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All Journal Pharmaciana: Jurnal Kefarmasian UNEJ e-Proceeding Kesmas Indonesia: Jurnal Ilmiah Kesehatan Masyarakat Indonesian Journal of Chemistry PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Ilmiah Medicamento Indonesian Community Journal Jurnal Farmasi Sains dan Praktis Prosiding University Research Colloquium Jurnal Farmasi Indonesia Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian Praeparandi: Jurnal Farmasi dan Sains
Sundhani, Elza
Universitas Muhammadiyah Purwokerto
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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TANTANGAN DAN PELUANG PERBAIKAN TENTANG PRAKTIK PERESEPAN OBAT ANTITUBERKULOSIS DI INDONESIA : TINJAUAN NARATIF Kautsarul Aziz; Githa Fungie Galistiani; Elza Sundhani
Praeparandi : Jurnal Farmasi dan Sains Vol 9 No 2 (2026): Praeparandi : Jurnal Farmasi dan Sains
Publisher : Fakultas Farmasi Universitas YPIB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51997/txv19455

Abstract

Tuberkulosis (TB) masih menjadi salah satu bagian dari permasalahan kesehatan terbesar didunia dan Indonesia menjadi salah satu negara yang memilki jumlah kasus TB tertinggi. Obat Anti Tuberkulosis (OAT) merupakan komponen utama dalam terapi TB, namun praktik peresepan di lapangan seringkali belum sesuai dengan pedoman nasional yang berlaku. Tinjauan naratif ini bertujuan untuk mengidentifikasi tantangan utama dalam praktik peresepan OAT serta mengeksplorasi peluang perbaikan yang dapat dilakukan di Indonesia. Pengumpulan data dilakukan dengan menelaah literatur ilmiah yang relevan dalam kurun waktu 5 tahun terakhir  melalui pencarian di Google Scholar. Hasil tinjauan menunjukkan bahwa tantangan utama meliputi ketidaksesuaian resep dengan pedoman, keterbatasan pelatihan bagi tenaga kesehatan, rendahnya kepatuhan pasien, fragmentasi layanan antara sektor publik dan swasta, serta keterbatasan akses terhadap obat dan fasilitas. Meskipun demikian, terdapat sejumlah peluang perbaikan seperti penguatan implementasi pedoman terapi, peningkatan kapasitas tenaga kesehatan melalui pelatihan, integrasi layanan kesehatan, serta pemanfaatan teknologi digital seperti sistem resep elektronik dan Video Observed Treatment (VOT). Studi ini menekankan pentingnya pendekatan kolaboratif dan sistematis untuk mewujudkan praktik peresepan OAT yang rasional, efektif, dan berkelanjutan dalam rangka mencapai target eliminasi TB di Indonesia.
Tinjauan potensi aktivitas ramuan herba sambiloto, herba meniran, dan daun kumis kucing dalam penanganan diabetik neuropati: Narative Review Anita Purnama Sari; Elza Sundhani; Retno Wahyuningrum
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.940

Abstract

Diabetic neuropathy is one of the most common microvascular complications among patients with diabetes mellitus, characterized by damage to peripheral nerves due to persistently high blood sugar levels, excessive oxidation and inflammation. Conventional treatments are often not effective enough in comprehensively addressing this problem, so strategies using medicinal plants are emerging as promising options. This study aims to review the potential pharmacological activities of three medicinal plants, namely sambiloto (Andrographis paniculata), meniran (Phyllanthus niruri), and cat's whisker (Orthosiphon aristatus), in the treatment of diabetic neuropathy. This study was conducted using the Narrative Review method with a literature search of two databases PubMed and ScienceDirect with an interval of publication years 2016-2026. A total of 16 articles were selected. The three types of plants showed significant pharmacological properties, including as antioxidants, anti-inflammatory, hypoglycemic, and neuroprotective. Sambiloto functions through andrographolide compounds that inhibit the NF-κB pathway and increase Nrf2 antioxidant activity. Meniran has an effect in lowering blood glucose levels and increasing the performance of antioxidant enzymes. Cat whisker plays a role in glucose control, kidney care, and inflammation in the system.  The results of this study are expected to provide an overview of additional therapies in overcoming diabetic neuropathy through the workings of Sambiloto, meniran, and cat's whiskers have complementary potential. The combination of these three plants offers a diverse approach, but further research is needed to assess synergistic effects, safety, and the most appropriate formulation as a modern herbal treatment.
NARRATIVE REVIEW: METHODS FOR MONITORING AND ANALYZING WARFARIN IN BLOOD Yuniarti, Windi Astika; Susilo, Rinto; Sundhani, Elza
Jurnal Farmasi Sains dan Praktis Vol 12 No 1 (May-August 2026)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/1vmxea58

