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All Journal Pharmaciana: Jurnal Kefarmasian Journal of Biomedicine and Translational Research PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman Indonesian Journal of Chemistry Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi JURNAL ANALIS LABORATORIUM MEDIK Pelita Masyarakat Jurnal Indah Sains dan Klinis FORTE JOURNAL Jurnal Farmanesia Jurnal Multidisiplin Madani (MUDIMA) JURNAL KIMIA SAINTEK DAN PENDIDIKAN Jurnal ABDIMAS MUTIARA Jurnal Indah Sains dan Klinis
Ahmad Hafizullah Ritonga
Institut Kesehatan Medistra Lubuk Pakam, Deli Serdang, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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EDUKASI KEPADA MASYARAKAT TENTANG POTENSI TANAMAN SEBAGAI OBAT TRADISIONAL PADA MASYARAKAT TANAH JAWA Harefa, Karnirius; Ritongga, Ahmad Hafizullah; Hestina; Sinaga, Arman Bemby
Jurnal Abdimas Mutiara Vol. 2 No. 2 (2021): JURNAL ABDIMAS MUTIARA
Publisher : Universitas Sari Mutiara Indonesia

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Abstract

Pulau Jawa merupakan salah satu penghasil produk tumbuhan obat terbesar di Indonesia. Jamu merupakan produk tumbuhan obat yang sudah lama digunakan secara tradisional di Jawa sejak masa kerajaan Hindu Budha. Oleh sebab itu, jamu sudah menjadi salah satu warisan budaya yang harus dilestarikan, khususnya bagi orang Jawa. Obat tradisional adalah bahan atau ramuan bahan yang berupa bahan tumbuhan, bahan hewan, bahan mineral, sediaan sarian (galenik) atau campuran dari bahan tersebut yang secara turun temurun telah digunakan untuk pengobatan, dan dapat diterapkan sesuai dengan norma yang berlaku di masyarakat. Tanaman Obat Keluarga (TOGA) pada hakekatnya adalah tanaman berkhasiat yang ditanam di lahan pekarangan yang dikelola oleh keluarga. Ditanam dalam rangka memenuhi keperluan keluarga akan obat-obatan tradisional yang dapat dibuat sendiri. Tujuan dari kegiatan Pengabdian kapada Masyarakat ini dilakukan untuk memberikan edukasi kepada masyarakat tentang potensi tanaman herbal pada masyarakat di sekitar Tanah Jawa sehingga mendukung animo masyarakat “bzct to nature”. Metode yang digunakan pada kegiatan ini adalah menggunakan ceramah yang sifatnya mengedukasi para peserta yang terdiri dari beberapa warga desa. Hasil pengabdian menunjukkan bahwa terjadi peningkatan pengetahuan masyarakat desa yang hadir pada saat kegiatan pengabdian tentang pemanfaatan tumbuhan sekitar sebagai obat tradisional. Hal ini terlihat dari kemampuan para peserta untuk menjawab pertanyaan dari tim pelaksana. Kesimpulan Pengabdian kepada Masyarakat ini adalah kegiatan edukasi ini telah terlaksana sesuai pelaksanaan dan rencana, mendapat sambutan yang baik dari pemerintah setempat dan masyarakat sekitar, sehingga masyarakat di Tanah Jawa, Kabupaten Simalungun, Sumatera Utara mendapatkan informasi.
Controlled release kinetics of furosemide from chitosan matrix tablets with hydroxypropyl methylcellulose phthalate coated Samran, Samran; Suprianto, Suprianto; Sumardi, Sumardi; Ritonga, Ahmad Hafizullah; Kusumastuti, Melati Yulia
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28097

