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All Journal Journal of Biomedicine and Translational Research Sinkron : Jurnal dan Penelitian Teknik Informatika PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat JOURNAL LA MEDIHEALTICO Al Khidma: Jurnal Pengabdian Masyarakat Asian Journal of Community Services (AJCS) Homeostasis: Jurnal Mahasiswa Pendidikan Dokter Journal of Global Pharma Technology CSRID
Fujiati ., Fujiati
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Effects of coal dust particulate matter exposure on H2O2, MDA, IL-13, TGF-β3 level and bronchioles sub-epithelial fibrosis in allergic asthma mice model Fujiati .
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (575.741 KB)

Abstract

Objective: Pulmonary fibrosis in asthma is marked by a rapid decline in lung function. Unfortunately, the environmental factors aggravating this condition are still poorly understood. To date, the pathomechanism of exposure to coal dust affecting the subepithelial fibrosis in asthma remains unclear. Methods: Twenty-fourth female BALB/C mice were divided into four group. The first group was control, the second was mice exposed to coal dust particulate matter (PM) (days 46-75), the third was OVA sensitized mice  (Initial sensitization on day 0 and 14, re-sensitization days 21-75), and the fourth was made of OVA-sensitized mice and exposed coal dust PM. Results: The results showed coal dust PM significantly decreased levels of IL-13 BAL (p-value=0.001) but significantly elevated H2O2 BAL levels (p-value=0.001) and increased sub-epithelial bronchial fibrosis thickness (p-value= 0.000). This was based on the scale of fibrosis (0=<5 μm, 1=5-10 μm; 2=11-15 μm; 3=>15 μm; score 0-1=mild; 1-2=moderate; and 3= severe). The combination of ovalbumin sensitization and PM coal dust caused severe fibrosis (score 3).There was no significant association between IL-13, TGF-β3, H2O2, and MDA BAL with sub-epithelial fibrosis thickness. Conclusions:  PM exposure to coal dust may increase sub-epithelial fibrosis of the bronchioles by a mechanism independent of inflammation and oxidative stress.Objective:Pulmonary fibrosis in asthma is marked by a rapid decline in lung function. Unfortunately, the environmental factors aggravating this condition are still poorly understood. To date, the pathomechanism of exposure to coal dust affecting the subepithelial fibrosis in asthma remains unclear. Methods: Twenty-fourth female BALB/C micewere divided into four group. The first group was control, the second was mice exposed to coal dust particulate matter (PM) (days 46-75), the third was OVA sensitized mice (Initial sensitization on day 0 and 14, re-sensitization days 21-75), and the fourth was made of OVA-sensitized mice and exposed coal dust PM. Results: The results showed coal dust PM significantly decreased levels of IL-13 BAL (p-value=0.001) but significantly elevated H2O2 BAL levels (p-value=0.001) and increased sub-epithelial bronchial fibrosis thickness (p-value=0.000). This was based on the scale of fibrosis (0=<5μm, 1=5-10μm; 2=11-15μm; 3=>15μm; score 0-1=mild; 1-2=moderate; and 3= severe). The combination of ovalbumin sensitization and PM coal dust caused severe fibrosis (score 3).There was no significant association between IL-13, TGF-β3, H2O2, and MDA BAL with sub-epithelial fibrosis thickness.Conclusions:  PM exposure to coal dust may increase sub-epithelial fibrosis of the bronchioles by a mechanism independent of inflammation and oxidative stress.
Pemeriksaan Kesehatan dan Pengobatan Gratis pada Masyarakat Bantaran Sungai Martapura (RT. 01 Desa Keliling Benteng Ulu) Husin, Gt Muhammad Irhamna; Silapurna, Endah Labati; Fujiati, Fujiati; Hayatie, Lisda
Al Khidma: Jurnal Pengabdian Masyarakat Al Khidma Vol. 4 No. 1 Januari 2024
Publisher : Sekolah Tinggi Ilmu Al-Qur'an (STIQ) Amuntai Kalimantan Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35931/ak.v4i1.3712

