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NATURAL PRODUCTS PHARMACEUTICAL STANDARDIZATION TOWARDS PHYTOPHARMACA FOR INDONESIAN TRADITIONAL MEDICINE DEVELOPMENT: STANDARDISASI FARMASITIKAL BAHAN ALAM MENUJU FITOFARMAKA UNTUK PENGEMBANGAN OBAT TRADISIONAL INDONESIA Yuslianti, Euis Reni; Bachtiar, Boy M; Suniarti, Dewi Fatma; Sutjiatmo, Afifah B
Dentika: Dental Journal Vol. 19 No. 2 (2016): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.925 KB) | DOI: 10.32734/dentika.v19i2.463

Abstract

There is a tendency back to nature treatment in Indonesian community because modern/synthetic medicines is expensive and have a various alarming side effects. That is why natural products medicine becomes more popular, aside from mass media promotions. Researches on natural products such as herbal medicine increases along with the desire to get phytofarmaca that can compete with modern medicines. The aims of this literature review are to discuss and provides information on pharmaceutical standardization of natural products toward phytopharmaca for developing Indonesian traditional medicine. Pharmaceutical standardization will strengthen the basic of pharmaceutical science in producing safe, efficacy, and qualify traditional medicine products. The pharmaceutical standardization consists of standardizing simplicial quality, safety, efficacy, and stable formulation of medicines for use in health services.
Uji toksisitas akut disclosing solutions buah naga super merah (Hylocereus costaricensis) freeze dry: studi eksperimental Yuslianti, Euis Reni; Dewi, Zwista Yulia; Al-wasi, Dimas Mohamad
Padjadjaran Journal of Dental Researchers and Students Vol 8, No 1 (2024): Februari 2024
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v8i1.53195

Abstract

ABSTRAKPendahuluan: Buah naga super merah memiliki kandungan zat besi, vitamin C, Vitamin B1, B2, B12, dan pigmen warna betasianin serta karoten. Betasianin dan karoten berpotensi untuk digunakan sebagai zat pewarna plak alami (disclosing solution), namun penggunaan disclosing solution buah naga super merah belum terbukti aman. Tujuan dari penelitian ini untuk mengetahui keamanan disclosing solution alami buah naga super merah freeze dry  melalui uji toksisitas akut. Metode: Metode penelitian ini adalah laboratorium eksperimental dengan menggunakan subjek penelitian hewan coba 48 ekor mencit jantan dan betina. Terdapat empat kelompok perlakuan yaitu kelompok negatif, kelompok pemberian dosis 1250 mg/kgBB, 2500 mg/kgBB, dan 5000 mg/kgBB. Uji toksisitas akut ini mengamati kematian, perubahan berat badan, perubahan perilaku, dan berat organ relatif pada mencit. Data dianalisis dengan menggunakan uji one way ANOVA apabila (p>0,05) dan uji Kruskal Wallis untuk data (p<0,05). Hasil: Disclosing solution buah naga super merah tidak menyebabkan kematian dan efek toksik pada mencit, tidak terdapat perbedaan bermakna pada perubahan berat badan dan perilaku mencit, serta terdapat perbedaan yang bermakna pada indeks organ jantan meliputi organ jantung, paru, ginjal dan limfa. Simpulan: Penggunaan bahan disclosing solution buah naga super merah freeze dry pada mencit aman dan tidak toksik berdasarkan hasil uji toksisitas akut.KATA KUNCI Disclosing solutions, buah naga super merah, uji toksisitas akut.Acute toxicity test of freeze dry super red dragon fruit (Hylocereus costaricensis) disclosing solutions: study experimental ABSTRACTIntroduction: Super red dragon fruit contains iron, vitamin C, Vitamin B1, B2, B12, and the color pigments betasianin and carotene. Betasianin and carotene have potential as natural plaque coloring agents (disclosing solution). The safety of the disclosing solutions made of super red dragon fruit has not been proven yet. The purpose of this study was to determine the safety of disclosing solutions agents made of freeze dried super red dragon fruit, through acute toxicity tests. Methods: This research method is an experimental laboratory using animals, with 48 male and female mice each. There are four treatment groups, namely the negative group, the group giving doses of 1250 mg/kgBW, 2500 mg/kgBW, and 5000 mg/kgBW. This acute toxicity test observed mortality, weight change, behavior change, and relative organ weight in mice. Data were analyzed using one way ANOVA test if (p>0.05) and Kruskal Wallis test for data (p<0.05). Results: The disclosing solution of super red dragon fruit did not cause death and toxic effects on mice, there were no significant differences in changes in body weight and behavior of mice, and there were significant differences in male organ indices including heart, lung, kidney and lymph organs. Conclusion: The administration of the disclosing solutions made of super red dragon fruit freeze dried in mice is safe and non-toxic based on acute toxicity tests.KEY WORDS: Disclosing solutions, super red dragon fruit, acute toxicity test. 
Differences in the use of super red dragon fruit extract and disclosing solution on plaque index using the HI BOGI application: cross-sectional study Fadillah, Rina Putri Noer; Rahmani, Hasna Fasya; Yuslianti, Euis Reni; Pribadi, Ari Prayogo
Padjadjaran Journal of Dental Researchers and Students Vol 8, No 1 (2024): Februari 2024
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v8i1.51176

