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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Nusantara Hasana Journal JPKM Cahaya Negeriku Jurnal Farmasi Ikifa Joseph THE SHINE CAHAYA DUNIA S-1 KEPERAWATAN
Gigih Kenanga Sari
Universitas An Nuur
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Other

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Uji Stabilitas Formulasi Sediaan Gel Nano Partikel Eksktrak Etanol Daun Singkong (Manihot esculenta Crantz) Wahyu Purwanjani; Maulita Saraswati; Gigih Kenanga Sari
Joseph: Journal of Science and Pharmacy Vol 2 No 1 (2022): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background; Peel-off gel masks are an alternative dosage form that can enhance user comfort and are expected to improve the antioxidant activity of papaya fruit. Papaya (Carica papaya) exhibits antioxidant activity due to the presence of components such as beta-carotene, vitamin C, and lycopene. Objective : This study aims to determine whether the methanol extract of papaya fruit can be formulated into a peel-off facial gel mask and to identify the optimal concentration of polyvinyl alcohol (PVA)—the main base ingredient of peel-off gel masks—that provides the best physical and chemical properties, as well as antioxidant activity with the most favorable IC50 value. Method; The extraction method used was maceration with methanol as the solvent. PVA was used at concentrations of 2.5%, 8.75%, and 17.5%. Physical property tests included organoleptic evaluation, adhesion test, and spreadability test, while chemical properties were evaluated using pH testing. Results; Based on the results, the methanol extract of papaya fruit can be successfully formulated into a peel-off facial gel mask. The formula containing 8.75% PVA met organoleptic standards, had an adhesion time of 20.16 ± 2.90 seconds, spreadability of 10.2 ± 1.28 cm, a pH value of 7.13, and an IC50 value of 80.52 µg/mL, indicating strong antioxidant activity. Conclusion : From the formulation and physical evaluation of the peel-off gel mask containing ethanol extract of tea leaves (Camellia sinensis L.), a thick brown gel with a characteristic tea leaf aroma was obtained. Evaluation results showed a pH value of 5, drying time of 20 minutes, spreadability within acceptable range, adhesion time of 8.73 seconds, and no irritation was observed during the irritation test, indicating that the peel-off gel mask is safe for use
UJI ANTIOKSIDAN DARI FORMULASI SEDIAAN FACE MIST EKSTRAK DAUN JAMBU AIR (Syzygium samarangense) Katharina Anrina; Gigih Kenanga Sari; Maulita Saraswati
Joseph: Journal of Science and Pharmacy Vol 3 No 1 (2023): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background :Antioxidants are compounds that can neutralize free radicals. One of the most frequently used antioxidant cosmetic preparations is face mist. Purpose : To make face mist preparations of water guava leaf extract (Syzygium samarangense) with good physical quality and IC50 value. Method : Water guava leaf extract (Syzygium samarangense) was macerated with 70% ethanol solvent and tested for water content, drying shrinkage, ethanol free, and chemical compound content. Next, evaluation of the preparation was carried out and antioxidant test were carried out on the face mist of water guava leaves (Syzygium samarangense) with concentrations of extract FI 3 grams, FII 5 grams, and FIII 7 grams using the UV-VIS spectrophotometric DPPH (1,1-diphenyl-2-picrylhydrazyl) method at wavelength of 517 nm with ratio of vitamin C. Result : This research shows that water guava leaf extract (Syzygium samarangense) can be used as a good face mist preparation and contains flavonoids, saponin, tannin, and triterpenoid which act as antioxidant. On the face mist preparation of guava leaf extract (Syzygium samarangense) produced good physical quality and the IC50 value at FI was 24,54 ppm, FII was 17,61 ppm, and FIII was 8,86 ppm, so that face mist preparation had the best antioxidant content is an FIII preparation with an IC50 value of 8,86 ppm. Conclusion : Water guava leaf extract (Syzygium samarangense) can be made into a face mist with good physical quality and produces the best antioxidant antivity in FIII preparations with an IC50 value of 8,86 ppm
UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 70% DAUN BELIMBING MANIS (Averrhoa carambola L.) DARI DESA TARUB TERHADAP BAKTERI Staphylococcus aureus Dhanisa Dwi Nugrahanti; Gigih Kenanga Sari; Mingle A Pistanty
Joseph: Journal of Science and Pharmacy Vol 3 No 1 (2023): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Acne or acne vulgaris is ranked as the most common disease in the world, with a prevalence of 9.4% of the world's population. Staphylococcus aureus bacteria has a percentage of 79% in causing acne. The content of secondary metabolites in plants can act as an antibacterial with a strong mechanism of action. One of them is starfruit leaves (Averrhoa carambola L.) which contain antibacterial properties such as alkaloids, flavonoids, tannins. There are many populations of this plant in Tarub Village, Tawangharjo District, Grobogan Regency Purpose: To determine the antibacterial effectiveness of 70% ethanol extract of sweet starfruit leaves (Averrhoa carambola L.) obtained in Tarub village against Staphylococcus aureus bacteria Method: Leaves of starfruit (Averrhoa carambola L.) were extracted by maceration method with 70% ethanol solvent and antibacterial test by paperdisk method with concentration variances of 60%, 75% 90%. Results: Phytochemical screening of starfruit leaf extract (Averrhoa carambola L.) contains alkaloids, flavonoids, tannins, terpenoids and saponins. Antibacterial test of sweet starfruit leaf extract produced the largest inhibition zone diameter of 14.29 mm at a concentration of 60%. Conclusion: Leaf extract of sweet star fruit effectively inhibits the growth of Staphylococcus aureus bacteria.
