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All Journal The Indonesian Biomedical Journal Medica Hospitalia Magna Neurologica Neurona Journal of Mechanical Engineering and Applied Technology
Pasmanasari, Elta Diah
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Automotive Engineering Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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Prenatal, Perinatal And Postnatal Risk Factors From Mother And Child To The Incidence Of Epilepsy Sibuea, Susan Megawati; Kustiowati, Endang; Samekto, Maria Immaculata Widiastuti; Tugasworo, Dodik; Bintoro, Aris Catur; Pasmanasari, Elta Diah
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.1042

Abstract

BACKGROUND: Epilepsy is a health problem that affects sufferers and their families, characterized by at least two seizures without provocation with an interval of more than 24 hours between seizures, one seizure without provocation with the possibility of recurring within 10 years, a diagnosis of epilepsy syndrome has been established. The risk of epilepsy can be influenced by the condition of the mother and child in the prenatal, perinatal and postnatal periods. AIMS: This study analyzed the risks of several prenatal, perinatal, and postnatal factors of mother and child as risk factors for epilepsy incidence. METHOD: A case control study was conducted at RSUP Dr. Kariadi Semarang from July 2022 to March 2023. A total of 90 eligible subjects  were divided into 45 case with epilepsy and 45 control with a non-epileptic diagnosis. Inclusion criteria were aged over 17 years to 40 years and exclusion criteria were subjects with mothers who had died or could not be interviewed, data were incomplete and had structural brain disorders or other diseases with clinical symptoms of seizures for the control group. The data obtained were analyzed  using chi squares test for bivariate association, followed by multivariate analysis with multiple logistic regression. RESULT: Maternal age during pregnancy (p=0.016), low birth weight (p=0.007), surgical birth (p=0.004), head trauma at the age of less than 6 years (p=0.008) have been shown to influence the occurrence of epilepsy with significance respectively. CONCLUSION: Prenatal factors of the mother which is maternal age during pregnancy, perinatal and postnatal factors of the child which are low birth weight, surgical birth, and head trauma at the age of less than 6 years are risk factors that influence the occurrence of adulthood epilepsy.
A 22-Years-Old Male with Tuberculoma of the Brain and Spinal Cord with Miliary Tuberculosis Simamora, Rosinondang Deolita; Retnaningsih; Pasmanasari, Elta Diah; Muhartomo, Hexanto
Magna Neurologica Vol. 3 No. 1 (2025): January
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v3i1.1782

Abstract

Background: Tuberculosis (TB) remains a significant health issue in Indonesia. Central nervous system (CNS) tuberculoma is one of the extrapulmonary TB diseases and accounts for approximately 1% of all cases. The emergence of this disease is primarily associated with a weakened immune system. However, several other factors, such as comorbidities, a history of inadequate TB treatment, and poor nutrition, also play a role in the development of tuberculoma. Case: A 22-year-old male complained of weakness in all four limbs for the past month, accompanied by tingling and numbness from both feet up to the T10-11 dermatome level. The patient has a history of seizures from one year ago, interrupted treatment for military tuberculosis, and malnutrition. An MRI of the head and whole spine with contrast revealed tuberculomas. The patient was treated with medication, including intravenous dexamethasone 5 mg every 8 hours, oral phenytoin 200 mg every 24 hours, and anti-tuberculosis therapy. Discussion: Tuberculoma in the central nervous system is rare, especially multiple tuberculomas co-occurring in the brain and spinal cord. MRI is a sensitive tool for diagnosing tuberculomas, characterized by the presence of a target sign. The combination of corticosteroids, antiepileptic drugs, and an entire course of anti-tuberculosis medications aims to address both the immediate neurological symptoms and the underlying infection. Conclusion: TB can present as lesions in the brain and spinal cord, requiring the ability to correlate clinical manifestations and radiological features to establish a diagnosis and necessitating adequate therapy.
Pengaruh Relaksasi Benson terhadap Kualitas Tidur Mahasiswa Fakultas Kedokteran Universitas Diponegoro Roselina, Jessica; Kesoema, Tanti Ajoe; Pasmanasari, Elta Diah; Basyar, Edwin
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.409

