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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. To Maega: Jurnal Pengabdian Masyarakat PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Kesehatan Tambusai Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat DEVOTE: Jurnal Pengabdian Masyarakat Global Jurnal Sains, Teknologi dan Kesehatan TAMPIASIH
Muhammad Junaedi
Institut Teknologi dan Kesehatan Aspirasi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Toxicity and α-Glucosidase Inhibitory Activity of Chromolaena odorata L. for Antidiabetic Herbal Tea Soufa Malita; Muhammad Junaedi
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 22 No. 1 (2026): June 2026
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol22.SMUMM1.44123

Abstract

Background: Coppasanda (Chromolaena odorata) is a weed plant containing secondary metabolites with potential antidiabetic activity by lowering blood glucose levels. This plant has been developed into a tea bag formulation. Previous studies reported that Coppasanda tea significantly reduced blood glucose levels in alloxan-induced rats; however, higher concentrations caused unstable glucose levels. Therefore, toxicity testing and α-glucosidase inhibitory assays are required to evaluate its safety and enzyme-inhibiting potential. Objectives: This study aimed to determine the toxicity profile and α-glucosidase inhibitory activity of Coppasanda tea bags. Methods: Acute toxicity testing was conducted in vivo using 30 mice divided into five groups: control (0.5% CMC-Na), P1 (50 mg/kg BW), P2 (300 mg/kg BW), P3 (1000 mg/kg BW), and P4 (2000 mg/kg BW). The α-glucosidase inhibition assay was performed in vitro using p-nitrophenyl-α-D-glucopyranoside (pNPG) as the substrate and α-glucosidase enzyme. Absorbance was measured using a spectrophotometer at 405 nm. Results: The toxicity test showed no toxic symptoms of Coppasanda tea bags, indicated by the absence of significant changes (P > 0.05) in body weight, mortality, clinical signs, and organ indices of the experimental animals. In vitro results demonstrated strong α-glucosidase inhibitory activity, with a maximum inhibition of 98% and an IC₅₀ value of 29 µg/mL. Conclusion: Coppasanda tea bags are non-toxic and exhibit strong α-glucosidase inhibitory activity, indicating potential as a safe antidiabetic herbal beverage.
Co-Authors Affan Gaffar Darma Karno Eli Handayani Hasfiani, Yuliatin Iqbal Sadjali Jayusman Iqbal Sadjali Jayusman Isnawati Karno, Darma Khairiyatun Sholihah Khairiyatun Sholihah Khairiyatun Sholihah Khairul Khalqi Lia Arian Apriani M Zainul Hafizi Malika, Riwayati Malita, Soufa Maria Ulfa Nadia Nurul Fitria Nasrullah Nasrullah Nasrullah Nasrullah Nisa’atul Mukaromah Nurul Alia Najihan Pegarista Rindiani Sholihah, Khairiyatun Soufa Malita Supiarmo, M. Gunawan Yulastini, Fitria