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All Journal Indonesian Journal of Tropical and Infectious Disease IDJP (Indonesian Journal of Pharmaceutics) Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya INDONESIAN JOURNAL OF URBAN AND ENVIRONMENTAL TECHNOLOGY Biomedika
Junior, Darren
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Energy Environmental Science Health Professions Medicine & Pharmacology Public Health

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Epidemiological and Clinical Features of Critical and Non-Critical Elderly COVID-19 Patients in Udayana University Academic Hospital: A Retrospective Study Purnamasidhi, Cokorda Agung Wahyu; Somia, I Ketut Agus; Junior, Darren; Suteja, Richard Christian; Adiputra, I Komang Hotra; Purnama, Giovanca Verentzia; Weisnawa, I Gede Purna; Jerry; Wulandari, Putu Kintan; Shanti, Dewa Ayu Fony Prema; Diksha, I Gusti Ngurah Ariestha Satya
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 1 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i1.43097

Abstract

Elderly COVID-19 patients have been associated with worse outcomes and have been presented with the highest mortality rate. However, studies on the clinical features and the differences between critical and non-critical elderly COVID-19 patients in Indonesia and even other countries are still lacking and rare. In this retrospective study, the epidemiological and clinical features of critical and non-critical elderly COVID-19 patients admitted to Udayana University Academic Hospital between April 2020 and March 2021 were analyzed and then compared. Of the 280 medical records analyzed, 60.7% were male and the median age was 65.0 years old. Based on the medical records, 18.2% of elderly patients met our criteria of critical patients. The most common symptoms presented in both category upon admission included fever and coughing. The most common comorbidity found in critical patients was heart disease and hypertension in non-critical patients. Laboratory results differences included leukocytes, neutrophils, lymphocytes, Neutrophil-to-Lymphocyte Ratio, platelets, SGOT, SGPT, and urea. Only 9.9% of critical patients and 6.1% of non-critical patients were given antiviral therapy. In contrast, 68.6% of critical patients and 76% of non-critical patients were given antibiotics. The mortality rate in critical patients was 70.6% and 0.4% in non-critical patients. Based on the results, a multimodal approach in the treatment of elderly COVID-19 patients is very essential. The higher mortality rate in elderly patients should be able to be reduced by giving early and timely antiviral therapy with the addition of effective choice of drugs.
External Validation of AI-powered GeNose C19 to Diagnose Volatile Organic Compounds in COVID-19 Patients Tested at Udayana University Academic Hospital Purnamasidhi, Cokorda Agung Wahyu; Darwinata, Agus Eka; Utama, I Made Susila; Merati, Ketut Tuti Parwati; Harkitasari, Saktivi; Junior, Darren; Diksha, I Gusti Ngurah Ariestha Satya; Suteja, Richard Christian
Biomedika Vol 16, No 2 (2024): Biomedika Agustus 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v16i2.3940

Abstract

In search for potential alternatives to RT-PCR, Gadjah Mada University developed GeNose C19 which was deemed to have high sensitivity, specificity, PPV, and NPV. The objective of this study is to contribute to the development of GeNose C19 by means of external validation conducted in Udayana University Academic Hospital, Bali. This was a cross-sectional study conducted on adults above 17 years old. Demographic variables, symptoms, vaccination status, GeNose C19 results, and RT-PCR results were measured. We analyzed the sensitivity, specificity, PPV, and NPV using respective appropriate formulas and the impact of other variables gathered towards accuracy by means of Chi-squared test, Mann-Whitney U test and independent-samples T test. The results showed that the subjects included in this study were 50.8% female and had a mean (IQR) age of 23.0 (21.0-27.5) years old. Only three subjects (2.5%) showed COVID-19-related symptoms such as cough (1.7%), flu (0.8%), fever (0.8%), and headache (0.8%). GeNose C19 yields a sensitivity of 83.1%, a specificity of 73.6%, PPV of 79.4%, and NPV of 78.0%. There were no variables that significantly affect the accuracy of GeNose C19. Further study is still required to validate GeNose C19’s performance in different environmental conditions and multiple different races.
 Antioxidant Potential of Usnea spp. Extract with Lysozyme Conjugation for the Prevention of Chronic Kidney Disease Progression Junior, Darren; Dewi, Luh Putu Widya Amritha; Indratmo, Novea; Indrayani, Agung Wiwiek
Indonesian Journal of Pharmaceutics Vol 6, Issue 1, Jan - April 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i1.57697

