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All Journal Pharmaciana: Jurnal Kefarmasian Journal of Biomedicine and Translational Research PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman Indonesian Journal of Chemistry Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi JURNAL ANALIS LABORATORIUM MEDIK Pelita Masyarakat Jurnal Indah Sains dan Klinis FORTE JOURNAL Jurnal Farmanesia Jurnal Multidisiplin Madani (MUDIMA) JURNAL KIMIA SAINTEK DAN PENDIDIKAN Jurnal ABDIMAS MUTIARA Jurnal Indah Sains dan Klinis
Ahmad Hafizullah Ritonga
Institut Kesehatan Medistra Lubuk Pakam, Deli Serdang, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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PEMANFAATAN LIMBAH KULIT NENAS DAN AMPAS TEBU SEBAGAI BAHAN DASAR DALAM PEMBUATAN KERTAS MENGGUNAKAN BAHAN PENGIKAT PATI LIMBAH KULIT PISANG KEPOK Barita Aritonang; Ahmad Hafizullah Ritonga; Eka Margareth Sinaga
JURNAL KIMIA SAINTEK DAN PENDIDIKAN Vol 3 No 2 (2019): Volume 3 Nomor 2 Tahun 2019
Publisher : Program Studi Kimia - Universitas Sari Mutiara Indonesia

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Abstract

This article explains about utilization pineapple leather waste and sugarcane bagasse as a basic material in manufacturing of paper using binder of starch kepok banana leather waste. The research objective is to determine the optimal composition manufacturing of paper from pineapple leather waste and sugarcane bagase with a variation of 80:20% and 70:30% using the alkalization separation method. Based on the results of research that has been carried out, the optimal composition between pineapple leather waste and sugarcane bagasse is 80:20%. The temperature and heating time, and the optimum NaOH concentration is 110 oC for 80 min with sodium hydroxide solution concentration of 2.5%, a pulp content of 74.26%, cellulose content of 84.18%, lignin content of 15.82% and a moisture content of 2.2%. All levels obtained have met the requirements of SNI 14-0444-1989 test for cellulose content, SNI 14-0492-1989 test for lignin content, and SNI 287: 2010 test for moisture content. Based on FT-IR spectrum analysis, pineapple leather waste and sugarcane bagasse are can be used as raw material for manufacturing of paper because of cellulose. This is indicated by the appearance of hydroxyl groups, pineapple leather and sugarcane bagasse which were observed at wave number 3320 cm-1. which shows the presence of cellulose. Based on SEM analysis, it shows that the surface structure of the morphology is getting tighter, it proves that the diameter of the resulting fiber is very small, because the smaller the diameter of the fiber, the better the mechanical properties. Based on the results of grammatical tests, the effect of sodium hydroxide solution concentration and starch binder can improve the mechanical properties, such as tensile index, crack resistance, and tear index. Pineapple leather waste and sugarcane baggase can be used as an alternative raw material to replace wood in manufacturing of paper.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN INSULIN (Smallanthussonchifolius) TERHADAP BAKTERI Bacillus cereus Kesaktian Manurung; Ahmad Ghazali; Ahmad Hafizullah; Ulfayani Mayasari
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Insulin leaves are known as one of the ingredients of traditional medicine. Insulin leaves contain potential substances such as tannins, alkaloids, flavonoids, saponins, and terpenoids which have antibacterial abilities. This study aims to determine the effectiveness of insulin leaf ethanol extract as an antibacterial. This research is an experimental study that includes the collection and processing of insulin leaf samples, examination of the characteristics of Simplisia, phytochemical screening, testing of the antibacterial diffusion method using a disk paper brace, and using the One Way ANOVA analysis method. The test results showed that the ethanol extract could inhibit bacterial growth at a concentration of 50 - 60% with an average resistor potential of 14.8 - 17.83 mm while Ampicillin as a comparison control averaged 33.62 mm. So that the ethanol extract of insulin leaves was effective in inhibiting the growth of Bacillus cereus bacteria with a minimum resistance concentration of 60 mg/ml. Keywords: Antibacterial, Bacillus cereus, insulin leaf extract
UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN BANGUN-BANGUN (Plectranthus amboinicus Lour.) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN Zuhairiah Zuhairiah; Yosy Cinthya Eriwaty Silalahi; Ahmad Hafizullah; Ariyanti Ariska
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Bangun-Bangun leaves contain phytochemical compounds such as phenolic compounds and flavonoids which have potential as antioxidant activity. This study aims to determine the antidiabetic activity of the ethanolic extract of Bangun-Bangun leaves on reducing blood glucose levels (KGD) of male white rats by using the glucose tolerance test method and the alloxan induction test. The study was conducted by grouping rats where each group consisted of 5 rats, the fasting KGD was measured. Then, a group I was given Na-CMC 1% BW, group II was given glibenclamide 0.45 mg/kg BW, group III was given EEDBB at a dose of 200 mg/kg BW, group IV was given EEDBB at a dose of 250 mg/kg BW and group V was given EEDBB dose of 300 mg/kg BW. In the glucose tolerance test, each group was given a 50% concentration of glucose solution. Furthermore, measurements of KGD were carried out at 30, 60, 90, and 120 minutes. In alloxan induction, 25 test animals weighing ±150-200 g that had been fasted were divided into 5 groups and then KGD was measured. The rats were then induced with a dose of 150 mg/kg BW of alloxan intraperitoneally. Diabetic rats were then given the test preparation orally for 15 consecutive days. Furthermore, glucose levels were measured on the 3rd, 5th, 7th, 9th, 11th, 13th, and 15th days. The results concluded that EEDBB can reduce blood glucose levels of male white rats induced by alloxan.
PENGARUH BAHAN PENGISI ORGANO-PRECIPITATED CALCIUM CARBONATE DALAM CAMPURAN PLA/LLDPE DENGAN ADANYA KOMPATIBILISER DITINJAU DARI SIFAT MEKANIK DAN FISIK Melinda Sela; Ahmad Hafizullah Ritonga
PROSIDING SEMINAR KIMIA Vol 1 No 1 (2022): Prosiding SNK 2022
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