Abstract

Warfarin is an oral anticoagulant with a narrow therapeutic index and high interindividual variability in pharmacokinetic and pharmacodynamic responses, requiring careful therapeutic monitoring to maintain efficacy and minimize adverse events. In clinical practice, anticoagulation monitoring is generally performed using the International Normalized Ratio (INR); however, INR values may be influenced by various factors such as drug interactions, dietary vitamin K intake, patient adherence, and genetic polymorphisms, potentially limiting its accuracy as a sole monitoring parameter. Therefore, direct measurement of plasma warfarin concentrations has gained attention as an additional approach to optimize individualized therapy. This narrative review aimed to evaluate and compare analytical methods used for monitoring and analyzing warfarin levels in blood, particularly high-performance liquid chromatography (HPLC) and liquid chromatography–tandem mass spectrometry (LC–MS/MS). Literature sources were obtained from PubMed and selected based on relevance to analytical methods for warfarin quantification published within the last ten years. The reviewed studies demonstrated that LC–MS/MS provides superior sensitivity, specificity, and low detection limits for accurate quantification of warfarin and its metabolites, while HPLC methods remain reliable, accurate, and applicable in routine clinical laboratories with more limited instrumentation. Several studies also reported that plasma warfarin concentration, especially the unbound fraction, may better reflect anticoagulant activity and bleeding risk in certain patient populations compared with INR alone. In conclusion, chromatographic methods are valuable tools for therapeutic drug monitoring of warfarin and may improve individualized anticoagulant therapy when combined with conventional INR monitoring.
Gambaran Pengetahuan, Sikap dan Perilaku Kelompok Aisyiyah Tentang Penggunaan dan Waktu Simpan Sediaan Farmasi Steril di PCA Kecamatan Purwokerto Timur: Overview of Knowledge, Attitudes, and Behavior of the Aisyiyah Group Regarding the Use and Shelf Life of Sterile Pharmaceutical Preparations in the PCA of East Purwokerto District Erza Genatrika; Elza Sundhani
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 11 No. 6 (2026): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v11i6.12217

Abstract

Sterile pharmaceutical preparations such as eye drops, nose drops, and ear drops have specific uses and shelf lives. Currently, based on the information obtained, the community, especially members of Aisyiyah PCA Purwokerto Timur, can easily obtain these sterile pharmaceutical preparations. The community's ignorance in using and storing these preparations can endanger their health. This community service activity aims to describe the knowledge, attitudes, and behavior of the Aisyiyah group regarding the use and shelf life of sterile pharmaceutical preparations in PCA Purwokerto Timur before and after training. The study uses a cross-sectional design with a quantitative approach. The number of respondents used is the total population attending the training. Of the 35 training participants, 20 (57.1%) had good knowledge, attitudes, and behavior before the training, and 15 (42.9%) had fairly good knowledge, attitudes, and behavior. Furthermore, after the training, 35 (100%) had good knowledge, attitudes, and behavior regarding the use and shelf life of sterile pharmaceutical preparations. Knowledge can influence the attitudes and behavior of Aisyiyah PCA Purwokerto Timur members regarding the use and shelf life of sterile pharmaceutical preparations.
Erratum to: In-use Stability of Hydrocortisone Injection Preparations at a Regional Referral Hospital in Central Java Erza Genatrika; Elza Sundhani; Eka Fitri Adriana; Ni Made Dharma Shantini Suena
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13794

