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Agustina Welhelmina Djuma
Poltekkes Kemenkes Kupang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Nursing Physics Public Health Social Sciences Veterinary Other

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-429 T/C and -374 T/A Polymorphisms in Receptor Advanced Glycation Endproducts (RAGE) gene in Type 2 Diabetic Patients with Diabetic Retinopathy at the Dr. Sardjito General Hospital Yogyakarta Djuma, Agustina Welhelmina; ., Sunarti; Hastuti, Pramudji
Indonesian Journal of Biotechnology Vol 17, No 1 (2012)
Publisher : Universitas Gadjah Mada

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Abstract

Receptor of advanced glycation endproduct (RAGE) plays an important role in the pathogenesis of diabetic vascular complications, such as diabetic retinopathy. The interaction between the RAGE and advanced glycation end product (AGE) leads to oxidative stress and could result in cellular activation and infl ammation. The production of AGE occurs normally during aging but it increases in hyperglycemia condition. The objective of this research was to investigate the association between -429 T/C and -374 T/A polymorphisms in RAGE gene with the risk of diabetic retinopathy (DR) of type 2 diabetic patients in Javanese population. This was a case control study which consisted of 40 type 2 diabetic patients with DR as case subjects and 40 type 2 diabetic patients without DR (NDR) as control subjects. Genotyping of polymorphism was performed by PCR-RFLP. Chi-square test and odds ratio models were used to evaluate the association of both polymorphisms and DR risk and to examine 2-SNP haplotype of -429 T/C and -374 T/A polymorphisms in RAGE gene on DR. The genotype frequencies of -429 T/C polymorphism in RAGE gene in DR subjects were TT = 72.5% and TC/CC = 27.5%; while in NDR subjects were TT = 80% and TC/ CC = 20%, with p = 0.431. The allele frequencies of -429 T/C polymorphism in DR subjects were T = 83.7% and C= 16.3%, while in NDR subjects were T = 87.5% and C = 12.5%, with p = 0.499. The genotype frequencies of -374T/A polymorphism in RAGE gene in DR subjects were TT = 67.5%, TA = 32.5% while in NDR subjects were TT =82.5%, TA = 17.5%, with p = 0.121. In DR subjects, the frequencies of T and A were 83.7% and16.3%, while in NDR subjects the frequencies of T and A were 91.2 % and 8.8%, with p = 0.151. Odds ratios of -429 T/C polymorphism were 1.52 (95% CI = 0.54 – 4.29) for TC/CC genotype and 1.358 (95% CI = 0.56 – 3.31) for C allele. Odds ratios of -374 T/A polymorphism were 2.27 (95% CI = 0.79 – 6.49) for TA genotype and 2.02 (95% CI = 0.76 – 5.37) for A allele. χ2-value for 2-SNP haplotype was p = 0.127. The -374 T/A polymorphism in RAGE gene was a stronger risk factor of DR than -429 T/C polymorphism in RAGE gene. There were not signifi cantly different of frequencies of genotypes, allele, and two-SNP haplotype of -429 T/C and -374 T/A polymorphisms in RAGE gene between DR subjects and NDR subjects.
PEMERIKSAAN KOLESTEROL DAN GULA DARAH PADA MASYARAKAT DI LASIANA KUPANG NUSA TENGGARA TIMUR Djuma, Agustina W.; Octrisdey, Karol; Bia, Mikhael B.; Tangkelangi, Marni; Wuan, Adrianus Ola; Nurdin, Kuntum Ekawati; Novicadlitha, Yoan; Susilawati, Ni Made
JURNAL PENGEMBANGAN KOMUNITAS Vol 2 No 2 (2018): December
Publisher : JURNAL PENGEMBANGAN KOMUNITAS