The poor compatibility between Polylactic Acid (PLA) and Linear Low-Density Polyethylene (LLDPE), which has a different polarity, has decreased its mechanical and physical properties. Availability of Linear Low-Density Polyethylene grafting Oleic Acid (LLDPE-g-OA) compatibilizer and Organo-Precipitated Calcium Carbonate (O-PCC) filler in the PLA/LLDPE blends can improve the quality of the mechanical and physical properties of the polymer blends. This study aims to determine the influence of O-PCC as filler in the PLA/LLDPE blends with the existence of the LLDPE-g-AO compatibilizer to improve its mechanical and physical properties and compare the results with Precipitated Calcium Carbonate (PCC) filler. This polymer composite was made via a blending method with a solvent system, where PLA was dissolved in chloroform while LLDPE and LLDPE-g-AO were dissolved in xylene. After they were dissolved, glycerol 1% was added, followed by the addition of O-PCC variations. This research shows that the higher the filler concentration, the lower the water absorption percentage, where the optimum results are obtained for the PLA/LLDPE/LLDPE-g-AO/O-PCC composites variation of (69.5:19.5:10). :1) with a tensile strength of 22.629 MPa with a water absorption percentage of 45.36%. Keywords: PLA, LLDPE, LLDPE-g-AO, O-PCC, Glycerol
EFEKTIVITAS KOMPATIBILISER LLDPE-g-AO DALAM CAMPURAN POLI ASAM LAKTAT (PLA)/LINEAR LOW-DENSITY POLYETHYLENE (LLDPE) TERHADAP SIFAT FISIS DAN MEKANIS Nengsi Handayanti Gaho; Ahmad Hafizullah Ritonga
PROSIDING SEMINAR KIMIA Vol 1 No 1 (2022): Prosiding SNK 2022
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Semi-biodegradable plastic is an alternative that is currently being developed in order to reduce environmental pollution due to excessive use of commercial plastics and produce plastics that have physical and mechanical capabilities that are almost the same (not much different) with commercial plastics. However, the problem that arises is the low compatibility of mixtures with different polarities on the physical and mechanical strength of semi-biodegradable plastics. This study aims to determine the effectiveness of the addition of a linear low-density polyethylene grafting oleic acid (LLDPE-g-AO) compatibility to a mixture of poly lactic acid (PLA) and linear low-density polyethylene (LLDPE) in terms of physical and mechanical properties tests. The mixing of PLA and LLDPE was carried out through a blending method with a solvent system, where PLA used chloroform, LLDPE and the LLDPE-g-AO compatibilizer used xylene, which was followed by the addition of 1% glycerol in the mixing of the two resulting solutions. The results of this study indicate that the addition of LLDPE-g-AO effectively resulted in an increase in the mechanical strength and water absorption of the PLA/LLDPE mixture. The results of testing the mechanical properties of the most optimum tensile strength is the mixture of PLA/LLDPE/LLDPE-g-AO (70:22.5:7.5) which is 3.8078 MPa with the results of the physical properties test for absorption of 3.66 %. Keywords: PLA, LLDPE, LLDPE-g-AO, tensile strength, water adsorption
Improvement of Mechanical, Thermal, and Morphological Properties of Organo-Precipitated Calcium Carbonate Filled LLDPE/Cyclic Natural Rubber Composites Ahmad Hafizullah Ritonga; Novesar Jamarun; Syukri Arief; Hermansyah Aziz; Denny Akbar Tanjung; Boy Isfa
Indonesian Journal of Chemistry Vol 22, No 1 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.68888

