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p-Index From 2020 - 2025
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All Journal International Journal of Integrated Health Sciences Diponegoro International Medical Journal (DIMJ) Berita Kedokteran Masyarakat
Sofa, Yulia Ratna
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Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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The Effect of Folic Acid Adjuvant on Cognitive Function on Patients with Chronic Schizophrenia Sofa, Yulia Ratna; Wardani, Natalia Dewi; sari, Linda Kartika; Hadiati, Titis; Muflihatunnaimah, Muflihatunnaimah
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.15219

Abstract

ABSTRACT   Background: Schizophrenia is a severe mental disorder that associated with daily life and social function deterioration and could be accompanied with cognitive deficits. Meanwhile, hyperhomocysteinemia (HHcy) is the increasing homocysteine (Hcy) level which might be the one of biological factor in schizophrenia. In recent study with healthy subjects, it was known that there was a correlation between total Hcy level and cognitive function. Folic acid is part of water-soluble vitamin B and expected to have important role in oxidative stress by preventing hyperhomocysteinemia.Objective: This study aimed to elaborate the effect of folic acid adjuvant to improve cognitive function in chronic schizophrenia patients.Methods: This was a double-blinded randomized controlled trial with pre and post-test clinical trial design. This study included 32 patients in control group and 32 patients in treatment group. MOCA-INA score was examined in all subjects on the first day. Then, all subjects were given standard antipsychotic treatment plus folic acid adjuvant / placebo during 3 week of hospitalized treatment and 1 week of outpatient treatment. When the 4-week treatment finished, the subjects were followed by MOCA-INA post-test.Results: In this study, we had the significant difference of pre and post-test MOCA-INA score in the control group (p<0.001), significant difference of pre and post-test MOCA-INA score in the treatment group (p<0.001), and significant difference of post-test MOCA-INA score between the control and treatment group (p<0.001).Conclusion: Folic acid adjuvants significantly improved cognitive function in chronic schizophrenic patients.  
Anemia and Aggression Among Patients with Schizophrenia in Amino Gondohutomo Psychiatric Hospital Noerhidajati, Elly; Sofa, Yulia Ratna; Woroasih, Sri; Hardini, Intan Tri
International Journal of Integrated Health Sciences Vol 13, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n1.4029

Abstract

Background: Anemia has been identified as a potential modifiable factor influencing aggression levels in individuals with schizophrenia.Objective: To investigate the association between anemia and incidence of aggression in patients with schizophrenia in Amino Gondohutomo Psychiatric Hospital, Semarang, Indonesia.Methods: A cross-sectional study was conducted between January 2022 and December 2023 on patients with schizophrenia in Amino Gondohutomo Psychiatric Hospital, Semarang, Indonesia. Subjects were selected using consecutive sampling technique, and individuals with affective mood disorder and lost to follow-up were excluded from the study. Data were obtained through patients’ medical records, PANSS-EC scores, and hemoglobin measuring devices. Chi-square test and logistic regression were applied for statistical analyses.Results: Of 100 participants, patients with schizophrenia presented with aggression were predominantly above 40 years old (26 patients, 81.3%), women (17 patients, 51.1%), and non-anemic (17 patients, 57.1%). Gender and anemia were significantly associated with aggression in patients with schizophrenia (p <0.05). Schizophrenic patients with anemia had a 7.68-fold greater risk (95% CI: 2.70 – 21.8) of aggression. Men with schizophrenia was associated with a 2.37-fold greater risk (95% CI: 1.00 – 5.60) of aggression.Conclusion: Anemia and men seems to be risk factors of aggression in patients with schizophrenia. Further multicenter studies with larger sample size is needed to support this finding.
Social media engagement patterns in relation to adolescent anxiety and depression: a systematic review Amanda, Qorry; Haryani, Deby Aprilia; Sofa, Yulia Ratna; Purwanto, Dannu; Maryam, Adiva Kalila; Basrowi, Ray Wagiu; Devi, Yuli Puspita
BKM Public Health and Community Medicine Vol 41 No 09 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v41i09.22664

Abstract

Purpose: Adolescents are increasingly immersed in social media environments that encourage curated self-presentation and social comparison. Global prevalence estimates from the World Health Organization indicate that 5.5% of adolescents aged 15–19 meet diagnostic criteria for anxiety disorders. While prior research emphasized screen time duration, emerging evidence suggests that how young people engage— primarily through passive, emotionally reactive, or appearance-focused behaviors—may be more predictive of internalising symptoms such as anxiety and depression. This systematic review aimed to synthesize observational evidence on associations between adolescent social media use and internalising symptoms, with particular attention to engagement patterns, psychosocial mediators, and contextual moderators. Methods: A comprehensive search across PubMed, Scopus, EBSCOhost, and AI-assisted platforms was conducted between April 14 and 25, 2025. Inclusion criteria were: observational design, adolescent population (10–19 years), validated measures of anxiety/depression, and exposure to social media use. Ten studies published between 2018 and 2025 met eligibility criteria (N=10). Data were synthesized narratively, with quality assessed using the JBI checklist. Results: Across studies, problematic use and passive scrolling were more strongly associated with anxiety and depression than total time spent online. Sleep disruption and appearance-based comparison consistently emerged as mediators, while gender, emotional reactivity, and socioeconomic background moderated vulnerability. Girls and gender- diverse adolescents reported higher psychological reactivity. Protective factors included physical activity and family support. Most studies were cross-sectional; only one referenced neurobiological pathways. Conclusion: Digital mental health risks in adolescents are driven less by screen exposure time and more by emotionally charged engagement styles. Interventions should prioritize resilience-building and digital literacy, while future research must incorporate longitudinal and biopsychosocial frameworks to capture the complexity of these associations better.
Co-Authors Amanda, Qorry Basrowi, Ray Wagiu Dannu Purwanto Elly Noerhidajati Hardini, Intan Tri Haryani, Deby Aprilia Linda Kartika Sari Maryam, Adiva Kalila Muflihatunnaimah, Muflihatunnaimah Natalia Dewi Wardani Titis Hadiati, Titis Woroasih, Sri Yuli Puspita Devi