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All Journal Journal of Environmental Science and Sustainable Development Journal of Earth Kingdom Journal of Sustainability, Society, and Eco-Welfare Public Health Risk Assesment Journal Holistic: Journal of Tropical Agriculture Sciences Bioculture Journal Waste Handling and Environmental Monitoring Social Agriculture, Food System, and Environmental Sustainability Journal of Waste and Sustainable Consumption
Arista, Nor Isnaeni Dwi
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Agriculture, Biological Sciences & Forestry Humanities Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Energy Environmental Science Health Professions Medicine & Pharmacology Public Health Social Sciences Veterinary

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Journal : Bioculture Journal

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Bridging agronomy and pharmacology the antidiabetic promise of Oldenlandia Arista, Nor Isnaeni Dwi; Akhsanitaqwim, Yochidamai
Bioculture Journal Vol. 3 No. 2: January (2026)
Publisher : Institute for Advanced Science, Social, and Sustainable Future

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61511/bioculture.v3i2.2026.2459

Abstract

Background: The growing global burden of diabetes and the limitations of current treatments require sustainable alternatives. This study aims to evaluate the potential of the weedy genus Oldenlandia as a novel, sustainable resource for diabetes management by synthesizing evidence from agronomy, phytochemistry, and pharmacology. Methods: A systematic literature review was conducted using major scientific databases. A multidisciplinary search strategy was employed, and the collected data were integrated using narrative synthesis. Findings: The analysis shows that Oldenlandia species are resilient plants requiring low agricultural inputs. They are rich in bioactive compounds like iridoids and flavonoids, and preclinical studies confirm significant antidiabetic effects, including lowered blood glucose and reduced inflammation via mechanisms such as AMPK-NF-κB pathway modulation. Conclusion: Oldenlandia presents a promising and sustainable candidate for developing new antidiabetic therapies, bridging traditional use with scientific validation. Novelty/Originality: This review offers a novel, integrated perspective that simultaneously evaluates the agronomic feasibility and pharmacological potential of a weed for diabetes treatment, a unique approach not commonly found in existing literature.
Co-Authors Akhsanitaqwim, Yochidamai Alifia, Annisa Dhienar Alimatul, Muftia M Andryan, Ricky Ani Kurniawati Ardiningtyas, Siti Azizah Arta, I Made Satria Dwi Awanis, Sabila Budiastuti, Maria Theresia Sri Deli, Syekh Zulfadli Arofah Hassan, Nugroho Himawan, Rifqi Husni Mubarok Ida Rumia Manurung lestari, wahyuni Malakiano, Anghia Callista Vaci Natalia, Cristina Evi Nurmalasari, Aprilia Ike NURUL AZIZAH Pratama, Rizhal Akbar Jaya Putri, Anita Hazimah Rahmawan, Hatika Rizva, Dian Novira Sandra Arifin Aziz Septiyanto, Arifin Setyaningrum, Desy Sinaga, Intan Lorenza SUPRIYONO Susanto, Dian Novita Undari, Desti Wicaksono, Abiet Ilham