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All Journal International Journal of Public Health Science (IJPHS) Window of Health : Jurnal Kesehatan Biota Proceedings Series on Health & Medical Sciences
As’ad, Suryani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Correlation of offspring thyroid function and maternal iodine status in iodine deficient-coastal area Ekawanti, Ardiana; As’ad, Suryani; Natsir, Rosdiana; Umar, Husaini; Irawati, Deasy; Kadriyan, Hamsu; Zubaidi, Fitriannisa Faradina; Ayunda, Rahmah Dara
International Journal of Public Health Science (IJPHS) Vol 13, No 3: September 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i3.23794

Abstract

Thyroid hormone is vital for children's growth and metabolism, relying on sufficient iodine levels for synthesis. Maternal intake determines iodine supply to fetuses and children under two years old. This study aimed to correlate offspring thyroid function with maternal iodine status in coastal areas. A cohort study was conducted, involving pregnant coastal residents. Maternal urinary iodine levels were measured via the ammonium persulfate method, while offspring thyroid stimulating hormones (TSHs) and free thyroxine hormone (fT4) levels were assessed using electro-chemiluminescence immunoassay (ECLIA). Iodine intake was determined through a semiquantitative food frequency questionnaire (FFQ). The correlation between offspring thyroid function and maternal iodine status was analyzed using Pearson’s correlation test. Differences in TSHs and fT4 levels among iodine status groups were examined using the One way-ANOVA test. Maternal iodine status was insufficient with a median urinary iodine of 125 μg/L, resulting in a 60.8% prevalence of iodine insufficiency. Iodine intake (62.20±43.45 μg/day) fell short of recommended levels (RDA). Offspring TSH was 2.29±1.07 μIU/mL, fT4 was 1.26±0.14 ng/dL. TSH and fT4 concentrations showed no significant inter-group differences (p=0.852, p=0.075). Offspring thyroid function did not correlate with maternal iodine status (TSHs: p=0.314; fT4: p=0.258). Offspring thyroid function did not correlate to maternal iodine status in a population of iodine-insufficient and mercury-contaminated coastal areas.
Piper crocatum and Aloe vera Difference Effectiveness in Complementary Treatment of Perineal Wounds Mubayyina, Firdaus; Alam, Gemini; Usman, Andi Nilawati; Ahmad, Mardiana; As’ad, Suryani; Raya, Indah
Biota Vol 15 No 1 (2022)
Publisher : Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/jb.v15i1.409

Abstract

Indonesia, with a maternal mortality rate (MMR) of 305 per 100,000 live births, is directly caused by post-partum hemorrhage (30.3%) and hypertension (27.1%). At the same time, post-partum infection ranks second as a contributor to maternal death after bleeding. Data from the Indonesian Demographic Health Survey (IDHS) showed that the incidence of perineal laceration or rupture was experienced by women who gave birth vaginally (75%). The prevalence of women who experience perineal tears is in the 25-30 years (24%) and women aged 32-39 years (62%). This study aimed to examine the differences in the effectiveness of Piper crocatum and Aloe vera in the complementary treatment of perineal wound healing in post-partum mothers. This study was a quasi-experimental pretest-posttest control group design with a total sampling method with a ratio of 1:1:1 for as many as 30 post-partum mothers with grade I and II injuries according to inclusion criteria with Intervention group red betel stew, aloe vera, and the Control group with perineal injuries at Gunung Sari Health Center and Sesela Health Center. The data observed were the degree of perineal wound healing using the REEDA scale (Redness, Edema, Ecchymosis, Discharge, and Approximation). The results showed differences in the effectiveness of Piper crocatum and aloe vera on perineal wound healing. The average results of the Mann-Whitney statistical test were on the 5th and 7th days (p-value< 0.005). This study shows that Piper crocatum can accelerate the healing of perineal wounds and become an alternative, complementary therapy in perineal wound healing.
The Antioxidant Effect of Ajwa Dates (Phoenix dactylifera L.) to Inhibit the Progression of Preeclampsia Threats on Pregnant Women through Malondialdehyde as Prooxidant Serum Marker Ida Royani; Andi Mappaware, Nasrudin; Nur Rezki, Nur Rezki; As’ad, Suryani
Window of Health : Jurnal Kesehatan Vol 7 No 2 (April 2024)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.vi.1324