Abstract

This study investigates the improvement of the mechanical, thermal, and morphological properties of linear low-density polyethylene (LLDPE)/cyclic natural rubber (CNR) after the addition of organo-precipitated calcium carbonate (O-PCC). The impact on the properties of the LLDPE/CNR/LLDPE-g-OA/O-PCC composites was investigated by a series of empirical experiments. First, the polymer composite was blended in the molten state using an internal mixer with a heating temperature of 160 °C and a rotation speed of 100 rpm. The LLDPE was placed in a chamber of internal mixer until melted, followed by CNR, LLDPE-g-OA, and O-PCC. The polymer composites with an O-PCC concentration of 5% obtained the optimal mechanical properties compared to other variations, with a tensile strength of 17.17 MPa and Young's modulus of 252.68 MPa. The presence of O-PCC resulted in better thermal stability and a change in the melting point temperature of 124 °C. The FTIR spectra of the polymer composite showed the specific characteristics of O-PCC at 872.1 cm–1. The morphology of the polymer composite indicates that the O-PCC is evenly dispersed in the polymer composite.
The Green Approach of Cerium Oxide Nanoparticle and Its Application for Photo-degradation of Phenol Dye Gusliani Eka Putri; Syukri Arief; Ahmad Hafizullah Ritonga; Wiya Elsa Fitri; Eliza Arman; Arniat Christian Telaumbanu; Rahmi Novita Yusuf
Indonesian Journal of Chemistry Vol 23, No 6 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.81657

Abstract

The approach to the synthesis of cerium oxide nanoparticles (CeO2NPs) using plants as capping agents has been widely researched because of its eco-friendly, low-cost, simple, effective, and reusability. In this research, we used Moringa oleifera leaf extract-mediated CeO2NPs. CeO2NPs were characterized by XRD, FTIR, SEM, TEM, and DRS UV-vis. The photocatalytic activity of CeO2NPs was tested using a phenol dye concentration of 7 mg/L with variations in photocatalyst weight of 10, 20, 30, 40, 50, 60, 70, 80, 90, and 100 mg under UV irradiation, respectively, with time variations of 15, 30, 45, 60, 75, 90, 105, 120, 135, and 150 min. SEM and TEM morphology results showed that the CeO2NPs were spherical and agglomerated. The crystal structure is cubic, with a crystal size of 18 nm with a band gap of 2.87 eV. CeO2NPs showed high photo-degradation phenol dye of 94.45% under visible light in 120 min irradiation time. The results show that M. oleifera leaf extract could be as inexpensive and safe for synthesizing other metal oxide nanoparticles, potentially having applications in the biomedical and environmental fields.
PLA/LLDPE/Organo-Precipitated Calcium Carbonate Composites Containing LLDPE-g-OA Compatibilizers: Mechanical, Physical, Thermal, and Morphology Ahmad Hafizullah Ritonga; Barita Aritonang; Gusliani Eka Putri; Khairiah Khairiah; Enzo Wiranta Battra Siahaan; Debi Meilani
Indonesian Journal of Chemistry Vol 23, No 6 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.86983

