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All Journal Indonesian Journal of Biotechnology Klinikal Sains (Jurnal Analis Kesehatan) Community Development Journal Jurnal Kesehatan Primer Journal of Indonesian Medical Laboratory and Science (JoIMedLabS)
Agustina Welhelmina Djuma
Prodi Teknologi Laboratorium Medis, Poltekkes Kemenkes Kupang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Nursing Social Sciences Other

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-429 T/C and -374 T/A Polymorphisms in Receptor Advanced Glycation Endproducts (RAGE) gene in Type 2 Diabetic Patients with Diabetic Retinopathy at the Dr. Sardjito General Hospital Yogyakarta Djuma, Agustina Welhelmina; ., Sunarti; Hastuti, Pramudji
Indonesian Journal of Biotechnology Vol 17, No 1 (2012)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.796 KB)

Abstract

Receptor of advanced glycation endproduct (RAGE) plays an important role in the pathogenesis of diabetic vascular complications, such as diabetic retinopathy. The interaction between the RAGE and advanced glycation end product (AGE) leads to oxidative stress and could result in cellular activation and infl ammation. The production of AGE occurs normally during aging but it increases in hyperglycemia condition. The objective of this research was to investigate the association between -429 T/C and -374 T/A polymorphisms in RAGE gene with the risk of diabetic retinopathy (DR) of type 2 diabetic patients in Javanese population. This was a case control study which consisted of 40 type 2 diabetic patients with DR as case subjects and 40 type 2 diabetic patients without DR (NDR) as control subjects. Genotyping of polymorphism was performed by PCR-RFLP. Chi-square test and odds ratio models were used to evaluate the association of both polymorphisms and DR risk and to examine 2-SNP haplotype of -429 T/C and -374 T/A polymorphisms in RAGE gene on DR. The genotype frequencies of -429 T/C polymorphism in RAGE gene in DR subjects were TT = 72.5% and TC/CC = 27.5%; while in NDR subjects were TT = 80% and TC/ CC = 20%, with p = 0.431. The allele frequencies of -429 T/C polymorphism in DR subjects were T = 83.7% and C= 16.3%, while in NDR subjects were T = 87.5% and C = 12.5%, with p = 0.499. The genotype frequencies of -374T/A polymorphism in RAGE gene in DR subjects were TT = 67.5%, TA = 32.5% while in NDR subjects were TT =82.5%, TA = 17.5%, with p = 0.121. In DR subjects, the frequencies of T and A were 83.7% and16.3%, while in NDR subjects the frequencies of T and A were 91.2 % and 8.8%, with p = 0.151. Odds ratios of -429 T/C polymorphism were 1.52 (95% CI = 0.54 – 4.29) for TC/CC genotype and 1.358 (95% CI = 0.56 – 3.31) for C allele. Odds ratios of -374 T/A polymorphism were 2.27 (95% CI = 0.79 – 6.49) for TA genotype and 2.02 (95% CI = 0.76 – 5.37) for A allele. χ2-value for 2-SNP haplotype was p = 0.127. The -374 T/A polymorphism in RAGE gene was a stronger risk factor of DR than -429 T/C polymorphism in RAGE gene. There were not signifi cantly different of frequencies of genotypes, allele, and two-SNP haplotype of -429 T/C and -374 T/A polymorphisms in RAGE gene between DR subjects and NDR subjects.
PEMERIKSAAN KOLESTEROL DAN GULA DARAH PADA MASYARAKAT DI LASIANA KUPANG NUSA TENGGARA TIMUR Djuma, Agustina W.; Octrisdey, Karol; Bia, Mikhael B.; Tangkelangi, Marni; Wuan, Adrianus Ola; Nurdin, Kuntum Ekawati; Novicadlitha, Yoan; Susilawati, Ni Made
JURNAL PENGEMBANGAN KOMUNITAS Vol 2 No 2 (2018): December
Publisher : JURNAL PENGEMBANGAN KOMUNITAS

