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All Journal Pharmaciana: Jurnal Kefarmasian UNEJ e-Proceeding Kesmas Indonesia: Jurnal Ilmiah Kesehatan Masyarakat Indonesian Journal of Chemistry PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Ilmiah Medicamento Indonesian Community Journal Jurnal Farmasi Sains dan Praktis Prosiding University Research Colloquium Jurnal Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian
Sundhani, Elza
Universitas Muhammadiyah Purwokerto
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Pemanfaatan Tanaman Obat Keluarga Sebagai Upaya Peningkatan Produktivitas Peserta Sekolah Perempuan Kelopak Gayatri Desa Gumelem Kulon Banjarnegara Sal Sabila Nadhifah Kurochman; Joya Injelita; Adinda Fayi Azizah; Revalina Avrillia Yulanda; Afifudin; Elza Sundhani
I-Com: Indonesian Community Journal Vol 3 No 3 (2023): I-Com: Indonesian Community Journal (September 2023)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33379/icom.v3i3.3185

Abstract

Pemanfaatan Tanaman Obat Keluarga (TOGA) sebagai salah satu alternatif pengobatan yang sangat potensial dikembangkan oleh masyarakat pedesaan. Luasnya lahan dan pekarangan di pedesaan dapat dimanfaatkan untuk dijadikan lahan TOGA, namun masyarakat tidak memiliki ilmu dan ketrampilan yang cukup. Kegiatan ini bertujuan untuk memberikan edukasi tentang khasiat TOGA dan cara mengolah lahan disekitar rumah untuk menjadi tempat budidaya TOGA pada kelompok sekolah perempuan kelopak Gayatri Desa Gumelem Kulon Banjarnegara. Metode yang digunakan meliputi penyuluhan tentang manfaat dan cara pengolahan serta praktek menanam TOGA. Hasil yang dicapai dari kegiatan ini yaitu meningkatnya pemahaman tentang jenis tanaman TOGA, klasifikasinya, cara pengolahan, pemanfaatan TOGA serta pentingnya tanaman TOGA untuk pengobatan serta mendapatkan ketrampilan berbudidaya TOGA dengan memanfaatkan pekarangan dan kebun disekitar rumah untuk menjadi tempat budidaya TOGA. Adanya kebun TOGA yang merupakan hasil luaran pengabdian ini selanjutnya diharapkan dapat dimanfaatkan untuk pengobatan atau dapat digunakan untuk memperbaiki perekonomian dengan menjual hasil TOGA.
Peningkatan Eksistensi Batik Gumelem Melalui Pelatihan Membatik Pada Sekolah Perempuan Kelopak Gayatri di Desa Gumelem Kulon Joya Injelita; Sal Sabila Nadhifah Kurochman; Adinda Fayi Azizah; Revalina Avrillia Yulanda; Afifudin; Elza Sundhani
I-Com: Indonesian Community Journal Vol 3 No 4 (2023): I-Com: Indonesian Community Journal (Desember 2023)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33379/icom.v3i4.3466

Abstract

Kajian ini secara umum bertujuan untuk mengetahui pengetahuan masyarakat terkait Batik Tulis Gumelem Kulon. Adapun tujuan khusus adalah untuk mengeksplorasi batik tulis Gumelem Kulon agar bertambahnya wawasan kepada masyarakat terkait proses pembuatan batik, menumbuhkan rasa cinta terhadap produk lokal terkhusus dikalangan muda-mudi, dan mengembangkan sektor pengrajin batik tulis di Desa Gumelem Kulon. Metode penelitian yang digunakan bersifat eksploratif. Semua data di dapat menggunakan teknik observasi, wawancara dan studi pustaka. Dari hasil penelitian dan pembahasan yang telah dilakukan dapat disimpulkan bahwa batik tulis Gumelem Kulon belum terlalu dikenal oleh masyarakat sekitar. Hasil penelitian dapat digunakan sebagai pembuka keberlanjutannya pada penelitian selanjutnya dalam rangka menemukan upaya lebih lanjut serta pendekatan-pendekatan yang tepat dalam meningkatkan minat serta bakat masyarakat supaya pedestrian batik tulis Gumelem Kulon dapat terjaga sampai saat nanti.
Molecular interactions of Andrographis paniculata Burm. f. Active Compound with Nuclear Receptor (CAR and PXR): An In Silico Assessment Approach Elza Sundhani; Agung Endro Nugroho; Arief Nurrochmad; Endang Lukitaningsih
Indonesian Journal of Chemistry Vol 22, No 1 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.67981

