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All Journal Medical Laboratory Technology Journal Jaringan Laboratorium Medis Tropical Health and Medical Research Journal Jurnal Rakat Sehat : Pengabdian Kepada Masyarakat Jurnal Karya Generasi Sehat
Ratih Dewi Dwiyanti, Ratih Dewi
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Pengaruh Lama Penyimpanan Jamu Beras Kencur terhadap Pertumbuhan Kapang Pinto Laksono, Fransiskus Xaverius Agung; Dwiyanti, Ratih Dewi; Rifqoh, Rifqoh; Insana, Aima
Jaringan Laboratorium Medis Vol. 4 No. 2 (2022): November 2022
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v4i2.8571

Abstract

During the Covid-19 pandemic, people began to maintain their health, by using herbal medicine as an alternative treatment. One type of herbal medicine used is jamu beras kencur because it has properties to increase stamina, increase appetite, and relieve aches and cough disorders. In the Regulation of the Minister of Health of the Republic of Indonesia No. 007 of 2012 carrying herbs such as jamu beras kencur does not require marketing authorization. The quality of the herbal medicine produced has not been confirmed as feasible from microbial contamination, especially in molds, the number of yeast molds in the jamu beras kencur must comply with BPOM standards Number 32 of 2019 namely AKK <103 colonies/mL. This study aimed to determine the effect of the storage time of jamu beras kencur on mold growth with storage treatments of 0 hours, 4 hours, 8 hours, 12 hours, and 24 hours at room temperature. This type of research is a Quasi Experiment with a research design of One Group Pretest-Postest Design. The results of this study showed that the average AKK value was 0 hours 0.2x100 colonies/mL, 4 hours 0.4x100 colonies/mL, 8 hours 0.4x100 colonies/mL. 12 hours 0.8x100 colonies/mL and 24 hours 2.2x100 colonies/mL. These results stated that the jamu beras kencur met the BPOM standard requirements Number 32 of 2019 which was AKK <103 Colonies/mL. The results of the Kruskal Wallis test obtained a sig value of 0.286, it was concluded that there was no effect of storage time for the jamu beras kencur on the growth of molds. The identification results on the jamu beras kencur obtained fungal species, namely Aspergillus flavus, Aspergillus niger, and Penicillium sp. Suggestions for further researchers can examine the effect of storage time on mold growth in other types of herbal medicine.
Antithrombotic Activity and Hemolysis Pattern of Fibrinolytic Protease-Producing Bacterial Isolates from the Coast of Tanjung Dewa, South Kalimantan Lutpiatina, Leka; Dwiyanti, Ratih Dewi; Insana, Aima; Rizal, Muhammad; Mufid, Muhammad
Medical Laboratory Technology Journal Vol. 11 No. 2 (2025): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i2.689

Abstract

Cardiovascular disease is a leading cause of death worldwide, with thrombosis playing a key role in the pathological process. Conventional antithrombotic therapy often causes side effects, necessitating alternatives based on biological resources. Marine microorganisms are known to produce fibrinolytic protease enzymes that can degrade fibrin and prevent blood clot formation. This study aimed to evaluate the differences in antithrombotic activity and hemolysis patterns of fibrinolytic protease-producing bacterial isolates obtained from the coast of Tanjung Dewa Beach, South Kalimantan. A total of 15 isolates were obtained from seawater, beach sand, mollusks, crabs, and barnacles, and then subjected to colony morphology identification, Gram staining, and spore observation. Proteolytic activity testing using Skim Milk Agar media showed that all isolates had proteolytic activity with varying indices, with PSR1 showing the highest index (3.4). Furthermore, fibrinolytic testing using the fibrin plate assay method showed that 10 isolates were capable of degrading fibrin, with AL8 and SP2 showing the highest fibrinolytic indices (3.12 and 3.11, respectively). Antithrombotic testing using the clot lysis method revealed that AL7 and SP1 exhibited the highest lysis percentages (82.05% and 88.88%, respectively). Anticoagulant activity, as determined by the Lee-White method, showed that SP2 significantly prolonged the coagulation time (142 seconds, 49.65%). Hemolysis pattern testing revealed variations in activity, with AL8 and PSR1 classified as gamma-hemolytic and therefore potentially safer. Statistical analysis showed no significant differences between isolates in terms of antithrombotic activity, anticoagulant activity, or hemolysis pattern (p > 0.05). These findings suggest that coastal bacterial isolates from Tanjung Dewa Beach, particularly AL8 and SP2, have the potential to serve as safe, natural antithrombotic agents, supporting the development of biomedical therapies for cardiovascular disease.
The Role of Biological and Environmental Factors in Infant Pneumonia: Findings from the 2023 Indonesian Health Survey Lutpiatina, Leka; Dwiyanti, Ratih Dewi; Insana, Aima
Tropical Health and Medical Research Vol. 8 No. 1 (2026): Tropical Health and Medical Research
Publisher : Baiman Bauntung Batuah Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35916/thmr.v8i1.150

