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All Journal Medula Language and Education Journal JURNAL KESEHATAN: JURNAL ILMIAH MULTI SCIENCES Bioscientist : Jurnal Ilmiah Biologi Jurnal Riset Teknik Pertambangan International Review of Practical Innovation, Technology and Green Energy (IRPITAGE) Sains Medisina Linguanusa : Social Humanities, Education and Linguistic JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Afriyani
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Literatur Review: Efek Samping Penggunaan Obat Hipertensi Sekar Anastry Putri; Dwi Aulia Ramdini; Afriyani; M. Fitra Wardhana
Medula Vol 13 No 4 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.773

Abstract

Hypertension is a major risk factor for cardiovascular disease. Hypertension also has another term, namely "silent killer" which can be interpreted that it is not uncommon for people with hypertension to find it difficult to realize or even not to feel the warning symptoms of their disease. Treatment for hypertensive patients is a treatment therapy that needs to be done in the long term or for life. The problem often occurs in the treatment of chronic diseases that require long-term treatment such as hypertension because there are still many patients who do not comply with the treatment therapy they should be undergoing. One of the causes of non-compliance is the presence of patients who experience side effects from treatment. A drug side effect is an unwanted event and is detrimental to the patient as a result of drug use. Side effects that often occur in amlodipine therapy are: palpitations, flushing, ankle edema, hypotension, headache and nausea. Captropil can cause hyperkalemia and dry cough. Side effects of beta blockers that can occur are insomnia, hallucinations and depression. Clonidine can cause side effects such as dry mouth with symptoms of dry and cracked lips. Treatment with hydrochlorothiazide generally causes complaints related to side effects of the drug including frequent urination, feeling weak and wanting to faint, and abnormal heart rate. The use of diuretics can cause increased levels of uric acid or hyperuricemia resulting in deposition of uric acid, acute arthritis, nephrolithiasis.
Faktor-Faktor yang Mempengaruhi Penggunaan Obat Herbal dan Obat Tradisional pada Pasien Hipertensi Sahanaz Zaqiyah Darozah; Dwi Aulia Ramdini; Afriyani; Oktafany
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1012

Abstract

The use of traditional medicine derived from various types of plants has become a culture and tradition in Indonesia. It is primarily used for treating metabolic and degenerative diseases, with hypertension being one of the notable examples. Hypertension stands as a leading cause of premature death worldwide. The global incidence of hypertension in 2015 reached 1.13 billion, with a prevalence ranging between 30-45%. Currently, approximately 75-80% of the world's population with hypertension decide to use herbal medicines because they can be tolerated by the body and have fewer associated side effects. The utilization of herbal and traditional medicines is widespread across various countries, including 29.4% in Iran, 21% in South Africa, 75.6% in Tanzania, 30.6% in Malaysia, and 54%-78% in Indonesia. Therefore, this article discusses factors influencing the use of herbal and traditional medicines among hypertensive patients. Factors known to influence the utilization of these medicines include gender, age, education, occupation, and medication adherence. Health professionals have to be concerned about herbal and traditional medicines use in hypertensive patients to ensure that the treatment is safe, effective, and minimizes the risk of side effects and drug interactions.
Systematic Literature Review: Pembentukan Kokristal Dengan Koformer Asam Karboksilat Metode Solvent Drop Grinding Dan Slurry Terhadap Kelarutan Zat Aktif Aprilia Yuniardi, Nikita; Afriyani; Ervina Damayanti; Muhammad Iqbal
Sains Medisina Vol 3 No 2 (2024): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v3i2.533

Abstract

Kelarutan merupakan faktor penting yang memengaruhi bioavailabilitas dan efektivitas terapi obat. Namun, sekitar 40% kandidat obat memiliki kelarutan rendah dalam air, yang menghambat penyerapan dalam tubuh. Salah satu solusi yang diterapkan dalam penelitian ini adalah teknik kokristalisasi dengan metode Solvent Drop Grinding dan Slurry, menggunakan koformer asam karboksilat untuk meningkatkan kelarutan zat aktif. Dalam studi ini, zat aktif seperti Promethazine, Sildenafil, Acyclovir, Simvastatin, dan Imidazopyridazine dimodifikasi melalui Solvent Drop Grinding, sementara Berberine, Carbamazepine, Ketoprofen, dan Theophylline menggunakan teknik Slurry. Hasil menunjukkan bahwa metode kokristalisasi ini efektif meningkatkan kelarutan zat aktif. Peningkatan tersebut terjadi akibat terbentuknya ikatan hidrogen antara zat aktif dan koformer, serta adanya fase kristal baru yang menandakan keberhasilan pembentukan kokristal. Penelitian ini mendukung potensi teknik kokristalisasi dengan metode Solvent Drop Grinding dan Slurry dalam meningkatkan kelarutan zat aktif yang rendah. Dengan demikian, teknik ini berpotensi digunakan dalam formulasi obat untuk meningkatkan bioavailabilitas senyawa yang memiliki keterbatasan kelarutan dalam air.
Literature Review: Modifikasi Bahan Aktif Farmasi (BAF) Dengan Metode Kokristal Zahra Fadilatusya'adah; Afriyani; Dwi Aulia Ramdini; Ramadhan Triyandi
Sains Medisina Vol 3 No 2 (2024): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v3i2.540