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Abstract

Pengabdian masyarakat institusi dosen dan mahasiswa politeknik kesehatan kementrian kesehatan kupang dilakukan pada 28 Oktober 2018. Kegiatan pengabdian masyarakat ini diselenggarakan secara bersama-sama jurusan keperawatan, kebidanan, keperawatan gigi, gizi, farmasi, kesehatan lingkungan dan analis kesehatan. Program studi analisis kesehatan memfokuskan pada beberapa pemeriksaan kesehatan salah satunya adalah pemeriksaan kadar kolesterol total dan glukosa darah menggunakan point of care testing (POCT) autocheck. Kegiatan pengabdian masyarakat ini bertujuan melakukan screening terhadap kadar kolesterol dan gula darah masyarakat sekaligus memberikan pemahaman tentang bahaya kadar kolesterol dan gula darah yang tinggi pada kesehatan. Masyarakat yang hadir dalam kegiatan pengabdian masyarakat ini adalah semua warga yang ada pada wilayah kelurahan lasiana kupang. Berdasarkan hasil pemeriksaan kadar kolesterol total dan gula darah masyarakat lasiana menunjukan rata-rata penduduk memiliki kadar kolesterol total dan gula darah yang normal namun yang menarik bahwa untuk kadar dengan risiko tertinggi pada jenis kelamin perempuan yaitu 19 %. Sedangkan kelompok laki-laki banyak yang memiliki nilai kolesterol yang relatif normal. Hal yang sama juga pada kadar glukosa darah sewaktu dimana masyarakat yang gula darah sewaktunya normal (106 -144 mg/dL) sebanyak 11 orang, kadar glukosa darah sewaktu rendah (106 mg/dL) terdapat pada 28 orang dan tinggi sebanyak 5 orang.   Kata Kunci : Kolesterol, Gula Darah, Lasiana
Karakteristik Pasien HIV/AIDS Yang Sedang Menjalankan Terapi Obat Antiretroviral DI RSUD Mgr. Gabriel Manek, SVD Atambua Norma Kambuno; Maria Herlinda Mali; Agustina Wilhelmina Djuma
JURNAL KESEHATAN PRIMER Vol 5 No 2 (2020): JKP (Jurnal Kesehatan Primer)
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/jkp.v5i2.439

Abstract

Background: HIV or Human Immunodeficiency Virus is a type of virus that attacks or infects white blood cells which causes a decrease in human immunity. AIDS or Acquired Immuno Deficiency Syndrome is a set of symptoms that arise due to decreased immunity caused by HIV. Objective: This study aims to find out the characteriction of HIV / AIDS patients who are currently undergoing antiretroviral drug therapy at RSUD Mgr. Gabriel Manek, SVD Atambua from 2017 to 2019. Methods: This research is a descriptive study. The place of research was conducted at RSUD Mgr. Gabriel Manek, SVD Atambua. The variable used in this study is a single variable which includes a description of the number of HIV / AIDS patients currently undergoing antiretroviral drug therapy at Mgr Gabriel Manek, SVD Atambua Hospital. The data are presented in tabular table in the form of frequency distribution, number of patients, age, marital status and employment. Results: The results showed that the number of HIV / AIDS sufferers at RSUD Mgr. Gabriel Manek, SVD Atambua from 2017-2019 were 448 patients, there were 306 patients treated with antiretroviral therapy, and 142 people were not. Conclusion: The number of HIV / AIDS sufferers undergoing antiretroviral therapy based on the age category 25-49 years old were 238 patients, there were 164 patients in women category, 250 patients were married people and in employment status there were 143 housewives. Latar Belakang: HIV atau Human Immunodeficiency Virus adalah virus yang menyerang atau menginfeksi sel darah putih yang menyebabkan turunnya kekebalan tubuh manusia. AIDS atau Acquired Immuno Deficiency Syndrome adalah sekumpulan gejala penyakit yang timbul karena turunnya kekebalan yang disebabkan oleh HIV. Tujuan: Penelitian ini bertujuan untuk mengetahui karakteristik pasien HIV/AIDS yang sedang menjalankan terapi obat antiretroviral di RSUD Mgr. Gabriel Manek, SVD Atambua tahun 2017 sampai 2019. Metode: Penelitian ini merupakan penelitian deskriptif. Tempat penelitian dilakukan di RSUD Mgr. Gabriel Manek, SVD Atambua. Variabel yang digunakan dalam penelitian ini adalah variabel tunggal yang meliputi gambaran jumlah pasien HIV/AIDS yang sedang menjalankan terapi obat antiretroviral di RSUD Mgr. Gabriel Manek, SVD Atambua. Data – data disajikan dalam bentuk tabel berupa distribusi frekuensi, jumlah penderita, umur, status perkawinan dan pekerjaan. Hasil: Jumlah penderita HIV/AIDS di RSUD Mgr. Gabriel Manek, SVD Atambua dari tahun 2017-2019 berjumlah 448 orang, yang menjalankan terapi antiretroviral sebanyak 306 orang dan tidak menjalankan terapi antiretroviral sebanyak 142 orang. Kesimpulan: Jumlah penderita HIV/AIDS yang menjalankan terapi antiretroviral berdasarkan karakteristik umur terbesar pada kalangan dewasa jenjang umur 25-49 tahun sebanyak 238 orang, karakteristik jenis kelamin tertingi pada perempuan sebanyak 164 orang, status perkawinan tertinggi yang telah menikah sebanyak 250 orang dan status pekerjaan tertinggi pada Ibu Rumah Tangga sebanyak 143 orang.
SISWA SD BEBAS KECACINGAN DI SD INPRES BESMARAK DAN SD GMIT BIUPU Agustina W Djuma; Ni Made Susilawati; Supriati Wila Djami; Agnes Rantesalu; Novian Agni; Winioliski L.O Rohi Bire; Neiny Prisy Foekh; Karol Octrisdey; Melany F. Bessie
Jurnal Pengabdian Masyarakat Sasambo Vol 2, No 1 (2020): November
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (753.263 KB) | DOI: 10.32807/jpms.v2i1.599

