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All Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan
Dilangga, Pad
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Pengaruh Pemberian Salmeterol-Flutikason Terhadap Kualitas Hidup Pasien Pasca Tuberkulosis Latief, Adhi Nugroho; Dilangga, Pad; Berawi, Khairun Nisa; Messah, Anse Diana Valentiene; Soemarwoto, Retno Ariza S.; Herdato, M. Junus Didiek; Lyanda, Apri; Kusumajati, Pusparini; Gozali, Achmad
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 6 (2025): Volume 12 Nomor 6
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i6.20152

Abstract

Pasien TB yang telah diobati kemungkinan akan tetap mengalami keluhan gejala pernapasan jangka panjang akibat komplikasi dari pasca TB yang memperburuk kualitas hidup. Penelitian Tae Hoon dkk, pemberian indakaterol inhalasi selama 8 minggu pada pasien pasca tuberkulosis yang mengalami sequele dan menyebabkan obstruksi mengalami perbaikan VEP1 sebesar 81,3mL. Tetapi belum ada penelitian yang menggunakan kombinasi bronkodilator dengan kortikosteroid pada pasien pasca tuberkulosis. Penelitian ini adalah penelitian eksperimental. Penelitian ini menggunakan metode randomized controlled trial dengan pola uji klinis tahap 2 Kohort Prospektif., untuk menganalisis pengaruh pemberian salmeterol-flutikason terhadap kualitas hidup pasien pasca tuberkulosis. Sebanyak 30 pasien pasca tuberkulosis berumur 18-85 tahun yang dipilih secara acak. Kemudian pasien akan diberikan penjelasan mengenai prosedur dan meminta inform consent dilakukan pemeriksaan dan perlakuan uji. Pasien kemudian diberikan form kuesioner untuk mengisi secara mandiri dengan panduan. Pasien ditimbang berat badan, diukur tinggi badan, dilakukan pemeriksaan saturasi oksigen, spirometri dan pemeriksaan foto toraks.  Pasien pasca tuberkulosis diberikan obat salmeterol-flutikason DPI dosis 250 mcg/50 mcg. Pasien menggunakan obat uji selama 3 bulan sebanyak 1 dosis hisapan. Setelah 3 bulan pasien akan di lakukan kembali tes jalan 6 menit, dilakukan pemeriksaan saturasi oksigen, spirometri dan pemeriksaan foto toraks. Terdapat pengaruh pemberian salmeterol-flutikason terhadap kualitas hidup pasien pasca tuberkulosis.
EVALUATION OF THE SENSITIVITY AND SPECIFITY OF THE TUBERCULOSIS SIGN AND SYMPTOM (TBSS) SCORE IN COMPARISON WITH CHEST RADIOGRAPHY AND RMT FOR DIAGNOSING TUBERCULOSIS AMONG BRICK KILN WORKERS Soemarwoto, Retno Ariza; Listiandoko, Raden Dicky; Valentiene Messah,, Anse Diana; Dilangga, Pad; Didiek Herdarto, Mohammad Junus; Hendarto, Gatot Sudiro; Febrihartati, Isura
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3076

Abstract

This cross-sectional study aimed to evaluate the sensitivity and specificity of the Tuberculosis Sign and Symptom (TBSS) score in comparison to chest radiography and the Rapid Molecular Test (RMT) among brick kiln workers. The study employed a total sampling method, involving 92 participants. Data collection was conducted from February to March 2024 in a brick kiln located in Saribumi Village, Gading Rejo District, Pringsewu Regency, Lampung Province. The majority of participants were female (77.3%), while males accounted for 22.8%. The most common age range was 41–60 years, representing 48.9% of the total sample. Regarding job categories, most workers were employed in the molding section. Screening with the TBSS score and chest radiography showed a sensitivity of 0.25, a specificity of 0.93, a positive predictive value of 0.14, and a negative predictive value of 0.96. The sensitivity and specificity of the RMT compared to the TBSS score could not be assessed as all RMT results were negative for TB. This limitation may be attributed to suboptimal sputum sample quality. The study concludes that while the TBSS score demonstrates high specificity and a strong negative predictive value, the diagnostic utility of the RMT could not be evaluated due to uniformly negative results.
The Contribution Hypoalbumin Status on Diagnosing LF-LAM TB Ag Versus Xpert MTB/Rif in Patients Pulmonary Tuberculosis Eksa, Dwi Robbiardy; Hendarto, Gatot Sudiro; Sinaga, Fransisca Tarida Yuniar; Dilangga, Pad; Herdato, M. Junus Didiek; Infianto, Andreas; Ekawati, Diyan; Gozali, Achmad; Ajipurnomo, Adhari
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3092