Abstract

The study aims to analyze the potential Herb-Drug Interactions (HDIs) of the chemical compound in Andrographis paniculate Burm. f. against Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR). The 1XVP and 1SKX obtained from the Protein Data Bank (PDB) were used as the targeted protein. The molecular docking analysis was done using the Molecular Operating Environment (MOE) and molecular dynamics simulation using Gromacs. The results of the docking analysis showed that 14-Deoxy-11,12-didehydroandrographolide had the strongest binding energy (1XVP-21.0998 Å) with the Arene-H binding type on Tyr326 and Andrographidine A had the strongest binding energy (1SKX-24.7363 Å) with the Arene-H binding type on Trp299. While Andrographolide is the major component, it also has a high affinity for the two PDB IDs (1XVP-17.4044 Å and 1SKX-21.8881 Å). Based on the RMSD value, the radius of gyration (Rg), and MM/PBSA on molecular dynamic simulations, it shows that the ligand and protein complex as a whole can bind strongly to amino acid residues at the active site. The complex also has sufficient stability and good affinity. Therefore, this study can predict the mechanism in HDIs, especially in CYP 450 expression through the activation pathways of CAR and PXR receptors.
POTENTIAL KETAPANG (Terminalia cattapa) LEAF EXTRACT AS A DOXORUBICIN CO-CHEMOTHERAPY AGENT ON BREAST (T47D) AND CERVIX (HeLa) CANCER CELL LINES Sundhani, Elza; Solehah, Senja Nur; Septiadi, Binaripan; Nurulita, Nunuk Aries
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.9845

Abstract

Doxorubicin (DOX) is chemotherapy for breast and cervical cancer with serious side effects. Ketapang (Terminalia cattapa) is a potential plant as a co-chemotherapy agent. The purpose of this research was to examine the sensitivity of DOX as a cytotoxicity drug in combination with ethanolic extracts of ketapang leaves (EKL) against T47D and HeLa cancer cells. Cytotoxicity was determined using the MTT assay, with DOX concentration series (0.625-40 nM for T47D and 0.5-6 M for HeLa) and EKL (50-1000 mg/mL) used in combination with the study. DOX and EKL combination assays utilizing their respective IC50 values were performed in T47D cells and HeLa cells, and the results were used to calculate the Combination Index (CI). Furthermore, the doubling time method was used to investigate the combination of DOX and EKL proliferation inhibition on both cell lines. DOX and EKL had IC50 values of 158 nM and 30 mg/mL for T47D, respectively, and 3.4 M and 640 mg/mL for HeLa cell growth. While DOX and EKL have a synergistic effect on T47D cells, their combined effect on HeLa cells is cytotoxic and dose-dependent. EKL increases the inhibitory effect of DOX on the proliferation of T47D and HeLa cancer cells. In T47D cells, the combination of DOX and EKL has a higher potential for cytotoxic and antiproliferative activity than in HeLa cells
The potentiation effect of Bawang Dayak (Sisyrinchium palmifolium L.) extract on T47D cell growth inhibition after 5-fluorouracil treatment Yuniarti, Azizah; Sundhani, Elza; Nurulita, Nunuk Aries
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.9480

