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All Journal E-Jurnal Medika Udayana Indonesian Journal of Tropical and Infectious Disease
Diksha, I Gusti Ngurah Ariestha Satya
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Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

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Aktivitas Antibakteri Ekstrak Etanol Bunga Kamboja Merah (Plumeria rubra L.) terhadap Pertumbuhan Bakteri Methicillin-resistant Staphylococcus aureus (MRSA) Diksha, I Gusti Ngurah Ariestha Satya; Artini, I Gusti Ayu; Trapika, I Gusti Made Gde Surya Chandra; Widhiartini, Ida Ayu Alit
E-Jurnal Medika Udayana Vol 13 No 5 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i05.P13

Abstract

Introduction: MRSA is an antibacterial resistance problem that requires serious treatment. The limitations of antibacterials make it difficult to treat infections. The development of alternative antibacterial is needed. Objectives: This study shows the antibacterial effect of ethanol extract of Plumeria rubra L. flowers against MRSA bacteria. Methods: This research is a true experimental research with the only post-test control group design. The Kirby-Bauer test method was used to evaluate the antibacterial activity of ethanol extract of Plumeria rubra L. flowers with concentrations of 20%, 40%, and 60% in triplicate. The test bacteria used MRSA ATCC 33591 bacteria. Antibacterial activity was assessed from the diameter of the inhibition zone formed in bacterial cultures on agar media. Results: The inhibition zone were not formed after ethanolic extract of Plumeria rubra L. flowers at various concentrations. These were not antibacterial activity shown from Plumeria rubra L. flowers extract at concentrations of 20%, 40%, and 60%. Conclusions: The ethanolic extract of Plumeria rubra L. flowers does not show antibacterial activity against MRSA bacteria. Keywords: Red frangipani flowers (Plumeria rubra L.), antibacterial activity, MRSA.
Epidemiological and Clinical Features of Critical and Non-Critical Elderly COVID-19 Patients in Udayana University Academic Hospital: A Retrospective Study Purnamasidhi, Cokorda Agung Wahyu; Somia, I Ketut Agus; Junior, Darren; Suteja, Richard Christian; Adiputra, I Komang Hotra; Purnama, Giovanca Verentzia; Weisnawa, I Gede Purna; Jerry; Wulandari, Putu Kintan; Shanti, Dewa Ayu Fony Prema; Diksha, I Gusti Ngurah Ariestha Satya
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 1 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i1.43097

Abstract

Elderly COVID-19 patients have been associated with worse outcomes and have been presented with the highest mortality rate. However, studies on the clinical features and the differences between critical and non-critical elderly COVID-19 patients in Indonesia and even other countries are still lacking and rare. In this retrospective study, the epidemiological and clinical features of critical and non-critical elderly COVID-19 patients admitted to Udayana University Academic Hospital between April 2020 and March 2021 were analyzed and then compared. Of the 280 medical records analyzed, 60.7% were male and the median age was 65.0 years old. Based on the medical records, 18.2% of elderly patients met our criteria of critical patients. The most common symptoms presented in both category upon admission included fever and coughing. The most common comorbidity found in critical patients was heart disease and hypertension in non-critical patients. Laboratory results differences included leukocytes, neutrophils, lymphocytes, Neutrophil-to-Lymphocyte Ratio, platelets, SGOT, SGPT, and urea. Only 9.9% of critical patients and 6.1% of non-critical patients were given antiviral therapy. In contrast, 68.6% of critical patients and 76% of non-critical patients were given antibiotics. The mortality rate in critical patients was 70.6% and 0.4% in non-critical patients. Based on the results, a multimodal approach in the treatment of elderly COVID-19 patients is very essential. The higher mortality rate in elderly patients should be able to be reduced by giving early and timely antiviral therapy with the addition of effective choice of drugs.
Co-Authors Adiputra, I Komang Hotra Cokorda Agung Wahyu Purnamasidhi I Gusti Ayu Artini I Ketut Agus Somia I.A.A. Widhiartini Jerry Junior, Darren Purnama, Giovanca Verentzia Shanti, Dewa Ayu Fony Prema Suteja, Richard Christian Trapika, I Gusti Made Gde Surya Chandra Weisnawa, I Gede Purna Wulandari, Putu Kintan