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All Journal Pharmascience Jurnal Biologi Tropis Community Empowerment Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Experimental and Clinical Pharmacy (JECP) Journal of Biotropical Research and Nature Technology Frontier Advances in Applied Science and Engineering
Decenly, Decenly
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Gambaran Histopatologi Hati dan Ginjal Mencit (Mus musculus) Setelah Pemberian Ekstrak Daun Bajakah Kalalawit (Uncaria gambir Roxb.) Gunawan, Yohanes Edy; Priyadi, Muhammad; Citrariana, Shesanthi; Saputra, Rizki Rachmad; Decenly, Decenly; Fauziah, Anisa Rahma; Febrianto, Yahya; Suprayogi, Thathit
Jurnal Pharmascience Vol 11, No 2 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.17733

Abstract

Secara empiris Bajakah Kalalawit (Uncaria gambir Roxb.) telah digunakan oleh masyarakat lokal Kalimantan karena dipercaya dapat menyembuhkan berbagai macam penyakit. Beberapa penelitian telah menunjukkan potensi aktivitas farmakalogis bajakah kalalawit dimulai dari bagian batang, akar dan lainnya. Namun, apabila tidak digunakan dengan tepat maka berpotensi dapat membahayakan penggunanya. Tujuan dari penelitian ini adalah menganalisis aspek toksikologi konsumsi ekstrak air daun bajakah kalalawit melalui gambaran histopatologi organ hati dan ginjal. Ekstraksi daun bajakah kalalawit menggunakan metode refluks dengan pelarut air dan uji histopatologi menggunakan pengamatan mikroskopis histologi pada organ hati dan ginjal mencit jantan (Mus musculus) melalui pemberian dosis ekstrak air daun bajakah kalalawit sebanyak 52,5 mg/KgBB, 105 mg/KgBB, dan 210 mg/KgBB selama 30 hari. Hasil penelitian menunjukkan bahwa pemberian ekstrak air daun bajakah kalalawit selama 30 hari dapat menimbulkan terjadinya degenerasi sel dan nekrosis sel pada organ hati maupun ginjal mencit. Dapat disimpulkan bahwa pemberian ekstrak air daun bajakah kalalawit dengan dosis 52,5 mg/KgBB, 105 mg/KgBB dan 210 mg/KgBB dapat menyebabkan perubahan histologi pada organ hati dan ginjal. Kata Kunci: Histologi, Ekstrak, Toksikologi, Mikroskopis, Nekrosis   Empirically, Bajakah Kalalawit (Uncaria gambir Roxb.) has been used by local Kalimantan communities because it is believed to cure various diseases. Several studies have shown the potential pharmacalogical activity of bajakah kalalawit starting from the stem, root and other parts. However, if not used properly, it can potentially harm the user.. The purpose of this study was to determine the toxicology aspects of consumption of bajakah kalalawit leaf water extract through histopathological images of liver and kidney organs. Extraction of bajakah kalalawit leaves using reflux method with water solvent and histopathology test using microscopic observation of liver and kidney histology of male mice (Mus musculus) which were treated with doses of bajakah kalalawit leaf water extract 52.5 mg/KgBW, 105 mg/KgBW, and 210 mg/KgBW for 30 days.  The results showed that the administration of bajakah kalalawit leaf water extract for 30 days can cause cell degeneration and cell necrosis in the liver and kidney organs of mice. It can be concluded that the administration of bajakah kalalawit leaf water extract at doses of 52.5 mg/KgBW, 105 mg/KgBW, and 210 mg/KgBW may contribute to histologic changes in the liver and kidney.
Phytochemical Profile and Antioxidant Activity of Bajakah Kalalawit Leaf Extract Priyadi, Muhammad; Gunawan, Yohanes Edy; Saputra, Rizki Rachmad; Decenly, Decenly; Citrariana, Shesanthi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 1 (2025): February 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i1.1321

Abstract

Natural products have long been recognized for their significant role in supporting human health, with natural ingredients playing an essential part in disease treatment and wellness across generations. The bajakah species, particularly bajakah kalalawit (Uncaria gambir Roxb.), has gained attention in recent research due to its potential bioactive compounds. Especially, its antioxidant properties from any part of plant has potential to explore. This study aims to determine the various secondary metabolite compounds possessed by bajakah kalalawit leaves and test their antioxidants. Bajakah kalalawit leaves were extracted using reflux with aqueous solvents, checked for phytochemical profiles using GC-MS, and conducted antioxidant tests using the DPPH method. Based on the phytochemical test, there are 22 predicted compounds in the extract and the antioxidant test results showed an IC50 value of 14.44 ppm. In conclusion, bajakah kalalawit leaf aqueous extract has antioxidant activity and is supported by bioactive compounds.
Empowering Talian Kereng Village farmer groups through independent organic fertilizer production based on local resources for sustainable agriculture Rosalina, Reny; Hermayantiningsih, Dwi; Priyadi, Muhammad; Decenly, Decenly; Putri, Alayya Adistia; Sametri, Ni Wayan Septia
Community Empowerment Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.12340

