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All Journal Jurnal Inovasi Farmasi Indonesia PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Gema Kesehatan Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Kesehatan Metro Sai Wawai Jurnal Mahasiswa Kesehatan Multicore International Journal of Multidisciplinary (MIJM) Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM)
Kadir, Mujtahid Bin Abd
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Multicore International Journal of Multidisciplinary (MIJM)

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Prediction of Sinensetin from Kumis Kucing (Orthosiphon aristatus) as Aspulvinone Dimethylallyltransferase Inhibitor for Anticancer Agent Prasetyawan, Fendy; Arifin, Chandra; Astutik, Widhi; Rohmah, Eka Hayati; Kadir, Mujtahid Bin Abd; Ariawan, M Wahyu; Marhenta, Yogi Bhakti; Mildawati, Ratna; Saristiana, Yuneka; Rofiq, Abd
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 1 (2025): May
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i1.3

Abstract

Sinensetin, a polymethoxylated flavone found in Orthosiphon aristatus (commonly known as Kumis Kucing), was evaluated in silico for its potential inhibitory activity against Aspulvinone Dimethylallyltransferase, an enzyme implicated in cancer-related biosynthetic pathways. The SMILES structure of sinensetin was retrieved from PubChem and analyzed using the PASS online prediction tool (www.way2drug.com). The results showed a high probability of activity (Pa = 0.865) and a very low probability of inactivity (Pi = 0.016), indicating that sinensetin is likely to act as a potent inhibitor of the enzyme. These findings suggest that sinensetin could be a promising anticancer agent candidate by targeting Aspulvinone Dimethylallyltransferase. Further studies are recommended to validate this prediction through molecular docking and biological assays.
Co-Authors Alimansur, Moh Antoro, Ester Lianawati Astutik, Widhi Chandra Arifin Datin An Nisa Sukmawati Elfred Rinaldo Kasimo, Elfred Rinaldo Fendy Prasetyawan Herman Kasimo, Elfred khusnul khotimah M. Wahyu Ariawan Marhenta, Yogi Bhakti Mildawati, Ratna Putri Larasati, Julyana Rofiq, Abd Rohmah, Eka Hayati Salmasfattah, Novyananda Sanjaya, Rochmad Kris savitri, Lisa Sulistyowati , Yuni Yuneka Saristiana Yuniarto, Prayoga Fery