Abstract

Introduction: Sleep is the basic need that should be fulfilled to help the body to work optimally. Sleep disorders are quite prevalent among medical students. Sleep deprived medical students experience decreased cognitive function, mood, alertness, and fatigue. Benson relaxation is a non-pharmacological therapy that can improve sleep quality in elderly. Limited study was published on the effect of Benson relaxation on young adults’ sleep quality. Aim: To analyze the effect of Benson relaxation on sleep quality in students of Faculty of Medicine Diponegoro University. Methods: A non-invasive quasi experimental study with one group pre and post-test design was conducted. Which involved 29 medical students from class of 2018-2021. Purposive sampling technique was performed. Benson relaxation was done for 14 consecutive days, 15 minutes every day. The subject’s sleep quality was assessed by the PSQI questionnaire before and after Benson relaxation treatment. Data was analyzed using IBM SPSS Statistics 22.0 and the test used was paired T-test. Results: The pre-test score mean was 9,38 ± 1,821 meanwhile the post-test score mean was 4,31 ± 2,106. There was statistically significant change in sleep quality before and after Benson relaxation (p = 0,004). Discussion: Benson relaxation increased sleep quality in students of Faculty of Medicine Diponegoro University. Keywords: Sleep quality, medical students, Benson relaxation
ERGONOMIC POSTURE CLASSIFICATION OF BENCH WORK UTILIZING MUSCLE DATA: A CASE STUDY IN EDUCATIONAL WORKSHOP Putri, Farika Tono; Purwati, Wiwik; Margana; Supriyo; Prawibowo, Hartanto; Pasmanasari, Elta Diah; Ismail, Rifky; Kadavi, Fadhil Muhammad; Muryanto
Journal of Mechanical Engineering and Applied Technology Vol. 3 No. 2 (2025): VOLUME 3 ISSUE 2 YEAR 2025 (JULY 2025)
Publisher : Politeknik Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32497/jmeat.v3i2.6674

Abstract

Occupational musculoskeletal disorders (MSDs) often result from prolonged non-ergonomic postures, especially in educational and industrial bench work activities. This study presents an approach to classify ergonomic and non-ergonomic working postures using surface electromyography (sEMG) signals and machine learning. sEMG data were recorded from four upper limb muscles during simulated bench work conditions. Time-domain and frequency-domain features were extracted from segmented EMG signals using sliding windows. Dimensionality reduction was performed using Principal Component Analysis (PCA), and classification was carried out using logistic regression. The proposed system achieved an overall classification accuracy of 75% in distinguishing ergonomic and non-ergonomic postures. Visualization using PCA and Linear Discriminant Analysis (LDA) showed clear class separation, validating the discriminatory power of the extracted features. While the small sample size and class imbalance were identified as limitations, the study demonstrates that a simple and interpretable model like Logistic Regression, when combined with proper feature engineering, can yield promising results.This work contributes to the development of low-cost, efficient, and interpretable ergonomic assessment tools. It is particularly relevant for vocational and educational environments where real-time posture monitoring and early prevention of MSDs are essential. Future research should focus on expanding the dataset, exploring deep learning methods, and implementing real-time wearable systems.
The Injected Plasma of Myasthenia Gravis Patient with A Low T-reg Level Caused Clinical Myasthenic Syndromes in Swiss-Webster Mice Pasmanasari, Elta Diah; Purwaningsih, Erni Hernawati; Retnaningsih, Retnaningsih; Purba, Jan Sudir; Octaviana, Fitri
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3086

Abstract

BACKGROUND: Myasthenia gravis (MG) is a rare autoimmune disease affecting neuromuscular junction involvement. The finding that T-reg level in MG patients was lower than that in normal persons leads to the idea that the primary pathology of the disease is T-reg dependent. The T-reg level of MG patients seems to be decreasing compared to that of normal persons. The study was conducted to observe the contribution of T-reg level in plasma injected into Swiss-Webster mice to develop clinically and pathologically myasthenic syndromes.METHODS: Swiss-Webster mice were grouped into three groups: the groups received plasma with normal, low, and high T-reg levels, respectively. The T-reg levels of the mice were measured with flow cytometry analysis and a human regulatory T-cell cocktail for T-cell surface cell marker. The motor function, interleukin (IL)-2, interferon (IFN)-γ, and thymus weight of mice were measured after the injection. Histopathological examination was performed to analyze mice’s muscles and thymus.RESULTS: The result identified that the motor function (2-week treatment group: p=0.021 and 3-week treatment group: p=0.032) and muscle width (p=0.014, p=0.032 and p≤0.001) were significantly lower in the low T-reg level plasma group compared to control and high T-reg level plasma groups. The thymus showed an increase in weight without an increase in the cortex-medulla ratio of the thymus, indicating hyperplasia. Both IL-2 and IFN-γ levels were lower in the low and high T-reg level groups compared with the control group, indicating the autoimmune process.CONCLUSION: Low T-reg level was associated with lower motor function, muscle width, increased thymus weight, as well as lower IL-2 and IFN-γ levels. T-reg level contributed to clinical myasthenic syndromes but not pathological findings. This research method is expected to be a basis for the development of animal models with Swiss-Webster mice.KEYWORDS: animal model, Myasthenia gravis, Swiss-Webster mice
Co-Authors Aris Catur Bintoro Dodik Tugasworo Edwin Basyar Endang Kustiowati Erni Hernawati Purwaningsih, Erni Hernawati Fitri Octaviana Hexanto Muhartomo, Hexanto Kadavi, Fadhil Muhammad Margana Margana Muryanto Prawibowo, Hartanto Purba, Jan Sudir Purwati, Wiwik Putri, Farika Tono Retnaningsih Retnaningsih Retnaningsih Rifky Ismail Roselina, Jessica Samekto, Maria Immaculata Widiastuti Simamora, Rosinondang Deolita Supriyo Susan Megawati Sibuea Tanti Ajoe Kesoema, Tanti Ajoe