Abstract

Sasaran kegiatan pengabdian kepada masyarkat oleh civitas akademika PSKPS FK ULM adalah masyarakat di RT 01, Desa Keliling Benteng Ulu, Kecamatan Martapura Barat, Kabupaten Banjar yang tinggal di bantaran sungai Martapura. Kegiatan pengabdian ini mempunyai tema Pemeriksaan Kesehatan Dan Pengobatan Gratis Pada Masyarakat Bantaran Sungai Martapura (RT. 01 Desa Keliling Benteng Ulu). Pemilihan masyarakat yang tinggal di bantaran sungai martapura menjadi salah satu motivasi untuk dilakukan pemeriksaan kesehatan dan pengobatan gratis. Beberapa penyakit yang teridentifikasi di lingkungan masyarakat RT. 01 diantaranya adalah 1) sebagian ibu-ibu dan bapa-bapa mengalami kebas di tangan baik sebagian atau kedua belah tangan, 2) terdapat sebagian warga mengalami mata perih, 3) Mayoritas masyarakat RT. 01 memiliki riwayat kolesterol yang tinggi, 4) Mayoritas masyaraka RT. 01 memiliki riwayat tensi darah yang tinggi dan 5) sebagian warga terlebih khusus para anak-anak dan remaja mengalami penyakit kulit. Fenomena yang ditemui di RT. 01 kemungkinan disebabkan karena habit gaya makan yang tidak terpola seperti suka makan gorengan dan berlemak. Di samping itu higiene dan sanitasi masyarakat dan lingkungan yang masih kurang bersih serta adanya agen penyakit di sekitarnya. Masyarakat yang sakit berupaya untuk melakukan sendiri dengan obat-obatan yang tersedia di warung terdekat dai ke Puskesmas. Upaya yang dilakukan ialah 1) pemberian edukasi kepada masyarakat mengenai makanan yang baik untuk dikonsumsi dan hidup bersih, 2) pemeriksaan sekaligus pengobatan gratis. Kegiatan ini dimulai dengan persiapan koordinasi dengan aparat desa dan jajarannya dilanjutkan dengan pemeriksaan dan pengobatan gratis, meliputi edukasi pola makan sehat dan hidup bersih, pengukuran berat badan, pengkuran tinggi badan, pemeriksaan tensi darah, pemeriksaan kolesterol, pemeriksaan gula darah, pemeriksaan asam urat dan pemeriksaan fisik yang dilakukan oleh dokter serta di akhir dengan pemberian obat.
PENGARUH MUSIK PANTING TERHADAP STRES PADA MAHASISWA PSKPS FK ULM ANGKATAN 2019 Ridho, Anisa Rifka; Khairiah, Siti; Noor, Meitria Syahadatina; Noorsifa, Noorsifa; Fujiati, Fujiati
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12358