Abstract

Pneumonia continues to be a leading cause of morbidity and mortality in infants, particularly in developing countries, making risk factor analysis crucial to support evidence-based prevention efforts. This study analyzed factors associated with pneumonia in 28,610 infants aged one year and under using data from the 2023 Indonesian Health Survey to provide a national overview of the distribution of cases and their determinants. This study used a cross-sectional design and analyzed demographic variables, health characteristics, and environmental factors using descriptive analysis, chi-square tests, and odds ratios. The study results showed a pneumonia prevalence of 0.9%, with an increased risk in low birth weight infants (OR 2.425; 95% CI: 1.688–3.483) and infants with a history of diarrhea (OR 2.051; 95% CI: 1.211–3.475), while breastfeeding reduced the risk of pneumonia (OR 0.590; 95% CI: 0.447–0.778). The data also showed greater susceptibility among male infants and those living in urban areas. These findings confirm that pneumonia in infants is influenced by a combination of biological, environmental, and behavioral factors, so public health interventions need to strengthen monitoring of at-risk infants, increase the coverage and quality of breastfeeding, prevent diarrhea, and control exposure to air pollution, especially in urban areas. These findings provide an empirical basis for developing more targeted and effective infant health policies.
Monocyte, Lymphocyte, and Monocyte–Lymphocyte Ratio Responses to Treatment Phases in Pulmonary Tuberculosis Patients Restu, Nurul Hidayathul Mahpudinah; Lutpiatina, Leka; Muhlisin, Ahmad; Dwiyanti, Ratih Dewi
Tropical Health and Medical Research Vol. 8 No. 1 (2026): Tropical Health and Medical Research
Publisher : Baiman Bauntung Batuah Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35916/thmr.v8i1.151

Abstract

Pulmonary tuberculosis is a chronic infectious disease that affects the balance of innate and adaptive immune responses, reflected in changes in hematological parameters, particularly monocyte and lymphocyte counts, and the monocyte-lymphocyte ratio (MLR). This study aimed to analyze differences in lymphocyte and monocyte counts and MLR values ??in pulmonary tuberculosis patients based on treatment phase. This cross-sectional analytical survey study involved 60 pulmonary tuberculosis patients divided into 0-month treatment groups, the intensive phase, and the continuation phase in Loa Kulu District from January to April 2025. Peripheral blood smears were stained with Giemsa to determine the percentage of lymphocytes and monocytes, and then the MLR value was calculated. Statistical analysis using one-way ANOVA showed significant differences in lymphocyte and monocyte counts between treatment groups (p<0.05). The mean lymphocyte count increased with treatment duration, while the mean monocyte count decreased, resulting in a decrease in the MLR value from 0.64 in the pre-treatment group to 0.29 in the intensive phase and 0.22 in the continuation phase. The decrease in MLR reflects an improved immune response balance and decreased systemic inflammation during tuberculosis therapy. The results of this study indicate that MLR demonstrated variation across treatment phases, suggesting its potential relevance in the clinical assessment of TB patients.
Co-Authors Ahmad Muhlisin Aisya Nahdiya Anggraini, Agnina Listya Anny Thuraidah, Anny Azmi, Dini Aulia fahani, Ayu Hafidh, Muhammad haitami haitami, haitami Insana, Aima Ipniliati, Eva leka lutpiatina, leka Mufid, Muhammad MUHAMMAD RIZAL Neni Oktiyani, Neni Nurlailah Nurlailah, Nurlailah Nurul Huda Pinto Laksono, Fransiskus Xaverius Agung Pratama, Haris Nurdin Restu, Nurul Hidayathul Mahpudinah Rifqoh Rifqoh, Rifqoh Rizkiyah, Risa Sa'adah, Sa'adah Sutiany, Ayu Sya’adah, Nurul Laili Ulfah, Putriana Yuli Susanti