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Pengabdian masyarakat institusi dosen dan mahasiswa politeknik kesehatan kementrian kesehatan kupang dilakukan pada 28 Oktober 2018. Kegiatan pengabdian masyarakat ini diselenggarakan secara bersama-sama jurusan keperawatan, kebidanan, keperawatan gigi, gizi, farmasi, kesehatan lingkungan dan analis kesehatan. Program studi analisis kesehatan memfokuskan pada beberapa pemeriksaan kesehatan salah satunya adalah pemeriksaan kadar kolesterol total dan glukosa darah menggunakan point of care testing (POCT) autocheck. Kegiatan pengabdian masyarakat ini bertujuan melakukan screening terhadap kadar kolesterol dan gula darah masyarakat sekaligus memberikan pemahaman tentang bahaya kadar kolesterol dan gula darah yang tinggi pada kesehatan. Masyarakat yang hadir dalam kegiatan pengabdian masyarakat ini adalah semua warga yang ada pada wilayah kelurahan lasiana kupang. Berdasarkan hasil pemeriksaan kadar kolesterol total dan gula darah masyarakat lasiana menunjukan rata-rata penduduk memiliki kadar kolesterol total dan gula darah yang normal namun yang menarik bahwa untuk kadar dengan risiko tertinggi pada jenis kelamin perempuan yaitu 19 %. Sedangkan kelompok laki-laki banyak yang memiliki nilai kolesterol yang relatif normal. Hal yang sama juga pada kadar glukosa darah sewaktu dimana masyarakat yang gula darah sewaktunya normal (106 -144 mg/dL) sebanyak 11 orang, kadar glukosa darah sewaktu rendah (106 mg/dL) terdapat pada 28 orang dan tinggi sebanyak 5 orang.   Kata Kunci : Kolesterol, Gula Darah, Lasiana
Karakteristik Pasien HIV/AIDS Yang Sedang Menjalankan Terapi Obat Antiretroviral DI RSUD Mgr. Gabriel Manek, SVD Atambua Norma Kambuno; Maria Herlinda Mali; Agustina Wilhelmina Djuma
JURNAL KESEHATAN PRIMER Vol 5 No 2 (2020): JKP (Jurnal Kesehatan Primer)
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/jkp.v5i2.439