Abstract

Abstract: Stress is a physical and psychological reaction that arises when individuals are faced with something threatening or when they are subjected to high pressure or demands. Stress can be prevented and overcome by listening to music. One of the music found in South Kalimantan is panting music which is instrumental music and according to research can reduce stress more quickly. This study aims to analyze the effect of panting music on stress. This research is a quasi-experimental study with the one group pretest-post test design method. Subjects in this study amounted to 30 people, determined by the theory of Gay and Diehl, with a correction factor of 20%. Research subjects were selected using simple random sampling method. Stress measurement was carried out using the PSS-10 questionnaire and the average before treatment was 21.3±7.022 and the average after treatment was 15.75±4.391. The analysis was carried out using the paired t test to obtain a value of p=0.000 so that it can be concluded that panting music has a significant effect on reducing stress in research subjects. Keywords: stress, PSS-10, music, panting Abstrak: Stres adalah merupakan suatu reaksi fisik dan psikis yang ditimbulkan apabila individu dihadapkan pada sesuatu yang mengancam atau ketika mendapatkan tekanan maupun tuntutan yang tinggi. Stres dapat dicegah dan ditanggulangi dengan mendengarkan musik. Salah satu musik yang terdapat di Kalimantan Selatan adalah musik panting yang merupakan musik instrumental dan menurut penelitian dapat menurunkan stres lebih cepat. Penelitian ini bertujuan untuk menganalisis pengaruh musik panting terhadap stres. Penelitian ini merupakan penelitian quasi experimental dengan metode one group pretest- post test design. Subjek pada penelitian ini berjumlah 30 orang, yang ditetapkan dengan teori Gay dan Diehl, dengan faktor koreksi 20%. Subjek penelitian dipilih dengan menggunakan metode simple random sampling. Pengukuran stres dilakukan dengan menggunakan kuesioner PSS-10 dan didapatkan rata-rata sebelum perlakuan 21,3±7,022 dan rata-rata setelah perlakuan 15,75±4,391. Analisis yang dilakukan dengan uji t berpasangan mendapatkan nilai p=0,000 sehingga dapat disimpulkan bahwa musik panting memiliki pengaruh yang bermakna terhadap penurunan stres pada subjek penelitian. Kata-kata kunci: stres, PSS-10, musik, panting
STUDI IN SILICO INTERAKSI KOBALT DAN MERKURI TERHADAP PROTEIN PADA KEJADIAN DIABETES MELITUS Aranda, Viren Lolita; Suhartono, Eko; Fujiati, Fujiati; Mashuri, Mashuri; Setiawan, Bambang
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11473

Abstract

The coal mining industry in South Kalimantan can cause heavy metal waste pollution in the aquatic environment if not managed wisely. Cobalt and mercury are heavy metals that can cause disruption of glucose homeostasis which can lead to diabetes mellitus. The toxicity of cobalt and mercury occurs as a result of interactions with proteins associated with diabetes mellitus, namely insulin receptors, PPARγ, protein kinase b and c-reactive protein. This study aims to determine the interaction of heavy metals cobalt and mercury on insulin receptors, PPARγ, protein kinase b and c-reactive protein with PDB ID: 2HR7, 1PRG, 3E87, 1GNH taken from the Protein Data Bank and using the molecular docking website MIB2: Metal Ion-Binding site prediction and modeling server. Docking results were visualized using the Chimera ver 1.16 application. Based on the docking results, it was found that the interaction between cobalt and mercury with insulin receptors, PPARγ, protein kinase b and c-reactive protein. Cobalt has the highest potential to bind to insulin receptors. While mercury has the highest potential to bind to protein kinase b. Mercury binds more strongly to insulin receptors, PPARγ, protein kinase b and c-reactive protein than cobalt. This interaction causes changes in protein conformation that have the potential to inactivate protein function. 
HUBUNGAN DEPRESI DENGAN KEJADIAN SELF-HARM PADA MAHASISWA PSKPS FAKULTAS KEDOKTERAN UNIVERSITAS LAMBUNG MANGKURAT BANJARMASIN Rahma, Rizkia Alifa; Khairiah, Siti; Noor, Meitria Syahadatina; Noorsifa, Noorsifa; Fujiati, Fujiati
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12405