Abstract

Rute oral menjadi pilihan utama untuk penghantaran obat karena kemudahan dan penerimaan pasien yang baik, namun rute ini memiliki tantangan yaitu bioavailabilitas nya yang rendah akibat kelarutan yang buruk. Salah satu solusi yang menjanjikan untuk meningkatkan kelarutan dan disolusi dari obat adalah dengan pembentukan kokristal, yaitu material yang terdiri dari zat aktif dan koformer yang berinteraksi melalui ikatan non-kovalen. Tinjauan ini ditujukan untuk memberikan ulasan mengenai kokristalisasi sebagai metode untuk memperbaiki sifat fisikokimia Bahan Aktif Farmasi (BAF). Tinjauan ini merujuk pada beberapa sumber referensi dari berbagai literatur terkait definisi kokristal, koformer, dan metode pembuatan kokristal. Kokristal merupakan metode yang efektif dan berpotensi meningkatkan kelarutan, disolusi, stabilitas, dan bioavailabilitas sehingga efek terapeutik dari suatu zat aktif dapat meningkat tanpa mengubah aktivitas farmakologinya. Aplikasi metode kokristal pada pembentukan kokristal asam usnat-N-Methyl-D-Clucamnie terbukti mampu meningkatkan kelarutan dan laju disolusi sebanyak 24 kali dan 23 kali lebih besar dibandingkan dengan senyawa murninya. Terdapat beragam metode pembuatan kokristal seperti, solvent drop grinding, dry grinding, slurry, solvent evaporation, spray drying, dan metode anti-solvent, dengan keunggulannya masing-masing dalam meningkatkan sifat zat aktif. Pemilihan metode pembuatan kokristal disesuaikan oleh sifat dari bahan aktif farmasi, koformer yang digunakan, dan ketersediaan dari teknologi yang mendukung.
The Footprint of Progressive Women’s Service In Anggana District, Kutai Kartanegara, East Kalimantan Afriyani; Normawati; Abdul Hopid; Sama Alee, Abdulrahman
Linguanusa : Social Humanities, Education and Linguistic Vol. 3 No. 1 (2025): Linguanusa : April 2025
Publisher : Insight School Academy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63605/ln.v3i1.91

Abstract

Introduction to The Problem: The implementation of Community Service in the Muhammadiyah organization brings many benefits and advantages for Muslims in Indonesia in general and Muhammadiyah members in particular. To find out how the contribution and implementation of community service in the field of upholding brotherhood and improving the quality of the community, this study conducted mini research in 2 Muhammadiyah schools in Anggana District, namely TK Aisyiyah Bustanul Athfal 1 Anggana and SD Muhammadiyah 1 Anggana, as well as research was also conducted at the Aisyiyah religious study in Anggana District. Purpose: To find out how the contribution and implementation of community service in the field of upholding brotherhood and improving the quality of the community. Design/methods/approach: The method used to collect data was by interview and observation. Findings: The results obtained were that the 'Aisyiyah study and Muhammadiyah schools in Anggana District have played a significant role in strengthening Islamic brotherhood and shaping students' character. Both have shown consistent efforts in realizing Islamic values in everyday life. 
IMPROVING STUDENTS’ LISTENING SKILLS BY USING THE SPOTIFY APP Fitri Novia; Kiki Rizki Amelia; Afriyani
Language and Education Journal Vol. 10 No. 1 (2025): Language and Education Journal
Publisher : Universitas Islam Ogan Komering Ilir Kayuagung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52237/dkqwb334

