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All Journal Padjadjaran Journal of Dentistry Jurnal Abdimas Kartika Wijayakusuma Journal of Health and Dental Sciences NuCSJo : Nusantara Community Service Journal World Health Digital Journal (wolgitj)
Henri Hartman, Henri
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Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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THE EFFECT OF ORAL RAMBUTAN HONEY ON ALKALINE PHOSPHATASE ACTIVITY IN DENTAL SOCKET WOUNDS HEALING PROCESS (IN VIVO) Khairunnisa, Zahra; Reni Yuslianti, Euis; Hartman, Henri
Journal of Health and Dental Sciences Vol. 5 No. 3 (2026): Journal of Health and Dental Sciences
Publisher : Fakultas Kedokteran Gigi Unjani

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Abstract

Tooth extraction is a procedure that causes injury to the dental socket, requiring a proper healing process. Rambutan honey contains flavonoids and calcium, which have been reported to accelerate wound healing by increasing alkaline phosphatase (ALP) activity in blood serum. This study aimed to analyze the effect of oral rambutan honey on ALP activity during dental socket wound healing. This laboratory experimental study involved 20 rabbits that underwent lower right incisor extraction. The subjects were divided into five groups: negative control, positive control, and three treatment groups. The positive control group received 255 mg of calcium, while the treatment groups were administered rambutan honey at doses of 0.7 mL (treatment 1), 1.4 mL (treatment 2), and 2.1 mL (treatment 3). Observations were conducted on days 0, 7, 14, and 40 to assess ALP activity levels. Data analysis was performed using ANOVA followed by the Post Hoc Tukey test, while the Kruskal-Wallis test was followed by the Mann-Whitney test. The results showed that oral administration of rambutan honey significantly increased ALP activity on days 7, 14, and 40 (p < 0.05). Among the tested doses, 0.7 mL was the most effective, as it promoted a rise in ALP activity within normal physiological limits. Oral rambutan honey has a significant impact on enhancing ALP activity during dental socket wound healing, suggesting its potential as a natural therapeutic agent for post-extraction recovery. DOI : 10.54052/jhds.v5n3.p243-252
Co-Authors Adinugraha, Irham M. Arifianti, Isti Arlette Suzy Puspa Pertiwi Djohan, Frita FS. El Fitriyah, Rhabiah El Fitriyah, Rhabial Euis Reni Yuslianti, Euis Fathonah, Dea Isny Irawan, Zidhan Isnaeni, Rheni S. Isryad, Widya Jakobus Runkat, Jakobus Khaerunnisa, Rahmadaniah Khairunnisa, Zahra Maskoen, Ani Melanie Putra Kusaeri, Ramadhani Putri Gunawan, Alvaezra Putri Noer Fadilah, Rina Rahaju, Asih Roosje Rosita Oewen, Roosje Rosita Saskia L. Nasroen, Saskia L. Sulaksana, Sutrania Dewi Suntana, Mutiara S. Trisusanti, Ratna Yetty Herdiyati, Yetty Yuslianti, Euis Reni Yuwaka, Sridewi Anggrainy Zwista Yulia Dewi, Zwista Yulia