Abstract

Abstract: Self-harm is the behavior of injuring or poisoning oneself, regardless of the underlying motivation, but not aiming to end one’s life. Depression is a risk factor for self- harm. When a person cannot bring up adaptive coping mechanisms to deal with depression, then someone will bring up maladaptive coping mecanisms, one of which is self-harm. This study aimed to explain and analyze the relationship between depression and self-harm in PSKPS students, Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin. The research method is analytic observation with cross sectional approach and sampling technique using proportional random sampling technique using beck depression inventory (BDI) and self-harm inventory (SHI) questionnaires. The data analysis using the chi- square test showed a p value of 0,000 (p<0,05), which means that there is a significant relationship between depression and the incidence of self-harm in college student. The depression can increase the risk of self-harm in PSKPS student, Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin. Keywords: depression, self-harm, beck depression inventory (BDI), self-harm inventory (SHI) Abstrak: Self-harm merupakan perilaku melukai atau meracuni diri sendiri terlepas dari apapun motivasi yang mendasarinya tetapi tidak bertujuan untuk mengakhiri hidup. Depresi merupakan salah satu faktor risiko terjadinya self-harm. Ketika seseorang tidak dapat memunculkan mekanisme koping adaptif untuk mengatasi depresi yang dialami, maka seseorang akan memunculkan mekanisme koping maladaptif diantaranya adalah self- harm. Tujuan dari penelitian ini adalah untuk menjelaskan dan menganalisis hubungan depresi dengan kejadian self-harm pada mahasiswa PSKPS Fakultas Kedokteran Universitas Lambung Mangkurat Banjarmasin. Metode penelitian adalah observasional analitik dengan pendekatan cross sectional dan pengambilan sampel dengan teknik proportional random sampling dengan menggunakan kuisioner beck depression inventory (BDI) dan self-harm inventory (SHI). Jumlah sampel sebanyak 260 mahasiswa. Hasil analisis data menggunakan uji chi-square menunjukkan nilai p value 0,000 (p<0,05) yang artinya terdapat hubungan yang bermakna antara depresi dengan kejadian self-harm pada mahasiswa. Depresi tersebut dapat meningkatkan risiko terjadinya self-harm pada mahasiswa PSKPS Fakultas Kedokteran Universitas Lambung Mangkurat Banjarmasin. Kata-kata kunci: depresi, self-harm, beck depression inventory (BDI), self-harm inventory (SHI)
HUBUNGAN DUKUNGAN TEMAN SEBAYA DENGAN TINGKAT STRES PADA MAHASISWA PSKPS FK ULM ANGKATAN 2019 Najiha, Aisya; Khairiah, Siti; Noor, Meitria Syahadatina; Noorsifa, Noorsifa; Fujiati, Fujiati
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12357

Abstract

Abstract: Stress is the ability to adapt, which, if not handled, will lead to destructive behavior or psychiatric disorders. Risk factors that can affect stress include peer support. Peer support is a helping assistance based on certain principles that involve aspects including information, attention, and assistance with tools that a person gets through interaction with the environment so that they can help someone solve their problems. This study aimed to explain the relationship between peer support and stress levels in the PSKPS FK ULM students of 2019. This research was conducted using a cross-sectional design on 60 students with a simple random sampling technique. The study showed that as many as 44 people (73%) who received moderate peer support experienced moderate stress. The relationship between peer support and stress levels has a p- value of 0.726 (p>0.05). These results can be concluded that there is no relationship between peer support and stress levels in the PSKPS FK ULM students of 2019. Keywords: stress level, peer support, Abstrak: Stres adalah kemampuan dalam menyesuaikan diri yang jika tidak dapat menangani akan menyebabkan perilaku yang tidak baik atau gangguan kejiwaan. Faktor risiko yang dapat mempengaruhi stres diantaranya adalah dukungan teman sebaya. Dukungan teman sebaya adalah pertolongan yang melibatkan aspek termasuk informasi, perhatian, dan dukungan bantuan dengan alat yang didapat seseorang melalui interaksi dengan sekitar sehingga dapat memberikan pertolongan dalam menangani masalahnya. Tujuan dari penelitian ini adalah untuk menganalisis hubungan dukungan teman sebaya dengan tingkat stres pada mahasiswa PSKPS FK ULM angkatan 2019. Metode penelitian ini dilakukan dengan rancangan cross sectional pada 60 mahasiswa dengan teknik pengambilan sampel menggunakan teknik simple random sampling. Hasil dari penelitian menunjukkan bahwa sebanyak 44 orang (73%) yang mendapat dukungan teman sebaya sedang yang mengalami stres sedang. Hubungan dukungan teman sebaya dengan tingkat stres memiliki p value sebesar 0,726 (p>0,05). Hasil yang didapat disimpulkan bahwa tidak ada hubungan dukungan teman sebaya dengan tingkat stres pada mahasiswa PSKPS FK ULM angkatan 2019. Kata kunci : tingkat Stres, dukungan teman sebaya
Effects of Coal Dust Exposure in Eosinophil and Interleukin (IL)-13 on Pulmonary Remodeling in Asthmatic Mice Models Fujiati, Fujiati; Haryati, Haryati
Journal of Biomedicine and Translational Research Vol 10, No 3 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i3.22243