Abstract

Sustained-release dosage forms were critical in drug delivery, ensuring controlled and prolonged release for optimal therapeutic outcomes. Chitosan (CH) has become pivotal in sustained-release tablet formulation due to its biocompatibility and mucoadhesive properties. This study aims to explore the release kinetics of furosemide (FS) from CH matrix tablets in a concurrent medium. The formulation involves a core tablet and coated tablet, with CH matrix as a binder and Hydroxypropyl Methyl Cellulose Phthalate (HPMCP) as a film-coated for the core tablet, and both are made using the wet granulation method. Assessment parameters include tablet hardness, disintegration, and FS release profiles across various media, analyzed using spectrophotometric methods to comprehend drug release kinetics with multiple models such as zero-order, first-order, Higuchi, and Korsmeyer-Peppas employed. In the press-coated tablet comprising core tablet CH as matrix uncoated with 20 mg CH per tablet core, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h, which displayed first-order release kinetics within 2-6 h and 6-16 h in concurrent media of pH 5.8 and 7.4. Notably, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h. Press-coated tablets incorporating CH matrix with HPCMP coated (CH-HPCMP), also containing 20 mg CH per tablet, exhibited diverse drug release kinetics. These tablets showed Korsmeyer-Peppas, zero-order, and first-order kinetics in pH 1.2, 5.8, and 7.4, respectively. The study suggests that a Press-coated tablet incorporating CH-HPMCP is suitable as the candidate for sustained-release formulations. The observed versatility in release kinetics across varying pH environments underscores the potential adaptability of these formulations in addressing diverse therapeutic needs.
Pembuatan Sabun Padat Antiseptik Ekstrak Etanol Kulit Jeruk Lemon (Citrus limon (L.) Burm. f.) Eka Margareth; Nova Florentina; Barita Aritonang; Ahmad Hafizullah
Jurnal Indah Sains dan Klinis Vol 2 No 3 (2021): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v2i3.34

Abstract

One of the herbal plants with antibacterial properties that it can use in solid antiseptic soap is lemon peel (Citrus limon (L.) Burm.F.). This study aims to determine the optimum composition of antiseptic solid soap preparations from the ethanolic extract of lemon peel based on the requirements set by SNI 06-4085-1996 and the antibacterial activity test. The antibacterial activity test was carried out by the good method. Examination of Simplicia characteristics was carried out by phytochemical screening test. The antiseptic solid soap preparation was performed by organoleptic test, pH test, homogeneity test, high foam test, and antibacterial activity test. The concentration variations of antiseptic solid soap preparations were F1(5%), F2(10%), and F3(15%). Based on the results of research that has been carried out, the results of phytochemical screening tests for lemon peels (Citrus limon (L.) Burm.F.) contain secondary metabolites, namely alkaloids, flavonoids, and triterpenoids that function as antibacterial. Antiseptic solid soap made from ethanolic extract of lemon peel has met the requirements set by SNI 06-4085-1996, namely a solid and homogeneous soap with a lemon scent with a pH of 8.71-10.52, high foam 4.7-4.9 cm, as well as free alkali in a safe condition against the skin. Based on the results of the antibacterial activity test of solid antiseptic soap, the ethanolic extract of lemon peel (Citrus limon (L.) Burm.F.) can inhibit the growth of Staphylococcus aureus bacteria. At a concentration of F1(5%) has a zone of moderate inhibition of 10.26 mm; at concentration F2(10%) has a strong inhibition zone of 11.78 mm; at the concentration of F3(15%) has a strong inhibition zone of 12.57 mm. Lemon peel extract can be formulated into a solid antiseptic soap with an optimum concentration of F3 (15%).
Purification of used Cooking Oil using a Combination of Activated Carbon and Bentonite Adsorbents Aritonang, Barita; Ritonga, Ahmad Hafizullah; Harefa, Karnirius; Wiratma, Dicky Yuswardi; Herlina
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2331

Abstract

The repeated use of cooking oil at high temperatures can significantly degrade its quality, as indicated by darkened color, unpleasant odor, elevated peroxide value (PV), and free fatty acid (FFA) levels. This deterioration can contribute to health risks such as obesity, high cholesterol, heart disease, and cancer. This study investigated the effectiveness of combined activated carbon and bentonite adsorbent in reducing peroxide value and free fatty acid levels in used cooking oil. The purification method involved an adsorption process using a combination of activated carbon derived from mangosteen peel waste and bentonite. The carbonization process was carried out at 600°C for 3 hours, followed by chemical activation with H?PO? at varying concentrations of 1M, 3M, and 5M. Bentonite was activated using 5M HCl. The results demonstrated that 5 grams of activated carbon from mangosteen peel, treated with 5M H?PO?, and bentonite activated with 5M HCl, were highly effective in lowering the peroxide value and free fatty acid levels in used cooking oil. Initially, the PV of the untreated used cooking oil was 16 meq O?/kg, reduced to 3.6 meq O?/kg after treatment with the combined adsorbents. Similarly, the FFA content decreased from 2.2% to 0.09%. Both peroxide value and free fatty acid levels met the standards set by SNI 3741:2013. In conclusion, using activated carbon and bentonite is an efficient method for purifying used cooking oil, as their strong adsorption capacity effectively reduces peroxide value and free fatty acid levels.
UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN GEDI (Abelmoschus manihot L.) TERHADAP MENCIT PUTIH JANTAN (Mus musculus) Ulda Andriani Sijabat; Ahmad Hafizullah Ritonga; Hasni Yaturramadhan Harahap
FORTE JOURNAL Vol 4 No 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i2.913