Abstract

ABSTRACT Introduction: Oral health has an important role in a person's health, however, low public awareness of dental and oral health causes high cases of dental and oral disease in Indonesia, one of which is plaque buildup and caries. Plaque index assessment can be a measuring tool for dental and oral hygiene, namely Patient Hygiene Performance (PHP) by giving a disclosing solution which can stain dental plaque. Disclosing solution, a current synthetic chemical, has an unpleasant taste, sometimes causing allergic reactions, and has the potential to be carcinogenic, so alternatives are needed. Among alternatives of natural materials which can be used is dragon fruit juice, as it has natural anthocyanin content and can help color the plaque. The aim of this research was to determine differences in using synthetic disclosing solution and dragon fruit juice on plaque index using the Halo Indonesia with Dentists (HI BOGI) application. Methods: This type of research was cross-sectional. Technique Cluster random sampling used in this research involved 84 junior high school students in Cimahi (a city in West Java). Results: This research showed that the PHP index through the HI BOGI application obtained a greater average plaque index value when using disclosing solution, namely 1.437, compared to dragon fruit juice, namely 0.907, with p value = 0.000 (significance atp<0,05). Conclusion: There are significant differences between plaque index measurements using synthetic disclosing solution and red dragon fruit juice using the HI BOGI application for junior high school students in Cimahi.KEYWORDS: index place,disclosing solution, dragon fruit juice, HI BOGI.Perbedaan indeks plak memakai ekstrak buah naga dan disclosing solution dengan menggunakan aplikasi HI BOGI: studi cross-sectionalABSTRAKPendahuluan: Kesehatan mulut memiliki peranan penting dalam kesehatan seseorang, namun rendahnya kesadaran masyarakat akan kesehatan gigi dan mulut menyebabkan tingginya kasus penyakit gigi dan mulut di Indonesia, salah satunya penumpukan plak dan menimbulkan karies. Penilaian indeks plak dapat menjadi alat ukur kebersihan gigi dan mulut, salah satunya adalah Patient Hygiene Performance (PHP) dengan pemberian disclosing solution yang mampu mewarnai plak gigi. Disclosing solution kimia sintetis saat ini memiliki rasa yang kurang enak, kadang menimbulkan reaksi alergi, serta berpotensi karsinogenik sehingga diperlukan alternatif pengganti. Di antara alternatif bahan alam yang dapat digunakan adalah sari buah naga, dengan adanya kandungan alami antosianin dan dapat membantu mewarnai plak. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan penggunaan disclosing solution sintetis dan sari buah naga terhadap indeks plak dengan menggunakan aplikasi Halo Indonesia Bersama Dokter Gigi (HI BOGI). Metode: Jenis penelitian ini adalah cross-sectional. Teknik cluster random sampling digunakan dalam penelitian ini dengan melibatkan siswa/i SMP di Kota Cimahi sebanyak 84 orang. Hasil: Penelitian ini menunjukkan indeks PHP melalui aplikasi HI BOGI didapat nilai rerata indeks plak pada menggunakan disclosing solution lebih besar yaitu 1,437 dibanding sari buah naga yaitu 0,907, dengan nilai p  = 0,000 (signifikasi pada p<0,05). Simpulan: Terdapat perbedaan yang signifikan antara pengukuran indeks plak menggunakan disclosing solution sintesis dan sari buah naga merah dengan memakai aplikasi HI BOGI pada siswa/i SMP di Kota Cimahi.KATA KUNCI: Indeks plak, disclosing solution, sari buah naga, HI BOGI.
Potential of Rambutan-Honey Antioxidants in Reducing Malondialdehyde Levels and Regenerating Hepatocyte Cells in Isoniazid-Rats Induced Yuslianti, Euis Reni; Ratwita, Welly; Koswara, Teja; Afra, Aldilla
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 1 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i1.7713