ANTIBACTERIAL ACTIVITY TESTING OF COLLASE LEAF EXTRACT (Centella asiatica L.) AGAINST Propionibacterium acnesBACTERIA Bentar Jatmiko; Gigih Kenanga Sari; Mingle A Pistanty
Joseph: Journal of Science and Pharmacy Vol 3 No 1 (2023): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Propionibacterium acnes or P.acnes is a normal skin flora bacteria, but can be the cause of opportunistic infections in the form of acne. Generally, acne is treated using antibacterials aimed at reducing the colonization of bacteria. The centtella asiatica plant (Centtella asiatica) is a plant of one genus as Centella. Research shows that leaf ethanol extract (Centtella asiatica) has antibacterial activity. Purpose: This study aims to determine the antibattery activity of Centella asiatica leaf extract against Propionibacterium acnes and adequate concentration in inhibiting the growth of Propionibacterium acnes. Method: Centella asiatica leaves (Centella asiatica) were extracted by maceration method using 70% ethanol solvent. The dieprolwh extract was carried out phytochemical tests and antibacterial activity tests with the well method against Propionibacterium acnes. Clindamycin positive control 20μg, DMSO negative control 10%. Results: Phytochemical test of ethanol extract of centella asiatica leaves containing
Determinan Health- Related Quality of Life Pasien Terapi Hemodialysis dengan Instrument EQ5D-5L Estuningtyas Ayu Hapsari; sutiyono; Gigih Kenanga Sari
Joseph: Journal of Science and Pharmacy Vol 3 No 1 (2023): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Chronic kidney disease is caused by an increase in serum creatinine values of 20% in the kidneys. One of the management therapies for chronic kidney disease is hemodialysis therapy. The EQ5D-5L instrument is an instrument that can be used to measure the quality of chronic kidney patients. The aim of the study was to determine the description of patients with hemodialysis therapy and determine the response of patients to hemodialysis therapy with EQ5D-5L. Method: The research method is quantitative descriptive. Data collection used the EQ5D-5L instrument with the inclusion criteria of patients diagnosed with chronic kidney disease in patients aged more than 19 years. Sampling using the accidental sampling method was 100 respondents. Data analysis uses univariate analysis determinants. Results: The results of the study showed that patients with the highest range were aged 45-64 with a percentage of 67%, the proportion of male had the highest value with a percentage of 63%, the highest CCI value was in the range 3-4 with a percentage of 44% and the most therapy implementation was less than 1 year of therapy with a percentage of 59%. The utility measurement results showed that the EQ5D-5L average value was 0.595 and the VAS average value was 80, for the EQ5D-5L SD value was 0.225 and the VAS SD value was 6.464, with the EQ5D-5L median value being 0.624 and the VAS median value being 80. The most dominant response was pain at 75% and anxiety at 62%. Conclusion: Conclusion. The results of the study showed that the age of hemolysis therapy was highest in men with an average EQ5D-5L utility value of 0.595 and an average VAS value of 80. The most dominant response was pain at 75% and anxiety at 62%  
Uji Stabilitas Sediaan Krim Ekstrak Daun Belimbing Wuluh (Averhoa blimbi L.) dengan Variasi Konsentrasi Emulgator Maulita Saraswati; Gigih Kenanga Sari; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 3 No 1 (2023): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Belimbing wuluh (Averrhoa bilimbi L.) has been widely utilized as a traditional medicinal ingredient due to its antioxidant and anti-inflammatory properties. A stable cream preparation formulation is very important to maintain the effectiveness of its active ingredients. Therefore, this study aims to evaluate the physical stability of Belimbing wuluh leaf extract cream preparation with variations in emulgator concentration. Purpose: To determine the effect of varying TEA concentration on cream stability, determining the effect of variations in stearic acid concentration on cream stability, determining the optimal concentration of TEA and stearic acid to obtain a stable cream formulation. Method: This study used an experimental method with a cream formulation containing stearic acid (10%, 12%, 14%) and triethanolamine (TEA) (4%, 5%, 6%). Stability evaluation was done through organoleptic test, pH, viscosity, spreadability, adhesiveness, and cycling test. Results: The cream preparation showed good homogeneity with a light brown color and characteristic odor of the extract. The pH value ranged from 7.50 to 8.04, in accordance with topical cream standards. Viscosity increased as the concentration of stearic acid and TEA increased. Spreadability and stickiness decreased after the accelerated stability test, but remained within acceptable limits. Conclusion: Cream formulations with a combination of stearic acid and TEA provide good physical stability. The formula with 14% stearic acid and 6% TEA showed more optimal physical characteristics than the other formulas  