Abstract

Prevalensi kecacingan di Indonesia masih tinggi. Kejadian tertinggi infeksi kecacingan di Indonesia yaitu pada anak umur kurang dari 12 tahun. Anak umur 2-9 tahun adalah kelompok anak usia balita dan anak usia sekolah dasar yang sangat rentan terkena penyakit kecacingan, kerena masih berperilaku ceroboh dan sering menggunakan tangan untuk meletakkan suatu benda di mulutnya. Selain itu pada masa ini, anak lebih banyak bermain dibandingkan belajar. Oleh karena itu, melakukan penyuluhan kecacingan dan cara pencucian tangan yang baik serta pemeriksaan kesehatan di SD sangat diperlukan. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk mengetahui apakah siswa SD Inpres Besmarak dan SD GMIT Biupu Kupang bebas kecacingan. Metode dilakukan dengan pemberian edukasi tentang kecacingan, pelatihan hygiene cara mencuci tangan yang benar, dan pemeriksaan kecacingan, Hb, serta golda pada siswa SD Inpres Besmarak dan SD GMIT Biupu, Kecamatan Nekamese. Berdasarkan hasil yang telah dilaksanakan menunjukkan bahwa SD Inpres Besmarak dan SD GMIT Biupu Kupang tidak ada yang terinfeksi cacing.
Hemoglobin Levels in Pulmonary Tuberculosis Patients who Consuming Anti-Tuberculosis Medicine Supriati Wila Djami; Agustina W Djuma; Marni Tangkelangi
Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Vol 12 No 4 (2022): Jurnal Ilmiah Permas: jurnal Ilmiah STIKES Kendal: Oktober 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

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Abstract

Tuberculosis (TB) is a lung infection characterized by pulmonary infiltrates and the formation of caseous granulomas, fibrosis, and cavities. TB is the second leading cause of death from infectious diseases worldwide, after the human immunodeficiency virus (HIV). To reduce the death rate due to TB, the government carried out the Find Drugs Until Heal program with examinations for 6-9 months to kill the Mycobacterium tuberculosis bacteria with anti-tuberculosis drugs, namely Isoniazid, Rifampicin, Ethambutanol, Streptomycin, and Pyrazinamide. Anti Tuberculosis Drugs can cause fever, nausea and hematological reactions such as anemia, agranulocytosis, eosinophilia and thrombocytopenia. The research method used is descriptive using a cross sectional approach, namely to find out the description of hemoglobin levels in Tuberculosis patients who consume Anti Tuberculosis Drugs. 60%, in the productive age of 31-50 years with a percentage of 67% and occurs in patients with two months of treatment, namely initial or intensive treatment with a percentage of 87%.
Analisis darah (hemoglobin, hematokrit, dan trombosit) pada pasien anak demam berdarah dengue Agni Yudhaswara, Novian; Djuma, Agustina Wilhelmina; Nurdin, Tri Wulandari
JURNAL KESEHATAN PRIMER Vol 8 No 1 (2023): JKP (Jurnal Kesehatan Primer)
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/jkp.v8i1.947

