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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Window of Health : Jurnal Kesehatan ad-Dawaa : Journal of Pharmaceutical Sciences Pharmaceutical Reports Journal of Multimedia Trend and Technology JURNAL PENGABDIAN MASYARAKAT YAMASI MPSJ
Irma Santi, Irma
Unknown Affiliation
Arts Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Ethanol Extract of Miana Leaf (Coleus atropurpureus Benth) As Analgetic Antiinflamation in Rats (Rattus novergicus): Ekstrak Etanol Daun Miana (Coleus atropurpureus Benth) sebagai Analgetik Antiinflamasi pada Tikus (Rattus novergicus) Sukmawati; Santi, Irma; Wati, Aulia; Aulya, Riska
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 8 No. 1 (2022): (March 2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2022.v8.i1.15678

Abstract

Background: Inflammation is a normal protective response to tissue injury caused by physical trauma, chemicals, or microbiological substances. The manifestation clinic of inflammation is pain. Miana leaves (Coleus atropurpureus Benth.) have chemical contents such as essential oils, phenols, flavonoids, and polyphenols. Flavonoids can protect lipid membranes from damage and inhibit cyclooxygenase, which is the first pathway for the synthesis of pain mediators such as prostaglandins. Objectives: This study aims to determine the effectiveness of ethanol extract of Miana leaves (Coleus atropurpureus Benth) (EEML) as analgesic and anti-inflammatory in rats (Rattus novergicus). Material and Methods: This study used The Pre-Posttest-Only Control Group Design, twenty male rats were divided into 5 groups namely negative control, positive control was given diclofenac sodium, treatment with EEML dose of 150 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW. Test of Antiinflammatory uses the Rat Hind Paw Edema method where the condition of inflammation in rats is induced with 5% egg white by subplantar. The measurement of edema in rat feet used a caliper every 30 minutes for 5 hours. While The measurement of analgesic testing used the method of nociception test which evaluates pain responses such as Staggering Gait, Vocalization, and Writhing. Results: The results of the measurement of the inflammatory parameters were analyzed with the One Way Anova test for the width of edema foot and Kruskal Walis for the thickness of edema foot. While the results of observing the pain response were analyzed with the Kruskal Walis test. Conclusions: This study concluded that the ethanol extract of Miana leaves has anti-inflammatory analgesic especially at a dose of 600 mg/kg BW which results are non-significant (p> 0.05) with a positive control group (sodium diclofenac).
GAMBARAN MAKROSKOPIK LIMPA TIKUS (Rattus norvegicus) PADA PEMBERIAAN EKSTRAK ETANOL DAUN GINSENG (Talinum paniculatum (Jacq.) Gaertn) YANG DIINDUKSI OVALBUMIN Multazania, Multazania; sahab, Fitria; Muarsih, Ahmad Juniardhy; Ashar, Muhammad Affan; Emelda, Andi; Putra, Bayu; Santi, Irma
Makassar Pharmaceutical Science Journal (MPSJ) Vol 3 No 1 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v3i1.331

Abstract

Fameflower Leaves (Talinum paniculatum (Jacq) Gaertn) are medicinal plants that communities have traditionally used due to their active compounds, such as saponins, flavonoids, tannins, triterpenes, sterols, and polyphenols found in both the leaves and roots. This study aimed to determine the dose of ethanol extract of fameflower leaves affecting the histology of the spleen in male rats (Rattus norvegicus) following ovalbumin antigen stimulation, as well as to observe changes in the spleen tissue structure after the extract treatment. The study used 20 Wistar rats divided into four groups. The rats were first adapted for 2 weeks and then fasted for 8 hours before the treatment—a group I served as the standard control. Group II was induced with ovalbumin antigen. Groups III and IV were induced with the antigen, and the ethanol extract of fameflower leaves was administered at doses of 0.4g/kgBW and 0.8g/kgBW, respectively. The extract was administered orally for 7 days to the test animals. On day 8, the test animals were sacrificed, and their spleens were harvested for histological preparation using the Hematoxylin-Eosin staining method. Microscopic observation showed no histological damage in the spleen, such as inflammation, degeneration, congestion, hemorrhage, or necrosis. Therefore, it can be concluded that the ethanol extract of Bugis Ginseng leaves did not affect the spleen of rats at doses of 0.4g/kgBW and 0.8g/kgBW
PENYULUHAN KESEHATAN: BAHAYA ROKOK BAGI KESEHATAN DI PONDOK PESANTREN AN NAHDLAH MAKASSAR St. Maryam; Emelda, Andi; Rahmawati; Razak, Rais; Santi, Irma; Amriati, Rezki
JURNAL PENGABDIAN MASYARAKAT YAMASI Vol. 3 No. 1 (2024): Jurnal Pengabdian Masyarakat Yamasi
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/jpmy.v3i1.329

Abstract

Smoking is one of the main risk factors for several chronic diseases that can result in death, so it can be a big problem for public health. Educational activities about the dangers of smoking for health were given to Aliyah students at the An-Nahdlah Islamic Boarding School in Makassar with a total of 40 participants. The aim of this activity is to increase students' awareness of the bad effects of smoking on health. This activity method begins with filling out a pre-test knowledge questionnaire about the dangers of smoking, which is then continued with counseling by the resource person and completing the post-test questionnaire again. The results of filling out the questionnaire after the counseling had increased, namely 90% of students understood the bad effects of smoking. During the counseling, students were very enthusiastic in listening to the presenters, so it is hoped that this activity will be encouraged, especially in the world of education.
Co-Authors , Faradiba Adawiyah, Rabiyah Al Al Ishak, Andi Afifatun Nisa Amriati Syarif, Rezky Amriati, Rezki Andi Emelda Arifin, Sukmawati Ashar, Muhammad Affan Aulia Wati, Aulia Aulya, Riska Awali, Muhammad Noer Bayu Putra, Bayu Dian Dwi Aninditia, Dian Dwi Dwi Lutfiyah, Evi Eka Wahyuningsih Hativa, Hativa Husain, Nurul Fadillah Intan, Tri Rahmaputri Nur Marlian, Ayu Mochammad Imron Awalludin Muarsih, Ahmad Juniardhy Multazania, Multazania Nurul Afiah Putrisari, Nur Awaliah Rachmat Kosman, Rachmat Rahmadani, Andi Syafirah Rahmawati Rais Razak, Rais Ramadhani, Fitrah Anggun Rizqi Nur Azizah sahab, Fitria St Maryam, St sukmawati Sukmawati Sukmawati