Abstract

Hepatotoxicity induced by prolonged administration of antituberculosis drugs such as isoniazid (INH) is associated with the production of free radicals. Rambutan-honey, rich in catalase enzyme, flavonoids, and vitamin C, exhibits antioxidant and immunomodulatory properties. This study purpose to assess the effect of rambutan-honey on malondialdehyde (MDA) levels and hepatocyte cell numbers in INH-induced rats. The research method using in vivo experimental study with a randomized posttest-only control group design. Thirty Wistar rats were divided into five groups: negative control(G1), positive control(G2), and three groups treated with rambutan-honey at doses of 250 mg/kgBW(G3), 500 mg/kgBW(G4), and 1000 mg/kgBW(G5). MDA levels were measured using the TBARS method on days 15 and 23, while hepatocyte cell numbers were assessed through histopathological examination using Hematoxylin-Eosin. Data were analyzed using One-Way ANOVA followed by Post-Hoc test. This study revealed that rambutan-honey at doses of 250, 500, and 1000 mg/kgBW significantly reduced MDA levels compared to controls, with a simultaneous increase in hepatocyte cell numbers (p=0.001). The conclusion of this research is the potential of rambutan-honey as an antioxidant and hepatoprotective agent, possibly mediated by its flavonoid content, which may stimulate superoxide dismutase activity akin to catalase enzyme and vitamin C.
EFFECT OF FREEZE-DRIED SUPER RED DRAGON FRUIT ANTHOCYANIN DISCLOSING SOLUTION ON DENTAL PLAQUE INDEX Yuslianti, Euis Reni; Faramayuda, Fahrauk; Nurhalizah, Dinda Siti
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20392

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Background: Accumulation of dental plaque can cause of dental and oral health problems such as caries and periodontitis. Dental plaque is colorless so it is difficult to see visually. Super red dragon fruit can be an alternative disclosing solution because it contains. Objectives: The purpose of this research was to determine the content and the effect of anthocyanin disclosing solution freeze dry super red dragon fruit on dental plaque index. Methods: This research is a type of the Experimental Laboratory and Quasi Experimental design research with post-test control group design method. Thirty samples were used and there were three treatment groups: the application of aquadest, super red dragon fruit disclosing solution, and synthetic disclosing solution. Super red dragon fruit freeze dry was tested for antioxidants and tested total anthocyanin levels using the pH difference method at Unjani Pharmaceutical Laboratory. Research on plaque index examination was carried out in the Integrated Dentistry Laboratory Unjani. Dental plaque index assessment is measured using PHPI (Patient Hygiene Performance Index) method. Data were analyzed using Kruskall Wallis and Mann-Whitney tests (p<0.05). Results: The results showed an anthocyanin content of 9.0764 mg/100 g and a significant difference in the anthocyanin disclosing solution freeze dry treatment of super red dragon fruit on the dental plaque index with a value of p = 0.000. Conclusion: In conclusion this research indicates that the freeze-dried super red dragon fruit disclosing solution contains anthocyanin and has an effect on the dental plaque index. This shows the potential of anthocyanin disclosing solution freeze dry super red dragon fruit can be used to detect and control dental plaque, but further research is needed to determine the length of time attached to anthocyanin disclosing solution super red dragon fruit to the tooth surface
Penyuluhan Antioksidan dari Tumbuhan untuk Kesehatan Pada Masyarakat Kampung Adat Cireundeu Kota Cimahi Juliastuti, Henny; Yuslianti, Euis Reni; Rakhmat, Iis Inayati; Handayani, Dewi Ratih; Faramayudha, Fahrauk; Riyanti, Soraya; Syam, Akhirul Kahfi; Rahaju, Asih; Suntana, Mutiara Sukma; Sabirin, Indah Puti R.; Khaerunnisa, Rahmadaniah; Adinugraha, Irham M.
Jurnal Abdimas Kartika Wijayakusuma Vol 5 No 2 (2024): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v5i2.385

