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Sri Hainil
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Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Nursing Public Health

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Journal : nusantara hasana journal

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AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN GAHARU ( Aquilaria malaccensis Lamk ) PADA MENCIT PUTIH JANTAN ( Mus Musculus ) Delladari Mayefis; Cindy Octavia; Sri Hainil; Rury Trisa Utami; Desy Maniarti Gusmali; Hesti Marliza; Nurliyasman, Nurliyasman
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1413

Abstract

Inflammation is a complex response that occurs in blood vessel tissue due to external or internal stimuli. One plant that is known to have anti-inflammatory properties is agarwood leaves (Aquilaria malaccensis Lam). This study aims to evaluate the effect of ethanol extract from gaharu leaves on anti-inflammatory activity in male white mice (Mus musculus) and to determine the most effective dose. The experimental animals were divided into five groups, including a control group that received Na CMC and diclofenac sodium. Inflammation induction was carried out through injection of egg white solution, and measurements were carried out periodically for six hours. The analysis results showed that a dose of 300 mg/KgBW of agarwood leaf extract provided the most significant anti-inflammatory effect compared to lower doses. 100 mg/kgBB and 200 mg/kgBB
UJI AKTIVITAS ANTIBAKTERI DARI EKSTRAK ETANOL DAUN MANGKOKAN (Polyscias Scutellaria) TERHADAP BAKTERI Bacillus cereus DAN Shigella dysentriae Sri Hainil; Rury Trisa Utami; Delladari Mayefis; Nurul Asiqin
Nusantara Hasana Journal Vol. 5 No. 5 (2025): Nusantara Hasana Journal, October 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i5.1710

Abstract

Mangkokan leaves (Polyscias scutellaria) are medicinal plants believed to treat the digestive tract, such as diarrhea, and abdominal pain, to use it by drinking a decoction of Mangkokan leaves as a traditional medicine. This study aims to determine the antibacterial activity of ethanol extract of Polyscias scutellaria leaves in inhibiting the growth of Bacillus cereus and Shigella dysentriae bacteria. The active compounds in Mangkokan leaves contain alkaloids, saponins, phenolics, and steroids. These ingredients can function as antibacterial. This study was carried out by maceration method using 96% ethanol solvent, and the viscous extract obtained tested to see the inhibition in Bacillus cereus and Shigella dysenteriae bacteria using the disc paper diffusion method with concentrations of 25%, 50%, 75%, and 100%. The positive control was chloramphenicol 30 μg/disk, and the negative control was DMSO 5% (Dimethylsulfoxide). The test results showed that Mangkokan leaf ethanol extract had antibacterial activity against Bacillus cereus bacteria with a (moderate) inhibitory response at a concentration of 100% of 7.96 mm. In comparison, Shigella dysentriae has an inhibitory response (moderate) at a concentration of 100% of 7.68 mm
AKTIVITAS ANTIJAMUR FRAKSI DAUN MANGKOKAN (Polyscias scutellaria) TERHADAP JAMUR TRICHOPHYTON RUBRUM Rury Trisa Utami; Sri Hainil; Hesti Marliza; Hafizah, Hafizah
Nusantara Hasana Journal Vol. 5 No. 10 (2026): Nusantara Hasana Journal, March 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i10.1922

Abstract

One of the natural ingredients that are often used as medicinal plants is mangkokan leaves (Polyscias scutellaria). Mangkokan leaves have the potential as an antifungal. Trichophyton rubrum is a fungus that infects human skin. The purpose of this study was to determine the antifungal activity of mangkokan leaf fractions (Polyscias scutellaria) against Trichophyton rubrum fungi. Fractionation was carried out using the liquid-liquid method using n-hexane, ethyl acetate and ethanol-water solvents. Testing was carried out using the disc paper diffusion method. The concentration of the fraction extract used was 600 µg/disk. The results showed that of the three fractions of mangkokan leaves (Polyscias scutellaria), the ethyl acetate fraction and the ethanol-water fraction had antifungal activity, while the n-hexane fraction did not have antifungal activity. Based on the research that has been done, it can be concluded that the fraction of mangkokan leaves (Polyscias scutellaria) has antifungal activity against Trichophyton rubrum fungus. Of the three fractions tested, the ethanol-water fraction has the highest antifungal activity with an average inhibition zone of 11.3 mm against Trichophyton rubrum fungus, the ethyl acetate fraction has an inhibition zone with an average of 4.5 mm while the n-hexane fraction has no inhibition zone. The three fractions have been compared with ketoconazole 30 µg/disk as a positive control and 10% DMSO as a negative control. From the comparison of fraction measurements against the positive control, the ethanol-water fraction is included in the strong category and the ethyl acetate fraction is included in the weak category.
Co-Authors Andi Bunga Dahlia Aprilya Sri Rachmayanti Aprilya Sri Rhacmayanti Aria Juanda Cindy Octavia Delladari Mayefis Desy Maniarti Gusmali Faziyana Faziyana Ghiffari, Habibie Deswilyaz Habibie Deswilyaz Hafizah Hafizah Henny Rachdiati Hesti Marliza Merry Ardini Nanda Siska Nurliyasman Nurliyasman Nurul Asiqin Oktasari Oktasari Rastria Meilanda Reny Haryani Rury Trisa Utami Selawati Selawati Senny Mey Pratiwi Shinta Sari Dewi Sri Budiasih Sri Rahayu Melpa Sari Suci Fitriani Sammulia Suhaera Suhaera Suhaera Yunisa Friscia Yusri