Abstract

Peradangan adalah respons biologis tubuh terhadap cedera atau infeksi, sementara daun gedi (Abelmoschus manihot L.) diketahui memiliki berbagai manfaat kesehatan, termasuk potensi antiinflamasi. Hal ini menjadikannya subjek penelitian dalam evaluasi aktivitas antiinflamasi terhadap mencit putih jantan (Mus musculus). Penelitian ini bertujuan untuk mengetahui adanya pengaruh ekstrak etanol daun gedi (Abelmoschus manihot L.) sebagaiiantiinflamasi yang diujikan pada mencit putih jantan. Metode yang digunakan pada penelitian ini yaitu udem buatan pada salah satu telapak kaki mencit yang diinduksi menggunakan karagenan 1%. Pengujian antiinflamasi ekstrak etanol daun gedi menggunakan 24 ekor mencit putih jantan yang dibagi dalam 6 kelompok perlakuan. Kelompok perlakuan tersebut terdiri dari kelompok normal yang tidak diberikan perlakuan apapun, kelompok kontrol positif yang diberikan natrium diklofenak, kelompok kontrol negatif yang diberi   perlakuan Na-CMC 1%, dan 3 kelompok ekstrak yang diberikan ekstrak etanol daun gedi dengan      konsentrasi 2%, 4% dan 6%. Persen radang pada keenam kelompok uji tersebut mengalami penurunan udem secara terus menerus yang dimulai sejak jam ke-1 sampai jam ke-6 setelah di induksi karagenan. Persen radang terbesar terjadi pada jam ke-1 pada kelompok suspensi Na-CMC kemudian diikuti oleh kelompok dengan konsentrasi 2%, 4%, 6%  dan natrium diklofenak. Persen inhibisi radang terbesar     dimiliki oleh kelompok natrium diklofenak kemudian di ikuti oleh kelompok ekstrak dengan konsentrasi 6%, 4%, dan 2%. Dapat disimpulkan bahwa persen inhibisi yang baik    terdapat pada EEDG konsentrasi 6% setelah natrium diklofenak kemudian diikuti EEDG konsentrasi 4% dan 2%. Hal ini menunjukan bahwa kelompok natrium diklofenak, EEDG konsentrasi 2%, 4%, 6% memiliki potensi sebagai agen antiinflamasi.
FORMULASI SEDIAAN LIP TINT BERBASIS EKSTRAK KULIT BAWANG DAYAK (Eleutherine bulbosa Mill. Urb) SEBAGAI PEWARNA ALAMI Hasni Yaturramadhan Harahap; Shofian Syarifuddin; Ahmad Hafizullah Ritonga; Herlina Herlina; Rizqa Hafizhah Harahap
FORTE JOURNAL Vol 5 No 1 (2025): Edisi Januari 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v5i1.1176