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Pengabdian masyarakat ini bertujuan untuk memberikan pengetahuan tentang manfaat antioksidan dari tumbuhan untuk meningkatkan kesadaran akan pentingnya kesehatan di kalangan masyarakat Kampung Adat Cireundeu, Kota Cimahi. Metode pengabdian masyarakat dilakukan melalui kegiatan penyuluhan yang melibatkan warga kampung untuk memahami konsep antioksidan, sumber alami dari tumbuhan yang kaya akan senyawa antioksidan, serta manfaatnya bagi kesehatan tubuh. Kegiatan penyuluhan ini mencakup ceramah, demonstrasi, dan sesi tanya jawab guna meningkatkan pemahaman masyarakat akan cara-cara sederhana dalam memanfaatkan tumbuhan sekitar sebagai sumber antioksidan. Hasil evaluasi menunjukkan peningkatan pengetahuan dan kesadaran masyarakat akan pentingnya mengonsumsi antioksidan dari buah, bunga, daun, batang, dan akar tumbuhan untuk menjaga kesehatan. Sebanyak 46 masyarakat Kampung Cireundeu mengisi pretes diakhiri dengan evaluasi yaitu mengisi postes untuk alat ukur sederhana mengevaluasi pemahaman masyarakat tentang tanaman antioksidan. Masyarakat yang terlibat mengikuti kegiatan dengan antusias dan berdasarkan postes menunjukkan nilai pemahaman terhadap materi yang diberikan sangat baik. Melalui pengabdian masyarakat ini, masyarakat diharapkan dapat menerapkan pengetahuan yang didapat untuk memperbaiki pola hidup sehat dengan memanfaatkan sumber daya alam yang tersedia di sekitarnya sebagai antioksidan. Hasil kegiatan menunjukkan terjadinya peningkatan pemahaman masyarakat terhadap manfaat antioksidan dari tumbuhan untuk kesehatan, sehingga diharapkan dapat berkontribusi pada peningkatan kesejahteraan masyarakat Kampung Adat Cireundeu, Kota Cimahi.
Pemeriksaan dan Penyuluhan Kesehatan Gigi Siswa SMA Muhamadiyah dan SMK PGRI Kota Cimahi Yuslianti, Euis Reni; Herawati, Hillda; Suntana, Mutiara Sukma; Puteri NF, Rina; Ulum, Bahrul
Jurnal Abdimas Kartika Wijayakusuma Vol 5 No 2 (2024): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v5i2.420

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Pengetahuan tentang kesehatan gigi di siswa sekolah sangat penting untuk menunjang kesehatan tubuh. Oleh karena itu perlu dilakukan satu upaya pencegahan untuk meningkatkan pengetahuan kesehatan gigi di SMA Muhammadiyah dan SMK PGRI Kota Cimahi. Pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan siswa SMA Muhammadiyah dan SMK PGRI mengenai kesehatan gigi. Metode pengabdian masyarakat menggunakan pemeriksaan kesehatan gigi mulut dan penyuluhan kepada 360 siswa melalui metode visual menggunakan power point dan video. Hasil pelaksanaan pengabdian masyarakat berupa hasil pemeriksaan kesehatan dan video materi kesehatan gigi yang diunggah di kanal youtube Fakultas Kedokteran Gigi Universitas Jenderal Achmad Yani Cimahi agar bisa diputar ulang dan dilihat siswa sekolah serta masyarakat luas. Berdasarkan hasil evaluasi menunjukkan bahwa program berjalan dengan lancar dan respon anak sekolah dan pihak sekolah sangat baik.
Effect of 20% ethanol extract of Subang pineapple gel on oral mucosa incisional wound length Sabirin, Indah Puti Rahmayani; Polii, Amanda Debora; Khaerunnisa, Rahmadaniah; Yuslianti, Euis Reni; Kristiana, Ris
Padjadjaran Journal of Dentistry Vol 34, No 3 (2022): November 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol34no3.36615