UJI STABILITAS FISIK SEDIAAN SERUM WAJAH EKSTRAK DAUN BELIMBING MANIS (Averrhoa carambola L.) DENGAN VARIASI KONSENTRASI PROPILEN GLIKOL SEBAGAI HUMEKTAN Devi Kurnia Saputri; Gigih Kenanga Sari; Estuningtyas Ayu Hapsari
Joseph: Journal of Science and Pharmacy Vol 4 No 1 (2024): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Sweet star fruit leaf (Averrhoa carambola L.) is a plant that contains antibacterial compounds such as alkaloids, flavonoids, saponins, tannins and triterpenoids that are used as acne therapy. Several product dosage forms have been developed for serum, one of which is in form slightly viscous. Humectants serve to improve the stability of the material over long period of time. Purpose: This research was conducted to find out at what oncentration propylene glycol as a humectant meets the physical stability test of a good serum preparations. Method: Sweet star fruit leaf (Averrhoa carambola L.) was extracted using the maceration method using methanol. The serum preparation consists of 3 formula with different concentrations of propylene glycol, namely formula I 15%, formula II 20% and formula III 25%. Evaluation of physical stability was carried out with 12 days in an accelerated test (Cycling test) with organoleptic testing parameters, homogeneity, pH, viscosity, adhesion and spreadability. Results: Serum preparations of weet star fruit leaf extract (Averrhoa carambola L.) in formula I, formula II and formula III have physical characteristics and stability that comply with SNI standards. Conclusion: The concentration of propylene glycol 25% in formula III shows the most stable serum stability properties compared to formula I and formula II  
UJI STABILITAS FORMULASI FACE TONER EKSTRAK DAUN PEGAGAN (Centella asiatica) DENGAN VARIASI KONSENTRASI GLISERIN Rumanis Afifah; Gigih Kenanga Sari; Maulita Saraswati
Joseph: Journal of Science and Pharmacy Vol 5 No 1 (2025): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: The cosmetics industry continues to grow with increasing interest in natural ingredients. Gotu kola leaves (Centella Asiatica) contain bioactive compounds with antioxidant, anti-inflammatory, and skin repair effects, making them potential ingredients for face toners. Toners refresh and balance the skin's pH, while glycerin acts as a humectant to maintain moisture, but its concentration affects the stability and comfort of the preparation. This study formulated a gotu kola extract face toner with varying glycerin concentrations and evaluated its stability through a cycling test (±4 °C and ±40 °C, six cycles). This test is important for assessing the physical and chemical quality of the product while meeting cosmetic registration requirements. Purpose: 1.To determine the compounds contained in gotu kola leaf extract (Centella Asiatica). 2. To determine whether there is an effect on physical quality and stability in variations of glycerin in gotu kola leaf extract (Centella Asiatica) face toner formulations. 3. To determine the face toner formulation that has good stability with variations in glycerin concentration.. Method: Pegagan leaves (Centella asiatica) were extracted using the maceration method with 70% ethanol solvent.   The extract obtained was subjected to phytochemical testing and TLC testing, followed by the preparation of formulations according to the predetermined formulation. A cycling test was conducted for 12 days with 6 cycles, followed by physical quality testing of the face toner formulation.Results: Pegagan extract compounds contain alkaloids, flavonoids, and tannins. There were no significant differences between formulations 1, 2, and 3 with variations in humectants (glycerin). Formulation F2 showed the most optimal stability because both viscosity and pH were relatively stable during six storage cycles. Conclusion: Based on this study, it was found that face toner preparations containing gotu kola leaf extract (Centella Asiatica) at concentrations of 2%, 4%, and 6% had fairly good physical stability parameters.
