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All Journal HAYATI Journal of Biosciences Science and Technology Indonesia INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Aqwal: Journal of Quran and Hadies Studies
Aulanni’am, Aulanni’am
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Environmental Science Health Professions Materials Science & Nanotechnology Physics Social Sciences

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Journal : Science and Technology Indonesia

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Potential Analysis of Snakehead Fish Albumin Extract (Channa striata) as Immunostimulant and Anti-Inflammatory in Indomethacin-Induced Inflammatory Bowel Disease (IBD) Rats Panjaitan, Tina Fransiskha Carolyn; Fiddaroini, Saidun; Suprayitno, Eddy; Aulanni’am, Aulanni’am; Hardoko, Hardoko
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.725-740

Abstract

Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal disorder driven by oxidative stress and immune dysregulation, often exacerbated by prolonged non-steroidal anti-inflammatory drug (NSAID) use. Conventional therapies provide symptomatic relief but are limited by severe adverse effects, necessitating safer alternatives. Channa striata (snakehead fish) is a rich source of albumin, essential amino acids, and bioactive compounds with potential immunomodulatory and anti-inflammatory effects. This study investigates the therapeutic efficacy of purified Channa striata albumin extract in an indomethacin-induced IBD rat model. Albumin was isolated via ammonium sulfate precipitation and characterized by SDS-PAGE, antioxidant activity (DPPH assay), and amino acid profiling. Rats were treated with Channa striata albumin (100-300 mg/kg BW) for 14 days post-indomethacin induction. Compared to controls and diclofenac-treated groups, the extract significantly reduced malondialdehyde (MDA) levels (up to 90.69%), improved jejunal histoarchitecture, and enhanced occludin expression. Immunohistochemistry showed a marked reduction in CD4+T cell infiltration, indicating immunomodulatory activity. These findings establish Channa striata albumin as a potent natural antioxidant and immunomodulator, offering a safer alternative to NSAIDs for IBD management.
Co-Authors Ahmad Taufiq Andi Tri Saputra Arie Srihardyastutie Eddy Suprayitno Fiddaroini, Saidun Hardoko Hardoko Hendra Susanto Krisnawati, Dyah Ika Nabila, Sofi sholeh, moch Sunaryono Sunaryono, Sunaryono Tina Fransiskha Carolyn Panjaitan, Tina Fransiskha Carolyn Tri Ardiyati Trijoyo Purnomo, Jerry Dwi Wuragil, Dyah Kinasih