Abstract

A plastic composite consisting of polylactic acid (PLA), linear low-density polyethylene (LLDPE), oleic acid-grafted linear low-density polyethylene (LLDPE-g-OA) compatibilizer, and organo-precipitated calcium carbonate (O-PCC) have been successfully made in the molten state. This study aims to characterize the mechanical, physical, thermal, and morphological characteristics of the PLA/LLDPE/O-PCC plastic composite in the presence of an LLDPE-g-OA compatibilizer. The plastic composite was prepared by blending PLA, LLDPE, LLDPE-g-OA, and O-PCC using an internal mixer with a heating of 160 °C and a rotation of 100 rpm. LLDPE and LLDPE-g-OA are put together into the inner mixer chamber until melted, followed by PLA and O-PCC. The most optimum plastic composite composition is PLA/LLDPE/LLDPE-g-g-OA/O-PCC (67.5:22.5:5:5). The mechanical properties showed an increase in tensile strength of 9.78 MPa. The physical properties showed that the minimum water absorption was 0.74%, the biodegradation in humus soil showed a degradation rate of 0.09% per day, and the thermal properties showed better stability with a melting point of 146.5 °C. The FTIR spectrum is similar to the polymer blend without O-PCC. The morphology indicates that the composite is compatible and homogeneous. This semi-biodegradable plastic composite has significant implications for reducing the accumulation of plastic waste in the environment.
Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Sikkam (Bischofia javanica Blume) dan Precipitated Calcium Carbonate (PCC) terhadap Mencit (Mus musculus) Barus, Ester Julianti Karolina; Ritonga, Ahmad Hafizullah; Herlina, Herlina
Jurnal Dunia Farmasi Vol 8, No 3 (2024): Edisi Agustus
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v8i3.6125

Abstract

Pendahuluan: Pengobatan inflamasi umumnya melibatkan penggunaan obat antiinflamasi golongan steroid maupun non-steroid. Namun, obat antiinflamasi non-steroid seringkali menimbulkan efek samping berupa iritasi lambung. Oleh karena itu, diperlukan pengembangan terapi inflamasi alternatif yang lebih aman, salah satunya dengan menggunakan ekstrak etanol daun sikkam (Bischofia javanica Blume) dan Precipitated Calcium Carbonate (PCC) yang berpotensi sebagai antiinflamasi. Tujuan: Penelitian ini bertujuan untuk mengevaluasi potensi antiinflamasi ekstrak etanol daun sikkam dan PCC pada mencit (Mus musculus). Metode: Hewan uji diinjeksi dengan karagenan 1% untuk menginduksi inflamasi, lalu diobati dengan Na-CMC 1%, diklofenak, EEDS (0.5 g, 1.0 g, 1.5 g), PCC (0.5 g, 1.0 g, 1.5 g), dan kombinasi EEDS dan PCC (0.25 g, 0.5 g, 0.75 g). Persen inflamasi dan persen inhibisi inflamasi diukur setiap jam selama 6 jam. Data aktivitas antiinflamasi dianalisis menggunakan uji Kolmogorov-Smirnov untuk memastikan distribusi normal. Data yang terdistribusi normal dan homogen (p 0,05) kemudian dianalisis dengan uji ANOVA satu arah dengan α sebesar 0,05, diikuti oleh uji Tukey sebagai post hoc. Hasil: Semua kelompok perlakuan menunjukkan efek antiinflamasi dari jam pertama hingga jam keenam. Kombinasi EEDS dan PCC menunjukkan efek antiinflamasi yang lebih kuat dibandingkan dengan Na-CMC. Kesimpulan: Ekstrak etanol daun sikkam (Bischofia javanica Blume) dan Precipitated Calcium Carbonate (PCC) memiliki potensi sebagai agen antiinflamasi yang efektif pada mencit.
The Impact of Butterfly Pea Flower (Clitoria ternatea L.) Extract on Atherosclerosis Biomarker Profiles in Obese White Rats (Rattus norvegicus L.) Harefa, Karnirius; Ritonga, Ahmad Hafizullah; Aritonang, Barita; Gurusinga, Rahmad; Wulan, Sri; Irmayani, Irmayani
Journal of Biomedicine and Translational Research Vol 10, No 1 (2024): April 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i1.20281