Abstract

Introduction: Dengue Hemorrhagic Fever (DHF) is an infection caused by the Dengue virus which is transmitted through the bites of Aedes aegypti and Aedes albopictus mosquitoes. Based on laboratory criteria, low platelet count (thrombocytopenia) and plasma leakage are important indicators for DHF. The purpose of this study was to analyze Hb levels, Ht levels, and platelet counts and their relationship in DHF patients so that when these values are at the threshold, health workers can anticipate and provide ideal care. Methods: This article is a descriptive retrospective study by taking secondary data at RSUD S.K. Lerik City of Kupang in 2020 with a total sample population of 135 DHF pediatric patients (0-11 years). Results: The results of this study, Hb values were below normal at 10.8 ± 1.4 g/dL in 52 (39%) patients, Ht values were above normal at 42.5 ± 2.3% in 81 (60%) patients, and platelet values were not normal or low 110,000 ± 12,500 per microliter of blood in 130 (97%). Researchers also wanted to show the relationship between Hb, Ht, and Platelets in the analysis with the Pearson Correlation Test (α = 0.05). Conclusion: The conclusion of this article is that there is no correlation between Hb and Ht and platelets, while Ht and platelets have a significantly low correlation (r=-0.32), which means that there is a relationship between high hematocrit and low platelet values in pediatric DHF patients so that patients DHF in children needs to be examined both.
Crystal sediment profile in the urine of public transportation drivers on route 2 in Kupang city Ledoh, Yaksem Yohanis; Djuma, Agustina Welhelmina; Kapitan, Lely Adel Violin
Journal of Indonesian Medical Laboratory and Science Vol 5 No 1: April 2024
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v5i1.121

Abstract

Background: Drivers have a profession that requires prolonged sitting, leading to the release of bone calcium into the bloodstream, which can trigger the formation of urinary stones or nephrolithiasis. Urinary stone (nephrolithiasis) is a condition where stones form in the urinary tract. Objectives: The aim of this study was to describe the crystal sediment profile in the urine of public transportation drivers on Route 2 in Kupang City. Materials and Methods: This descriptive study involved 16 public transportation drivers on Route 2 in Kupang City as research subjects. Data were collected through interviews.  Results: The results showed the presence of various crystals in the urine sediment, including Calcium Oxalate crystals (25%), Calcium Carbonate crystals (18.75%), Uric Acid crystals (12.5%), and Amorphous crystals (6.25%).  Conclusions: Based on the characteristics and habits of the respondents, it was found that frequent urinary retention, drinking less than 1 liter of water per day, and consuming supplemented or carbonated drinks were the three main factors affecting urine sedimentation in public transportation drivers on Route 2 in Kupang City.
Perbandingan Kadar Bilirubin Direk Pada Pengkonsumsi Alkohol Dan Yang Tidak Mengkonsumsi Alkohol Agustina Wilhelmimna Djuma; Yofita Weo Kapa
JURNAL INFO KESEHATAN Vol 15 No 2 (2017): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

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Abstract

Consuming large and continuous amounts of alcohol can cause damage to the body's metabolic system. One of the body's metabolic systems that can be damaged by alcohol is the liver. Alcohol can damage liver cells and can cause various types of liver diseases, such as liver cirrhosis. Liver cirrhosis can be identified from several types of liver function tests, one of which is by examining the levels of direct bilirubin in the serum. The purpose of this study was to examine differences in direct bilirubin levels in alcohol consumption and those who did not consume alcohol. The type of research used was an analytic observation with a case-control study design with 20 subjects who drank alcohol as a case group and 20 subjects who did not consume alcohol as a control group. Measurement of direct bilirubin levels using 24i biolis and unpaired t-test statistics was used to analyze differences in bilirubin levels in both groups. The results of examination of direct bilirubin levels in the case group showed that the average direct bilirubin level was 0.22 mg/dL and the average number in the control group was 0.15 mg/dL, whereas in the unpaired statistical test P value was obtained <0,05. These results showed that there were significant differences in direct bilirubin levels between the case group and the control group.
Uji Tuberkulosis Laten Pada Kontak Serumah Pasien BTA Positif Dengan Metode Mantoux Test Norma Tiku Kambuno; Yunita Helmina Senge; Agustina W. Djuma; Elisabeth N. Barung
JURNAL INFO KESEHATAN Vol 17 No 1 (2019): Jurnal Info Kesehatan
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol17.Iss1.239

