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All Journal Jurnal Medika Cendikia (e-Journal) Jurnal Pengabdian Masyarakat DEDIKASI Ekalaya: Jurnal Pengabdian Kepada Masyarakat Indonesia Journal of Pharmacopoeia
Sugiah, Sugiah
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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PENYULUHAN KADAR CRP (C-REACTIVE PROTEIN) PADA PENDERITA TUBERKULOSIS DI KECAMATAN CILAWU SEBAGAI PENANDA ADANYA INFLAMASI Nurisani, Astari; Mamay, Mamay; Mutmaina, Gina Nafsa; Sugiah, Sugiah; Pratama, Wisnu Arya
Ekalaya: Jurnal Pengabdian Kepada Masyarakat Indonesia Vol. 2 No. 2 (2023): Ekalaya Journal
Publisher : Nindikayla Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57254/eka.v2i2.57

Abstract

Infection due to tuberculosis bacteria will cause inflammation in the body which will stimulate the emergence of C-Reactive Protein as a biomarker of inflammation. C-Reactive Protein (CRP) is a polypeptide molecule of the pentraxin group which is produced in the liver and controlled by cytokines especially Interleukin-6 (IL-6). CRP is useful for monitoring disease progression. CRP concentration is related to disease severity, infection and treatment effect. The purpose of this community service is to see CRP (C-Reactive Protein) levels in tuberculosis sufferers in the Cilawu sub-district and provide an understanding of CRP examination. The method used is counseling with LCD and examination of CRP levels in tuberculosis patients. The sufferers are collected in a house that has been mutually agreed upon. The results of the activity were that most of those present had CRP examination results on the 30 samples that had been examined, 24 people (80%) had positive results, and 6 people (20%) had negative results. CRP levels in positive tuberculosis patients obtained various results between 6 mg/L to 192 mg/L. Conclusion: the results of this community service illustrate that there is an inflammatory response of CRP to tuberculosis bacterial infection. After carrying out counseling and examining CRP levels, the community, especially tuberculosis sufferers, became aware and interested in carrying out CRP examinations as a form of monitoring the level of infection they were suffering from
Antibiotics And Bacterial Resistance: A Global Challenge That Needs To Be Addressed Sugiah, Sugiah; Fadli, Fadli; Hariati , Fitria; Cendekiawan, Khrisna Agung
Journal of Pharmacopoeia Vol. 2 No. 1 (2025): MARCH-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/mwb7an91

Abstract

This study aims to explore the global challenges faced in addressing bacterial resistance to antibiotics, which are now one of the most serious health threats in the world. This study was conducted through the Systematic Literature Review (SLR) method by searching scientific articles from various databases such as PubMed, Scopus, and Google Scholar using the keywords "antibiotic resistance", "global health", "treatment failure", and "resistance mechanisms". The articles analyzed are publications in the last 10 years, focusing on the causes of resistance, their impact on global health, and countermeasures that have been carried out. The results of the study show that antibiotic resistance is mainly caused by the inappropriate use of antibiotics in the medical and non-medical sectors, lack of distribution supervision, and lack of development of new antibiotics. To overcome this, a comprehensive approach is needed, including increasing public education and health workers, strengthening regulations, and developing alternative therapies such as phagotherapy and vaccines. Without proper treatment, antibiotic resistance can lead to infection treatment failure, increased mortality rates, and burden the global health system
IMPROVING COMMUNITY HEALTH THROUGH HEALTH SCREENING FOR POSYANDU CADRES AND THE COMMUNITY OF JAYARAGA VILLAGE Andhika Lungguh Perceka, Andhika Lungguh Perceka; Hasbi Taobah Ramdani, Hasbi Taobah Ramdani; N. Ai Erlinawati, N. Ai Erlinawati; Herlin Rusyan, Herlin Rusyani; Sugiah, Sugiah; Gina Mutmainna, Gina Mutmainna; Wieda Widyatry Qarragita, Wieda Widyatry Qarragita; Dani Sujana, Dani Sujana; Yogi Rahman Nugraha, Yogi Rahman Nugraha
Jurnal Pengabdian Masyarakat DEDIKASI Vol 6 No 01 (2025): Jurnal Pengabdian Masyarakat DEDIKASI
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jdk.v6i01.161