PENGARUH VARIASI KONSENTRASI TRIETHANOLAMINE TERHADAP STABILITAS FISIK LOTION EKSTRAK DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) Yulia Rika Femina; Gigih Kenanga Sari; Maulita Saraswati
Joseph: Journal of Science and Pharmacy Vol 5 No 1 (2025): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Fragrant pandan leaves (Pandanus amaryllifolius Roxb.) are known to contain various secondary metabolites such as alkaloids, flavonoids, tannins, saponins, and terpenoids, making them potentially useful as ingredients in herbal cosmetic formulations, especially lotions. Triethanolamine acts as an emulsion stabilizer for oil-in-water (O/W) emulsions. Variations in triethanolamine concentration are expected to affect the physical stability of the lotion, thus further research is needed to optimize the formulation. Purpose: This study aims to evaluate the effect of triethanolamine concentration on the physical stability of formulated pandan leaf lotion, and to determine the triethanolamine concentration that is most stable and effective. Method: Fragrant pandan leaves were extracted with ethanol through maceration. The lotion preparation consisted of 4 formulations with different concentrations of triethanolamine (0%, 2.5%, 3%, and 3.5%). Physical stability was evaluated through organoleptic tests, homogeneity, pH, viscosity, spreadability, adhesiveness, and type of emulsion under room temperature, cooling, and storage conditions for 6 cycles. The data were analyzed using ANOVA, if the data were not normal, the Kruskal–Wallis test was used. Results: The preparation of lotion from the extract of fragrant pandan leaves (Pandanus amaryllifolius Roxb.) in formula 0, formula I, formula II, and formula III has physical characteristics and stability that comply with SNI standards Conclusion: The lotion preparation with 3.5% triethanolamine concentration shows the most stable lotion properties compared to formulation 0, I, and formula II.
UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK DAUN BELIMBING MANIS (Averrhoa carambola L.)TERHADAP Staphylococcus epidermidis Indriani Dini Mustava; Gigih Kenanga Sari; Supriyanto
Joseph: Journal of Science and Pharmacy Vol 5 No 1 (2025): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: A major factor in the development of acne is bacterial activity within infected hair follicles. One of the bacteria involved in acne formation is Staphylococcus epidermidis. Star fruit leaf extract (Averrhoa carambola L.) contains alkaloids, flavonoids, tannins, triterpenoids, and saponins, which can act as antibacterial agents. Purpose: This study aims to formulate gel preparations of star fruit leaf extract (Averrhoa carambola L.) at concentrations of 3%, 4%, and 5%, and to evaluate their antibacterial activity against Staphylococcus epidermidis. Method: Star fruit leaves were extracted using the maceration method with 70% ethanol. The extract was formulated into gel preparations at concentrations of 3%, 4%, and 5%, followed by antibacterial activity testing against Staphylococcus epidermidis using the well diffusion method. Results: The study showed that the star fruit leaf extract (Averrhoa carambola L.) contains alkaloids, flavonoids, saponins, tannins, and triterpenoids. The gel formulations exhibited antibacterial activity with inhibition zones of 8,61 mm, 9.48 mm, and 11,50 mm for the 3%, 4%, and 5% concentrations, respectively. Conclusion: The gel preparation of star fruit leaf extract (Averrhoa carambola L.) with the highest antibacterial activity was the Formula 3 gel containing 5% extract
Co-Authors Amanda Risky Damayanti Anisa Eka Pafitri Anita Dwi Septiarini Anita Lufianti Bentar Jatmiko Bentar Jatmiko Devi Kurnia Saputri Dhanisa Dwi Nugrahanti Dina Permata Sari Ella Laela Musyarofah Estuningtyas Ayu Hapsari Indriani Dini Mustava Katharina Anrina Maulita Saraswati Mingle A Pistanty Nazdia Putri Nur Afiana Ning Febriani Novia Julianti Rara Erika Rumanis Afifah Sindy Mellyana Putri Siti Zulifat Supriyanto sutiyono Wahyu Purwanjani Yulia Rika Femina