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Irwandi Irwandi
Fakultas Farmasi, Universitas Pendidikan Muhammadiyah Sorong, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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UJI DAYA HAMBAT EKSTRAK DAUN PUCUK MERAH (S.OLEANA) TERHADAP PERTUMBUHAN BAKTERI STAPHYLOCOCCUS AUREUS Sri Wahyuni; Irwandi Irwandi; Angga Bayu Budiyanto
Jurnal Kesehatan Tambusai Vol. 7 No. 2 (2026): JUNI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i2.59324

Abstract

Infeksi adalah kondisi penyakit, disebabkan oleh bakteri patogen. Penggunaan senyawa antibakteri berperan penting dalam menghambat pertumbuhan bakteri dan banyak dimanfaatkan dalam penanganan infeksi bakteri. Penelitian ini dilakukan untuk mengidentifikasi kandungan senyawa metabolit sekunder pada yang tanaman daun pucuk merah (Syzgium.oleana), menguji aktivitas antibakteri terhadap bakteri staphylococcus aureus. Metode yang digunakan adalah difusi cakram (disk diffusion) dengan variasi konsentrasi esktrak 10%, 15%, dan 20%. Hasil analisis menunjukkan bahwa daun pucuk merah (S.oleana) mengandung senyawa metabolit sekunder berupa alkaloid, flavonoid, tanin dan saponin. Aktivitas antibakteri ditunjukkan melalui terbentuknya zona hambat pada masing-masing konsentrasi yaitu 7,05 mm (10%), 5,22 mm (15%), dan 9,98 mm (20%) dengan kategori daya hambat sedang.  Berdasarkan hasil penelitian dapat disimpulkan bahwa daun pucuk merah memiliki kandungan metabolit sekunder dan berpotensi sebagai agen antibakteri terhadap bakteri S.aureus, meskipun peningkatan konsentrasi tidak menunjukkan peningkatan aktivitas yang bersifat linear.
Pengaruh Perbedaan Metode Ekstraksi Terhadap Kadar Total Flavonoid dan Alkaloid Bonggol Buah Merah (Pandanus conoideus L.) Innal Saitis; A.M. Muslihin; Lukman Hardia; Angga Bayu Budiyanto; Irwandi Irwandi; Marzella Dea Rossardy; Wahyuni Watora; Justitia Cahyani Fadli; Wiwit Ayu Fitrianti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1666

Abstract

Background: Red fruit (Pandanus conoideus L.) is an endemic plant of Papua that has been traditionally used to treat various diseases. Its biological activities are associated with the presence of secondary metabolites, particularly flavonoids and alkaloids. Objective: This study aimed to identify the secondary metabolites and evaluate the effect of different extraction methods on the total flavonoid and alkaloid contents of ethanolic extracts of red fruit (Pandanus conoideus L.) stem core. Methods: Extraction was performed using three different methods, namely maceration, Soxhlet extraction, and reflux extraction with ethanol as the solvent. Secondary metabolites were identified qualitatively, while total flavonoid and alkaloid contents were determined spectrophotometrically. Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, terpenoids, steroids, and tannins in the ethanolic extract of red fruit stem core. The total flavonoid contents obtained by maceration, Soxhlet extraction, and reflux extraction were 218.966 mgQE/g (21.89%), 104.023 mgQE/g (10.40%), and 247.701 mgQE/g (24.77%), respectively. The total alkaloid contents obtained by maceration, Soxhlet extraction, and reflux extraction were 145.770 mgAE/g (14.58%), 65.767 mgAE/g (6.58%), and 76.433 mgAE/g (7.64%), respectively. Conclusion: The extraction method affected the total flavonoid and alkaloid contents obtained from the sample. Reflux extraction produced the highest total flavonoid content (247.701 mgQE/g), whereas maceration produced the highest total alkaloid content (145.770 mgAE/g). Therefore, reflux was the most effective method for flavonoid extraction, while maceration was the most effective method for alkaloid extraction from the stem core of red fruit (Pandanus conoideus L.).
Aktivitas Ekstrak Batang Akar Laka (Dalbergia parviflora Roxb.) Terhadap Pertumbuhan Jamur Trichophyton rubrum Amran Rexana Djumaty; Irwandi Irwandi; A.M. Muslihin
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1590

