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All Journal Pharmacy Reports Jurnal Riset Farmasi Bandung Conference Series: Pharmacy
Bambang Tri Laksono
Prodi Farmasi, Fakultas Farmasi Dan Sains, Universitas Islam Bandung, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Formulasi Minuman Kopi Cokelat Herbal Akar Wangi dan Kayu Manis sebagai Peningkat Daya Ingat pada Mencit Adisti; Gita Cahya Eka Darma; Bambang Tri Laksono
Bandung Conference Series: Pharmacy Vol. 4 No. 2 (2024): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v4i2.14827

Abstract

Abstract. Antioxidants in plants can protect the brain from oxidative stress, which can lead to memory decline. This study aims to develop a herbal coffee chocolate drink formula containing vetiver root and cinnamon, with the potential to enhance memory. The research began by extracting coffee, vetiver root, and cinnamon using a stovetop method with the aid of a moka pot. The final formula selected for testing was Formula 3, consisting of a mixture of 10% coffee, vetiver root, and cinnamon extract, 0.06% stevia liquid, 10% milk, and chocolate to make up 100% of the volume. Memory testing was conducted using the Y-maze method. Test animals were divided into four groups, with three groups previously subjected to stress (except for the negative control group) by being placed in 50 mL centrifuge tubes under alternating dark and light conditions every 2 hours for 7 days. The drink was administered for 14 days, and the parameter measured was the time taken by the mice to find food. The results indicated that the drink had memory-enhancing activity, as evidenced by a significant difference in the latency time to find food between the positive control group and the group receiving the drink. Abstrak. Antioksidan dalam tumbuhan mampu melindungi otak dari stres oksidatif yang bisa mengakibatkan penurunan daya ingat. Penelitian ini bertujuan untuk membuat formula minuman kopi cokelat herbal akar wangi dan kayu manis yang berpotensi meningkatkan daya ingat. Penelitian dimulai dengan mengekstraksi kopi, akar wangi, dan kayu manis menggunakan metode stove top dengan bantuan alat moka pot. Formula akhir yang dipilih untuk diuji adalah formula 3, yang terdiri dari campuran 10% ekstrak kopi akar wangi kayu manis, 0,06% cairan stevia, 10% susu dan cokelat ad 100%. Pengujian daya ingat dilakukan menggunakan labirin Y. Hewan uji dibagi menjadi empat kelompok yang sebelumnya diinduksi stres (kecuali kelompok kontrol negatif) dengan ditempatkan dalam tabung sentrifuga 50 mL dalam kondisi gelap dan terang secara bergantian setiap 2 jam selama 7 hari. Minuman diberikan selama 14 hari dan parameter yang diukur adalah waktu yang dibutuhkan mencit untuk menemukan makanan. Hasil penelitian menunjukkan bahwa minuman ini memiliki aktivitas peningkat daya ingat, yang ditunjukkan oleh perbedaan signifikan dalam waktu latensi menemukan makanan antara kelompok kontrol positif dan kelompok yang diberikan minuman.
Tingkat Kepatuhan Minum Obat dan Tingkat Kesembuhan Pasien Tuberkulosis Paru di Puskesmas Sindangkerta Cianjur Sherly Nasya Aprilia; Suwendar; Bambang Tri Laksono
Bandung Conference Series: Pharmacy Vol. 4 No. 2 (2024): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v4i2.15065

