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Chlorhexidine Mouthwash Use and Blood Glucose Trends by Age and Gender: Penggunaan Obat Kumur Klorheksidin dan Tren Glukosa Darah Berdasarkan Usia dan Jenis Kelamin Dwi Wahyu Indrawati; Lely Ika Mariyati; Andika Aliviameita; Anis Khoirin Hayati; Paramitha Amelia Kusumawardani
Academia Open Vol. 10 No. 1 (2025): June
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.11385

Abstract

General Background: Oral health is intricately associated with systemic health, particularly in the aging population where chronic conditions such as diabetes are prevalent. Specific Background: Chlorhexidine 0.2% mouthwash is widely used to reduce oral microbial load, potentially influencing systemic inflammation and metabolic markers. Knowledge Gap: However, the systemic impact of routine chlorhexidine use, especially on glycemic regulation in older adults, remains insufficiently explored. Aims: This cross-sectional study aimed to evaluate the association between the use of 0.2% chlorhexidine mouthwash and random blood glucose (RBG) levels, while considering age and gender influences. Results: Among 90 respondents, predominantly aged ≥40 years (82%), 34% reported regular chlorhexidine use. Users showed a lower mean RBG (120 mg/dL) compared to non-users (128 mg/dL), though the difference was not statistically significant (p > 0.05). Gender-based analysis also revealed no significant differences. Novelty: This study contributes novel insight by highlighting a possible, albeit non-significant, trend toward improved glycemic status in chlorhexidine users. Implications: While not conclusive, these findings suggest that consistent oral hygiene via chlorhexidine may support systemic health maintenance in older adults, reinforcing the need for longitudinal studies on its metabolic effects. Highlights: Highlights a potential link between oral hygiene and blood glucose control. Shows lower average glucose in chlorhexidine users, though not significant. Supports further research on systemic benefits of mouthwash use in elderly. Keywords: Chlorhexidine 0.2%, Blood Glucose, Oral Health, Aging Population, Cross-Sectional Study
Probiotics' Function in Enhancing the Health of Periodontal Tissue : A Comprehensive Analysis of Recent Data Novita Pratiwi; Dwi Wahyu Indrawati
Malahayati Nursing Journal Vol 7, No 8 (2025): Volume 7 Nomor 8 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v7i8.21445

Abstract

Periodontal disease is one of the common dental and oral health problems and can cause damage to the dental supporting tissue if not treated properly. Various approaches have been developed to prevent and treat this disease, one of which is the use of probiotics. Probiotics are known to help maintain the balance of the oral microbiota, reduce inflammation, and inhibit the growth of pathogenic bacteria that contribute to periodontal disease. This study aims to review the role of probiotics in improving periodontal tissue health based on recent studies. The method used in this review involved searching and selecting journals from various scientific databases relevant to the topic of probiotics and periodontal health. The inclusion criteria included studies that addressed the effects of probiotics on periodontal health, while the exclusion criteria were applied to studies with methodologies that were unclear or irrelevant to the focus of the study. The results of the review show that probiotics, especially from the genera Lactobacillus and Bifidobacterium, have the potential to reduce gingival inflammation, reduce the depth of periodontal pockets, and improve overall periodontal health. The main mechanisms found involve competition with pathogenic bacteria, modulation of immune responses, as well as the production of natural antimicrobial compounds. In conclusion, probiotics have the potential to be an effective adjunct therapy in maintaining the health of periodontal tissue. However, more research is needed to determine the optimal dosage, duration of use, as well as its long-term effectiveness in periodontal care.
Oral Health Education to Improve Literacy and Oral Care Practices Among Older Adults in Boro Village, Sidoarjo Regency Dwi Wahyu Indrawati; Anis Khoirin Hayati; Novita Pratiwi; Nurul Maulidah; Faisal Hamdi; Dedi Fardiaz
Shihatuna : Jurnal Pengabdian Kesehatan Masyarakat Vol 6 No 1 (2026): April
Publisher : FKM UIN Sumatera Utara Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/shihatuna.v6i1.26810

Abstract

The decline in oral health among the elderly remains a persistent community issue, primarily influenced by limited health literacy, reduced motor abilities, and a lack of regular preventive care. This community service program focused on improving oral health literacy and promoting proper daily oral hygiene practices among older adults through targeted educational interventions. The purpose of this activity was to enhance participants' understanding of common oral problems in aging, including dental caries, periodontal disease, and denture-related conditions, as well as to strengthen their skills in performing effective and safe oral care at home. The program employed an interactive approach consisting of health education sessions, visual demonstrations of toothbrushing and denture-cleaning techniques, and guided practice with direct supervision. Additional supporting materials were provided to reinforce learning retention. The results of the program indicated a noticeable increase in participants' knowledge, greater confidence in performing oral hygiene independently, and improved awareness of the importance of routine dental check-ups. Participants also reported better understanding of the relationship between systemic conditions-such as diabetes and hypertension-and oral health status. In conclusion, this community engagement activity effectively improved oral health literacy and encouraged better oral care behaviors among the elderly. Sustained implementation of periodic education, collaboration with community health cadres, and integration of oral health promotion into routine elderly health services are recommended to support longterm improvements in oral health and overall well-being.
Viabilitas Fibroblast Freeze – Dried Amniotic And Fresh Amniotic In BHK21 Cell Dwi wahyu indrawati; Chiquita Prahasanti; Ernie Maduratna Setyawatie
Eduvest - Journal of Universal Studies Vol. 4 No. 6 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i6.1455