Abstract

Salah satu sediaan kosmetik yang digemari oleh wanita adalah pewarna bibir yaitu Liptint . Lip tint merupakan jenis lipstik yang memiliki bentuk yang berbeda dari umumnya, yakni dalam bentuk cairan. Tujuan penelitian yaitu  Formulasi  sediaan liptint dari ekstrak kulit bawang dayak (Eleutherine Bulbosa Mill.Urb) sebagai pewarna alami. Metode penelitian ini yaitu  eksperimental dengan pembuatan ekstrak , pembuatan formulasi sediaan dan pemriksaan mutu fisik sediaan seperti uji organoleptis , uji homegenitas , uji pH , uji daya oles , uji iritasi , uji kesukaan dengan konsentrasi bervariasi yaitu 5%, 10%, 15%. Hasil uji organoleptis pada warna menunjukkan bahwa pada F1 menghasilkan warna merah cerah, F2 menghasilkan warna merah pekat dan F3 menghasilkan warna merah kecoklatan , memiliki tektur yang lembut warna yang bagus dan memiliki aroma (tuttyfruity Assence) . Uji Homogenitas menunjukan hasil liptint yang homogen, daya oles yang baik, ph F1 (5) , F2 (5) , F3 (6), uji iritasi lip tint menunjukkan tidak adanya reaksi iritasi pada panelis, uji kesukaan menyatakan bahwa formulasi lip tint yang paling disukai adalah F3. Kesimpulan bahwa Formulasi lip tint yang paling disukai oleh panelis adalah F2 (10%) ditinjau dari tekstur, warna dan aroma.
ANTIBACTERIAL ACTIVITY OF TARO LEAVES EXTRACTCOMBINED WITH ZnO AND ORGANO-ZnO AGAINST Staphylococcus aureus Ahmad Hafizullah Ritonga; Imel Santika; Hasni Yaturramadhan Harahap; Barita Aritonang
FORTE JOURNAL Vol 5 No 1 (2025): Edisi Januari 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v5i1.1197

Abstract

Staphylococcus aureus is a pathogenic bacterium commonly associated with serious human infections, leading to various health complications. Zinc oxide (ZnO) is well known for its antibacterial properties, while Organo-ZnO, a modified form of ZnO incorporating organic compounds, exhibits even stronger antibacterial potential. Due to their therapeutic properties, Taro leaves (Colocasia esculenta L.) have a long history of traditional use for treating various ailments, including burns and boils. This study aims to identify the active compounds in taro leaves that function as antibacterial agents and to evaluate the combined antibacterial activity of taro leaf extract with ZnO and Organo-ZnO against Staphylococcus aureus. The research was conducted as a laboratory experiment. Phytochemical screening revealed that the taro leaf extract contains alkaloids, flavonoids, tannins, and saponins, which may contribute to its antibacterial effects. Antibacterial activity tests against Staphylococcus aureus showed inhibition zones of 8.5 mm for taro leaf extract, 8.8 mm for 5% ZnO, and 10 mm for 5% Organo-ZnO. The combination of taro leaf extract with 5% ZnO resulted in an inhibition zone of 9.1 mm, while the combination with 5% Organo-ZnO exhibited the highest inhibition zone of 10.7 mm. These results suggest that the ethanol extract of taro leaves possesses significant antibacterial activity against Staphylococcus aureus, and its effectiveness is further enhanced when combined with ZnO and Organo-ZnO. The combination with Organo-ZnO demonstrates the greatest antibacterial potential, indicating its promise for further development in antibacterial applications.
DETERMINANT FACTORS ASSOCIATED WITH DISCIPLINE AND WORK MOTIVATION OF OFFICERS HEALTH AT PUSKESMAS PLUS PERBAUNGAN SERDANG BEDAGAI DISTRICT Lely Masnita; Ahmad Hafizullah R; Novita Br Ginting
JURNAL KESMAS DAN GIZI (JKG) Vol. 6 No. 1 (2023): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jkg.v6i1.1884

Abstract

The problem with the low coverage of health services at puskesmas is partly due to the low performance of health workers who are not yet optimal. This is due to low motivation and discipline of health workers. Based on initial observations of several health workers at the Plus Perbaungan Health Center, it was found that there were problems with the discipline and work motivation of health workers. The purpose of this study was to determine the relationship between the determinant factors (goals and abilities, sanctions, achievement, recognition and responsibility) with the discipline and work motivation of health workers at the Health Center Plus Perbaungan. The research design used in this research is an analytical survey using a cross sectional study approach. The population of this study was all 78 health workers with a sample using a total sampling technique of 78 people. Data collection methods are primary data, secondary and tertiary data. The data analysis used was univariate and bivariate analysis using the chi-square statistical test. And what will happen in the study shows that there is a relationship between goals and abilities with a p value (0.000), sanctions p (0.000), firmness p (0.000) and recognition p (0.000) with discipline and work motivation, while achievement p (0.683) and responsibility p (0.577) have no relationship with discipline and work motivation. The conclusion of this study is that there is a relationship between goals and abilities, punishment, firmness and recognition with discipline and motivation, while achievement and responsibility have no relationship with discipline and work motivation in health workers.
EDUKASI KEPADA MASYARAT KANDUNGAN MERKURI PADA IKAN TUNA KEMASAN KALENG Silalahi, Yosy Cinthya Eriwaty; Hafizullah Ritonga, Ahmad; Adiansyah, Adiansyah
Jurnal Abdimas Mutiara Vol. 1 No. 1 (2020): JURNAL ABDIMAS MUTIARA
Publisher : Universitas Sari Mutiara Indonesia