Abstract

Abstract. 10.6 million people fall ill with tuberculosis (TB) worldwide, including 5.8 million men, 3.5 million women, and 1.3 million children. The level of compliance with the use of pulmonary tuberculosis drugs is very important, because if it is not regular in its treatment and not on time it will cause drug resistance. This study aims to determine the relationship between the level of compliance and the recovery rate of pulmonary tuberculosis patients at the Sindangkerta Health Center, using the pill count adherence equation. This study was conducted with a descriptive observational design using a retrospective cohort study method by looking at the correlation between compliance and recovery. The population was 166 and the sample was taken by purposive sampling method by looking at the sample that entered the inclusion criteria of 119. Abstrak. 10,6 juta orang jatuh sakit terkena penyakit Tuberkulosis (TBC) diseluruh dunia. termasuk 5,8 juta pria, 3,5 juta wanita, dan 1,3 juta anak-anak. Tingkat kepatuhan penggunaan obat Tuberkulosis paru sangat peting, karena jika tidak teratur dalam pengobatannya dan tidak tepat waktu maka akan menyebabkan terjadinya resistensi Obat. Penelitian ini betujuan untuk mengetahui hubungan Tingkat kepatuhan dan tingkat kesembuhan pasien Tuberkulosis Paru di Puskesmas Sindangkerta, dengan menggunakan persamaan pill count adherence. Penelitian ini dilakukan dengan desain observasional deskriptif menggunakan metode studi Kohort secara retrospektif dengan melihat korelasi antara kepatuhan dan kesembuhan. Populasi sebanyak 166 dan sampel diambil dengan metode purposive sampling dengan melihat sampel yang memasuki kriteria inklusi sebanyak 119.
Efektivitas Penyembuhan Luka Sayat Ekstrak dan Fraksi Ekstrak Daun Mahkota Dewa Inka Siti Rabiah, Inka Siti Rabiah; Suwendar; Bambang Tri Laksono
Jurnal Riset Farmasi Volume 5, No. 1, Juli 2025, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v5i1.6741

Abstract

Abstract. Wounds are a condition characterized by damage to body tissue. This study was motivated by the high prevalence of wounds based on Riskesdas 2018 showing the prevalence of cuts in Indonesia at 20.1% of the population. This study aims to determine the wound healing activity of the extract and fraction of the mahkota dewa leaf extract (Phaleria macrocarpa (Scheff.) Boerl.) and to determine the effectiveness of the extract and fraction of mahkota dewa leaf extract on wound healing using male Swiss webster gallus mice. The method used in this test is incision induction with a length of 1.5 cm. In this study, the wound healing activity of the extract, n-hexane fraction, ethyl acetate fraction, and water fraction were tested with successive concentrations of 5%. The results showed that the extract and fraction of the extract had wound healing activity, seen based on wound closure on the 3rd to 14th day. The n-hexane fraction had the best effect on wound healing because it was detected to have metabolite compounds, namely alkaloids, flavonoids, polyphenols, quinones, and steroids. Based on statistical tests, there was a significant difference (P<0.05) against the comparison group. Abstrak. Luka merupakan suatu kondisi yang ditandai dengan kerusakan pada jaringan tubuh. Penelitian dilatar belakangi oleh tingginya prevalensi luka berdasarkan Riskesdas tahun 2018 menunjukkan bahwa prevalensi luka sayat di indonesia sebesar 20,1% jiwa. Penelitian ini bertujuan untuk mengetahui Aktivitas penyembuhan luka dari ekstrak dan fraksi ekstrak daun mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.) dan mengetahui efektivitas antara ekstrak dan fraksi ekstrak daun mahkota dewa terhadap penyembuhan luka dengan menggunakan mencit jantan galus swiss webster. Metode yang digunakan pada pengujian ini yaitu induksi sayat dengan panjang 1,5 cm. Pada penelitian ini dilakukan pengujian aktivitas penyembuhan luka pada ekstrak, fraksi n-hexan, fraksi etil asetat, dan fraksi air dengan konsentrasi berturut-turut 5%. Dari hasil penelitian menunjukkan bahwa ekstrak dan fraksi ekstrak memiliki aktivitas penyembuhan luka, dilihat berdasarkan adanya penutupan luka pada hari ke-3 hingga hari ke-14. Adapun fraksi n-hexan memiliki efek paling baik dalam penyembuhan luka karena terdeteksi memiliki senyawa metabolit yaitu alkaloid, flavonoid, polifenol, kuinon, dan steroid. Adapun berdasarkan uji statistik terdapat perbedaan yang signifikan (P<0,05) terhadap kelompok pembanding. 
Keamanan Proton Pump Inhibitor (PPI) pada Kehamilan : Kajian Literatur Sistematik Tria Septiani, Tria Septiani; Fetri Lestari; Bambang Tri Laksono
Jurnal Riset Farmasi Volume 5, No. 1, Juli 2025, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v5i1.6742