Abstract

In 2023, the global prevalence of tuberculosis (TB) reached 8.2 million cases. This represents the highest recorded figure associated with delayed diagnostics and a rising incidence of tuberculosis cases. Tuberculosis prevalence is elevated among individuals with compromised immune systems, including those with HIV and hypoalbuminemia, who exhibit increased vulnerability to infection. The challenge of sputum ejection impedes diagnosis, highlighting the need for a rapid and economical early detection method. The LF-LAM TB-Ag assay provides an alternative method for determining the presence of Lipoarabinomannan in urine, which is a component of the Mycobacterium tuberculosis cell wall. This study evaluated the efficacy of the LF-LAM TB-Ag assay compared to the Xpert MTB/RIF method for diagnosing tuberculosis. A comparative cross-sectional study was conducted at Abdoel Moeloek Hospital in Lampung Province, Indonesia, between January 2023 and June 2024. A total of 52 suspected pulmonary tuberculosis patients, who were HIV-negative and had hypoalbumin status, were evaluated using both the LF-LAM TB-Ag and Xpert MTB/RIF assays. The Wilcoxon and Chi-square tests have been utilised to assess the efficacy of LF-LAM TB-Ag in comparison to Xpert MTB/RIF. A p-value below 0.002 was considered statistically significant. Xpert MTB/RIF demonstrated improved diagnostic accuracy for tuberculosis in individuals with hypoalbuminemia. This study emphasises the necessity for early detection of pulmonary tuberculosis in patients with hypoalbuminemia. The combining of LF-LAM TB-Ag with Xpert MTB/RIF improves detection, especially among high-risk populations, thereby enabling prompt treatment and enhanced disease management.
Analysis of Respondent Characteristics Regarding The Severity of Community-acquired Pneumonia Patients at Dr. H. Abdul Moeloek Hospital, Lampung. Sanjaya, Rizki Putra; Herdato, M. Junus Didiek; Ajipurnomo, Adhari; Herliyana, Lina; Dilangga, Pad; Soeprihatini, Retno Ariza; Lyanda, Apri; Hendarto, Gatot Sudiro; Sinaga, Fransisca Tarida Yuniar; Kusumajati, Pusparini
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3096

Abstract

Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide, particularly among the elderly and immunocompromised patients. Various factors, including age, gender, bacterial pattern, comorbidities, and Pneumonia Severity Index (PSI) score, influence CAP severity. Understanding these characteristics is crucial for optimizing treatment strategies and predicting clinical outcomes. This descriptive-analytical cross-sectional study was conducted at Dr. H. Abdul Moeloek Hospital, Lampung, from December 2022 to January 2023. A total of 102 CAP patients were analyzed based on their age, gender, bacterial pattern, comorbidities, and PSI score. Data were processed using IBM SPSS 21.0, with Pearson correlation applied to assess relationships between variables. A statistically significant correlation was found between age and PSI score (p = 0.018), with a low-strength positive correlation (R = 0.234). This suggests that as age increases, CAP severity also increases (p = 0.011). However, no significant correlations were found between PSI score and gender, bacterial pattern, or diabetes mellitus. This study confirms that age is a significant factor influencing CAP severity, emphasizing the need for early screening and intervention in elderly patients. Although gender, bacterial pattern, and diabetes mellitus were not significantly correlated with CAP severity. 
Pengaruh Kadar Albumin Terhadap Prognosis Pada Pasien ARDS Karena Infeksi Paru Sari, Pralia Winda; Sinaga, Fransisca Tarida Yuniar; Hidayat, Hidayat; Dilangga, Pad; Herdato, M. Junus Didiek; Infianto, Andreas; Ekawati, Diyan; Ajipurnomo, Adhari; Gozali, Achmad
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 8 (2025): Volume 12 Nomor 8
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i8.20269

Abstract

Acute Respiratory Distress Syndrome (ARDS) merupakan edema paru nonkardiogenik dan suatu kasus kegawatdaruratan yang disebabkan oleh faktor risiko. Penyakit ARDS pertama kali dilaporkan sebagai serangkaian kasus dari Denver pada tahun 1967. Karakteristik ARDS antara lain terjadi pada fase akut, dengan edema alveolar, yang ditandai hipoksemia akut, serta beberapa penurunan fungsi organ. Epidemiologi ARDS sebesar 10,4% dari total pasien Intensive Care Unit (ICU) di Indonesia ARDS. Tujuan dari penelitian ini untuk mengetahui peran albumin sebagai prognosis pada pasien ARDS. Penelitian analisis observasional dengan menggunakan desain kohort prospektif, dan pengambilan data menggunakan data primer. Teknik pengambilan sampel menggunakan consecutive sampling sebanyak 39 peserta yang dirawat di RS Abdul Moeloek dengan kriteria usia lebih dari 19 tahun dan ARDS disebabkan oleh infeksi paru akibat bakteri,virus dan jamur, serta bersedia mengikuti penelitian. Penelitian dilakukan selama 1 tahun dari bulan januari sampai Desember 2023. Dari 39 sampel penelitian didapatkan sebanyak 23 orang pria dan 16 orang perempuan. Hasil penelitian menunjukkan ARDS ringan sebanyak 10 orang, ARDS sedang sebanyak 13 orang, dan ARDS berat sebanyak 16 orang. Dari 39 pasien sebanyak 82,1% memiliki nilai hipoalbuminemia. Hasil penelitian menunjukkan terdapat hubungan yang signifikan antara albumin dengan prognosis pada ARDS (p value= 0,044).
Co-Authors Ajipurnomo, Adhari Apri Lyanda Didiek Herdarto, Mohammad Junus Ekawati, Diyan Eksa, Dwi Robbiardy Febrihartati, Isura Gatot Sudiro Hendarto, Gatot Sudiro Gozali, Achmad Herdato, M. Junus Didiek Herliyana, Lina Hidayat Hidayat Infianto, Andreas Khairun Nisa Kusumajati, Pusparini Latief, Adhi Nugroho Listiandoko, Raden Dicky Messah, Anse Diana Valentiene Rizki Putra Sanjaya Sari, Pralia Winda Sinaga, Fransisca Tarida Yuniar Soemarwoto, Retno Ariza Soemarwoto, Retno Ariza S. Soeprihatini, Retno Ariza Valentiene Messah,, Anse Diana