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All Journal Padjadjaran Journal of Dentistry Journal of Health and Dental Sciences Yarsi Dental Journal Jurnal Pengabdian Masyarakat Kesehatan Gigi FOKGII
Suriyah, Wastuti Hidayati
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Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Molecular docking analysis between anti-apoptosis EGFR and four coumarins, and four carbazole alkaloids: in silico study Afriza, Dhona; Suriyah, Wastuti Hidayati; Ichwan, Solachuddin Jauhari Arief; Knights, Joe
Padjadjaran Journal of Dentistry Vol 36, No 1 (2024): March 2024
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol36no1.52467

Abstract

Introduction: The anti-apoptotic protein EGFR is typically overexpressed in the majority of head and neck squamous cell carcinomas (HNSCC) and has been targeted for genetic therapy. The Clausena excavata plant is an evergreen shrub that has been widely used for various disease therapies, including cancer. Coumarin and carbazole alkaloids are the plant's primary active ingredients. This study aims to determine the molecular interaction between EGFR and several coumarins (clauslactone E, dentatin, nordentatin, clausenidin) and carbazole alkaloids (7- hydroxyheptaphylline, clausine E, 2,7 - dimethoxy - 9H - carbazole - 3- carbaldehyde,and 2,7 – dimethoxy - 9H - carbazole – 3-carboxylic acid). Methods: This research was carried out in silico using the molecular docking method. Molecular docking analysis was performed using AutoDock Vina, AutoDockTools 1.5.6., Pymol, and Discovery Studio Biovia 2021. The three-dimensional structure of the EGFR protein was retrieved from the RCSB Protein Data Bank. Ligands were obtained from the PubChem Compound Database. The comparison ligand was doxorubicin. Molecular docking results were analyzed based on binding affinity, amino acid interactions, visualization of docking results, and Lipinski's rule of five. Results: All of the investigated ligands with the EGFR receptor had strong binding affinity (-6.8 and -8.3 kcal/mol), almost the same as the comparison ligand (-8.2 kcal/mol). Each interaction also produced a different number of amino acid residues. Conclusion: These four coumarin compounds and four carbazole alkaloid compounds are considered potential EGFR inhibitors and anticancer candidates.KeywordMolecular docking, anticancer, oncogene protein, natural compunds
Effectiveness of Powered Toothbrushes Compared to Manual Toothbrushes in Reducing Plaque and Gingivitis: A Systematic Review Solachuddin, Ayako Aziza; Solachuddin, Shafa Syahida; Zakki, Muhamad; Riyadi , Nugroho Ahmad; Suriyah, Wastuti Hidayati
YARSI Dental Journal Vol. 2 No. 2 (2025): YARSI DENTAL JOURNAL
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ydj.v2i2.260

Abstract

Introduction: Toothbrushing is a fundamental daily practice for plaque removal. Dental plaque is a complex microbial biofilm that serves as a primary etiological factor for caries, gingivitis, and periodontitis. While manual toothbrushes (MTB) are widely used and considered effective, powered toothbrushes (PTB) are found to be a better alternative with numerous clinical trials proving their efficacy. Objective: To evaluate the effectiveness of PTB compared to MTB in reducing plaque and gingivitis based on existing literature. Methods: A systematic search was conducted to obtain clinical trials that compares plaque and gingivitis reduction with PTB and MTB usage across all age groups, using three databases - Pubmed, Scopus, and ScienceDirect. Discussion: 18 studies (69%) fully supported the hypothesis that PTB caused significantly greater reduction in plaque and gingivitis than MTB. However, seven studies (27%) found no significant differences between the two types, while one study (4%) partially supported the hypothesis, where it found PTB to be superior for plaque reduction but not for gingivitis. Overall, PTB were superior in reducing plaque and gingivitis, particularly in general populations. However, the benefits were less consistent in specific populations, such as orthodontic patients and individuals with special needs. Both oscillating-rotating and sonic PTB were comparable in their effectiveness. Conclusion: PTB are more effective than manual toothbrushes for improving plaque and gingival health in most populations. Further research is needed to address specific populations and optimise oral hygiene strategies tailored to their needs.
Edukasi Kesehatan Gigi dan Mulut dengan Pemanfaatan “Jurnal Gigiku: Seri Kanak-Kanak” pada Siswa TK Islam Terpadu Insan Madani Jakarta Hatta, Ridhayani; Attamimi, Fathimah Azzahrah; Nurfianti, Nurfianti; Suriyah, Wastuti Hidayati; Setianingtyas, Prastiwi; Jusup, Chrisni Octavia; Arsista, Dede; Ardinansyah, Agus; Umniyati, Helwiah
Jurnal Pengabdian Masyarakat Kesehatan Gigi FOKGII (JPMKG FOKGII) Vol. 2 No. 2 (2025): Agustus 2025
Publisher : Forum Komunikasi Kedokteran Gigi Islam Indonesia