Abstract

Abstract. Proton pump inhibitors (PPIs) are commonly used drugs in the management of chronic diseases such as GERD, gastritis, and peptic ulcers. However, physiological changes in pregnant women lead to changes in the long-term safety of PPI use. The purpose of this study was to review the safety of PPIs in pregnancy to identify potential adverse drug reactions (ROTDs) that can be taken into consideration in clinical practice. The method used was a systematic literature review conducted by searching for articles in the last 10 years using the PubMed and Science Direct databases. Then filtering articles using Mendeley and critical appraisal with JBI tools to identify potential bias in each article. Three were a total of 3 articles that discussed the use of PPIs in pregnant patients that met the inclusion and exclusion criteria. The results of the literature study from the three articles discussed ROTD due to the use of PPIs during pregnancy, namely preeclampsia, eclampsia, and congenital malformations due to esomeprazole. Abstrak. Proton Pump Inhibitor (PPI) merupakan obat yang umum digunakan dalam penanganan penyakit kronis seperti GERD, gastritis, dan tukak lambung. Namun, perubahan fisiologis pada ibu hamil menyebabkan perubahan keamanan jangka panjang dari penggunaan PPI. Tujuan dari penelitian ini yaitu untuk menelaah keamanan PPI pada kehamilan sehingga dapat mengidentifikasi potensi reaksi obat tidak diinginkan (ROTD) yang dapat menjadi pertimbangan pelaksanaan praktik klinis. Metode yang digunakan yaitu kajian literatur sistematik yang dilakukan dengan pencarian artikel dalam 10 tahun terakhir menggunakan database PubMed dan Science Direct. Kemudian dilakukan penyaringan artikel menggunakan Mendeley dan critical apprisal dengan tools JBI untuk mengidentifikasi potensi bias pada setiap artikel. Terdapat total 3 artikel yang membahas mengenai penggunaan PPI pada pasien ibu hamil yang memenuhi kriteria inklusi dan eksklusi. Hasil studi literatur dari ketiga artikel membahas mengenai ROTD akibat penggunaan PPI selama kehamilan yaitu preeklampsia, eklampsia, dan malformasi kongenital akibat esomeprazole.
Hubungan Kualitas Hidup dengan HbA1c Pasien Pengguna Antidiabetes Oral di RSUD Bandung Kiwari 10060321013, Lutfi Anggita; Fetri Lestari; Bambang Tri Laksono
Bandung Conference Series: Pharmacy Vol. 5 No. 2 (2025): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v5i2.18929

Abstract

Abstract. Type 2 diabetes mellitus (T2DM) is a progressive chronic disease that requires long-term Oral Antidiabetic Drugs (OAD) therapy which impacts quality of life. Decreased quality of life in T2DM patients is often associated with uncontrolled HbA1c levels. This study aims to analyze the relationship between the quality of life of patients using oral antidiabetic drugs and HbA1c levels. This study was conducted at Bandung Kiwari Hospital during April 2025 using an analytical observational approach based on cross-sectional method. Data were collected through the Diabetes Quality of Life Brief Clinical Inventory (DQoL-BCI) questionnaire, which evaluates the physical, psychological, and social and environmental health aspects of T2DM patients. HbA1c levels were known through medical records. The results showed that patients' quality of life was poor with an average score of 52.50. And there is no significant relationship between the quality of life of T2DM patients using oral antidiabetic drugs with HbA1c levels statistically with a p-value> 0.05. Abstrak. Diabetes melitus tipe 2 (DMT2) adalah penyakit kronis progresif yang memerlukan terapi Oral Antidiabetic Drugs (OAD) jangka panjang yang berdampak pada kualitas hidup. Penurunan kualitas hidup pasien DMT2 sering kali dihubungkan dengan kadar HbA1c yang tidak terkendali. Penelitian ini bertujuan untuk menganalisis hubungan kualitas hidup pasien pengguna antidiabetes oral dengan kadar HbA1c. Studi ini dilakukan di RSUD Bandung Kiwari selama periode April 2025 menggunakan pendekatan observasional analitik berbasis metode cross-sectional. Data dikumpulkan melalui kuesioner Diabetes Quality of Life Brief Clinical Inventory (DQoL-BCI), yang mengevaluasi aspek kesehatan fisik, psikologis, serta hubungan sosial dan lingkungan pasien DMT2. Kadar HbA1c diketahui melalui rekam medis. Hasil penelitian menunjukkan kualitas hidup pasien cukup buruk dengan skor rata-rata 52,50. Serta tidak terdapat hubungan yang signifikan antara kualitas hidup pasien DMT2 pengguna obat antidiabetes oral dengan kadar HbA1c secara statistik dengan nilai p-value >0,05.
Profil Pasien DM Tipe 2 dengan Neuropati Pengguna OAD di RSUD Bandung Kiwari 10060321003, Dela Kurniasih; Umi Yuniarni; Bambang Tri Laksono
Bandung Conference Series: Pharmacy Vol. 5 No. 2 (2025): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v5i2.18934

