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All Journal Jurnal Kesehatan Indonesian Journal of Pharmaceutical Science and Technology Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi LOYALITAS: Jurnal Pengabdian Kepada Masyarakat Pharmaceutical Reports Journal of Global Pharma Technology BULLET : Jurnal Multidisiplin Ilmu
Sukmawati Syarif, Sukmawati
Fakultas Farmasi Universitas Muslim Indonesia Makassar
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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PENETAPAN KADAR VITAMIN C LIMBAH KULIT BUAH APEL MANALAGI (Pyrus malus L.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS A. Muflihunna; Adli Dzil Ikram; Sukmawati Sukmawati
As-Syifaa Jurnal Farmasi Vol 14, No 2 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i2.902

Abstract

Vitamin C is a vitamin that is water soluble and one vitamin that is needed by the body. To meet the intake of vitamin C needed source of vitamin a derived from fruits, one of which is Appel Part of the appel , which is still rarely used is its skin. Apple peel is very beneficial for health however the situation is only considered as waste that has not been utilized well. This study aims to determine the levels of vitamin C on the skin of the Apple (Pyrus mallus L)  by the method of spectrofotometry uv-visible wavelength 243 nm. This research uses experiments with purely research stage comprised sample preparation, qualitative test, making the solution of the parent raw, quantitative test, determination of wavelength of maximum vitamin and creation of calibration surve. Based on the research that has been done, the result of the qualitative test to prove the presence of high content of vitamin C contained in appel peels, with the highest level obtained in the skin of the plantain by 13,534 mg/g extract
POTENTIAL OF ASTAXANTHIN FROM ASIAN TIGER SHRIMP (Penaeus monodon) SHELL EXTRACT AS AN ANTIBACTERIAL AND ANT INFLAMATORY sukmawati syarif
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Asian tiger shrimp (Penaeus monodon) shell is an industrial waste which becomes one of the sources of carotenoids in the form of astaxanthin (3.3’-dihydroxy-β, β′-carotene-4.4′-dione) which has a very potential biological activity because it can work on target molecules. Astaxanthin in Asian tiger shrimp shell is well known to be lipophilic, being insoluble in water but soluble in organic solvents, one of which acetonitrile. The characteristics of astaxanthin were obtained through qualitative and quantitative analyses using FTIR (Fourier Transform Infra-Red) and HPLC (High Performance Liquid Chromatography). Furthermore, antibacterial and anti-inflammatory activities had been tested. Based on the research results done on the inhibition of Asian tiger shrimp (Penaeus monodon ) shell extract on the 5th growth of the test bacteria, the tiger shrimp shell extract had antibacterial activity on Eschericia coli., Streptococcus mutans, Pseudomans auriginosa, Salmonella typhi, Staphylococcus aureus which was characterized by the presence of clear zone / inhibition zone / Oligodynamic zone which showed the effect of tiger shrimp shell extract in killing and inhibiting the growth of test bacteria. Besides, An anti-inflammatory testing through extracting chemical components with acetonitrile solvent with several concentrations showed that the anti-inflammatory activity with a concentration of 1000 ppm with % stability on erythrocyte membrane obtained 60.516%, indicating that the higher the concentration used, the better was the anti-inflammatory effect.
Kajian In Silico Senyawa Aktif Kayu Jawa (Lannea Coromadelica) Sebagai Antiinflamasi Melalui Penghambatan Mediator TNF-alpha Dan COX-2 Sukmawati Syarif; Andi Muflihunna
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.46074

