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All Journal International Journal of Public Health Science (IJPHS) Window of Health : Jurnal Kesehatan Biota Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Proceedings Series on Health & Medical Sciences Preventif : Jurnal Kesehatan Masyarakat
As’ad, Suryani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Correlation of offspring thyroid function and maternal iodine status in iodine deficient-coastal area Ekawanti, Ardiana; As’ad, Suryani; Natsir, Rosdiana; Umar, Husaini; Irawati, Deasy; Kadriyan, Hamsu; Zubaidi, Fitriannisa Faradina; Ayunda, Rahmah Dara
International Journal of Public Health Science (IJPHS) Vol 13, No 3: September 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i3.23794

Abstract

Thyroid hormone is vital for children's growth and metabolism, relying on sufficient iodine levels for synthesis. Maternal intake determines iodine supply to fetuses and children under two years old. This study aimed to correlate offspring thyroid function with maternal iodine status in coastal areas. A cohort study was conducted, involving pregnant coastal residents. Maternal urinary iodine levels were measured via the ammonium persulfate method, while offspring thyroid stimulating hormones (TSHs) and free thyroxine hormone (fT4) levels were assessed using electro-chemiluminescence immunoassay (ECLIA). Iodine intake was determined through a semiquantitative food frequency questionnaire (FFQ). The correlation between offspring thyroid function and maternal iodine status was analyzed using Pearson’s correlation test. Differences in TSHs and fT4 levels among iodine status groups were examined using the One way-ANOVA test. Maternal iodine status was insufficient with a median urinary iodine of 125 μg/L, resulting in a 60.8% prevalence of iodine insufficiency. Iodine intake (62.20±43.45 μg/day) fell short of recommended levels (RDA). Offspring TSH was 2.29±1.07 μIU/mL, fT4 was 1.26±0.14 ng/dL. TSH and fT4 concentrations showed no significant inter-group differences (p=0.852, p=0.075). Offspring thyroid function did not correlate with maternal iodine status (TSHs: p=0.314; fT4: p=0.258). Offspring thyroid function did not correlate to maternal iodine status in a population of iodine-insufficient and mercury-contaminated coastal areas.
Piper crocatum and Aloe vera Difference Effectiveness in Complementary Treatment of Perineal Wounds Mubayyina, Firdaus; Alam, Gemini; Usman, Andi Nilawati; Ahmad, Mardiana; As’ad, Suryani; Raya, Indah
Biota Vol 15 No 1 (2022)
Publisher : Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/jb.v15i1.409

Abstract

Indonesia, with a maternal mortality rate (MMR) of 305 per 100,000 live births, is directly caused by post-partum hemorrhage (30.3%) and hypertension (27.1%). At the same time, post-partum infection ranks second as a contributor to maternal death after bleeding. Data from the Indonesian Demographic Health Survey (IDHS) showed that the incidence of perineal laceration or rupture was experienced by women who gave birth vaginally (75%). The prevalence of women who experience perineal tears is in the 25-30 years (24%) and women aged 32-39 years (62%). This study aimed to examine the differences in the effectiveness of Piper crocatum and Aloe vera in the complementary treatment of perineal wound healing in post-partum mothers. This study was a quasi-experimental pretest-posttest control group design with a total sampling method with a ratio of 1:1:1 for as many as 30 post-partum mothers with grade I and II injuries according to inclusion criteria with Intervention group red betel stew, aloe vera, and the Control group with perineal injuries at Gunung Sari Health Center and Sesela Health Center. The data observed were the degree of perineal wound healing using the REEDA scale (Redness, Edema, Ecchymosis, Discharge, and Approximation). The results showed differences in the effectiveness of Piper crocatum and aloe vera on perineal wound healing. The average results of the Mann-Whitney statistical test were on the 5th and 7th days (p-value< 0.005). This study shows that Piper crocatum can accelerate the healing of perineal wounds and become an alternative, complementary therapy in perineal wound healing.
The Antioxidant Effect of Ajwa Dates (Phoenix dactylifera L.) to Inhibit the Progression of Preeclampsia Threats on Pregnant Women through Malondialdehyde as Prooxidant Serum Marker Ida Royani; Andi Mappaware, Nasrudin; Nur Rezki, Nur Rezki; As’ad, Suryani
Window of Health : Jurnal Kesehatan Vol 7 No 2 (April 2024)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.vi.1324