Abstract

5-Fluorouracil (5-FU) is chemotherapy agents that used in breast cancer treatment that has toxic effects such as myelotoxicity. its effectiveness relatively low. Bawang Dayak has been widely empirically used as a breast cancer treatment. This study's aims were to determine the sensitivity of 5-FU against T47D cells, as single and its combination with EBD, to determine apoptotic induction, and the inhibitory effect of T47D cell cycle. The cytotoxic assay was using the MTT method with the concetration of 5-FU (0-600μg / mL) and EBD (0-250μg / mL). Apoptotic induction analysis were determined by PI/annexin V. Both of apoptotic and cell cycle analysis was performed by flowcytometry. The results of the 5-FU and EBD cytotoxic test on T47D cells obtained IC50 274μg/mL and 75μg/mL, respectively. The combination of 5-FU and EBD has a mild to strong synergistic effect (CI 0.829 and 0.779). its ombined treatment induced apoptosis in T47D cells by 21.33%. Combination of these combinations caused cell accumulation in G0-G1 phase of 57.11%, greater than control (41.20%). Provision of 5-FU and EBD combination treatments causes disturbance and damage to cells that cause cell cycle arrest in the G0-G1 phase and can not proceed to the next phase. The combination of 5-fluorouracil and EBD has a synergistic effect as breast cancer co-chemotherapy is able to induce apoptosis against T47D cells by triggering cell accumulation in G0-G1 phase. The extract of Bawang Dayak has a high potential to be developed as co-chemotherapy in breast cancer.
REVIEW: ADVERSE DRUG REACTIONS AND PHARMACOKINETIC CHARACTERISTICS OF LINEZOLID AS A THERAPY FOR DRUG RESISTANT TUBERCULOSIS Retnaningsih, Ririn; Susilo, Rinto; Sundhani, Elza
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1735

Abstract

Introduction: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that remains a global health challenge. One of the main problems in TB treatment is the emergence of drug resistance, such as in multidrug-resistant tuberculosis (MDR-TB). Linezolid is a class of oxazolidinones used as second-line therapy in the treatment of drug-resistant TB. However, its use is not free from serious adverse drug reactions such as peripheral neuropathy, myelosuppression, and lactic acidosis. Therefore, understanding the pharmacokinetic profile and adverse drug reactions of linezolid is important to increase the effectiveness of therapy and minimize the risk of toxicity. Objective: This study aimed to evaluate the adverse drug reactions caused by linezolid and analyze its pharmacokinetic characteristics in the treatment of drug-resistant tuberculosis (TB). Methods: This article is a literature review that collects data from national and international scientific sources over the past 10 years (2015-2025), including the addition of comparative studies or meta-analyses, as well as inclusion criteria, such as articles that discuss the pharmacokinetics, adverse drug reactions, and use of linezolid in drug-resistant tuberculosis therapy, either in clinical trials, observational studies, or relevant therapeutic guidelines. Results: Based on the results of various studies, linezolid has an oral bioavailability approaching 100%, which allows oral and intravenous administration with almost equivalent doses. Its pharmacokinetic profile shows an elimination half-life of approximately 5-7 hours, with primary metabolism via nonenzymatic oxidation in the liver and excretion in the urine as inactive metabolites. These characteristics make linezolid a flexible option for drug-resistant tuberculosis therapy..
STUDY OF ADVERSE DRUG REACTIONS OF LINEZOLID IN DRUG RESISTANT TUBERCULOSIS PATIENTS Susilo, Rinto; Sundhani, Elza; Setyaningsih, Indah; Retnaningsih, Ririn; Nurjanah, Ucu; Endang Ayu Prihatini, Nok
Jurnal Farmasi Sains dan Praktis Vol 11 No 2 (May-August 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i2.12472