Abstract

 Background: Clitoria ternatea L., commonly known as butterfly pea flower, has gained attention as a potential agent in the prevention and treatment of atherosclerosis due to its rich content of bioactive compounds, such as anthocyanin, a type of flavonoid renowned for its potent antioxidant and anti-inflammatory properties, along with its ability to enhance the immune system.Objective: This study aimed to elucidate the positive impact of butterfly pea flower extract on atherosclerosis biomarker profiles.Methods: The approach framework used in this research is a true experimental laboratory with a Control Group Post-Test design. Obese male white rats were selected as the research subjects. Thirty-six obese white rats were randomly divided into six groups using the Completely Randomized Design (CRD) method. The data collected were VCAM and IL-6 levels from the blood serum of obese white rats tested using an ELISA photometer. The tunica intima thickness was measured using a microscope. Data were analyzed employing SPSS 18 software, utilizing one-way ANOVA statistical tests and post hoc Tukey tests.Results: The research showed that with the increase in Butterfly Flower Extract (BPFE) dose, there was a consistently lower level of inflammatory biomarkers, such as VCAM-1 and IL-6, compared to positive controls and other variations, as well as tunica intima thickness was thinning than others. A dose of 600 mg/kg BW (P3 group) had VCAM-1 levels up to 30.40 ± 6.71 ng/mL, IL-6 levels up to 17.70 ± 8.29 ng/mL, and tunica intima thickness up to 3.18 ± 1.24 µm.Conclusion: BPFE effectively lowers inflammatory biomarkers and thins the tunica intima thickness in obese white rats at 600 mg/kg BW dose. It may offer promising therapeutic potential in addressing atherosclerosis. 
Co-Authors Adiansyah Adiansyah Adiansyah, Adiansyah Ahmad Ghazali Ardiansyah Ardiansyah Aritonang, Barita Ariyanti Ariska Arniat Christian Telaumbanu Barito Aritonang Barus, Ester Julianti Karolina Boy Isfa Boy isfa Debi Meilani Denny Akbar Tanjung Denny Akbar Tanjung Denny Akbar Tanjung Dicky Yuswardi Wiratma Eka Margareta Sinaga Eka Margareth Eliza Arman Hasni Yaturramadhan Harahap Hendri Faisal Herlina Herlina H Herlina Herlina Hermansyah Aziz Hestina Ida Ayu Putu Sri Widnyani Imel Santika Irmayani Irmayani Jenny Ria Sihombing Karnirius Harefa Kesaktian Manurung Khairiah, Khairiah Kusumastuti, Melati Yulia Lely Masnita Liver Iman Putra Zai Maniur Arianto Melinda Sela Nengsi Handayanti Gaho Nova Florentina Nova Florentina Ambarwati Novesar Jamarun Novita Br Ginting Putri, Gusliani Eka Rahmad Gurusinga Rahmi Novita Yusuf Rima Anggeraini Rizqa Hafizhah Harahap Salomo Sijabat Samran, Samran Shofian Syarifuddin Siahaan, Enzo W.B Siahaan, Maniur Arianto Sinaga, Arman Bemby Sri Wulan, Sri Suarnikan Hulu Sumardi . Suprianto Suprianto Syukri Arief Ulda Andriani Sijabat Ulfayani Mayasari Wiya Elsa Fitri Yosy Cinthya Eriwaty Silalahi Yosy Cinthya Eriwaty Silalahi Yulidar Laila Safitri Zuhairiah Nasution, Zuhairiah