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All Journal Jurnal MIPA PHARMACON Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ The Studies of Social Sciences Jurnal Abdi Insani Jurnal Perempuan dan Anak Indonesia Indonesian Biodiversity Journal Indonesian Biodiversity Journal
Julianri Sari Lebang, Julianri Sari
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Journal : Jurnal MIPA

 1 
Perbandingan Profil Penetrasi Formula Krim Antioksidan dari Ekstrak Perikarpium Buah Manggis (Garcinia mangostana) dengan Variasi Penetration Enhancer Siampa, Jainer Pasca; Lebang, Julianri Sari; Antasionasti, Irma; Nurmiati, Nurmiati
Jurnal MIPA Vol 10, No 1 (2021)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jmuo.10.1.2021.31146

Abstract

Paparan sinar matahari dengan kandungan radiasi UV merupakan salah satu faktor pencetus radikal bebas penyebab penuaan dini (Photoaging), yang ditandai dengan hiperpigmentasi, kerutan, dan menurunnya elastisitas kulit. Solusi permasalahan ini adalah penggunaan antioksidan yang dapat menangkal terbentuknya radikal bebas. Tujuan dari penelitian ini adalah untuk membuat formula krim antioksidan dari ekstrak perikarpium kulit manggis dengan perbedaan penetration enhancer untuk mendapatkan persentase penetrasi dan retensi terbaik di kulit. Ekstrak perikarpium buah manggis dibuat dengan metode maserasi menggunakan etanol 70% kemudian diukur aktivitas antioksidannya dan kandungan fenoliknya, selanjutnya digunakan sebagai bahan aktif dalam formula krim. Formula F1-F3 dibuat kemudian dievaluasi karakteristik fisiknya dan dilakukan pengujian penetrasi secara in vitro. Pengujian penetrasi secara in vitro dilakukan terhadap F2 dan F3 yang mengandung ekstrak. Hasil IC50 ekstrak terhadap DPPH sebesar 7,514 µg/mL dan kandungan fenolik sebesar 112,70 ± 0,80 mgGAE/g. Nilai persentase penetrasi, persentase retensi, dan nilai flux secara berturut-turut untuk F2 sebesar 9,96% ± 0,075%; 37,951% ± 0,103%; 3,037 ± 0,023 µg/cm2.jam dan F3 sebesar 7,872% ± 0,078% ;  33,874% ± 0,259%; 2,400 ± 0,024 µg/cm2.jam. Dari hasil analisis statistik, disimpulkan bahwa F2 adalah formula terbaik dengan karakteristik fisik yang homogen, memiliki warna kekuningan, tipe emulsi m/a, pH sediaan 6, daya lekat 11,05 ± 0,87 detik, dan diameter daya sebar 6,20 ± 0,10 cm.Sun exposure with UV radiation is one of the triggers for free radicals that cause premature aging (photoaging), characterized by hyperpigmentation, wrinkles, and decreased skin elasticity. The solution to this problem is the use of antioxidants that can prevent the formation of free radicals. The purpose of this study was to formulate an antioxidant cream dosage form from pericarpium extract of mangosteen pericarpium with different penetration enhancers to obtain the best percentage of penetration and retention in the skin. Pericarpium extract of mangosteen fruit was prepared by maceration method using 70% ethanol, then the antioxidant activity and the phenolic content were measured and were used as an active ingredient in the cream formula. Formula F1-F3 were made, their physical characteristics were evaluated, and in vitro penetration testing was carried out. In vitro penetration testing was carried out on F2 and F3 containing extracts. The IC50 value of the extract against DPPH was found to be 7.514 µg/mL and the phenolic content was found to be 112,70 ± 0,80 mgGAE/g. The percentage of penetration, retention percentage, and flux value were 9.96% ± 0.075%, 37.951% ± 0.103%, 3.037 ± 0.023 µg/cm2.hour respectively for F2 and 7.872% ± 0.078% , 33.874% ± 0.259%,  2.400 ± 0.024 µg/cm2.hour, respectively for F3. From the results of statistical analysis, it was concluded that F2 was the best formula with homogeneous physical characteristics, had a yellowish color, emulsion type w/o, pH value of 6, adhesion of 11.05 ± 0.87 seconds, and diameter of spreadability of 6.20 ± 0.10 cm.
Profil Penetrasi Sediaan Gel Antioksidan Ekstrak Kayu Manis (Cinnamomum burmanii) dengan Variasi Hydrocolloid sebagai Gelling agent Siampa, Jainer Pasca; Wiyono, Weny Indayany; Lestari, Utami Sasmita; Lebang, Julianri Sari; Antasionasti, Irma
Jurnal MIPA Vol 11, No 1 (2022)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jm.v11i1.35787