Abstract

Background: HIV or Human Immunodeficiency Virus is a type of virus that attacks or infects white blood cells which causes a decrease in human immunity. AIDS or Acquired Immuno Deficiency Syndrome is a set of symptoms that arise due to decreased immunity caused by HIV. Objective: This study aims to find out the characteriction of HIV / AIDS patients who are currently undergoing antiretroviral drug therapy at RSUD Mgr. Gabriel Manek, SVD Atambua from 2017 to 2019. Methods: This research is a descriptive study. The place of research was conducted at RSUD Mgr. Gabriel Manek, SVD Atambua. The variable used in this study is a single variable which includes a description of the number of HIV / AIDS patients currently undergoing antiretroviral drug therapy at Mgr Gabriel Manek, SVD Atambua Hospital. The data are presented in tabular table in the form of frequency distribution, number of patients, age, marital status and employment. Results: The results showed that the number of HIV / AIDS sufferers at RSUD Mgr. Gabriel Manek, SVD Atambua from 2017-2019 were 448 patients, there were 306 patients treated with antiretroviral therapy, and 142 people were not. Conclusion: The number of HIV / AIDS sufferers undergoing antiretroviral therapy based on the age category 25-49 years old were 238 patients, there were 164 patients in women category, 250 patients were married people and in employment status there were 143 housewives. Latar Belakang: HIV atau Human Immunodeficiency Virus adalah virus yang menyerang atau menginfeksi sel darah putih yang menyebabkan turunnya kekebalan tubuh manusia. AIDS atau Acquired Immuno Deficiency Syndrome adalah sekumpulan gejala penyakit yang timbul karena turunnya kekebalan yang disebabkan oleh HIV. Tujuan: Penelitian ini bertujuan untuk mengetahui karakteristik pasien HIV/AIDS yang sedang menjalankan terapi obat antiretroviral di RSUD Mgr. Gabriel Manek, SVD Atambua tahun 2017 sampai 2019. Metode: Penelitian ini merupakan penelitian deskriptif. Tempat penelitian dilakukan di RSUD Mgr. Gabriel Manek, SVD Atambua. Variabel yang digunakan dalam penelitian ini adalah variabel tunggal yang meliputi gambaran jumlah pasien HIV/AIDS yang sedang menjalankan terapi obat antiretroviral di RSUD Mgr. Gabriel Manek, SVD Atambua. Data – data disajikan dalam bentuk tabel berupa distribusi frekuensi, jumlah penderita, umur, status perkawinan dan pekerjaan. Hasil: Jumlah penderita HIV/AIDS di RSUD Mgr. Gabriel Manek, SVD Atambua dari tahun 2017-2019 berjumlah 448 orang, yang menjalankan terapi antiretroviral sebanyak 306 orang dan tidak menjalankan terapi antiretroviral sebanyak 142 orang. Kesimpulan: Jumlah penderita HIV/AIDS yang menjalankan terapi antiretroviral berdasarkan karakteristik umur terbesar pada kalangan dewasa jenjang umur 25-49 tahun sebanyak 238 orang, karakteristik jenis kelamin tertingi pada perempuan sebanyak 164 orang, status perkawinan tertinggi yang telah menikah sebanyak 250 orang dan status pekerjaan tertinggi pada Ibu Rumah Tangga sebanyak 143 orang.
ANALISIS FAKTOR PENULARAN VIRUS HEPATITIS B KONTAK SERUMAH DI DI DESA BONE KABUPATEN KUPANG Agustina Welhelmina Djuma; Diana Ayu Eiga Julianty; Wilhelmus Olin; Agustina Setia
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 2 (2023): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i2.3818

Abstract

Virus Hepatitis B (VHB) dari famili Hepadnaviridae merupakan penyebab terjadinya penyakit Hepatitis B. Pajanan VHB menyebabkan keluaran klinis yaitu hepatitis akut dan Hepatitis kronik. Hepatitis akut akan sembuh dan membentuk kekebalan terhadap penyakit ini, sedangkan hepatitis yang berkembang menjadi kronik akan berakibat pada peradangan hati akut atau menahun. Pada beberapa kasus perkembangan peradangan hati akut ataupun menahun dapat menjadi sirosis hati. Virus Hepatitis B dtransmisikan secara vertikal dan horizontal. Penularan dari ibu kepada janinya melalui plasenta pada masa perinatal merupakan penularan vertikal, sedangkan penularan melalui cairan tubuh penderita Hepatitis B antara lain air liur, darah, atau cairan tubuh dan kontak seksual merupakan jenis penularan secara horizontal. Penelitian ini bertujuan menganalisis karakteristik, perilaku berisiko dan tingkat pengetahuan dari anggota keluarga yang kontak serumah dengan penderita Hepatitis B di Desa Bone. Jenis penelitian ini observasional analitik menggunakan rancangan cross sectional. Perilaku berisiko dan tingkat pengetahuan diukur menggunakan kuisioner. Analisis Chi-Square untuk mengkaji faktor yang berhubungan dengan penularan Hepatitis B. Responden pada penelitian ini berjumlah 40 orang. Hasil penelitian menunjukkan 37,5% responden dengan HBsAg positif terdapat pada laki-laki 20% dan 17,5% pada perempuan. Responden dengan HBsAg positif terbanyak pada kelompok usia 26-45 tahun sebesar 27,5%. Usia merupakan faktor yang berhubungan dengan Hepatitis B (p<0,05). Tidak ditemukan adanya hubungan antara beberapa kebiasaan yang dapat berisiko menularkan VHB, yaitu penggunaan alat pribadi bersama (p>0,05) dengan kejadian Hepatitis B. Meskipun tingkat pengetahuan masyarakat tentang Hepatitis B tergolong rendah (69,4%), namun tingkat pengetahuan responden di Desa Bone tidak merupakan faktor yang ada hubungannya dengan kejadian Hepatitis B.
Analisis darah (hemoglobin, hematokrit, dan trombosit) pada pasien anak demam berdarah dengue Agni Yudhaswara, Novian; Djuma, Agustina Wilhelmina; Nurdin, Tri Wulandari
JURNAL KESEHATAN PRIMER Vol 8 No 1 (2023): JKP (Jurnal Kesehatan Primer)
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/jkp.v8i1.947