Abstract

Background: Coal dust is an environmental factor contributing to the risk of respiratory diseases. However, clinical evidence on the effects of coal dust in lung remodelling is currently lacking, especially the effect of eosinophils and IL-13. This study investigates how eosinophil and IL-13 affect pulmonary remodeling in coal dust and asthma combination models.Methods: An experimental study was conducted using BALB/c mice aged 6 to 12 weeks with a weight range of 20-25 g. There were 10 mice in each of the three treatments. Groups were sensitized with normal saline, ovalbumin (OVA)-sensitized, and OVA-sensitized + coal dust. The parameters of lung remodeling (the thickness of epithelium, smooth muscle thickness, the number of goblet cells, and subepithelial fibrosis) and the number of eosinophils were measured with histomorphometry analysis. Total IL-13 concentrations were measured using an IL-13 ELISA kit. The data group of a combination of OVA + coal dust was analyzed using the path analysis method.Results:  From path analysis, it was found that Eosinophils (b=0.006; 95%CI=-2.594 to 2.606; p=0.000) had positive, direct, and statistically significant effects on IL-13. Eosinophil's indirect effect on epithelium thickness and subepithelial fibrosis thickness via IL-13. Interleukine-13 had positive, direct, and statistically significant effects on epithelium thickness (b=0.67; 95%CI=-0.129 to 1.471; p=0.010) and subepithelial fibrosis thickness (b=0.682; 95%CI=0.301 to 1.062; p=0.000).Conclusion: Eosinophils' indirect effect on lung remodeling via IL-13 and IL-13 directly affects airway remodeling, especially epithelium and subepithelial fibrosis components.
Landing Page (LPg) Sebagai Media Digital Marketing Dalam Memulai Usaha Di SMK Swasta Gajah Mada Sembiring, Hilda Elsera Br; Fujiati, Fujiati; Dewi, Rofiqoh; Tanjung, Dahriani Hakim; Verina, Wiwi; Sanjaya, Andi
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 1 (2025)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v6i1.10293

Abstract

Kehadiran digital marekting saat ini memudahkan segala kalangan dalam memulai bisnis dengan tepat dan sesuai dengan target yang dituju. Belanja di internet juga bukanlah sebuah hal baru yang dilakukan calon pembeli ketika mencari informasi produk yang akan dibeli [1]. Salah satu teknologi tersebut Landing Page yang dapat digunakan sebagai media pemasaran online yang dapat menjangkau calon pembeli, penggunaannya bisa dilakukan dan di kontrol dimana saja tanpa menguras waktu dan tenaga serta hanya membutuhkan modal berupa smartphone ataupun laptop (sejenisnya) [2]. Salah satu peran Landing page adalah dapat mengubah pengunjung menjadi pelanggan sebagi wujud prospek potensial dan gerbang konversi dalam pemasaran digital [3]. Untuk itu dibutuhkan sebuah pelatihan Landing page kepada siswa/i Sekolah Menengah Kejuruan (SMK) sebagai dasar awal praktek memulai bisnis ketika selesai sekolah karena salah tujuan siswa/i SMK ketika tamat sekolah yaitu siap kerja dan berwirausaha [4]. Oleh karena itu siswa/i SMK selalu di latih dan diajarkan secara langsung mengenai praktek dalam memulai bisnis dan berkarir. Hal tersebut menjadi salah satu tujuan dari pelatihan ini yaitu untuk membekali siswa/i dalam berwirausaha digital dengan memanfaatkan platform Landing page agar mendapatkan calon pembeli yang prospek sesuai dengan bisnis yang dipasarkan.
Analysis of Risk Factors for Anemia in Pregnant Women in the Sebabi Health Center Working Area Multiansyah, Multiansyah; Noor, Meitria Syahadatina; Fujiati, Fujiati; Suhartono, Eko; Musafaah, Musafaah
Journal La Medihealtico Vol. 5 No. 6 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i6.1839