Abstract

The prevalence of chronic kidney disease worldwide has been reported to increase every year with hypertension serving as the leading cause. The recommended treatment for chronic kidney disease patients with a history of hypertension is antihypertensive medications, which could cause side effects from prolonged use. Hence, the authors sought out a possible novel modality by implementing antioxidant properties from beard lichen (Usnea spp.) extract. Literature search was conducted on trusted scientific databases, including Google Scholar, PubMed, DOAJ, and Cochrane. The pathophysiology of hypertension in the progression of chronic kidney disease could mainly be attributed to the presence of inflammation and oxidative stress, which could be attenuated by the use of antioxidants. Lichens are a class of complex living organisms resulting from a symbiosis that allows them to synthesize various beneficial phytochemicals. Usnic and stictic acid derived from Usnea spp. are part of phenolic compounds that display strong antioxidant activities. In order for these antioxidants to have a focused effect on the kidneys, a kidney-targeted drug delivery system should be considered with lysozyme conjugation being the most studied method. The combination of Usnea spp. extract’s antioxidant capabilities with lysozyme conjugation could serve as a potential novel modality in the specific prevention of chronic kidney disease progression.                 Keywords: antioxidant; chronic kidney disease; lysozyme conjugation; Usnea                       spp. 
Mesial Temporal Lobe Epilepsy as a Common but Elusive Case: A Case Report Junior, Darren; Wulandari, Putu Kintan; Harkitasari, Saktivi; Sumardika, I Wayan; Sumadewi, Komang Trisna
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.22259

Abstract

Epilepsy is a common neuronal disorder that could include partial or generalized seizures due to abnormal brain electrical activity. A 32-year-old female patient was presented to the emergency room with a chief complaint of seizure. The seizure semiology started with epigastric pain, which then progressed into sudden speech arrest. Afterward, the patient experienced left-sided head movement followed by jerkings on the left hand. The patient then became unconscious and experienced full body rigidity. Physical examinations, vital signs, and laboratory results showed no abnormalities. Diagnostic assessments only showed unspecific signs of diffuse cerebral edema through a CT Scan and an atrophy of the right hippocampus with a slight increase in FLAIR signal intensity and dilatation of the right lateral ventricle pericornu through MRI. The patient was given phenytoin and folic acid twice daily. The presence of right mesial temporal sclerosis served as a possible cause of epilepsy in this patient despite having several obscurities. The patient showed atypical signs of generalized tonic seizure progression, adult-onset seizures, and increased MRI FLAIR signal intensity. More detailed examinations and constant reports of epilepsy cases are highly needed among physicians to provide more specific methods and tools to diagnose, classify, and treat epilepsy in the future.
UNDERSTANDING LEVEL OF PKK BANJAR PURWA SANTHI BENOA ON MEDICAL MASK WASTE MANAGEMENT AND STRENGTHENING HEALTH PROTOCOLS IN CONTROLLING COVID-19 INFECTION Adiputra, I Komang Hotra; Harmayani, Kadek Diana; Susilawathi, Ni Made; Purnamasidhi, Cokorda Agung Wahyu; Witarini, Komang Ayu; Biantara, I Wayan Arya; Sukrama, I Dewa Made; Weisnawa, I Gede Purna; Jerry; Wulandari, Putu Kintan; Junior, Darren; Shanti, Dewa Ayu Fony Prema; Warmadewanthi, I Dewa Ayu Agung
INDONESIAN JOURNAL OF URBAN AND ENVIRONMENTAL TECHNOLOGY VOLUME 6, NUMBER 1, APRIL 2023
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/urbanenvirotech.v6i1.15335

Abstract

The increase in mask waste and a lack of understanding about the management of single-use mask waste raises the potential for environmental pollution and COVID-19 transmission. Aim: This study aimed to assess the level of understanding of medical mask waste management and strengthening health protocols in controlling COVID-19 infection in Banjar Purwa Santhi, Benoa, Badung Regency. Methodology and Results: A cross-sectional method and descriptive study design were used with a sample of 100 respondents selected via stratified sampling. The research and service activities at Banjar Purwa Santhi Benoa include public campaign and assessment of the level understanding of medical mask waste management. Based on univariate analysis, 91% of respondents know that mask waste contains hazardous and toxic substances. If mask waste is disposed carelessly, 98% of respondents stated that it can pollute the environment, and 98% of respondents also stated that it has the potential to become a means of transmitting COVID-19. However, 85% of respondents disposed of the masks in the household trash. Conclusion, significance and impact study: Respondents had a good level of knowledge about health protocols and mask waste management but have not separated masks from household waste. By holding the community service activity, it is hoped that changes in community behavior will occur.
Co-Authors Adiputra, I Komang Hotra Agung Wiwiek Indrayani Agus Eka Darwinata Biantara, I Wayan Arya Cokorda Agung Wahyu Purnamasidhi Dewi, Luh Putu Widya Amritha Diksha, I Gusti Ngurah Ariestha Satya I Dewa Made Sukrama I Ketut Agus Somia I Wayan Sumardika I.D.A.A Warmadewanthi Indratmo, Novea Jerry Kadek Diana Harmayani Ketut Tuti Parwati Merati Komang Ayu Witarini Purnama, Giovanca Verentzia Saktivi Harkitasari, Saktivi Shanti, Dewa Ayu Fony Prema Sumadewi, Komang Trisna Susilawathi, Ni Made Suteja, Richard Christian Utama, I Made Susila Weisnawa, I Gede Purna Wulandari, Putu Kintan