Abstract

The estimated number of DR TB patients in Indonesia is increasing. High adverse drug reactions have the potential to affect the success of DR TB patient treatment. Linezolid is one of the drugs in combination with DR TB therapy that has the potential to cause adverse drug reactions in the form of hematological disorders and visual impairment. This study aims to determine the incidence of Linezolid ADRs, including the incidence, severity, and risk factors associated with the occurrence of ADRs. This type of study is observational with a cross-sectional design conducted retrospectively in DR TB patients at the lung clinic of Hospital 'X" and Hospital "Y" in Indonesia. The results of the study showed that the incidence of ADRs suspected of Linezolid that met the criteria was 70 patients out of a total of 215. The most common type of ADRs was hematological disorders at 89%, the rest were visual impairment. The type of regimen and type of ADRs correlate with the severity of ADRs. It is necessary to monitor drug levels in the blood in order to monitor and prevent the potential for more severe ADRs so that therapy can be individualized.
In-Use Stability Sediaan Injeksi Hidrokortison di Rumah Sakit Rujukan Daerah Jawa Tengah Genatrika, Erza; Sundhani, Elza; Fitri, Adriana Eka
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11538

Abstract

Hydrocortisone Sodium Succinate 50mg injection is widely used in perinatology wards. These wards cater to newborns (0-28 days), low birth weight (<2.5 kg), or premature babies (<37 weeks), requiring special handling. The use of this injection requires a very small dose, so one vial of hydrocortisone injection can be used for more than one patient. Therefore, the remainder of this hydrocortisone injection is often stored for 24 hours in the refrigerator which will later be reused on other patients. This study aims to determine the in-use stability of hydrocortisone injection stored for 24 hours at 4oC and 25oC. This is certainly to improve patient safety. The data collection technique uses an observational method on hydrocortisone injection samples with 3 replications. In-use stability is assessed from the results of organoleptic tests, pH tests, viscosity tests, determination of drug levels using UV-VIS spectrophotometry and sterility tests. Testing was conducted on days 0, 1, 2, 3, 7, 14 and 30. The results of the study showed that hydrocortisone injection preparations stored for 1 day at 4°C or 25°C in the perinatology ward were no longer physicochemically stable (concentration). Chemical degradation began on day 1, then microbial contamination occurred immediately after completion of compounding in the ward (day 0). This is because reconstitution was not carried out in a clean room in accordance with USP <797>. It can be concluded that hydrocortisone injection preparations prepared in this hospital are not recommended for administration to patients after 1 day of storage and must be compounded in a clean room.
FOURIER TRANSFORM INFRA RED SPECTROSCOPY UNTUK IDENTIFIKASI MINYAK BABI DALAM MINYAK BUMBU MIE INSTAN IMPOR Utami, Pri Iswati; Ryandita, Ika; Sundhani, Elza
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Mie instan impor yang beredar terkadang tidak mencantumkan label halal. Identifikasi bahan tidak halal khususnya babi penting dilakukan untuk membantu masyarakat memperoleh produk halal. Tujuan penelitian ini adalah mengidentifikasi minyak babi dalam minyak bumbu mie instan impor menggunakan metode spektrofotometri Fourier Transform Infra Red (FTIR) yang dikombinasikan dengan kemometrik Principal Component Analysis (PCA) dan Partial Least Square (PLS). Sampel kalibrasi dibuat dengan variasi minyak babi dan minyak nabati. Masing-masing sampel kalibrasi dibuat spektrum FTIR pada bilangan gelombang 4000 – 650 cm-1. Spektrum FTIR yang diperoleh menunjukkan adanya 2 pita serapan khas minyak babi, yaitu pada 1226,73 dan 1111 cm-1. Analisis PCA menghasilkan score plot yang menunjukkan terpisahnya minyak babi dan minyak kedelai di kuadran yang berbeda. Analisis PLS menghasilkan persamaan Y = 0,9921x + 0,3963 dengan nilai R2 0,992103 ; nilai RMSEP 0,0072 dan nilai RMSEC 2,1998. Hasil penentuan Limit of Detection (LOD) menunjukkan bahwa metode FTIR mampu mendeteksi minyak babi dalam sampel kalibrasi pada konsentrasi 1%. Hasil analisis terhadap sampel minyak bumbu pada lima merek sampel mie instan impor menunjukkan tidak ada sampel yang terdeteksi adanya minyak babi.
Hepatoprotective Activity of the Combined Leaf Extracts of Syzygium Polyanthum and Moringa oleifera Against AntituberculosisDrug-Induced Hepatotoxicity in Rats SUNDHANI, ELZA; Sigit Prasuma, Galar; Firda Ramadhani, Reninta
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/rezxt096

