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All Journal Journal of Agromedicine and Medical Sciences Journal of Islamic Pharmacy Journal of Islamic Medicine Jurnal Ilmiah Kesehatan Media Husada The Avicenna Medical Journal INTERNATIONAL JOURNAL OF SOCIETY REVIEWS (INJOSER)
Zainabur Rahmah
Department Of Parasitology, Faculty Of Medicine And Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Pregnancy Complication Due to Malaria in Mice BALB/C : The Role of TNF-α, Anemia, and Low Birth Weight Milliana, Alvi; Indriana, Nurfianti; Rahmah, Zainabur
Journal of Islamic Medicine Vol 7, No 1 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i1.20828

Abstract

Background : Malaria infection in pregnant women or called placental malaria is characterized by the accumulation of Plasmodium-infected red blood cells in the intervillous space of the placenta. This causes adverse perinatal outcomes such as stillbirth, low birth weight, premature birth, and small neonates of gestational age while in the mother it causes anemia. Inflammatory responses such as TNF-α expression can promote complications in pregnancy. TNF-α plays an important role in the immune response in acute malaria but inhibits erythropoiesis. Objective : This study aims to determine the relationship between malaria infection and TNF-α expression with the incidence of anemia and birth weight in pregnant mice infected with Plasmodium berghei. Methods: Twenty BALB/C pregnant mice were divided into 2 groups, control group (10 pregnant mice without infection) treatment group (10 pregnant mice infected with Plasmodium berghei). TNF-α expression was observed by immunohistochemical method using anti-TNF-α Chip Grade antibody from abcam, anemia examination using Cyanmethemoglobin and all fetuses were weighed using an analytical balance. Statistical analysis using Structural Equation Modeling. Results: Malaria infection causes high expression of TNF-α in the placenta (tcount=2.97≥ ttable = 1.96), causes anemia (tcount=1,97≥ttable = 1.96) and causes low fetal weight tcount=2,16 ≥ ttable =1, 96. Conclusion: Malaria infection can cause high expression of TNF-α in the placenta causing anemia and low birth weight of the fetus
Social Support Build Resilience in Multidrug-Resistant Tuberculosis Patients: A Cross-Sectional Study in MDR-TB Patient Support Group Akbar, Putri Wulan; Rachma, Lailia Nur; Rahmah, Zainabur; Firdaus, Mohammad Iqbal; Nanggali, Bryka Vian
The Avicenna Medical Journal Vol. 5 No. 2 (2024): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/zax66z29

Abstract

Background: Multidrug-resistant tuberculosis (MDR-TB) patient faces multi-dimensional challenges due to the physical factor, long-term treatment, negative stigma, and psychosocial challenge. Addressing these issues patient requires a resilience. The formation of resilience is influenced by both internal and external factors, including social support. This study purposed to assess the social support impact on resilience in MDR-TB patients. Methods: This study was an observational analytic study with cross sectional design. A total of 33 respondents with MDR-TB confirmed, a member of MDR-TB support group, and under treatment were involved. The social support level was measured using the ISEL-12 (Interpersonal Support Evaluation List) questionnaire, while the level of resilience was assessed using the CD-RISC-25 (Connor-Davidson Resilience Scale). Spearman correlation test in SPSS Ver 24.0 was used to examine the relationship between social support and resilience among patients with MDR-TB. Results: Majority of respondents (17 respondents, 51.6%) have good social support and 23 respondents (69.7%) exhibited a good level of resilience. The Spearman correlation test revealed a significant positive correlation between social support and resilience, with a p-value of 0.030 and a moderate strength correlation coefficient (r) of 0.378. Conclusion: This finding showed that good social support toward MDR-TB patients gives positive impact to patients’ resilience. Thus strengthens the system of social support in support group is important to decrease the psychosocial challenges and help to succeed the treatment.
Co-Authors Abdul Malik Setiawan Adnani, Basyar Alvi Milliana Astari, Lina Fitria Avin Ainur Fitrianingsih Doby Indrawan Firdaus, Moh. Iqbal Indriana, Nurfianti Iwal Reza Ahdi Lailia Nur Rachma Muhammad Iqbal Firdaus, Muhammad Iqbal Nanggali, Bryka Vian Nurfianti Indriana Purnomo S, Fahrurrozi Hari Putri Wulan Akbar Riskiyana, Riskiyana