Abstract

Abstract. Diabetes mellitus (DM) is a chronic metabolic disease that can cause various complications, one of which is diabetic neuropathy. This complication is common in patients with type 2 DM and requires long-term treatment, including the use of oral antidiabetic drugs (OAD). This study aims to determine the profile of patients with type 2 diabetes mellitus with neuropathy complications who use OAD at Bandung Kiwari Regional Hospital. This is an observational study conducted at Bandung Kiwari Regional Hospital from February to May 2025. Data were obtained through demographic data and review of patient medical records. The results obtained stated that the majority of respondents were female (78.95%), aged 56–65 years (39.47%), had an elementary school/Islamic elementary school education (36.84%), worked as housewives (60%), and had suffered from DM for 1–5 years (47.37%). Absrtrak. Diabetes melitus (DM) merupakan penyakit metabolik kronis yang dapat menyebabkan berbagai komplikasi, salah satunya adalah neuropati diabetik. Komplikasi ini umum terjadi pada pasien DM tipe 2 dan memerlukan penanganan jangka panjang, termasuk penggunaan obat antidiabetes oral (OAD). Penelitian ini bertujuan untuk mengetahui profil pasien diabetes melitus tipe 2 dengan komplikasi neuropati yang menggunakan OAD di RSUD Bandung Kiwari. Penelitian ini merupakan studi observasional yang dilakukan di RSUD Bandung Kiwari pada Februari hingga Mei 2025. Data diperoleh melalui data demografi dan telaah rekam medis pasien. Hasil penelitian yang diperoleh menyatakan bahwa mayoritas responden berjenis kelamin perempuan (78,95%), berusia 56–65 tahun (39,47%), berpendidikan SD/MI (36,84%), bekerja sebagai ibu rumah tangga (60%), dan telah menderita DM selama 1–5 tahun (47,37%).
Formulasi Ekstrak Daun Alpukat dan Rimpang Kunyit dalam Sediaan Gummy Candy Nasta Inka Aprilia Prayoga; Gita Cahya Eka Darma; Bambang Tri Laksono
Bandung Conference Series: Pharmacy Vol. 6 No. 1 (2026): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i1.23485