Abstract

Hypertension in pregnancy, including preeclampsia, is still a significant problem worldwide and is one of the top three causes of maternal death in Indonesia. The pathophysiology of the disease is unclear yet, but vascular dysfunction due to oxidative stress is thought to play a role. Ajwa dates are known for their antioxidant effects due to their higher phenolic and flavonoids than other dates. The study aimed to determine the impact of consuming seven Ajwa dates each day on the progression of preeclampsia as assessed by changes in malondialdehyde (MDA) levels. Forty pregnant women with gestational age more than 20 weeks were randomly assigned into two groups: the samples of the control group were 10, who were encouraged to consume lots of fruits and vegetables, and the samples of the intervention group were 30, who consumed seven pieces of Ajwa dates every day for eight weeks. MDA measurements were carried out pre-and post-intervention. The intervention group showed a significant reduction in MDA levels following the 8-week intervention period. Consumption of seven Ajwa dates every day can reduce MDA levels significantly and, thus, has the potential to inhibit the progression of preeclampsia in pregnant women who are at risk of preeclampsia based on stress oxidative mechanism.
Pengaruh Intermittent Fasting terhadap Penurunan Ekspresi mRNA Gen Tumor Necrosis Factor-Alpha pada Mencit (Mus Musculus) Basir, Muhammad; Hatta, Mochammad; As’ad, Suryani; Patellongi, Ilhamjaya
Proceedings Series on Health & Medical Sciences Vol. 7 (2025): Proceedings of the 1st National Seminar on Global Health and Social Issue (LAGHOSI)
Publisher : UM Purwokerto Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pshms.v7i.1454

Abstract

Saat ini perkembangan berbagai penyakit degeneratif sangat pesat. Pesatnya perkembangan penyakit tersebut telah mendorong masyarakat luas untuk memahami dampak yang ditimbulkannya. Intermittent fasting bisa membantu mencegah munculnya kanker (salah satu penyakit degeneratif) karena selama puasa sel-sel tubuh berada dalam mode protektif sehingga menjaga tubuh dari serangan penyakit. Intermittent fasting mengurangi status inflamasi tubuh dengan menghambat ekspresi sitokin proinflamasi terutama Tumor Necrosis Factor Alpha (TNF-?). Penelitian ini bertujuan menguji pengaruh intermittent fasting terhadap ekspresi mRNA gen TNF-?. Penelitian ini adalah experiment dengan rancangan Pretest-Posttest with Control Group untuk menguji adanya pengaruh intermittent fasting terhadap ekspresi mRNA Gen TNF-?. Subyek penelitian ini adalah 10 ekor mencit yang dibagi 2 kelompok yaitu kelompok perlakuan (intermittent fasting) dan kelompok kontrol. Penelitian dilaksanakan di Laboratorium Imunologi dan Biologi Molekuler Bagian Mikrobiologi Fakultas Kedokteran Universitas Hasanuddin Makassar sebagai tempat pemeliharaan dan perawatan hewan coba serta pemeriksaan ekspresi mRNA Gen TNF-?. Penelitian dilaksanakan selama 30 hari. Hasil penelitian memperlihatkan adanya penurunan rerata nilai ekspresi mRNA gen TNF-? subyek sebelum dan setelah intermittent fasting dengan nilai ?=0,013 (?<0,05) menunjukkan bahwa ada pengaruh yang bermakna antara intermittent fasting terhadap penurunan ekspresi mRNA Gen TNF-?. Kesimpulannya terjadi penurunan ekspresi mRNA gen TNF-? setelah intermittent fasting.
Kadar 8-Oxo-7, 8-Dihydro-2’-Deoxyguanosine (8-Oxo-Dgsn) Dalam Urine Sebagai Biomarker Penuaan Pada Pasien Tb Paru Wijaya, Cathrine Meryani; Santoso, Arif; Hamid, Firdaus; As’ad, Suryani; Bukhari, Agussalim; Zainuddin, Alfian
Preventif : Jurnal Kesehatan Masyarakat Vol. 12 No. 2 (2021): Volume 12 No.2 (2021)
Publisher : Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/preventif.v12i2.448

