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All Journal Medula JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Pengabdian Kepada Masyarakat (JPKM) Tabikpun Sains Medisina Jurnal Farmasi SYIFA
Junando, Mirza
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

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A Comprehensive Evaluation of Antibiotic Usage: Establishing a Foundation for Effective Antimicrobial Stewardship Suri, Nurma; Junando, Mirza; Afriyana, Regi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.298-311

Abstract

Background: The intensive care unit (ICU) is a significant area of antibiotic use, accounting for a substantial proportion of the overall antibiotic consumption. The inappropriate use of antibiotics in such settings has a notable impact on the emergence of antimicrobial resistance. Objective: This study evaluated the rationality of antibiotic use in the ICU of RSUD Abdul Moeloek Hospital in Lampung Province. Methods: This study was conducted between December 2022 and February 2023 using a prospective method and purposive sampling. An evaluation was conducted using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) system for quantitative analysis and Gyssens criteria for qualitative assessment. The research subjects comprised 55 individuals, the majority of whom were male (58.2%), aged > 65 years (29.1%), remained in the ICU for less than seven days (78.2%), and subsequently continued their treatment in a non-ICU (69.1%). Results: Quantitative analysis demonstrated that the total number of antibiotics administered in this study was 394.83 DDD, with a DDD/100 patient-day value of 113.78. Ceftriaxone was the most frequently prescribed antibiotic (219 DDD), whereas gentamicin was the least frequently prescribed (1 DDD). Qualitative analysis revealed that 17.6% of the patients exhibited irrational antibiotic use. Conclusion: Irrational use of antibiotics was observed in the following categories: IV A (1.1%); IV D (2.2%); III A (2.2%); III B (2.2%) IIA, (3.3%); IIB (5.5%); and I (1.1%). The study concluded that there was still a considerable degree of irrational antibiotic use.
Co-Authors Afriyana, Regi Al Rasyid, Muhammad Irfan Andrifianie, Femmy Asep Sukohar Atri Sri Ulandari Az Zahra, Ghina Nazhifah Cathartica, Allamanda Damayanti, Ervina Dwi Anjani, Galuh Febyolla, Citra Lucky Hakim, Fatiyah Kamilah Lubna Farhana Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Oktafany, Oktafany Oktoba, Zulpakor Pardilawati, Citra Yuliyanda Putri, Asyifa Adinda Ramdini, Dwi Aulia Rani Himayani Rasmi Zakiah Oktarlina Suri, Nurma Thahir, Salsabila Anggraini Triyandi, Ramadhan