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Abstract

Ikan tuna merupakan salah satu komoditas perikanan Indonesia yang potensial, terbesar kedua setelah udang. Kebutuhan dasar manusia terdiri dari kebutuhan primer, sekunder dan tersier. Kebutuhan yang terpenting untuk berlangsung hidup adalah kebutuhan primer, salah satunya adalah kebutuhan pangan. Merkuri merupakan logam berat yang dapat memberikan efektoksik pada tubuh sehingga dapat menyebabkan kematian. Tujuan dari kegiatan pengabdian masyarakat ini dilakukan untuk memberikan informasi dan edukasi kepada masyarakat kandungan merkuri pada ikan tuna kemasan kaleng. Hasil kegiatan pelaksanaan program pengabdian masyarakat dalam bentuk penyuluhan kepada masyarakat adanya kandungan merkuri pada ikan tuna kemasan kaleng. Selama ini masyarakat mengkonsumsi ikan tuna kemasan kaleng tanpa mengetahui kandungan merkuri yang terdapat didalamnya. Merkuri dapat memberikan efektoksik pada tubuh sehingga dapat menyebabkan kematian. Sehingga masyarakat mengetahui kandungan merkuri pada ikan tuna kemasan kaleng sehingga dapat menjaga kesehatan. Kesimpulan bahwa penyuluhan terlaksana sesuai pelaksanaan dan rencana, mendapat sambutan yang baik dari pemerintah setempat Desa Rambung Kecamatan Sibolangit Kabupaten Deli Serdang, Sumatra Utara, masyarakat sekitar mendapatkan informasi serta pengetahuan dan menerapkan informasi tersebut bagi keluarga.
Co-Authors Adiansyah Adiansyah Adiansyah, Adiansyah Ahmad Ghazali Ardiansyah Ardiansyah Aritonang, Barita Ariyanti Ariska Arniat Christian Telaumbanu Barito Aritonang Barus, Ester Julianti Karolina Boy Isfa Boy isfa Debi Meilani Denny Akbar Tanjung Denny Akbar Tanjung Denny Akbar Tanjung Dicky Yuswardi Wiratma Eka Margareta Sinaga Eka Margareth Eliza Arman Hasni Yaturramadhan Harahap Hendri Faisal Herlina Herlina H Herlina Herlina Hermansyah Aziz Hestina Ida Ayu Putu Sri Widnyani Imel Santika Irmayani Irmayani Jenny Ria Sihombing Karnirius Harefa Kesaktian Manurung Khairiah, Khairiah Kusumastuti, Melati Yulia Lely Masnita Liver Iman Putra Zai Maniur Arianto Melinda Sela Nengsi Handayanti Gaho Nova Florentina Nova Florentina Ambarwati Novesar Jamarun Novita Br Ginting Putri, Gusliani Eka Rahmad Gurusinga Rahmi Novita Yusuf Rima Anggeraini Rizqa Hafizhah Harahap Salomo Sijabat Samran, Samran Shofian Syarifuddin Siahaan, Enzo W.B Siahaan, Maniur Arianto Sinaga, Arman Bemby Sri Wulan, Sri Suarnikan Hulu Sumardi . Suprianto Suprianto Syukri Arief Ulda Andriani Sijabat Ulfayani Mayasari Wiya Elsa Fitri Yosy Cinthya Eriwaty Silalahi Yosy Cinthya Eriwaty Silalahi Yulidar Laila Safitri Zuhairiah Nasution, Zuhairiah