on the 2018 Basic Health Research (Riskesdas) data, the prevalence rate of heart disease in the country reached 1.5%. Hypertension has been identified as one of the main risk factors that can trigger heart failure. This study aims to analyze the correlation between the profiles of heart failure patients and the effectiveness of combination antihypertensive therapies involving Beta Blocker–ACEI, Beta Blocker–ARB, and Beta Blocker–Diuretic in patients hospitalized at Dr. Loekmono Hadi Regional Hospital, Kudus. The study employed an observational analytic method with a cross-sectional approach using patient medical records. The data were collected from Dr. Loekmono Hadi Regional Hospital, Kudus. The sample population included heart failure patients who received combination antihypertensive therapy (Beta Blocker–ACEI, Beta Blocker–ARB, or Beta Blocker–Diuretic) during their inpatient care in 2024. The sampling technique used was total sampling, with 77 patients meeting the established inclusion and exclusion criteria. Data analysis was performed using univariate and bivariate methods supported by the Chi-Square test. The most commonly used combination therapy was Beta Blocker + Diuretic, administered to 36 patients (46.8%). The average blood pressure of heart failure patients before therapy was 143.81/83.05 mmHg, and after therapy, it was 126.10/76.23 mmHg. Most patients (69 patients or 89.6%) achieved normal blood pressure levels (<140/90 mmHg) post-therapy. Chi-Square analysis indicated a significant correlation between age (p=0.04) and therapy effectiveness. In contrast, no significant association was found between gender (p=1.000) or the type of combination therapy used (p=0.895) and therapeutic outcomes.
EVALUASI KETEPATAN PEMBERIAN ANTIBIOTIK PADA PASIEN ANAK-ANAK DI RAWAT JALAN RUMAH SAKIT KARANGGEDE SISMA MEDIKA BOYOLALI Annisa Zulfa Hamida; Eko Retnowati; Istiannatus Sunnah
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 03 (2026): Volume 11 Nomor 03, September 2026 Released
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i03.64511

Abstract

The use of antibiotics in pediatric patients requires special evaluation due to the risk of inappropriate therapy and its contribution to antibiotic resistance. Differences in pharmacokinetic characteristics in children necessitate rational and standardized antibiotic use. This study aimed to evaluate the appropriateness of antibiotic use among outpatient pediatric patients aged 0–12 years at Karanggede Sisma Medika Hospital, Boyolali, using the Gyssens method to assess the rationality of antibiotic therapy. This study employed a descriptive observational design with a retrospective approach using 190 medical records. The inclusion criteria consisted of outpatient pediatric medical records of patients receiving antibiotic therapy with complete demographic and clinical data, while patients referred to other hospitals were excluded. Data were analyzed univariately to describe the frequency distribution and percentages of patient characteristics and the appropriateness of antibiotic use. The results showed that most antibiotic use was rational (93.89%), while inappropriate use accounted for 6.11%, including incorrect dosage (0.76%), inappropriate antibiotic selection (3.05%), and antibiotic administration without indication (2.29%). These findings indicate that antibiotic use among outpatient pediatric patients was generally appropriate; however, periodic evaluation remains necessary to prevent antibiotic resistance. Keywords: Antibiotics, Pediatric Patients, Outpatient Care, Gyssens Method, Antibiotic Rationality
Co-Authors Abdilla Mahmud Arrafiq Akhyasin Akhyasin Annisa Zulfa Hamida Apriliasari, Fiona Ayu Aprilia Atika Sari Endang Setyowati Fahrudin Arif Galih Kurniawan Hasriyani Hasriyani, Hasriyani Intan Adevia Rosnarita Istiannatus Sunnah Leily Hardianti Rosiana marsito - Muhamad Khudzaifi Muhammad Nurul Fadel Nor Khaini Podo Yuwono Riana Putri Rahmawati Ridyasari Kamela Devi Ulviani Yulia Husna Ummi Nurus Salamah Vivin Rosita Zulia Tri Rahayu