Abstract

Amniotic membrane is the inner most lining of the human placenta that is normally discanded after parturition. The membrane has numerous growth factors, proteins and stem cell reserves that help in accelerating wound healing with regeneration of the lost tissues. The preserved human amniotic membrane is a novel tissue engineerrined biomaterial that is recently trial in field of medicine dentistry to regenerate the lost tissues and accelerate repair. This review paper unfolds the inherent structure, properties, mechanisms and the application of this neglected tissue that makes it a potential for regeneration especially in the field of oral and periodontal surgeries. This research has been conducted to measure the difference of viabilitas fibroblast concentration between fresh amniotic and freeze – died amniotic membranes. Experimental three group test design was exployed with amniotic membrane. Amniotic membrane was divided into two parts. The first parts was without preservation amniotic, the test with BHK21 cell for control group, the second part was with reservation freeze –dried amniotic and the last experiment was with preservation fresh amniotic membrane. The result experiment are viabilitas fibroblast freeze – dried amniotic more than fresh amniotic membrane.
Expression Of Osteoblasts In Periodontitis With Material Preservation Pocket Technique Gengigel® (Hyaluronic Acid 0.2%) Dwi Wahyu Indrawati; Ernie Maduratna Setyawatie; A. Retno Pudji Rahayu; Rizky Briliant Syah Manurung; Anis Khoirin Hayati
Eduvest - Journal of Universal Studies Vol. 4 No. 10 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i10.1503

Abstract

Hyaluronic acid as a socket preservation material can absorb large amounts of hydration and regulate appropriate pressure in the surrounding tissue, resulting in expansion of the extracellular space. The socket preservation technique used is a solution to bone loss due to tooth extraction. However, research on the hyaluronic acid (Gengigel) material in sockets with periodontitis has not yet been clearly studied. In this study, we will see an increase in the number of osteoblasts in the alveolar bone after tooth extraction in Wistar rats with periodontitis. To determine the increase in the number of osteoblasts after administering Hyaluronic acid to the tooth sockets of Wistar rats with periodontitis. An increase in the number of osteoblast cells was observed using a multi-head light microscope in 5 areas of the preparation at 400x magnification. The measurement results from 5 areas are averaged and a calculation is obtained for one preparation. There are 2 groups that will be used in this research, namely the Control group (without treatment), HA (given Gengigel). Each group was tested at 14 and 21 days after administering the material. The research results showed that the Hyaluronic Acid (Gengigel) group had a higher number of osteoblast cells than the control group. The one-way ANOVA test showed an average significance result of 0.000 (p < 0.05) for all groups. This indicates that there was a significant change in each treatment group. Giving hyaluronic acid to the tooth sockets of Wistar rats with periodontitis can increase the number of osteoblast cells.
Effectiveness of Family Support In Antiretroviral Therapy and Complications of HIV/AIDS (Clinical Research at the VCT Polyclinic Gambiran Regional Kediri City Hospital) Anis Khoirin Hayati; Dwi Wahyu Indrawati; Dedi Fardiaz; Joni Haryanto; Agus Hayatal Falah
Eduvest - Journal of Universal Studies Vol. 4 No. 12 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i12.1627

Abstract

HIV/AIDS is a frightening disease for Indonesian society today, so that people with HIV/AIDS often get excessive stigma and discrimination. The design of this study was an observational quantitative study with a cross sectional approach with a research focus directed at analyzing family support and service quality on the utilization of the VCT Poly and compliance of HIV / AIDS patients in undergoing antiretroviral therapy (ARV). at Gambiran Hospital, Kediri City with a sample of 109 respondents taken by Accidental Sampling technique. The results showed that most respondents had sufficient family support, namely 56 respondents (51.4%). Most respondents rated the quality of service in the moderate category as many as 56 respondents (51.4%). Most respondents had moderate utilization as many as 55 respondents (50.5%). Most respondents were not compliant with antiretroviral therapy (ARV), as many as 65 respondents (59.6%). The results of the study using the Path Analysis Test showed a p-value <0.05, so H0 was rejected and H1 was accepted, so it was concluded that there was a significant effect of family support and service quality through the use of VCT Poli on the compliance of HIV / AIDS patients in undergoing antiretroviral therapy (ARV) at Gambiran Hospital, Kediri City. Compliance of HIV / AIDS patients in undergoing antiretroviral therapy (ARV) is influenced by family support, service quality and utilization in the VCT Poly itself. So that patients need to be given good support and improve the quality of services available at the VCT Poly.
IN VITRO ANTIBACTERIAL EFFECT OF DIODE LASER ON Porphyromonas gingivalis ASSOCIATED WITH PERIODONTITIS Dwi Wahyu Indrawati; Anis Khoirin Hayati; Rizky Briliant Syah Manurung; Muhammad Rizky Akbar Manurung; Agus Hayatal Falah
Journal of Vocational Health Studies Vol. 10 No. 1 (2026): July 2026 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V10.I1.2026.72-78

Abstract

Background: Antibiotic resistance has become a major global health concern, including in periodontal therapy. Therefore, alternative antimicrobial approaches that do not rely on antibiotics are required. Purpose: This study aims to evaluate the in vitro antibacterial effect of the diode laser on Porphyromonas gingivalis associated with periodontitis. Method: This study employed an in vitro experimental design with a control group and a treatment group. A diode laser with a wavelength of 660 - 900 nm was applied to the P. gingivalis cultures with exposure times of 5, 10, and 15 seconds. The bacterial growth was assessed by measuring the inhibition zone diameter. Result: The results demonstrated a significant reduction in P. gingivalis growth following diode laser irradiation, with longer exposure times producing larger inhibition zones. Conclusion: Diode laser irradiation exhibited significant in vitro antibacterial activity against P. gingivalis. These findings indicate that diode lasers have potential as an alternative antimicrobial modality in periodontal therapy and warrant further investigation through in vivo and clinical studies.