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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Farmasi Klinik Indonesia The Indonesian Biomedical Journal Narra J Jurnal Natural Trends in Infection and Global Health
Firdausa, Sarah
Department Of Internal Medicine, Faculty Of Medicine Universitas Syiah Kuala, Darussalam, Indonesia 23111
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health

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Journal : Jurnal Natural

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TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY Suryawati Suryawati; Safrida Safrida; Firdausa Sarah; Azizah Vonna; Vera Dewi Mulia
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.553 KB) | DOI: 10.24815/jn.v19i3.13405

Abstract

Treatment of diabetes mellitus is intended to reduce the risk of blindness, kidney failure, neuropathy and heart disease that can develop due to the chronic increase in the blood glucose level. The selected hypoglycemic agents should be effective, safe and readily available. The widely used agents work by interrupting enzymes responsible for glucose regulation. Those enzymes are α-amilase, α-glucosidase, dipeptidyl peptidase-IV, aldose reductase and angiotensin converting enzyme. A medicinal plant, fenugreek (Trigonella foenum-graecum) has been used as an antidiabetic folk medicine. This review provides information related to in vitro studies showing antihyperglycemic activity of fenugreek along with an in vivo study in animals. In addition, potential phytochemicals that have been isolated from this plant are described and play a role in the searching for the most potent agents for diabetes mellitus therapy.
The blood glucose lowering effect of Malaysian Tinospora crispa in rats SARAH FIRDAUSA; MAUNG MAUNG CHO; KHIN MAUNG MAUNG; NILAR AUNG; NORSIDAH KUZAIFAH; SURYAWATI SURYAWATI
Jurnal Natural Volume 20 Number 1, February 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1193.549 KB) | DOI: 10.24815/jn.v20i1.15907

Abstract

Diabetes is defined as a chronic hyperglycemia which should be countered by the effective, safe and readily available hypoglycemic agents. Herbal is among alternatives that has been used by society for years but lacks of documented evidences. Tinospora crispa (TC) is enriched by phytochemicals which potentially reduce blood glucose thus is useful for diabetic patients. This study aimed to investigate the potency of TC inreducing blood sugar and body weight. It involved 30 healthy rats divided into 5 groups namely: normal control, normal fed with TC extract, diabetic, TC-treated diabetic (dose 500 mg/kg w/w), and vitamin E-traeted diabetic rats (60 IU). The body weight and fasting blood glucose were measured each week for 1 month. The administration of TC extract 500 mg/kg (w/w) helps to maintain body weight in diabetic rats and reduce the fasting blood glucose. TC is highly potent as hypoglycemic agents therefore needed to be explored further.
TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY Suryawati Suryawati; Safrida Safrida; Firdausa Sarah; Azizah Vonna; Vera Dewi Mulia
Jurnal Natural Volume 19 Number 3, October 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i3.13405

Abstract

Treatment of diabetes mellitus is intended to reduce the risk of blindness, kidney failure, neuropathy and heart disease that can develop due to the chronic increase in the blood glucose level. The selected hypoglycemic agents should be effective, safe and readily available. The widely used agents work by interrupting enzymes responsible for glucose regulation. Those enzymes are α-amilase, α-glucosidase, dipeptidyl peptidase-IV, aldose reductase and angiotensin converting enzyme. A medicinal plant, fenugreek (Trigonella foenum-graecum) has been used as an antidiabetic folk medicine. This review provides information related to in vitro studies showing antihyperglycemic activity of fenugreek along with an in vivo study in animals. In addition, potential phytochemicals that have been isolated from this plant are described and play a role in the searching for the most potent agents for diabetes mellitus therapy.
The blood glucose lowering effect of Malaysian Tinospora crispa in rats SARAH FIRDAUSA; MAUNG MAUNG CHO; KHIN MAUNG MAUNG; NILAR AUNG; NORSIDAH KUZAIFAH; SURYAWATI SURYAWATI
Jurnal Natural Volume 20 Number 1, February 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v20i1.15907

Abstract

Diabetes is defined as a chronic hyperglycemia which should be countered by the effective, safe and readily available hypoglycemic agents. Herbal is among alternatives that has been used by society for years but lacks of documented evidences. Tinospora crispa (TC) is enriched by phytochemicals which potentially reduce blood glucose thus is useful for diabetic patients. This study aimed to investigate the potency of TC inreducing blood sugar and body weight. It involved 30 healthy rats divided into 5 groups namely: normal control, normal fed with TC extract, diabetic, TC-treated diabetic (dose 500 mg/kg w/w), and vitamin E-traeted diabetic rats (60 IU). The body weight and fasting blood glucose were measured each week for 1 month. The administration of TC extract 500 mg/kg (w/w) helps to maintain body weight in diabetic rats and reduce the fasting blood glucose. TC is highly potent as hypoglycemic agents therefore needed to be explored further.
Co-Authors . Vera Dewi Mulia, Troef Soemarno Aini, Zahratul Azizah Vonna Azizah Vonna Budiono Budiono Cut T. Ramadhani Djoko Santoso Djoni Susanto Erwin Astha Triyono Fauzul Husna Hafni Andayani Hijra Novia Suardi Hilda Maysarah Iflan Nauval Ivan Hoesada James Hutagalung KHIN MAUNG MAUNG Masyfufah, Lilis MAUNG MAUNG CHO Nani Safuni NILAR AUNG NORSIDAH KUZAIFAH R. Heru Prasetyo S Suryawati Safrida Safrida Siti Saleha Subhan R. Pamungkas Suryantoro, Satriyo Dwi SURYAWATI SURYAWATI Suryawati Suryawati Suryawati Suryawati T. Hidayat Syah Teuku Mamfaluti Vera Nova Zulfa Zahra