Abstract

Erratum to: Jurnal Ilmiah Medicamento 2025; 11(2): 185-192 DOI original article: https://doi.org/10.36733/medicamento.v11i2.11538 After the publication of this article, errors were identified in the in-text citation, in Tables 2, 3, and 4, and in the reference list. The publisher wishes to apologize for any inconvenience this may have caused.
Narrative Review: Evaluasi Penggunaan Antibiotika Empiris pada Pasien Pneumonia Dewasa: Narrative Review: Evaluation of Empirical Antibiotic Use in Adult Pneumonia Patients Farah Nurul Hidayah; Yulistiani Yulistiani; Elza Sundhani
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 23 No. 01 Juli 2026
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pneumonia merupakan salah satu penyakit infeksi saluran pernapasan bawah yang paling sering terjadi. Pada pneumonia terjadi peradangan pada parenkim paru yang disebabkan oleh mikroorganisme. Di Indonesia, menurut Riset Kesehatan Dasar (Riskesdas) tahun 2022, terdapat 310.871 kasus pneumonia. Jumlah ini diperkirakan akan terus meningkat setiap tahun. Bakteri patogen penyebab pneumonia yang paling umum adalah Mycobacterium pneumoniae, Streptococcus pneumoniae, dan Haemophilus influenzae, sedangkan virus patogen penyebab pneumonia tersering adalah rhinovirus, virus influenza, dan virus parainfluenza. Dalam pembuatan narrative review ini, dimulai dengan melakukan proses pencarian artikel/jurnal di beberapa database seperti Scopus dan Google Scholar menggunakan kata kunci Community Pneumonia, Empirical Antibiotic, DDD, Gyssens, dan Clinical Outcome. Artikel/jurnal penelitian dipublikasikan dalam kurun waktu 5 tahun terakhir (2020-2025). Analisis kuantitatif antibiotika dengan metode ATC/DDD menunjukkan bahwa penggunaan antibiotika empiris terbesar adalah Ceftriaxone (golongan sefalosporin generasi 3), Levofloxacin (golongan fluorokinolon), dan Moxifloxacin (golongan kinolon). Analisis kualitatif antibiotika menggunakan alur Gyssens dan PPAB, di mana ketepatan pemberian antibiotika hasilnya bervariasi: ada yang persentase ketepatannya lebih besar, ada yang persentase ketepatannya lebih kecil. Semakin bertambah usia pasien, akan semakin meningkat risiko terkena penyakit pneumonia, dan penderita pneumonia dewasa didominasi oleh laki-laki. Adapun hubungan rasionalitas penggunaan antibiotika empiris dengan luaran klinis, hasilnya ada yang tidak berpengaruh pada outcome klinis dan ada hasil yang menunjukkan tingkat perbaikan klinis 70,7% lebih tinggi pada penggunaan antibiotika sesuai pedoman yang berpengaruh terhadap outcome klinis pasien.
Co-Authors Adinda Fayi Azizah Afifudin Agung Endro Nugroho Anita Purnama Sari Ardiasa Prakoso Arief Nurrochmad Azizah Yuniarti Binar Asrining Dhiani Della Caya Nur Syarifah Diniatik Dwi Hartanti Eka Fitri Adriana Endang Ayu Prihatini, Nok Endang Lukitaningsih Farah Nurul Hidayah Fifi Rahmawati Fitri, Adriana Eka Genatrika, Erza Githa Fungie Galistiani Hamidah Haryanti Rahma Ika Nurzijah Ika Ryandita Irma Amalia Irsalina Nurul Putri Joya Injelita Kautsarul Aziz Lita Ratriyana Zumrohani Much Ilham Novalisa Aji Wibowo Muhamad Rifki Ni Made Dharma Shantini Suena Nina Nurhayati Dian Utami Nunuk Aries Nurulita Nunuk Aries Nurulita Nunuk Aries Nurulita Nur Fajrina Nurjanah, Ucu Nurulita, Nunuk Aries Pri Iswati Utami Pri Iswati Utami Retnaningsih, Ririn Retno Wahyuningrum Revalina Avrillia Yulanda Rian Ulva Rizki Hasanah Rima Anggita Pratiwi Ryandita, Ika Sal Sabila Nadhifah Kurochman Septiadi, Binaripan Setyaningsih, Indah Solehah, Senja Nur Susilo, Rinto Yulistiani Yulistiani Yuniarti, Azizah Yuniarti, Azizah Yuniarti, Windi Astika Zaenal Arifin Misgi Candra Dasa Zainur Rahman Hakim