Abstract

This Community Service Activity (PkM) aims to identify risk factors for diabetes mellitus (DM) as one of the comorbidities that exacerbate the condition of the elderly. The expected outcome of this activity is for residents to be aware of the risk factors for the disease and their own health conditions, particularly regarding DM. It is hoped that this activity will increase community awareness about DM management. The activity was attended by 50 residents of Jayaraga Village, Tarogong Kidul District, Garut Regency. The results of the activity revealed that 7 individuals (14%) confirmed having diabetes mellitus, 31 individuals (62%) had hypertension, and 12 individuals (24%) had gout. Therefore, through this community service initiative, we conducted a health screening program that included free blood pressure checks, uric acid tests, and blood sugar level measurements, as well as weight checks and health education, particularly on diabetes and its prevention methods. With the implementation of this community service initiative, we hope that the health-related issues in Jayaraga Village, Tarogong Kidul Sub-district, Garut Regency, can be addressed to some extent.
THE BLOOD CREATININE LEVELS OF HYPERTENSIVE PATIENTS OF PRODUCTIVE AGE AT THE CIKAJANG COMMUNITY HEALTH CENTER Rismawati, Rismawati; Mutmaina, Gina Nafsa; Sugiah, Sugiah; Nurisani, Astari; Arbila, Meisya
Jurnal Medika Cendikia Vol 11 No 01 (2024): Jurnal Medika Cendikia
Publisher : Karsa Husada Health Institute Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmc.v11i01.244

Abstract

The incidence of hypertension is on the rise with the passage of time, attributed to the increasing prevalence of unhealthy lifestyle changes. The productive age signifies a stage in the evolution of life where individuals are at the peak of activity, characterized by heightened levels of engagement that tend to result in health issues. Hypertension can lead to organ damage, notably the kidneys, as indicated by elevated levels of creatinine in the blood. The aim of this study is to ascertain the levels of blood creatinine in hypertensive patients of productive age at the Cikajang Community Health Center. This descriptive study analyzes blood creatinine levels in hypertensive patients using the Jaffe Reaction method, with a sample size of 30 respondents obtained through accidental sampling technique. The study's findings reveal that 19 participants (64%) have normal creatinine levels, 10 participants (33%) have high creatinine levels, and 1 participant (3%) has low creatinine levels. The study concludes that the majority of respondents have normal creatinine levels, nearly half of the respondents have high creatinine levels, and a small portion of respondents have low creatinine levels
The Immunomodulatory Potential of Hesperidin from Garut Orange Peel (Citrus nobilis var. chrysocarpha) Against Human Metapneumovirus (HMPV) Infection: Based on In Vivo Mouse Model Study sugiah, sugiah; Dadang Muhammad Hasyim, Dadang Muhammad Hasyim; Marsha Yulianti, Marsha Yulianti; Akbar Nurjamil, Akbar Nurjamil; N. Ai Erlinawati, N. Ai Erlinawati
Jurnal Medika Cendikia Vol 12 No 02 (2025): Jurnal Medika Cendikia
Publisher : Karsa Husada Health Institute Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmc.v12i02.371

Abstract

Acute respiratory infections (ARIs), including those caused by Human Metapneumovirus (HMPV), remain a global health concern, and no specific therapy or vaccine is currently available. Hesperidin, the main flavonoid in Garut orange peel (Citrus nobilis var. chrysocarpha), is known for its anti-inflammatory, antiviral, and immunomodulatory activities. This study was an in vivo pilot study using 35 male Balb/c mice divided into seven groups: normal control, negative control (5% imiquimod), positive control (levamisole), and hesperidin-treated groups at 50, 100, and 150 mg/kg body weight, either alone or in combination with imiquimod. Observed parameters included total leukocytes, lymphocytes, neutrophil-to-lymphocyte ratio (NLR), body weight, organ weight, and lung histology. Hesperidin was extracted using 70% ethanol and identified by thin-layer chromatography (TLC).Results showed that body weight data were normally distributed, with no significant differences between groups (p > 0.05), indicating that hesperidin was safe at the tested doses. Hematological analysis revealed significant differences in leukocyte counts (p = 0.001), lymphocytes (p = 0.002), and NLR (p = 0.001). Imiquimod induced systemic inflammation, as evidenced by increased leukocytes, lymphocytes, NLR, and lung inflammation scores. Hesperidin exhibited dose-dependent immunomodulatory effects; the 100 mg/kgBW dose combined with imiquimod produced the most optimal results, characterized by low NLR and a histology score of 0, reflecting controlled inflammation and effective adaptive immune activation. In contrast, the 150 mg/kgBW dose triggered excessive inflammatory responses.
Co-Authors Akbar Nurjamil, Akbar Nurjamil Arbila, Meisya Astari Nurisani Dadang Muhammad Hasyim, Dadang Muhammad Hasyim Dani Sujana, Dani Sujana Fadli Fadli Gina Mutmainna, Gina Mutmainna Hariati , Fitria Hasbi Taobah Ramdani, Hasbi Taobah Ramdani Herlin Rusyan, Herlin Rusyani Khrisna Agung Cendekiawan Mamay, Mamay Marsha Yulianti, Marsha Yulianti Mutmaina, Gina Nafsa N. Ai Erlinawati, N. Ai Erlinawati Perceka, Andhika Lungguh Pratama, Wisnu Arya Rismawati Rismawati Wieda Widyatry Qarragita, Wieda Widyatry Qarragita Yogi Rahman Nugraha