Abstract

Akar laka (Dalbergia parviflora Roxb.) is a traditional medicinal plant used by communities in North Maluku to treat various types of wounds and skin conditions; however, scientific research on the antifungal activity of this plant’s stem is still limited. This study aims to identify the content of secondary metabolites and evaluate the antifungal activity of akar laka stem extract against the growth of Trichophyton rubrum in vitro. This is a laboratory experimental study conducted using the maceration method with 95% ethanol as a solvent to obtain a concentrated extract, followed by phytochemical screening to identify the classes of secondary metabolites. Antifungal activity testing was performed using the disk diffusion method with extract concentrations of 5%, 10%, and 15%, with ketoconazole used as the positive control and aqua pro injection as the negative control. The results showed that from 200 grams of crude drug, 43 grams of concentrated extract were obtained with a yield of 21.5%. Phytochemical screening results indicated the presence of alkaloids, saponins, and tannins, while flavonoids were not detected. In the antifungal activity test, the extract did not form an inhibition zone at any of the tested concentrations against T. rubrum, whereas the positive control exhibited a very strong inhibition zone of 26.7 mm. Based on the research results, it can be concluded that the extract of the akar laka stem (D. parviflora Roxb.) contains several secondary metabolites but did not exhibit antifungal activity against T. rubrum at the tested concentrations.
Studi Fitokimia Senyawa Aktif Ekstrak Batang Nelambo suon (Rubiaceae) Marzella Dea Rossardy; A.M. Muslihin; Wahyuni Watora; Angga Bayu Budiyanto; Lukman Hardia; Irwandi Irwandi; Alyssa Mileta Aponno; Hikmahtul Putri Utami
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1333

Abstract

Background: Papua has high biodiversity with significant potential as a source of traditional medicinal plants, including Nelambo suon (Rubiaceae), which has been empirically used by local communities. However, scientific information regarding the active compounds in its stem bark remains limited. Objective: This study aimed to identify the secondary metabolite groups present in the ethanol extract of Nelambo suon stem bark through phytochemical screening. Methods: The research was conducted experimentally using the maceration method with 80% ethanol as the solvent. The stem bark simplicia was extracted and qualitatively screened for alkaloids, flavonoids, tannins, and saponins using specific reagents. Results: The results showed that the ethanol extract of Nelambo suon stem bark contained alkaloids, flavonoids, tannins, and saponins, indicated by characteristic color changes, precipitate formation, and foam production. Conclusion: These findings suggest that Nelambo suon stem bark is a potential source of bioactive compounds and may be further developed as a herbal medicinal material based on local wisdom.
Co-Authors A. M. Muslihin Alyssa Mileta Aponno Amran Rexana Djumaty Angga Bayu Budianto Angga Bayu Budiyanto Angga Bayu Budiyanto Angga Bayu Budiyanto Arum Pramitha Sari Astuti, Ratih Arum Dika Rahayu Eva Maya Sari Fadhillah Eka Rahmadani Fitriani Faidatul Hikmah Gabriela Reyna Rumi Heti Aisyah Hikmahtul Putri Utami Innal Saitis Justitia Cahyani Fadli Kris Theisalexander Taran Levina Virginia Hermawan Lukman Hardia Mahmud Sulthon Khoiruzaman Marzella Dea Rossardy Meliani Meliani Muh Ishar Difinubun Muh. Dahlan Wael Muhammad Andy Irfan Muhammad Raihan Bagaskara Nazla Wati Sanaky Rasi Fitri Yanti Tuasikal Ratih Arum Astuti Sri Wahyuni Syahrul H Fabanyo Vivid Wantari Wahyuni Watora Waode Nurwahida Windi Nur Fadilah Wiwik Triyani Wiwik Wiwit Ayu Fitrianti Yusnita La Goa