Abstract

Introduction: Dengue Hemorrhagic Fever (DHF) is an infection caused by the Dengue virus which is transmitted through the bites of Aedes aegypti and Aedes albopictus mosquitoes. Based on laboratory criteria, low platelet count (thrombocytopenia) and plasma leakage are important indicators for DHF. The purpose of this study was to analyze Hb levels, Ht levels, and platelet counts and their relationship in DHF patients so that when these values are at the threshold, health workers can anticipate and provide ideal care. Methods: This article is a descriptive retrospective study by taking secondary data at RSUD S.K. Lerik City of Kupang in 2020 with a total sample population of 135 DHF pediatric patients (0-11 years). Results: The results of this study, Hb values were below normal at 10.8 ± 1.4 g/dL in 52 (39%) patients, Ht values were above normal at 42.5 ± 2.3% in 81 (60%) patients, and platelet values were not normal or low 110,000 ± 12,500 per microliter of blood in 130 (97%). Researchers also wanted to show the relationship between Hb, Ht, and Platelets in the analysis with the Pearson Correlation Test (α = 0.05). Conclusion: The conclusion of this article is that there is no correlation between Hb and Ht and platelets, while Ht and platelets have a significantly low correlation (r=-0.32), which means that there is a relationship between high hematocrit and low platelet values in pediatric DHF patients so that patients DHF in children needs to be examined both.
Crystal sediment profile in the urine of public transportation drivers on route 2 in Kupang city Ledoh, Yaksem Yohanis; Djuma, Agustina Welhelmina; Kapitan, Lely Adel Violin
Journal of Indonesian Medical Laboratory and Science Vol 5 No 1: April 2024
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v5i1.121

Abstract

Background: Drivers have a profession that requires prolonged sitting, leading to the release of bone calcium into the bloodstream, which can trigger the formation of urinary stones or nephrolithiasis. Urinary stone (nephrolithiasis) is a condition where stones form in the urinary tract. Objectives: The aim of this study was to describe the crystal sediment profile in the urine of public transportation drivers on Route 2 in Kupang City. Materials and Methods: This descriptive study involved 16 public transportation drivers on Route 2 in Kupang City as research subjects. Data were collected through interviews.  Results: The results showed the presence of various crystals in the urine sediment, including Calcium Oxalate crystals (25%), Calcium Carbonate crystals (18.75%), Uric Acid crystals (12.5%), and Amorphous crystals (6.25%).  Conclusions: Based on the characteristics and habits of the respondents, it was found that frequent urinary retention, drinking less than 1 liter of water per day, and consuming supplemented or carbonated drinks were the three main factors affecting urine sedimentation in public transportation drivers on Route 2 in Kupang City.
Co-Authors Agni Yudhaswara, Novian AGUSTINA SETIA Astuti, Aldiana Banunu, Ayorince Herlinalt Gloria Bia, Mikhael B. Dewu, Sherly Diana Ayu Eiga Julianty Kambuno, Norma T. Kapa, Yofita Weo Karol Octrisdey Ledoh, Yaksem Yohanis Lely Adel Violin Kapitan Maria Herlinda Mali Marni Tangkelangi Ni Made Susilawati Norma Kambuno Novicadlitha, Yoan Nurdin, Kuntum Ekawati Nurdin, Tri Wulandari Olin, Wihelmus OLLA, FRENGKI Pramudji Hastuti, Pramudji Rafael Paun, Rafael Sunarti . TALAEN, MARCE SELVINCE Wilhelmus Olin Wuan, Adrianus Ola