Abstract

Abstract. Gummy candy has been widely developed due to its chewy texture, acceptable taste, and ease of consumption. The physical characteristics of gummy candy are strongly influenced by the composition of formulation components and their interactions. This study aimed to optimize the base formulation of gummy candy containing a combination of avocado leaf and turmeric rhizome extracts using a 2² factorial design, with emphasis on the interaction between texture-forming agents. Gelatin (A) and mannitol concentration (B) were selected as factors at two levels, while the evaluated responses included gumminess, chewiness, hardness, and moisture content. Texture Profile Analysis (TPA) and moisture analysis were conducted, followed by statistical evaluation of main effects and interactions. The results demonstrated that the interaction between gelatin and mannitol significantly affected all observed responses. Increasing gelatin concentration contributed to higher hardness and gumminess, whereas mannitol strengthened gel structure and reduced moisture content. The interaction of both factors produced a more balanced texture profile compared to individual effects. A formulation containing 20% gelatin and 8% mannitol was identified as the optimum formulation, providing stable texture characteristics and appropriate moisture content. These findings indicate that factorial design is an effective approach for optimizing gummy candy formulations based on natural ingredients. Abstrak. Gummy candy banyak dikembangkan karena memiliki tekstur yang kenyal, rasa yang dapat diterima, serta kemudahan konsumsi. Karakteristik utama gummy candy sangat dipengaruhi oleh komposisi bahan penyusunnya dan interaksi antar komponen formulasi. Penelitian ini bertujuan untuk mengoptimasi basis formulasi gummy candy kombinasi ekstrak daun alpukat dan rimpang kunyit menggunakan desain faktorial 2² dengan fokus pada interaksi antar bahan pembentuk tekstur. Konsentrasi gelatin (A) dan manitol (B) pada dua level sebagai faktor. Sedangkan respon yang diamati meliputi gumminess, chewiness, hardness, dan kadar air. Evaluasi dilakukan menggunakan Texture Profile Analysis (TPA) dan moisture analyzer, kemudian dianalisis secara statistik terhadap efek utama dan interaksi. Hasil analisis menunjukkan interaksi gelatin dan manitol memberikan pengaruh signifikan terhadap respon yang diamati. Peningkatan konsentrasi gelatin berkontribusi terhadap peningkatan hardness dan gumminess, sedangkan manitol berperan dalam memperkuat struktur gel dan menurunkan kadar air sediaan. Interaksi kedua faktor menghasilkan karakteristik tekstur yang lebih seimbang dibandingkan efek tunggal masing-masing faktor. Formula dengan gelatin 20% dan manitol 8% ditetapkan sebagai formula optimum karena menghasilkan profil tekstur yang stabil dan kadar air yang sesuai dengan karakteristik gummy candy yang diharapkan. Hasil penelitian ini menunjukkan bahwa desain faktorial efektif digunakan sebagai pendekatan optimasi formulasi gummy candy berbasis bahan alam.
Analisis Pola Peresepan Obat Asma pada Anak Di RS. Rotinsulu Bandung Alief Ergin Az-Zikra Husaeni; Bambang Tri Laksono; Andrian Hoerul Anwar
Bandung Conference Series: Pharmacy Vol. 6 No. 1 (2026): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i1.23518