Abstract

The prevalence rate of anemia among pregnant women in East Kotawaringin Regency in 2021 was 14%, in 2022 it decreased to 13.7% and in 2023 it increased to 16%. To determine the relationship between the incidence of anemia in pregnant women at Sebabi Health Center. The study was analytical observational using a cross sectional approach with a population of 300 people, 83 people were obtained as samples using proportionate random sampling technique. The research instrument was a questionnaire. The dependent variable: anemia. Independent variables: age, parity, knowledge, attitude, culture, education level and income. Bivariate analysis using chi square and multivariate using multiple logistic regression. The results showed there was a relationship between parity (p=0.000), knowledge (p=0.000), culture (p=0.004), and education level (p=0.000) while there was no relationship between age (p=0.174) attitude (p=0.147), and income (p=0.176) with the incidence of anemia in pregnant women. Parity was most associated with the incidence of anemia among pregnant women (exp(B)=10.061). There is an association between culture, parity, knowledge, education level and no association between age, parity, and income with anemia incidence. The parity variable is the most associated with the incidence of anemia among pregnant women.
Prevention of Hypertension through the Use of Homemade Herbs and Supplements Fujiati, Fujiati; Isnaini, Isnaini; Joharman, Joharman; Audhah, Nelly Al; Asnawati, Asnawati; Hayatie, Lisda; Sari, Annida Permata; Irawanto, Irawanto
Asian Journal of Community Services Vol. 3 No. 12 (2024): December 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ajcs.v3i12.12913

Abstract

Globally, approximately 1.28 billion individuals are affected by hypertension, a Non-Communicable Disease (NCD) that represents the second leading risk factor for premature death. Hypertension raises the risk of cardiovascular disease, a global health challenge. Hypertension can result from a lack of information on the disease. Hypertension can be controlled and prevented at the community level through education, the introduction of antihypertensive plants, and training in herbal supplements. To improve public health in West Martapura, counseling and training sessions were held with the PKK. Visual media, leaflets, and demonstrations were used. The mean posttest scores for knowledge about hypertension prevention and control, knowledge of herbal plants with antihypertensive properties, and knowledge and skills in making health supplements from herbal plants were 90.5, 89.0, and 84.5, respectively.
Co-Authors Andi Sanjaya Aranda, Viren Lolita Asnawati Asnawati Bambang Setiawan Dahriani Hakim Tanjung, Dahriani Hakim Dwi Setyohadi, Dwi Eko Suhartono Halawa, Darma Haryati Haryati Husin, Gt Muhammad Irhamna Irawanto Isnaini Isnaini Joharman Joharman Joharman Joharman Lisda Hayatie, Lisda Mashuri Mashuri Meitria Syahadatina Noor Multiansyah, Multiansyah Musafaah Musafaah Najiha, Aisya Nelly Al Audhah Nelly Al Audhah Noorsifa, Noorsifa Rahma, Rizkia Alifa Ridho, Anisa Rifka Rofiqoh Dewi Salim, Rinrin Meilani Sari, Annida Permata Sembiring, Hilda Elsera Br Silapurna, Endah Labati Silapurna, Endah Labaty Sinaga, Mikha Siti Khairiah, Siti Wiwi Verina, Wiwi