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Abstract

Kesehatan gigi dan mulut pada anak usia dini memegang peranan penting dalam menunjang tumbuh kembang optimal. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan kebiasaan sehat siswa dalam menjaga kesehatan gigi dan mulut melalui media edukatif "Jurnal Gigiku: Seri Kanak-Kanak" di TK Islam Terpadu Insan Madani, Jakarta. Metode pelaksanaan terdiri dari tiga tahapan, yaitu (1) perencanaan dan penyusunan materi edukasi berbasis jurnal interaktif, (2) pelaksanaan edukasi melalui sesi interaktif yang melibatkan siswa, guru, dan orang tua, serta (3) monitoring dan evaluasi dengan membandingkan hasil pretest dan posttest serta mengumpulkan umpan balik. Hasil evaluasi menunjukkan peningkatan pengetahuan siswa secara signifikan, dari 61,5% pada pretest menjadi 100% pada post-test. Selain itu, terjadi perubahan positif dalam kebiasaan menjaga kebersihan gigi dan mulut, serta peningkatan keterlibatan orang tua dalam mendampingi anak. Program ini terbukti efektif dalam meningkatkan literasi kesehatan gigi dan mulut pada anak usia dini dan berpotensi untuk direplikasi secara lebih luas dan berkelanjutan.
ZEBRAFISH AS AN EMERGING IN VIVO MODEL IN DENTOMAXILLOFACIAL RESEARCH Suriyah, Wastuti Hidayati; Aziza Solachuddin, Ayako; Razi Ryoshi Solachuddin, Ar
Journal of Health and Dental Sciences Vol. 5 No. 2 (2025): Journal of Health and Dental Sciences
Publisher : Fakultas Kedokteran Gigi Unjani

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Abstract

Animal models are vital in dental research for studying dentomaxillofacial anomalies, disease mechanisms, and therapeutic strategies. Conventional models, such as those using rodents and higher mammals, provide valuable insights but raise ethical, financial, and translational challenges. Zebrafish (Danio rerio), widely established in biomedical sciences, offer distinctive advantages including genetic similarity to humans, transparent embryos, rapid development, and low maintenance costs. Despite their potential, their use in dental research remains relatively limited. This review evaluates current and emerging applications of zebrafish in dentistry based on peer‑reviewed literature and institutional resources. Research highlights three main areas. In tooth and craniofacial development, zebrafish contribute insights into odontogenesis, regeneration, and congenital anomalies through continuous tooth replacement and conserved pathways such as bone morphogenetic protein (BMP) and Hedgehog. In dental material studies, zebrafish embryos serve as sensitive models for assessing systemic and craniofacial toxicity of fluorides, nanoparticles, alloys, bioceramics, and resin-based monomers. In oral cancer research, transparent zebrafish lines and xenograft models enable real-time visualisation of tumor progression, metastasis, and treatment response, supporting high-throughput drug screening. Although limitations such as the absence of permanent dentition and anatomical differences restrict direct translation, zebrafish provide a rapid, ethical, and cost-effective complement to mammalian models—advances in genetics and imaging promise to expand their role in dental research and strengthen their translational relevance. DOI : 10.54052/jhds.v5n2.p113-126
Co-Authors Ardinansyah, Agus Arsista, Dede Attamimi, Fathimah Azzahrah Aziza Solachuddin, Ayako Dhona Afriza Helwiah Umniyati Ichwan, Solachuddin Jauhari Arief Jusup, Chrisni Octavia Knights, Joe NURFIANTI NURFIANTI, NURFIANTI Razi Ryoshi Solachuddin, Ar Ridhayani Hatta, Ridhayani Riyadi , Nugroho Ahmad Setianingtyas, Prastiwi Solachuddin, Ayako Aziza Solachuddin, Shafa Syahida Zakki, Muhamad