Abstract

Oral antituberculosis drugs (OAT) used repeatedly can negatively impact the liver. Natural compounds with high antioxidant potential could be used as hepatoprotective agents. This study aims to determine the hepatoprotective activity of the combination ethanolic leaf extract of Syzygium polyanthum (SPEE) and Moringa oleifera (MOEE) in rats administered with OAT. The hepatoprotective activity of the combination of SPE and MOE was determined by calculating the SGOT and SGPT levels of rats administered rifampicin (RMP), pyrazinamide (PZA), and isoniazid (INH) for 14 days. An experimental study using eight groups: standard control (CMCM-Na), negative control treatment with OAT (RMP 100 mg/kg BW; PZA: 252 mg/kg BW INH 50 mg/kg BW), positive control (OAT + Curcumin 100 mg/kg BW), OAT+SPEE 150 mg/kg BW group, OAT+MOEE 400 mg/kg BW group, and 3 group OAT + combination SPEE and MOEE (25%: 75%; 50%:50%; 75%:25%). SGPT & SGOT levels were determined using spectrophotometry with analytical methods using specific SGPT & SGOT reagent kits at 340 nm. After 14 days of OAT administration, SGOT levels increased by 1.3-fold, and SGPT levels increased by 1.8-fold compared to baseline levels. This considerable increase is still considered mild hepatotoxicity. The combination of SPEE: MOEE (25%:75%) was most effective in decreasing SGOT levels by 23.5%, or 1.3-fold, whereas the combination treatment of SPEE: MOEE (75%; 25%) was most effective in reducing SGPT levels by 51.56%, or 2-fold. The ratio value of the decrease in SGOT and SGPT levels from single SPEE and MOEE and the combination of both (p>0.05). The combination treatment of SPEE and MOEE in rats administered OAT showed an additive effect and could evolve as a hepatoprotective substance.
Co-Authors Adinda Fayi Azizah Afifudin Agung Endro Nugroho Ardiasa Prakoso Arief Nurrochmad Azizah Yuniarti Binar Asrining Dhiani Della Caya Nur Syarifah Diniatik Dwi Hartanti Endang Ayu Prihatini, Nok Endang Lukitaningsih Fifi Rahmawati Firda Ramadhani, Reninta Fitri, Adriana Eka Genatrika, Erza Hamidah Haryanti Rahma Ika Nurzijah Ika Ryandita Irma Amalia Irsalina Nurul Putri Joya Injelita Lita Ratriyana Zumrohani Much Ilham Novalisa Aji Wibowo Muhamad Rifki Nina Nurhayati Dian Utami Nunuk Aries Nurulita Nunuk Aries Nurulita Nunuk Aries Nurulita Nur Fajrina Nurjanah, Ucu Nurulita, Nunuk Aries Pri Iswati Utami Pri Iswati Utami Retnaningsih, Ririn Revalina Avrillia Yulanda Rian Ulva Rizki Hasanah Rima Anggita Pratiwi Ryandita, Ika Sal Sabila Nadhifah Kurochman Septiadi, Binaripan Setyaningsih, Indah Sigit Prasuma, Galar Solehah, Senja Nur Susilo, Rinto Yuniarti, Azizah Yuniarti, Azizah Zaenal Arifin Misgi Candra Dasa Zainur Rahman Hakim