Abstract

Proses penuaan merupakan proses fisiologis yang tidak dapat dihindari. Pengukuran 8-oxo-dGsn dalam urin berpotensi sebagai cara baru untuk mengevaluasi proses penuaan dalam menentukan dan memperkirakan usia fisiologis. Penelitian ini betujuan untuk mengetahui kadar 8-Hydroxy-deoxyguanosine (8-OHdG) dalam urin sebagai biomarker penuaan pada pasien tuberculosis paru. Penelitian ini menggunakan pendekatan case control yakni penderita TB paru sebagai kelompok kasus dan kelompok orang sehat sebagai control dengan jumlah sampel sebanyak 50 orang (25 orang kasus dan 25 orang kontrol). Data dianalisis dengan menggunakan SPSS 21.0 (SPSS, Inc. Chicago, IL) dengan tingkat kemaknaan α=0.05.Hasil penelitian menunjukkan bahwa Kadar 8-Hydroxy-deoxyguanosine (8-OHdG) dalam urin sebagai biomarker penuaan pada kelompok kasus rata-rata 3.21±0.88. Kadar 8-Hydroxy-deoxyguanosine (8-OHdG) dalam urin sebagai biomarker penuaan pada kelompok kontrol rata-rata 2.38±0.71. Ada korelasi positif antara umur dengan kadar 8-Hydroxy-deoxyguanosine (8-OHdG) dalam urin sebagai biomarker penuaan (p < 0,001), dimana semakin bertambah umur maka kadar 8-Hydroxy-deoxyguanosine (8-OHdG) semakin tinggi. Terdapat perbedaan yang bermakna (p:0.001) secara statistik kadar 8-Hydroxy-deoxyguanosine (8-OHdG) sebagai biomarker penuaan antara kelompok kasus dengan kelompok kontrol. Kesimpulan penelitian ini adalah Tuberculosis paru mempercepat proses penuaan yang ditandai dengan peningkatan kadar 8-Hydroxy-deoxyguanosine (8-OHdG) dalam urine sebagai biomarker penuaan.
Health-Promotion Approaches to Postpartum Hypertension: Systematic Review of Causes and Management in Maternal Health Rauf, Efri Leny; Chalid, St. Maisuri T.; Idris, Irfan; As’ad, Suryani; Jayanti, Ira
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 12: DESEMBER 2025 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v9i1.9120

Abstract

Introduction: Postpartum hypertension remains one of the leading causes of maternal morbidity and mortality worldwide. This condition may persist from gestational hypertension, preeclampsia, or chronic hypertension, and can also develop de novo postpartum. Understanding its etiology, risk factors, and management strategies is essential to improving maternal health outcomes and preventing long-term cardiovascular complications. Methods: This study applied a systematic review design based on the Arksey and O’Malley framework, guided by the PEOS (Population, Exposure, Outcome, Study Design) model. A comprehensive literature search was conducted across PubMed, ScienceDirect, EBSCO, and Google Scholar databases for studies published between 2009 and 2023 using the keywords “postpartum hypertension,” “causes,” and “management.” Out of 120 identified studies, 20 met the inclusion criteria and were critically appraised using the Hawker Quality Assessment tool. Results: Postpartum hypertension is most frequently associated with preeclampsia, chronic hypertension, and gestational hypertension; however, iatrogenic causes such as bromocriptine therapy and excessive sodium intake were also identified. Most women experience a transient rise in blood pressure within the first 5 days postpartum, attributed to increased intravascular volume. The majority of studies emphasized inadequate screening and follow-up during the first week after delivery, with up to one-third of patients remaining untreated. Recent interventions, including digital monitoring systems and eHealth-based self-management, demonstrated improved outcomes in detection and patient adherence. Conclusion: Effective management of postpartum hypertension requires timely diagnosis, structured follow-up, and coordinated transition to primary care for long-term cardiovascular risk reduction. Health-care providers must enhance awareness and clinical competence, as complications from misdiagnosis or undertreatment remain common yet preventable through integrated postpartum surveillance and health-promotion strategies.
Co-Authors Ahmad, Mardiana Andi Mappaware, Nasrudin Andi Nilawati Usman Ardiana Ekawanti Arif Santoso Ayunda, Rahmah Dara Bukhari, Agussalim Deasy Irawati Gemini Alam Hamid, Firdaus Ida Royani Ilhamjaya Patellongi Indah Raya IRFAN IDRIS Jayanti, Ira Kadriyan, Hamsu Mubayyina, Firdaus Muhammad Basir Natsir, Rosdiana Nur Rezki, Nur Rezki Rauf, Efri Leny St. Maisuri T. Chalid Umar, Husaini Wijaya, Cathrine Meryani Zainuddin, Alfian Zubaidi, Fitriannisa Faradina