Abstract

A crucial component of learning a language is developing one's listening skills. However, students struggled with their listening skills. The issues included dialects, unclear pronunciation, a lack of vocabulary, and the audio's speed. Students' listening skills issues might be resolved with the help of the Spotify app. The study aimed to determine whether there was a significant difference in the listening skills of students who received instruction using the Spotify application compared to those who did not. This study was carried out using a quasi-experimental method. To examine the data, a t-test was employed. Based on the independent sample t-test results, it was revealed that pvalue (0.000) was less than ɑvalue (0.05) and the t-test achieved (5.362) was greater than the t-table (2.0345). It indicated that students who received instruction using the Spotify app and those who did not have significantly different listening skills. Thus, students can learn how to listen better by using the Spotify app as a teaching tool
Pengaruh Pemilihan Pelarut Terhadap Rendemen Ekstrak Daun Teh Hijau(Camellia sinensis) Menggunakan Metode Ekstraksi Maserasi Pasaribu, Risma Kristina Uli; Iqbal, Muhammad; Rahayu, Ihsanti Dwi; Afriyani; Triyandi, Ramadhan
Sains Medisina Vol 3 No 5 (2025): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v3i5.734

Abstract

Teh hijau (Camellia sinensis) mengandung beragam senyawa bioaktif seperti polifenol, flavonoid, dan alkaloid yang memiliki manfaat farmakologis. Ekstraksi senyawa-senyawa ini dapat dilakukan dengan metode maserasi, yang efektivitasnya sangat dipengaruhi oleh jenis pelarut yang digunakan. Penelitian ini adalah studi literatur yang bertujuan untuk mengevaluasi pengaruh pemilihan pelarut terhadap rendemen ekstrak daun teh menggunakan metode maserasi. Data dikumpulkan dari 10 artikel ilmiah yang relevan yang diterbitkan antara tahun 2015 dan 2025. Kriteria inklusi meliputi artikel penelitian asli yang menggunakan metode maserasi untuk ekstraksi daun teh, memuat data rendemen ekstrak, dan ditulis dalam bahasa Indonesia atau Inggris. Artikel yang tidak menggunakan metode maserasi, tidak menyajikan data rendemen, atau diterbitkan di luar rentang tahun yang ditentukan, serta artikel non-ilmiah seperti ulasan umum atau laporan berita, dieksklusi dari penelitian ini. Tinjauan literatur menunjukkan bahwa pelarut dengan polaritas tinggi, seperti etanol 96% dan aquadest, menghasilkan rendemen ekstrak yang lebih tinggi dibandingkan pelarut non-polar seperti kloroform dan n-heksan. Etanol 96% memberikan rendemen tertinggi sebesar 37,87%, sementara kloroform hanya menghasilkan 3,58%. Temuan ini menegaskan bahwa pemilihan pelarut yang tepat sangat penting untuk efisiensi ekstraksi dan kualitas ekstrak yang dihasilkan. Penelitian ini menyoroti pentingnya polaritas pelarut dalam proses maserasi untuk mengoptimalkan perolehan senyawa bioaktif dari daun teh.
Prediksi Airblast Akibat Kegiatan Peledakan Overburden Batubara Afriyani; Yuliadi; Elfida Moralista
Jurnal Riset Teknik Pertambangan Volume 5, No. 1, Juli 2025, Jurnal Riset Teknik Pertambangan (JRTP)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrtp.v5i1.6723

Abstract

Abstract. PT Cipta Kridatama Binuang Mitra Bersama Blok Dua (CK-BMBBD) merupakan perusahaan pertambangan batubara yang melakukan pemberaian dengan metode peledakan. Kegiatan ini berpotensi menimbulkan dampak negatif seperti airblast, ground vibration, dan flying rock. Penelitian ini fokus pada airblast, yaitu gelombang kejut dari ledakan bahan peledak. Airblast dapat membahayakan kesehatan manusia jika melebihi ambang batas, sehingga perlu diteliti. Tujuan penelitian adalah mengetahui nilai airblast, persamaan multiple linear regression, serta metode prediksi paling valid berdasarkan koefisien korelasi. Metodologi yang digunakan adalah metode teoritis (USBM dan McKenzie), multiple linear regression, dan artificial neural network (ANN). Data yang digunakan meliputi airblast dalam desibel, maksimum charge, dan jarak pengukuran. Analisis dilakukan menggunakan statistik untuk mengevaluasi hubungan hasil prediksi dan data aktual. Pengukuran dibandingkan dengan SNI 7570 tahun 2023 yang menetapkan ambang batas 110 dB. Regulasi ini mengatur penggunaan bahan peledak agar sesuai standar. Hasil menunjukkan nilai airblast 45 dB(A) – 77 dB(A), masih aman karena di bawah ambang batas. Prediksi menggunakan ANN menghasilkan nilai R² sebesar 0,9221, menunjukkan hubungan sangat valid antara hasil prediksi dan data aktual. Abstract. PT Cipta Kridatama Binuang Mitra Bersama Blok Dua (CK-BMBBD) is a mining company engaged in coal commodities. The company conducts clearing using the blasting method. Blasting activities may cause negative impacts such as airblast, ground vibration, and flying rock. This research focuses on airblast that occurs due to blasting activities. Airblast is a shock wave produced by the explosion of explosives. Airblast can pose health risks if it exceeds the threshold value, therefore research is necessary. This study aims to determine airblast values, formulate a multiple linear regression equation, and identify the most valid prediction method based on the correlation coefficient. The methodologies used are theoretical methods (USBM and McKenzie), multiple linear regression, and artificial neural network (ANN). The data used include airblast in decibels, maximum charge, and measurement distance. Statistical analysis is applied to evaluate the relationship between predicted and actual airblast data. Airblast measurements were compared to the standard reference, SNI 7570 of 2023, which sets a threshold of 110 dB. This regulation governs the use of explosives to ensure compliance with regulatory standards. The results showed airblast values ranging from 45 dB(A) to 77 dB(A), indicating safety. ANN prediction yielded an R² value of 0.9221, showing very strong validity.
EFFECTIVENESS OF SOME NON PATHOGENIC ENDOPHYTIC BACTERIA NUTMEG ON VIABILITY OF ORIGIN PLANT SEED RICE (Oryza sativa L) Saiful Mahdi; Danar Hadisugelar; Dianawati; Afriyani; Safrizal
International Review of Practical Innovation, Technology and Green Energy (IRPITAGE) Vol. 5 No. 1 (2025): March-June 2025
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54443/irpitage.v5i1.2968