Abstract

Background. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Latent tuberculosis is one of the conditions that occur when exposed to TB bacteria but does not show clinical symptoms. Vulnerable family members infected with TB due to difficulty avoiding contact with patients. The tuberculin skin test is one of the tests used to diagnose latent TB. The purpose of this study was to determine the description of latent TB in-home contact with smear-positive TB patients. Determine the relationship between latent TB with age, gender, education, occupation, and smoking status. Method. The type of research is correlation analytic research with a cross-sectional design with a total sample of 22 people. Results. Based on the results of the study as many as 15 people (68.2%) with induration > 10 mm, and 7 people (31, 8%) with induration <10 mm. While based on the results of statistical tests to see the relationship between the influence of age, sex, education level, occupation and smoking status with latent TB status obtained approx significant> 0.05. Conclusion. Thus the prevalence of latent TB at home contact with positive smear patients was 68.2% and there was no relationship between age, sex, education level, occupation and smoking status with TB status.
Relationship between Alcohol Consumption and Impaired Liver Function Agustina W. Djuma; Novian A. Yudhaswara; Suzanne Patricia Dardeau
JURNAL INFO KESEHATAN Vol 18 No 2 (2020): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol18.Iss2.474

Abstract

East Nusa Tenggara is a province of high alcohol abuse in Indonesia. Ngada Regency has a prevalence of 38.8%. The high prevalence is inseparable from traditional factors and socio-cultural norms which strongly influence the habit of consuming alcohol, the cold temperature in this area further strengthens this habit. The impact of alcohol consumption is the emergence of various types of diseases, one of which is impaired liver function such as alcoholic liver disease. The objective of this study is to determine the relationship between alcohol consumption and impaired liver function in communities in Bajawa and Golewa Districts, Ngada Regency. This research method is an observational analytic with cross-sectional design. The research subjects were 55 people who consumed alcohol in Golewa and Bajawa Districts, who had met the inclusion criteria. Alcohol consumption was measured by the AUDIT (The Alcohol Use Disorders Identification Test) questionnaire, while the parameter for liver disorders was the level of Gamma Glutamyl Transferase (GGT). The prevalence of liver dysfunction based on GGT examination was 15%. Meanwhile, the relationship between alcohol consumption and impaired liver function was tested with the Spearman correlation with α 0.05, the correlation value was p = 0.413, which means it has a moderate or significant, not too strong relationship. It is recommended that the people of Ngada Regency reduce alcohol consumption so that it can reduce the risk of impaired liver function.
Co-Authors Agnes Desiana Paa Agnes Rantesalu AGUSTINA SETIA Aldiana Astuti Asmulyati S Saleh Astuti, Aldiana AYORINCE BANUNU Ayorince Herlinalt Gloria Banunu Banunu, Ayorince Herlinalt Gloria Bia, Mikhael B. Dewu, Sherly Diana Ayu Eiga Julianty Elisabeth N. Barung Juliana Christyaningsih Kambuno, Norma Kambuno, Norma T. Kapa, Yofita Weo Karol Octrisdey Ledoh, Yaksem Yohanis Lely Adel Violin Kapitan Mali, Maria Herlinda Maria F Vinsensia D P Kewa Niron Maria Herlinda Mali Marni Tangkelangi Melany F. Bessie Neiny Prisy Foekh Ni Made Susilawati Norma Kambuno Norma T. Kambuno NORMA TIKU KAMBUNO Norma Tiku Kambuno Novian Agni Yudhaswara Novicadlitha, Yoan Nurdin, Kuntum Ekawati Nurdin, Tri Wulandari OLIN, WILHELMUS OLLA, FRENGKI OTTO SAHAT MARTUA SILAEN Pramudji Hastuti, Pramudji Rafael Paun, Rafael SHERLY DEWU Sherly Dewu Sunarti . Supriati Wila Djami Suzanne Patricia Dardeau TALAEN, MARCE SELVINCE Tobianus Hasan Wilhelmus Olin Winioliski L.O Rohi Bire Wuan, Adrianus Ola Yofita Weo Kapa Yunita Helmina Senge