Abstract

Kayu jawa (Lannea coromandelica) merupakan salah satu tanaman yang banyak digunakan secara empiris oleh masyarakat di Sulawesi Selatan sebagai obat tradisional karena memiliki efek farmakologis seperti antiinflamasi yang merupakan respon protektif normal terhadap berbagai proses fisiologis di dalam tubuh serta memiliki efek biologis yang dapat bekerja pada target molekul. Inflamasi adalah respon perlindungan normal terhadap cedera jaringan yang disebabkan oleh trauma fisik, bahan kimia berbahaya, atau agen mikrobiologi. Tujuan penelitian ini adalah untuk mengetahui senyawa kimia apakah pada tanaman Kayu jawa (Lannea coromandelica) yang berpotensi sebagai antiinflamasi dengan mekanisme penghambatan reseptor TNF-α dan COX-2. Metode penelitian ini adalah  in silico menggunakan metode molecular docking dengan perangkat lunak Autodock. Tahapan penelitian antara lain simulasi doking reseptor dengan ligan uji kemudian di validasi, setelah itu di visualisasi menggunakan  discovery studio, kemudian dilanjutkan pada tahapan data analisis serta prediksi ADME. Adapun hasil penelitian Senyawa 3-hydroxy-4’,5,7-trimethoxyflavanone terhadap COX-2 dan senyawa uji morin terhadap TNF-α berpotensi sebagai antiinflamasi dengan kemampuan lebih rendah dibandingkan dengan liga alami untuk berkatan dengan sisi aktif pda reseptor target. Selanjutnya penelitian ini diharapkan menjadi pilot project produksi sediaan obat antiinflamasi yang dapat digunakan oleh masyarakat luas
Uji Aktivitas Antioksidan Fraksi N-Heksan Dari Akar Tanaman Qust Al Hindi (Saussurea lappa) Menggunakan Metode DPPH Nurul Muthmainnah Salam; Sukmawati Syarif; A. Muflihunna
BULLET : Jurnal Multidisiplin Ilmu Vol. 2 No. 4 (2023): BULLET : Jurnal Multidisiplin Ilmu (INPRESS)
Publisher : CV. Multi Kreasi Media

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Abstract

Qust Al Hindi (Saussurea lappa) is a type of medicinal plant which is used as an antioxidant, anticancer, anti-inflammatory and antimicrobial because it contains phytochemical compounds such as flavonoids, terpenoids, and alkaloids.In addition, there are also chlorogenic acid compounds that function as antioxidants. This study aims to analyze the antioxidant activity of the n hexane fraction of the roots of Qust al Hindi (Saussurea lappa) using the DPPH free radical scavenging method. This type of research is a laboratory experiment using a spectrophotometer method based on calculating the IC50 value of the n-hexane fraction of the sample on DPPH free radical activity. The stages of this research began with sample preparation, sample extraction and fractionation, measurement of maximum wavelength, and testing of the antioxidant activity of the sample n-hexane fraction and quarcetin standard. The results of this study are for the percent reduction of 35,26%; the regression equation value of the sample n-hexane fraction is y = 0,0652x + 12,305 ( r = 0,9996 ); and IC50 value of 284,6 µg/mL. The results of study illustrate that the n-hexane fraction of the roots of qust al hindi has potential as an antioksidant activity against DPPH free radical.
Antioxidant Activity of Ethanol Extract on Qust Al Hindi (Saussurea lappa) Roots Using the FRAP Method Putry, Dhevy Try; Syarif, Sukmawati; Rahmawati, Rahmawati
Pharmaceutical Reports Vol 3, No 1 (2024): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i1.289

Abstract

Qust al hindi (Saussurea lappa) is a plant that has antioxidant activity, especially in the roots. Qust al hindi contains several chemical compounds including flavonoids, steroids, terpenes, alkaloids, sesquiterpenes, costunolide, dehydrococtus lactones, cynaropicrin, and chlorogenic acid. This study aims to determine the antioxidant activity of the ethanol extract of qust al hindi root using the FRAP method. Samples that had become powder were extracted using the soxhletation method with 96% ethanol and obtained a % rendition of 5.302%. The extract obtained was measured using a UV-Vis spectrophotometer at a maximum wavelength of 718 nm after being mixed with several FRAP reagents, using a quercetin standard. The results of the antioxidant analysis showed that the average antioxidant activity of the ethanol extract of the qust al hindi root (Saussurea lappa) using the Frap method was 10.3671 mgQE/g extract. Which means that the antioxidant activity of each g of extract is equivalent to the antioxidant activity of 10.3671 mg of quercetin.
Co-Authors A. Muflihunna A. Muflihunna A. Muflihunna A. Mumtihanah Mursyid Adli Dzil Ikram Aminah Aminah Andi Muflihunna Aulia Wati Dian Rahmawati Harira Hadi Harti Widiastuti Hendra Herman Mamat Pratama Masdiana Tahir Miftahuljanna Miftahuljanna Milka Flaning Nurnaningsih Nurnaningsih Nurul Inayah Nurul Muthmainnah Salam Pirman AP Putry, Dhevy Try Rachmat Kosman Rachmat Kosman, Rachmat Rahmawati, Rahmawati Zainal Abidin