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All Journal Indonesian Journal of Tropical and Infectious Disease Science and Technology Indonesia
Nainggolan, Ita Margaretha
Departement Of Clinical Pathology, School Of Medicine And Health Sciences, Atma Jaya Catholic University Of Indonesia, Jakarta, Indonesia/Eijkman Research Center For Molecular Biology, The National Research And Innovation Agency, Cibinong, Bogor, Ind
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Re-Emergence of Ampicillin Sensitive Salmonella Typhi and the Increase of Ciprofloxacin Resistance in Typhoid Fever Treatment in Asia: A Systematic Review Tanjaya, Felicity; Nathan, Johan; Nainggolan, Ita Margaretha; Moehario, Lucky; Thantry, Anita Devi Krishnan; Tunru, Andi Miyanza Lakipadada; Sean, Sherlyn
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.42305

Abstract

Typhoid fever is a disease caused by Salmonella Typhi infection. In 2000, 2.16 million people were affected worldwide, with more than 90% morbidity and mortality in Asia. Ampicillin is the first-line antibiotic used for typhoid management. However, the rise in resistance to first-line antibiotics has shifted ciprofloxacin as an alternative.  This study aimed to describe the trends in ciprofloxacin- and ampicillin-resistant Salmonella Typhi in Asia. This study was a systematic review that conformed to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Search was indicated toward studies on Salmonella Typhi susceptibility toward ciprofloxacin and ampicillin were identified using PubMed, Cochrane Library, and ProQuest. Of the 1542 studies found, only 16 fulfilled the criteria. In 1996, Salmonella Typhi was not found to be resistant to ciprofloxacin, whereas 3.5% was resistant to ampicillin. In 2005, ciprofloxacin resistance increased to 19.3%, whereas ampicillin resistance decreased to 13.3%. In 2005-2014, a larger number of Salmonella Typhi isolates resistant to ciprofloxacin than to ampicillin. Furthermore, during 2016-2019, resistance to ciprofloxacin increased from 8.1% to 95%, while ampicillin resistance increased from 27.5% to 85.2%. This the high ampicillin resistance in South and East Asia. In Asia, there was an increase in ciprofloxacin-resistant Salmonella typhi from 1996 to 2019, whereas ampicillin-resistant Salmonella Typhi decreased from 1996 to 2015.  Between 2016 and 2019, contrasting evidence was found in East Asia and South Asia, where resistance toward ampicillin increased.
Potential of Secretome Hydrogel for Wound Healing in LPS- and Scratch-Induced BJ Cells as an Inflammation Model Widowati, Wahyu; Rahmat, Deni; Faried, Ahmad; Nainggolan, Ita Margaretha; Priyandoko, Didik; Wargasetia, Teresa Liliana; Sugiaman, Vinna Kurniawati; Triharsiwi, Dwi Nur; Qlintang, Sandy; Murti, Harry; Azis, Rizal; Jeffrey, Jeffrey
Science and Technology Indonesia Vol. 10 No. 4 (2025): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.4.1242-1254

Abstract

Wound healing often requires specialized interventions to accelerate recovery due to prolonged inflammation and limited regenerative factors. Umbilical Cord Mesenchymal Stem Cells secretome (UCMSCs) comprises various cytokines and growth factors that can promote wound healing. This study aims to analyze the potential of a secretome-based hydrogel as a wound-healing agent using BJ fibroblast cells induced by lipopolysaccharide (LPS) and scratch injury as an inflammation model. The secretome hydrogel was formulated using Carbopol, Hydroxypropyl Methylcellulose (HPMC), Hydroxyethyl Cellulose (HEC), and secretome. Cytotoxicity was conducted using the WST-8 assay, while cell migration was evaluated through a scratch assay. Tumor Necrosis Factor-???? (TNF-????), Nuclear Factor kappa-B (NF-????B), and Interleukin-8 (IL-8) gene expression were analyzed via qRT-PCR. Additionally, malondialdehyde (MDA) levels were measured for oxidative stress assessment, whereas Connective Tissue Growth Factor (CTGF) and Transforming Growth Factor-????1 (TGF-????1) levels were quantified using ELISA and colorimetric assays. The secretome hydrogel exhibited no cytotoxic effects on BJ fibroblast cells and significantly enhanced cell migration. Moreover, it reduced the TNF-????, IL-8, and NF-????B expression, indicating anti-inflammatory activity. The hydrogel also decreased MDA levels while increasing TGF-β1 and CTGF expression, suggesting antioxidant properties and enhanced tissue regeneration in the inflammatory model. The secretome-based hydrogel presents a promising therapeutic approach for promoting chronic wound healing by modulating inflammation, reducing oxidative stress, enhancing tissue regeneration, and stimulating fibroblast migration.
Co-Authors Ahmad Faried Azis, Rizal Didik Priyandoko Harry Murti Jeffrey ., Jeffrey Moehario, Lucky Nathan, Johan Qlintang, Sandy RAHMAT, DENI Sean, Sherlyn Tanjaya, Felicity Teresa Liliana Wargasetia Thantry, Anita Devi Krishnan Triharsiwi, Dwi Nur Tunru, Andi Miyanza Lakipadada Vinna Kurniawati Sugiaman, Vinna Kurniawati WAHYU WIDOWATI