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All Journal Sebatik Jurnal Kesehatan Medika Kartika : Jurnal Kedokteran dan Kesehatan Safari : Jurnal Pengabdian Masyarakat Indonesia Ranah Research : Journal of Multidisciplinary Research and Development
Novian Budi Santoso
Kedokteran, Universitas Ciputra Surabaya
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Journal : Jurnal Kesehatan

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Penghambatan Senyawa di dalam Kopi terhadap Protein Fibronektin dan Protein Shroom: Kajian Gangguan Neurulasi Primer Secara in Silico Santoso, Novian Budi; Susanto, Susanto; Adrianto, Hebert; Kharisma, Viol Dhea
Jurnal Kesehatan Vol 13 No 2 (2022): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v13i2.2641

Abstract

Coffee drinking habits exist in Indonesian culture. Coffee as the primary source of caffeine is here the effect of embryotoxicity on paralysis, wrong brain. The brain is going on so that the body is a curiosity. Fibronectin and shroom proteins play in the primary stacking cage, which is the seasoning of the nerve roof. This study aimed to predict molecular inhibition of compounds in coffee in fibronectin protein and shroom protein in silica. The research method used samples of ligands and target proteins from the PubChem database and protein databank, then analyzed using PyRx, Discovery Studio, and PyMol software. The results of the study of literature there are five compounds in coffee. As a result of molecular docking simulation analysis, caffeine compounds (CID 2519) had lower total binding energy (-9.9 kcal/mol) in other combinations in fibronectin and shroom proteins. There are six residues of the amino acid fibronectin and 5 in shroom with caffeine. There are chemical bonds provided for caffeine compounds consisting of hydrophobic, alkyl, Van der Waals, and electrostatic. Caffeine can inhibit fibronectin and shroom protein activity and in vitro and in vivo tests to validate bioinformatics results.
Co-Authors Afifah, Balqis Bravimasta, Bracovanca Diwayestara Cindy Clara Sari Elita Halimsetiono Elizabeth Sulastri Nugraheni Etha Rambung Firmanto, Ian Ardhiya Hanna Tabita Hasianna Silitonga Hebert Adrianto Jemima Lewi Santoso Kharisma, Viol Dhea Makhrus Ali Najmul Laila Ni Njoman Juliasih Nurul Illahi Muhammad Risha Ronald Torang M Panggabean Ronald Torang Marsahala Panggabean Sayogo, William Susanto Susanto Victor Kurniawan Yuwono Victor Setiawan Tandean