Abstract

Abstract. Asthma is a chronic inflammatory disease of the airways characterized by bronchial hyperresponsiveness and recurrent symptoms such as shortness of breath, coughing, and wheezing. According to the Global Initiative for Asthma (GINA) report in 2023, more than 262 million people worldwide are living with asthma, making it a significant global health problem, particularly among children. This study aimed to analyze the prescribing patterns of asthma medications in pediatric patients at Dr. H.A. Rotinsulu Lung Hospital, Bandung, during the period from January 2020 to December 2024. The research employed a descriptive study design with a cross-sectional approach and retrospective data collection. Data were obtained from medical records and prescription records of pediatric asthma patients aged 0–18 years who were diagnosed with ICD-10 codes J45.x–J46.x. A total sampling technique was applied, resulting in 100 prescription records that met the inclusion and exclusion criteria. The results showed that asthma prevalence was slightly higher in male children (52%) compared to female children (48%). Based on age distribution, asthma cases were most frequently observed in adolescents aged 12–18 years (49%). Regarding prescribing patterns, the most commonly used class of medication was Short-Acting Beta Agonists (SABA), accounting for 46% of prescriptions, with salbutamol being the most frequently prescribed drug. Other medications prescribed included Short-Acting Muscarinic Antagonists (SAMA), Inhaled Corticosteroids (ICS), Long-Acting Beta Agonists (LABA), and Leukotriene Receptor Antagonists (LTRA). Abstrak. Asma merupakan penyakit peradangan kronis pada saluran napas yang ditandai dengan hiperreaktivitas bronkus dan gejala berulang seperti sesak napas, batuk, serta mengi. Berdasarkan laporan Global Initiative for Asthma (GINA) tahun 2023, lebih dari 262 juta orang di dunia hidup dengan asma. Penelitian ini bertujuan untuk menganalisis pola peresepan obat asma pada pasien anak di Rumah Sakit Paru Dr. H.A. Rotinsulu Bandung selama periode Januari 2020 hingga Desember 2024. Penelitian menggunakan desain deskriptif dengan pendekatan cross-sectional dan pengambilan data retrospektif dari rekam medis serta catatan resep pasien asma anak usia 0–18 tahun yang terdiagnosis dengan kode ICD-10 J45.x–J46.x. Teknik pengambilan sampel dilakukan secara total sampling dan diperoleh 100 data resep yang memenuhi kriteria inklusi dan eksklusi. Hasil penelitian menunjukkan bahwa prevalensi asma pada anak laki-laki sedikit lebih tinggi (52%) dibandingkan anak perempuan (48%). Berdasarkan kelompok usia, kasus asma paling banyak ditemukan pada usia remaja 12–18 tahun (49%). Profil peresepan menunjukkan bahwa golongan obat yang paling sering digunakan adalah Short-Acting Beta Agonist (SABA) sebesar 46%, dengan salbutamol sebagai obat yang paling banyak diresepkan. Selain itu, obat lain yang juga digunakan meliputi Short-Acting Muscarinic Antagonist (SAMA), Inhaled Corticosteroid (ICS), Long-Acting Beta Agonist (LABA), dan Leukotriene Receptor Antagonist (LTRA).
Evaluation of prescribing rationality for rheumatoid arthritis patients at a regional hospital in Indonesia Alya Fauziah Zahra; Umi Yuniarni; Bambang Tri Laksono
Pharmacy Reports Vol. 5 No. 3 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.109

Abstract

Rheumatoid arthritis requires long-term pharmacotherapy with disease-modifying antirheumatic drugs, corticosteroids, and non-steroidal anti-inflammatory drugs. Irrational prescribing can lead to treatment failure, adverse effects, and increased healthcare costs. This study evaluated prescribing rationality for rheumatoid arthritis patients at RSUD Al Ihsan, Bandung, Indonesia, during 2023. A retrospective cross-sectional design was employed, analyzing medical records of 81 outpatients using five rationality criteria: appropriate indication, appropriate drug, appropriate dose, appropriate patient, and appropriate dosing interval. Results showed complete compliance for appropriate indication (100%) and appropriate drug selection (100%). However, deficiencies were identified in dose appropriateness (81.82%), patient appropriateness (97%), and dosing interval appropriateness (81.82%). Dose-related errors involved diclofenac sodium prescribed below therapeutic range and etoricoxib exceeding recommended doses. Patient-related inappropriateness included diclofenac sodium use in four elderly patients over 65 years without documented gastroprotection. Interval-related errors involved etoricoxib and meloxicam prescribed more frequently than recommended. Overall prescribing rationality was 92.1%, indicating generally appropriate practices with specific areas requiring improvement through clinical decision support systems, prescriber education, and regular prescribing audits.
Profil Pengobatan Berbasis Karboplatin-Paklitaksel pada Pasien NSCLC stadium IV di suatu RS khusus Paru Periode 2023-2024 Eliza Noufal Utami; Bambang Tri Laksono; Andrian Hoerul Anwar
Jurnal Riset Farmasi Volume 6, No. 1, Juli 2026, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v6i1.10086