Abstract

The exposure of sunlight consisting UV radiation has been reported to be the main cause of skin cancer and contribute about 80% of the incidence of skin damage. In an attempt to overcome this problem, antioxidant agents have been used both orally and topically. Compared to oral administration, topical route has been found to be preferred due to the direct action to the desired site. Amongst topical preparation, gel possesses numerous because it provides a cool and fresh sensation. Here, we developed gel antioxidant containing cinnamon extract as active ingredient. Cinnamon was selected as it has a very strong antioxidant activity. This study aimed to obtain the penetration profile of the antioxidant gel of cinnamon extract prepared from two different hydrocolloid agents. The gels were made using various concentrations of Carbopol 940 and NaCMC. The prepared gels were further characterized for their antioxidant capacities using the DPPH free radical scavenging method and their total phenolic contents using the spectrophotometric method. The formulation possessing the strongest antioxidant capacity was continued for ex vivo penetration study using Franz diffusion cells. The results exhibited that the total phenolic value of the cinnamon extract obtained was 908.38 ± 6.54 mg GAE/g extract. The penetration percentages for the formula with Carbopol and NaCMC bases were 53.310 ± 1.217% and 27.969 ± 1.151%, respectively, and the retention percentages were 28.495 ± 0.031% and 18.356 ± 0.191%, respectively. Based on these findings, we concluded that cinnamon extract could potentially be formulated into antioxidant gel preparations and formulas based on Carbopol showed the best penetration profile.
Pengaruh Pemberian Sari Buah Salak (Salacca zalacca) terhadap Profil lipid dan Berat Badan Tikus Model Hiperlipidemia dan Obesitasda Datu, Olvie Syenni; Lebang, Julianri Sari; Rumondor, Erladys Melindah
Jurnal MIPA Vol 11, No 1 (2022)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jm.v11i1.36530

Abstract

Cardiovaskular disease is the number one cause of death in the world, an estimated 17.9 million people die each year. Several risk factors that contribute to the occurrence of heart disease such as hypertension, diabetes mellitus, hyperlipidemia, and obesity. Snake Fruit is a fruit that is available in large quantities both in volume and variety. Snake Fruit is rich in antioxidants that can be used to treat hyperlipidemia and overweight. North Sulawesi is one of the centers of Snake Fruit production, especially in the southeast Minahasa area. This study aimed to test the effectiveness of Snake Fruit juice on the lipid profile of hyperlipidemic and obese rats induced by a high-fat diet in the form of used cooking oil, quail egg yolk and 0.01% PTU solution. The study used 5 groups, namely the negative control group was given aquadest, the positive control group was given simvastatin and the treatment group was given Snake Fruit juice with concentrations of 2%, 4% and 8%. The parameters observed in this study were body weight, lipid profile, and glucose profile. blood. The study showed that the administration of Snake Fruit juice had a significant effect on the lipid profile of rats for all parameters on the lipid profile and had a significant effect on weight loss and blood glucose levels where p < 0.05 and there was no significant difference between each treatment group in both lipid profile parameters. , body weight and blood glucose levels.
Co-Authors Antasionasti, Irma Ariem, Feiby Datu, Olvie Syenni Edwin de Queljoe Elly Suoth ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Ghanny, Ath Thariq Fadhli Adhimul Ghanny Hariyanto, Yuanita Amalia Karlah L. R. Mansauda Kawatu, Chelsea Khairuddin Lestari, Utami Sasmita Meilani Jayanti Nurmiati Nurmiati Nursamsiar Nursamsiar Paulina yamlean Rundengan, Gerald Edward Sedu, Anissa Siampa, Jainer Pasca Sukriani Kursia, Sukriani Sumual, Priskila Feicy Turangan, Pricilia Dona Widdhi Bodhi Wiyono, Weny Indayany Yudistira, Adhitya