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All Journal SCRIPTA SCORE Scientific Medical Journal Heart Science Journal Asian Australasian Neuro and Health Science Journal (AANHS-J) Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED)
Teuku Bob Haykal
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Association between atherogenic index of plasma and coronary lesion severity in NSTEMI patients Nasution, Umi Hazzar; Sitepu , Andika; Haykal, Teuku Bob; Siregar, Yasmine; Lubis, Hilfan Ade Putra; Ketaren, Andre Pasha; Hasan, Harris
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.13

Abstract

Background: Early identification of the severity of coronary lesions is very important to determine the appropriate management strategy, especially in patients with non-ST-elevation myocardial infarction (NSTEMI). Objective: This study aimed to determine the relationship between the Atherogenic Index of Plasma (AIP) and the severity of coronary lesions in NSTEMI patients. Methods: This study was an analytical observational cross-sectional design conducted at Haji Adam Malik Hospital, Medan, in 2023. Data were collected from medical records of NSTEMI patients and coronary angiography results. Statistical analysis was performed to assess the relationship between AIP and the severity of coronary lesions, including bivariate tests and multivariate logistic regression. Result: A total of 101 NSTEMI patients were included in this study. AIP values were significantly higher in patients with moderate to severe coronary lesions compared to those with mild lesions. An AIP ≥ 0.434 showed a sensitivity of 64.1% and specificity of 67.6% in predicting moderate to severe lesions. Multivariate analysis showed that AIP was the strongest independent predictor of coronary lesion severity, along with age, diabetes mellitus, and ejection fraction. Conclusion: AIP is significantly associated with the severity of coronary lesions in NSTEMI patients and can be used as a simple yet effective risk indicator.
Evaluating the MEDAN score: An alternative diagnostic instrument to acute myocardial infarction for resource-limited settings Napitupulu, Friendina; Lubis, Anggia Chairuddin; Teuku Bob Haykal; Lubis, Hilfan Ade Putra; Kamal Kharrazi Ilyas; Harris Hasan
Heart Science Journal Vol. 7 No. 3 (2026): Predicting Restenosis in Coronary Artery Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.03.7

Abstract

Background: Acute Myocardial Infarction (AMI) is one of the leading cause of death worldwide. Limited access to biomarker testing, especially troponin, poses a significant challenge for rapid and accurate diagnosis, particularly in resource-limited settings. We previously proposed Myocardial infarction Early DiAgnosis instrumeNt (MEDAN) score as a tool for predicting AMI. Objective: To conduct internal validation and assess the reproducibility of the MEDAN score in distinct patient cohorts. Methods: This study was conducted at Adam Malik Hospital in Medan, Sumatera Utara. A research form was used to gather data from electronic medical records. Data were collected retrospectively from January to December 2024 and prospectively since January 2025. Chi-square tests were applied to determine sensitivity values, specificities, negative predictive value (NPV), and positive predictive value (PPV). ROC analysis was used to compare MEDAN score to the HEART and GRACE scores. Result: This study included 685 patients: 417 with AMI and 268 without AMI. Patients with AMI had higher heart rate as well as HEART, GRACE, and MEDAN scores, but lower systolic blood pressure. The MEDAN score demonstrated a sensitivity of 78.2%, specificity of 60.7%, PPV of 71.2%, and NPV of 69%. The MEDAN score showed good diagnostic ability, outperforming the HEAR score and GRACE score without troponin point, but remained less effective than HEART and GRACE scores when troponin was included. Conclusion: The MEDAN score demonstrates good diagnostic ability for detecting AMI and may serve as practical alternative in healthcare facilities with limited access to biomarker testing.
Tp-e/QTc ratio as a potential non-invasive marker of coronary lesion severity assessed by SYNTAX score in non-ST segment elevation myocardial infarction Ginting, Yehezkiel Bastanta; Sitepu, Andika; Ketaren, Andre Pasha; Hasan, Harris; Lubis, Anggia Chairuddin; Haykal, Teuku Bob; Ginting, Daniel
Heart Science Journal Vol. 7 No. 3 (2026): Predicting Restenosis in Coronary Artery Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.03.8

Abstract

Background: Accurate assessment of coronary lesion burden in the initial stage is the basis for appropriate therapy in NSTEMI patients. As a parameter derived from the ECG that reflects ventricular repolarization variability, the Tp-e/QTc ratio is suggested as a noninvasive predictor for assessing anatomical complexity. Objective: Investigating the relationship of Tp-e/QTc with the severity of coronary lesions on angiography assessed using the SYNTAX score, in patients with NSTEMI. Methods: Utilized a retrospective cohort approach with a cross-sectional design. In total, 141 patients were selected by utilizing purposive sampling. The Tp-e and QTc intervals were manually measured from 12-lead ECGs using the tangent method, and the Tp-e/QTc ratio was calculated. SYNTAX scores were independently determined by two interventional cardiologists. Data were analyzed using bivariate and multivariate analyses. Result: Higher SYNTAX group (0.26 ± 0.047) had higher Tp-e/QTc than lower SYNTAX group (0.21 ± 0.052). Tp-e/QTc showed a positive correlation with SYNTAX score (r = 0.395; p < 0.001) and remained an independent predictor (β = 0.332; p = 0.001). The ROC curve displayed strong discrimination (AUC = 0.817), a cut-off of 0.24 yielded 82.7% sensitivity and 76.4% specificity. Conclusion: Tp-e/QTc is associated with angiographic complexity in NSTEMI and may support early risk stratification prior to angiography.
Co-Authors Abdullah Afif Siregar Achmad, Aziz Akbar, Nizam Zikri Andra, Cut Aryfa Andriyani, Yunilda Ardini, Tengku Winda Barus, Melvin Nova Gunawanto Brahmana, Andrew Timanta Cut Aryfa Andra Daniel Ginting Dina Arwina Dalimunthe, Dina Arwina Faustine, Elaine Ferhat, Muhammad Ginting, Yehezkiel Bastanta Harris Hasan Hasan, Harris Hasan, Refli Ilyas, Kamal Kharrazi Indharty, R. R. Suzy Kamal Kharrazi Ilyas Ketaren, Andre Pasha Khairunnisah, Dina Lubis, Ahmad Feriansyah Lubis, Anggia Chairuddin Lubis, Hilfan Ade Putra Mukhtar, Zulfikri Napitupulu, Friendina Nasution, Ali Nafiah Nasution, Umi Hazzar Purba, Joy Wulansari Raynaldo, Abdul Halim Reynaldo, Abdul Halim Safri, Zainal Sarastri, Yuke Siregar, Abdullah Afif Siregar, Yasmine Sitepu , Andika Sitepu, Andika Sumbayak, Novra Christy Grace Syarifuddin, Fairuz Yang, Jason Yasmine Fitrina Siregar Zulfikri Mukhtar