Abstract

Abstract. Advanced-stage non-small cell lung cancer (NSCLC) remains a major clinical challenge, as most patients are diagnosed at an advanced stage and require systemic therapy. Platinum-based chemotherapy, particularly the carboplatin–paclitaxel combination, is still widely used in clinical practice, especially in patients without actionable target mutations. This study aimed to describe patient demographic characteristics and the chemotherapy treatment profile of carboplatin–paclitaxel–based therapy in stage IV NSCLC patients at a specialized lung hospital during the 2023–2024 period. This study employed an observational retrospective design using secondary data obtained from medical records. A total of 135 patients met the inclusion criteria and were included in the analysis. The results showed that most patients were male (72.59%), with the largest age group being 56–65 years (49.63%). The majority of patients were from informal employment backgrounds and presented with advanced clinical conditions, commonly accompanied by chronic obstructive pulmonary disease (52.6%). All patients received carboplatin–paclitaxel chemotherapy administered intravenously at 21-day intervals, while the use of targeted therapy was limited. These findings indicate that platinum-based chemotherapy remains the mainstay of treatment for stage IV NSCLC in routine clinical practice at specialized lung hospitals. Abstrak. Kanker paru non-small cell lung cancer (NSCLC) stadium IV masih menjadi permasalahan klinis utama karena sebagian besar pasien terdiagnosis pada stadium lanjut dan memerlukan terapi sistemik. Kemoterapi berbasis platinum, khususnya kombinasi karboplatin–paklitaksel, masih banyak digunakan dalam praktik klinis, terutama pada pasien tanpa mutasi target yang dapat diterapi secara spesifik. Penelitian ini bertujuan untuk menggambarkan karakteristik demografi pasien serta profil pengobatan kemoterapi berbasis karboplatin–paklitaksel pada pasien NSCLC stadium IV di suatu rumah sakit khusus paru periode 2023–2024. Penelitian ini menggunakan desain observasional deskriptif dengan pendekatan retrospektif memanfaatkan data sekunder dari rekam medis. Sebanyak 135 pasien yang memenuhi kriteria inklusi dan eksklusi dilibatkan dalam analisis., menggunakan data sekunder dari rekam medis pasien. Subjek penelitian berjumlah 135 pasien yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan bahwa mayoritas pasien berjenis kelamin laki-laki (72,59%) dengan kelompok usia terbanyak pada rentang 56–65 tahun (49,63%). Sebagian besar pasien berasal dari kelompok pekerjaan informal dan datang dengan kondisi klinis yang sudah lanjut, disertai penyakit penyerta terbanyak berupa penyakit paru obstruktif kronik (52,6%). Seluruh pasien menerima kemoterapi kombinasi karboplatin dan paklitaksel dengan rute intravena dan interval setiap 21 hari, sementara penggunaan terapi target relatif rendah. Temuan ini menunjukkan bahwa kemoterapi berbasis platinum masih menjadi tulang punggung pengobatan NSCLC stadium IV dalam praktik klinis di rumah sakit khusus paru.
Co-Authors 10060321003, Dela Kurniasih 10060321013, Lutfi Anggita Adelia Nanda Maulana Adisti Alief Ergin Az-Zikra Husaeni Alya Fauziah Zahra Alya Fauziah Zahra Amalia Arofah Amelia Agustin Andrian Hoerul Anwar Annisa Nur Hasna Fauziyah Arlina Prima Putri Avi Admikowati Bagas Hadi Panoreh Devita Desria Dinda Shafa Nabila Dini Farizah Eliza Noufal Utami Faisal Syahrul Abidin Fetri Lestari Fetri Lestari Fina Apriliani Gita Cahya Eka Darma Hanifa Rahma Hasna Afiyah Kosasih Inka Siti Rabiah, Inka Siti Rabiah Ira Kartika Jasmine Sekar Galuh Putri Kintari Nabila Mohamad Vito Gandana Muhamad Akbar Dirgana Muhammad Ilham Al Ghifari Muhtaj Farhan Maulana Akbar Mutiara Dewi Fitaloka Nashwa Fika Nafillah Nasta Inka Aprilia Prayoga Nibras Rojwa Putri Azahra Rafiolla Anapuar Rani Ratnasari Ria Novalita Pramudita Rifda Maulvi Haq Sherly Nasya Aprilia Siti Hazar Suwendar Suwendar Suwendar Syahirah Anissa Arief Taufik Muhammad Fakih Tria Septiani, Tria Septiani Umi Yuniarni