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All Journal Buletin Farmatera Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Indonesian Journal of Health Sciences Research and Development (IJHSRD) Jurnal Kesehatan Tambusai Buletin Kedokteran dan Kesehatan Prima Eduvest - Journal of Universal Studies Journal of General Procedural Dermatology and Venereology Indonesia Jurnal Multidisiplin Indonesia
Oentari, Widyaningsih
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Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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TELANG FLOWER EXTRACT IN OBESE WHITE MALE WISTAR RAT MODEL DERMAPEN WOUND HEALING: HAIR GROWTH AND HISTOPATHOLOGICAL SKIN TISSUE CHARACTERISTICS Fransisca, Silvia; Harmila, Riva Nita; Oentari, Widyaningsih
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.24576

Abstract

Hair and skin defend against environmental hazards. Antioxidants like flavonoids and peptides in Telang flowers can improve health and treat many diseases. Telang flower extract cream (Clitoria ternatea) was tested for its effects on hair development, dermapen scar healing, and histopathology in obese male Wistar strain white rats (Rattus norvegicus). The Pharmacology and Therapy Laboratory, Department of Medicine, University of North Sumatra, conducted a true experimental research study with a post-test-only control group design from October to December 2023. The samples were 24 Wistar rats in 4 groups. Telang flower extract was given to groups 1, 2, 3, and 4 at 2.5%, 5%, and 7% per kg per body weight. Research data was handled with SPSS 25.0 for Windows. Treatment group 3 received 7% Telang flower extract and had the most hair growth. Telang flower extract at 2.5%, 5%, and 7% concentrations improves wound healing and has dense collagen. Thus, Telang flowers accelerate wound healing and hair development in fat persons.
Antibacterial activity of ashitaba leaf extract against Streptococcus pneumoniae Hutabarat, Tommy Daniel Patar P.; Suandy, Suandy; Natali, Oliviti; Djuang, Michelle Hendriani; Akbar, Khainir; Oentari, Widyaningsih; Putri, Riri Rizan; Dalimunthe, Siti Aisyah
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7824

Abstract

Infection by Streptococcus pneumoniae represents a significant global health concern, necessitating the exploration of novel antimicrobial agents, particularly in light of escalating antibiotic resistance. This study aimed to identify the phytochemical constituents and to evaluate the antibacterial activity of an ethanol extract of Ashitaba leaves (Angelica keiskei) against S. pneumoniae. This experimental study employed a post-only control group design. Extraction was performed using ethanol via maceration, followed by qualitative phytochemical screening. Antibacterial activity was assessed using the disc diffusion method at concentrations of 50, 100, and 150 mg/mL, with ciprofloxacin as a positive control. Inhibition zone data were analysed using non-parametric statistical tests. Phytochemical screening indicated the presence of flavonoids, alkaloids, saponins, tannins, glycosides, and steroids/triterpenoids. The extract demonstrated antibacterial activity with mean inhibition zones of 16.57 mm at 50 mg/mL, 26.23 mm at 100 mg/mL, and 29.87 mm at 150 mg/mL. Statistical analysis revealed no significant difference in inhibition zones among the three extract concentrations, whereas all concentrations differed significantly from the positive control, ciprofloxacin (53.67 mm). It is concluded that the ethanol extract of Ashitaba leaves contains diverse bioactive compounds and exhibits significant in vitro antibacterial activity against S. pneumoniae, although its efficacy remains inferior to the synthetic antibiotic ciprofloxacin.
Co-Authors Dalimunthe, Siti Aisyah Djohan Djohan Djuang, Michelle Hendriani Filzah, Cut Echi Razita Sabrina Fitri Puspita Fransisca, Silvia Harmila, Riva Nita Hutabarat, Tommy Daniel Patar P. Jusuf, Nelva Karmila Khainir Akbar, Khainir Lubis, Adhayani Nasution, Khairina Natali, Oliviti Nurhayati, Raja Pratama, Oky Putri, Riri Rizan Raja Siambaton, Michael Bahal Remenda Siregar, Remenda Roesyanto-Mahadi, Irma D Rudi Chandra Sari, Ari Karmila Sihombing, Fenny Theresia Suandy, Suandy Sutrisno, Angie Regina Trishna, Trishna Valensia, Valensia Yahwardiah Siregar