Abstract

Hypertension in pregnancy, including preeclampsia, is still a significant problem worldwide and is one of the top three causes of maternal death in Indonesia. The pathophysiology of the disease is unclear yet, but vascular dysfunction due to oxidative stress is thought to play a role. Ajwa dates are known for their antioxidant effects due to their higher phenolic and flavonoids than other dates. The study aimed to determine the impact of consuming seven Ajwa dates each day on the progression of preeclampsia as assessed by changes in malondialdehyde (MDA) levels. Forty pregnant women with gestational age more than 20 weeks were randomly assigned into two groups: the samples of the control group were 10, who were encouraged to consume lots of fruits and vegetables, and the samples of the intervention group were 30, who consumed seven pieces of Ajwa dates every day for eight weeks. MDA measurements were carried out pre-and post-intervention. The intervention group showed a significant reduction in MDA levels following the 8-week intervention period. Consumption of seven Ajwa dates every day can reduce MDA levels significantly and, thus, has the potential to inhibit the progression of preeclampsia in pregnant women who are at risk of preeclampsia based on stress oxidative mechanism.
Pengaruh Intermittent Fasting terhadap Penurunan Ekspresi mRNA Gen Tumor Necrosis Factor-Alpha pada Mencit (Mus Musculus) Basir, Muhammad; Hatta, Mochammad; As’ad, Suryani; Patellongi, Ilhamjaya
Proceedings Series on Health & Medical Sciences Vol. 7 (2025): Proceedings of the 1st National Seminar on Global Health and Social Issue (LAGHOSI)
Publisher : UM Purwokerto Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pshms.v7i.1454

Abstract

Saat ini perkembangan berbagai penyakit degeneratif sangat pesat. Pesatnya perkembangan penyakit tersebut telah mendorong masyarakat luas untuk memahami dampak yang ditimbulkannya. Intermittent fasting bisa membantu mencegah munculnya kanker (salah satu penyakit degeneratif) karena selama puasa sel-sel tubuh berada dalam mode protektif sehingga menjaga tubuh dari serangan penyakit. Intermittent fasting mengurangi status inflamasi tubuh dengan menghambat ekspresi sitokin proinflamasi terutama Tumor Necrosis Factor Alpha (TNF-?). Penelitian ini bertujuan menguji pengaruh intermittent fasting terhadap ekspresi mRNA gen TNF-?. Penelitian ini adalah experiment dengan rancangan Pretest-Posttest with Control Group untuk menguji adanya pengaruh intermittent fasting terhadap ekspresi mRNA Gen TNF-?. Subyek penelitian ini adalah 10 ekor mencit yang dibagi 2 kelompok yaitu kelompok perlakuan (intermittent fasting) dan kelompok kontrol. Penelitian dilaksanakan di Laboratorium Imunologi dan Biologi Molekuler Bagian Mikrobiologi Fakultas Kedokteran Universitas Hasanuddin Makassar sebagai tempat pemeliharaan dan perawatan hewan coba serta pemeriksaan ekspresi mRNA Gen TNF-?. Penelitian dilaksanakan selama 30 hari. Hasil penelitian memperlihatkan adanya penurunan rerata nilai ekspresi mRNA gen TNF-? subyek sebelum dan setelah intermittent fasting dengan nilai ?=0,013 (?<0,05) menunjukkan bahwa ada pengaruh yang bermakna antara intermittent fasting terhadap penurunan ekspresi mRNA Gen TNF-?. Kesimpulannya terjadi penurunan ekspresi mRNA gen TNF-? setelah intermittent fasting.
Co-Authors Ahmad, Mardiana Andi Mappaware, Nasrudin Andi Nilawati Usman Ardiana Ekawanti Ayunda, Rahmah Dara Deasy Irawati Gemini Alam Ida Royani Ilhamjaya Patellongi Indah Raya Kadriyan, Hamsu Mubayyina, Firdaus Muhammad Basir Natsir, Rosdiana Nur Rezki, Nur Rezki Umar, Husaini Zubaidi, Fitriannisa Faradina