Abstract

ABSTRACTIntroduction: Incisional wound in oral mucosa is usually performed during oral surgery but can also be caused by injury. Although wounds can naturally heal, the application of medicine might help accelerate wound healing. Proving the effectiveness of natural ingredients is currently being promoted because Indonesia owns many plants that are used empirically. The use of natural substances is also supported because it is relatively easy to obtain and safe if used properly. Subang Pineapple (Ananas comosus L. Merr) is one of the produce of West Java that people consume and empirically use on wounds. Its fruit and core contain active ingredients that affect wound healing, such as bromelain enzyme, flavonoids, saponin, and alkaloids. This study aims to determine the effect of fruit ethanol extract gel of Subang pineapple on Wistar rats oral incisional wound observed from wound length. Methods: 25 rats were divided into five groups: baseline, negative control, positive control with 10% povidone-iodine, positive control with AloclairTM gel, and treatment group with 20% pineapple ethanol extract gel used as wound model on the buccal mucosa. The length of the incisional wound area was examined on days 0, 3, 7, and 14. Measurement of wound length was performed using a periodontal probe. Results: The mean of wound length was smaller especially on day 3 in the treatment group. Post-Hoc Mann-Whitney test (p<0.05 considered significant) showed the wound decrease with Subang pineapple extract was better than the negative control (p=0.008) and povidone-iodine group (p=0.007) but didn’t show a significant difference with the Aloclair™ gel group (p=0.0118). Conclusion:  Topical application of pineapple extract affected oral mucosa incisional wound healing and had a potential to accelerate wound closure. Further study with different concentrations and another type of wound can be suggested.Keywords: incisional wound; pineapple extract; subang pineapple; wound healing
The potential of rambutan honey toothpaste in reducing the dental plaque index: a quasi Experimental study Yuslianti, Euis Reni; Ningrum, Anindya Sekar Ayu; Endrowahyudi, Hartanto
Padjadjaran Journal of Dentistry Vol 35, No 3 (2023): November 2023
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol35no3.50310

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ABSTRACTIntroduction: The accumulation of dental plaque is a common cause of dental and oral health problems such as caries and periodontitis, therefore it is necessary to control plaque. Brushing is the most effective way to control plaque. Currently, there are various toothpastes used by the people, one of which is herbal toothpaste. One of the herbal toothpastes that has an antibacterial potential is rambutan honey toothpaste. The purpose of this study was to analyze the effectiveness of rambutan honey toothpaste in reducing the dental plaque index. Methods: this research was Quasi Experimental design research with a pre-test post-test control group design. The twenty samples were divided into three treatment groups, namely the group that brushed teeth with base toothpaste, rambutan honey toothpaste, and aquadest. All samples were asked to brush their teeth using base toothpaste, rambutan honey toothpaste, and aquadest twice, after using toothpaste for one day, the plaque index was measured by the Silness and Loe method. Data were analyzed using Kruskal-Wallis and post hoc Mann-Whitney tests (p<0.05). Results: There was a significant difference between the plaque index score before and after using rambutan honey toothpaste with a p value=0.005 (p≤0.05). The results also showed the effect of brushing teeth with base toothpaste, rambutan honey toothpaste, and aquadest on plaque index with a value of p=0.005 (p≤0.05). The results showed that there was no significant difference in dental plaque index between base toothpaste and rambutan honey toothpaste with a p value=0.583. Conclusion: Rambutan honey toothpaste has a potential in reducing the dental plaque index.Keywords: plaque index, rambutan honey, toothpaste
Application of Rambutan Honey Toothpaste with Color Indicator Effect on Salivary Malondialdehyde Levels Yuslianti, Euis Reni; Widyasari, Ratih; Arif, Bayu Syamsul
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol. 13 No. 2 (2024): November
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v13i2.22087

Abstract

Oxidative stress in the oral cavity, driven by an imbalance between free radicals and antioxidants, can lead to lipid peroxidation, as reflected by elevated malondialdehyde (MDA) levels in saliva. Proper oral hygiene, such as regular tooth brushing, is vital in mitigating oxidative damage. This study aimed to evaluate the effects of rambutan honey toothpaste with a color indicator on reducing oxidative stress in the oral cavity by measuring salivary MDA levels. This research was conducted using a laboratory experimental design, with saliva samples collected from students at the Faculty of Dentistry, Universitas Jenderal Achmad Yani. Participants were assigned to five groups: rambutan honey toothpaste with a color indicator (RHTCI), rambutan honey toothpaste without a color indicator (RHT), color-indicated toothpaste without honey (TCI), base toothpaste (BT), and distilled water (DW). The thiobarbituric acid reactive substances (TBARs) method was applied to assess MDA levels, and statistical analysis was conducted using Kruskal-Wallis and Mann-Whitney tests. The results showed a significant reduction in salivary MDA levels following the use of RHTCI (p = 0.0001). A notable difference was also found between RHTCI and TCI (p = 0.001), while no significant difference was observed between RHTCI and RHT (p = 0.190). These findings suggest that rambutan honey toothpaste with a color indicator effectively reduces salivary MDA levels, highlighting its potential antioxidant benefits.