Abstract

This study aimed to determine the effectiveness of several non-pathogenic endophytic bacteria isolated from nutmeg plants on the viability of rice seeds. The experimental design used was a non-factorial completely randomized design (CRD) with three replications. The study included 14 endophytic bacterial treatments and one control. The research was conducted at the Biological Control Laboratory, Plant Protection Study Program, Faculty of Agriculture, Syiah Kuala University, Banda Aceh, from August 2023 to September 2023. The results showed that the application of non-pathogenic endophytic bacteria from nutmeg had a highly significant effect on rice seed viability, particularly on growth potential and germination. The highest seed viability was observed in the treatment with the bacterial isolate S - S AG 1 I. Endophytic bacterial isolates from nutmeg plants were proven to enhance the viability of Ciherang rice seeds, especially in terms of growth potential and germination. The isolate S - S AG 1 I produced the best results, with a growth potential of 84.4% and germination rate of 77.8%
Aktivitas Pupisida Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi L.) terhadap Kematian Pupa Aedes aegypti L. Islami, Suryadi; Hardiansyah, Ridwan; Afriyani; Hafizh, Ahmad Fauzan; Temun, Jedo Muchamad Tias
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 3 (2025): September
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i3.15389

Abstract

This study aimed to determine the pupicidal activity of ethanol extract from bilimbi ( Averrhoa bilimbi L.) leaves against Ae. aegypti pupal mortality. A true experimental design was employed to evaluate the toxicity of various ethanol extract concentrations against pupae over treatment periods of 24 and 48 hours. Mortality rates were recorded and calculated using the WHO mortality formula, and lethal concentrations (LC50 and LC90) were determined via probit analysis to identify concentrations causing 50% and 90% pupal mortality. The results showed that the ethanol extract exhibited dose-dependent pupicidal activity, with the highest mortality observed at 4% concentration, achieving 97.33% mortality after 48 hours. The LC50 values were 2.378% at 24 hours and 1.425% at 48 hours, indicating an increased effectiveness over time. The findings suggest that the ethanol extract of bilimbi leaves has potential as a natural pupicide, offering an eco-friendly alternative for controlling Ae. aegypti populations. Further studies are needed to optimize formulation and field application for sustainable mosquito vector management.
Co-Authors Abdul Hopid Akbar, Muhammad Farhan Anggraini, Triana Aprilia Yuniardi, Nikita Citra Yuliyanda Pardilawati Damayanti, Ervina Danar Hadisugelar Dianawati DWi Aulia Ramdini Elfida Moralista Ervina Damayanti Fitri Novia Hafizh, Ahmad Fauzan Hardiansyah, Ridwan Ihsanti Dwi Rahayu Kiki Rizki Amelia Leo Hasmal, Aditia M. Fitra Wardhana Marcellia, Selvi Muhammad Iqbal Muhammad Iqbal Normawati Oktafany Pasaribu, Risma Kristina Uli Ramadhan Triyandi Safrizal Sahanaz Zaqiyah Darozah Saiful Mahdi Sama Alee, Abdulrahman Sekar Anastry Putri Suryadi Islami Temun, Jedo Muchamad Tias Triyandi, Ramadhan Yuliadi Zahra Fadilatusya'adah