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All Journal Pharmasipha Jurnal Kesehatan Poltekkes Kemenkes RI Pangkalpinang Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kesehatan Tambusai Jurnal Farmasi dan Sains Indonesia (JFSI) JIFI (Jurnal Ilmiah Farmasi Imelda) Prosiding Seminar Informasi Kesehatan Nasional JUKEJ: Jurnal Kesehatan Jompa Science and Community Pharmacy Journal Jurnal Ilmiah Farmasi Indonesia (JIFIN)
Septiarini, Anita Dwi
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Formulasi Tablet Hisap Ekstrak Etanol Daun Kemangi (Ocimum Sanctum L.) dengan Natrium Karboksimetilselulosa Sebagai Bahan Pengikat Terhadap Sifat Fisik Tablet: Formulation Of Basil Leaf (Ocimum Sanctum L.) Ethanol Extract with Carboxymethyl Cellulose as A Binding Material: Physical Properties of Tablets Karimka, Muhammad Ihsan; Septiarini, Anita Dwi; Permata, Bangkit Riska
Jurnal Ilmiah Farmasi Indonesia (JIFIN) Vol 1 No 02 (2023): JIFIN: Jurnal Ilmiah Farmasi Indonesia
Publisher : UIMA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jifin.v1i02.2723

Abstract

So far, the basil plant (Ocimum sanctum L.) has been used by the community as a fresh vegetable to overcome the problem of bad breath. Ethanol extract in basil can inhibit the growth of pathogenic bacteria in the mouth. This study aims to make lozenges of basil extract with different concentrations of CMC-Na as a binder and to determine the effect of CMC-Na concentrations on the physical properties of lozenges. Lozenges were made by the wet granulation method with 0% CMC-Na binder variation for formula I; 1% for formula II; 3% for formula III; 5% for formula IV; 7% for formula V. Granules are compressed using a single punch tablet machine. The results showed that the use of CMC-Na as a binder in the manufacture of lozenges of basil extract in all formulas produced lozenges that met the requirements, except for formulas I and II. The best hardness test results were in formula V, with a value of 5.28 kg/cm2, while the best friability test was in formula IV, with a value of 0.32%. The best dissolving time test results were in formula V with a dissolving time of 6 minutes 33 seconds. The results of the taste response test showed that formula V had the most delicious taste response. The effect of binder concentration can affect the physical properties of the tablet. Variations in the binder influence each formula. The greater the binder, the greater the level of hardness increases.
Penetapan Kadar Flavonoid dan Uji Aktivias Antioksidan Ekstrak Etanol Daun Ketapang (Terminalia catappa L.) dengan Metode ABTS: Determination of Flavonoid Levels and Antioxidant Activity Test of Ethanol Etract Ketapang Leaf (Terminalia catappa L.) Using ABTS Method Ningsih, Wahyuni; Septiarini, Anita Dwi; Veranita, Weri
Jurnal Ilmiah Farmasi Indonesia (JIFIN) Vol 1 No 01 (2023): JIFIN: Jurnal Ilmiah Farmasi Indonesia
Publisher : UIMA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jifin.v1i01.2445

Abstract

Ketapang leaves (Terminalia catappa L.) is a plant that contains chemical compounds such as flavonoids, alkaloids, tannins, triterpenoids or steroids, resins, and saponins. This compound has potential as an antioxidant in absorbing and neutralizing free radicals. This study aims to determine the levels of flavonoid compounds, to determine whether the ethanol extract of ketapang leaves has antioxidant activity as expressed by the IC50 value and to determine the antioxidant power of the ethanol extract of ketapang leaves. The extract was prepared by maceration method using 96% ethanol. Determination of flavonoid levels and antioxidant activity was carried out using a UV-Vis spectrophotometer. Antioxidant activity based on the free radical scavenging ability of the compound ABTS was measured at a wavelength of 740 nm at 17 minutes. The results of determining the levels of flavonoids in the ethanol extract of ketapang leaves were 17,710 QE. Antioxidant activity is expressed in the value of 50% Inhibitory Concentration (IC50) with a yield of 23.531 ppm in ethanol extract. Ketapang leaf ethanol extract has a very strong antioxidant activity.
UJI EFEKTIVITAS EKSTRAK ETANOL 70% DAUN SUKUN (Artocarpus altilis) TERHADAP PENYEMBUHAN LUKA SAYAT PADA KELINCI PUTIH JANTAN NEW ZEALAND WHITE Syahadatun, Iknacia; Hidayat, Rahmat; Septiarini, Anita Dwi
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 1 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i1.1972

Abstract

Cuts are a common type of wound and require proper treatment to accelerate the healing process and prevent infection. Breadfruit leaves (Artocarpus altilis) are known to contain flavonoids, tannins, and saponins, which have anti-inflammatory and antiseptic properties and can stimulate tissue regeneration. This study aimed to determine the effectiveness of a 70% ethanol extract of breadfruit leaves on wound healing and to determine the most effective concentration. This study used an experimental method with male New Zealand White rabbits as test animals. The rabbits were divided into six treatment groups: a positive control (bioplacenton®), a negative control (distilled water), no treatment, and groups with extract concentrations of 25%, 50%, and 75%. The treatments were administered twice daily for 14 days. Data were analyzed using a one-way ANOVA followed by a LSD (Least Significant Different. The results showed that a 70% ethanol extract of breadfruit leaves at a concentration of 75% provided the best wound healing effect, nearly comparable to the positive control. This effectiveness is thought to stem from active compounds that work synergistically to accelerate tissue regeneration.
Co-Authors Achsantya, Raden Roro Karyna Cindy Andhika, Intan Fatna Ayuningsih, Qurotha Azizah, Indah Wafiq Fitria, Vina Handayani, Sri Irma, Desy Ayu Karimka, Muhammad Ihsan Listyani, Tiara Ajeng Nafis, Mifthakhul Jannah Ainun Ningsih, Wahyuni Nugraha, Novanda Satria Nur Azmi, Tasya Nabila Permata, Bangkit Riska Pratama, Kharisma Jayak Rahmat Hidayat Rohmana, Vivin Marwiyati Syahadatun, Iknacia Veranita, Weri Yuliana, Irma