Abstract

Talian Kereng Village, located in Katingan Hilir District, Central Kalimantan, faces challenges regarding the availability of fertilizers for upland rice farmers on peatlands, with a heavy reliance on government-subsidized chemical fertilizers. To address this issue, a community empowerment program was implemented to promote independent organic fertilizer production using local resources. The program involved education and training for the Maju Bersama farmer group on the production of decomposers, liquid organic fertilizer (eco enzyme), and compost from household waste and harvest residues. The results showed a significant increase in knowledge, where initially, 53.9% of participants had limited understanding of decomposer and eco enzyme production, but after the training, 95.3% of participants fully comprehended the material. Furthermore, all participants became skilled in producing organic fertilizers. This program is expected to enhance farmers' self-sufficiency in meeting fertilizer needs, reduce dependence on chemical fertilizers, and support agricultural sustainability in Talian Kereng Village.
Education on the integration of probiotic fish pellet production with aquaponic technology as a solution for food self-sufficiency Praja, Rian Ka; Dwijayanti, Rts. Sherly; Saputra, Rizki Rachmad; Decenly, Decenly; Suma, Joy Angel Aria; Harianja, Henrigen
Community Empowerment Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.12345

Abstract

This community service program was carried out in Talian Kereng Village, Katingan Regency, Central Kalimantan, with the aim of enhancing food self-sufficiency through training on probiotic-based fish pellet production and the implementation of aquaponic technology. The program involved 15 participants and included theoretical training sessions, practical fish feed production, and aquaponic system installation. Evaluation results indicated a significant increase in knowledge, with the average score rising from 40% to 85%. A total of 90% of participants successfully practiced fish pellet production with the correct composition, while 80% were able to independently operate the aquaponic system. The program also featured the handover of fish pellet production technology and the aquaponic system to the local fish farming group. Despite challenges related to the availability of probiotic ingredients and aquaponic system management, this initiative has opened opportunities for further development in rural fisheries and agriculture.
Aktivitas Psikostimulan Tanaman Bajakah (Spatholobus suberectus) : Studi In Silico Terhadap Protein 4M48-Dopamine Transporter Priyadi, Muhammad; Saputra, Rizki Rachmad; Gunawan, Yohanes Edy; Citrariana, Shesanthi; Decenly, Decenly; Febrianto, Yahya
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p149-154

Abstract

Bajakah plants (Spatholobus suberectus) have been widely used by Dayak tribes in Kalimantan with various properties that are believed and have also been studied for various tests of phytochemical compound content and pharmacological tests. Secondary metabolite compounds from bajakah (Spatholobus suberectus) have potential as psychostimulant compounds. The purpose of this study was to investigate the psychostimulant activity of bajakah plants (Spatholobus suberectus) through analysis of the interaction between bajakah secondary metabolite compounds and the 4M48-Dopamine Transporter receptor (PDB: 4M48), which is one of the dopamine transporter proteins. Ligand and receptor interactions were analyzed using molecular docking method with Autodock Vina 4 application with nortriptyline compound as native ligand and 15 secondary metabolite compounds for testing. The results of docking analysis showed that the standard ligand nortriptyline compound has an affinity value of -10.2 kcal/mol. There are 3 compounds from bajakah that have affinity values close to the standard compounds plathymenin, butein and eriodictyol with affinity values of -9.7 kcal/mol, -9.4 kcal/mol and -9.2 kcal/mol respectively. Based on the analysis conducted, it can be concluded that bajakah plants (Spatholobus suberectus) have the potential to be developed as psychostimulant therapy.
Growth Response of Some Leguminous Plants to Peat Water from Central Kalimantan Decenly, Decenly; Tuju, Fandi; Anggoro, Rahayu Opi
Journal of Biotropical Research and Nature Technology Vol. 1 No. 2 (2023): Borneo
Publisher : Prodi Biologi FMIPA Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52850/borneo.v1i2.8016

Abstract

Legumes are cultivated plants that are widely used by the community. In central Kalimantan, especially in Palangka Raya city, the legume is planted by the community as a garden plant which is consumed daily. The condition of acidic peatlands in Central Kalimantan is a limiting factor for plant growth. This study aims to determine the effect of peat water from the Sabangau River in Central Kalimantan on the germination of legume plants. The study used 4 (four) types of plants such as Vigna radiata L, Vigna unguiculata L, Phaseolus vulgaris L, and Glycine max L using a Completely Randomized Design (CRD). The plant seeds were first soaked in peat water for 3 (three) hours, then transferred to a medium covered with cotton and watered using the same water. Observations were made from the first day to the seventh day. The results showed that 3 (three) types of plants such as Vigna radiata L, Vigna unguiculata L, and Phaseolus vulgaris L were able to grow using peat water as a medium, while soybeans could not germinate. The results show that out of these three types of plants, Vigna radiata L has a better growth rate than Vigna unguiculata L and Phaseolus vulgaris L. Statistical tests using ANOVA analysis showed no significant differences between the three types of plants that grow.
Growth Response of Long Beans (Vigna unguiculata) and Mung Beans (Vigna radiata) to the Application of Different Types of Water Fadia Khoirunnisa Sukowati; Lauren Felia Ramai; Widhi Ayu Arwani; Widya Krestina; Decenly, Decenly
Frontier Advances in Applied Science and Engineering Vol. 1 No. 2 (2023)
Publisher : Tinta Emas Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59535/faase.v1i2.152

Abstract

Germination begins with imbibition or the entry of water that will activate various physiological components of the seed. So it is known that water has an important role in initiating the early stages of plant growth and development. The process of growth and development can be influenced by the type of water around it. This study aims to determine the growth response in Long Beans (Vigna unguiculata) and Mung Beans (Vigna radiata) to the application of various types of water, namely river water, peat water, rainwater and tap water. The seeds were soaked for 3 hours before planting. Then transferred to the planting media. Furthermore, for 7 days, observations were made along with watering the seeds using the treatment water. The parameters observed were the number of germinated seeds, sprout length, and root length on the seventh day. The data obtained were analyzed and processed using IBM SPSS software through parametric test (One-way ANOVA) and non-parametric test (Independent-Samples Kruskal-Wallis Test). Based on statistical tests, it is known that there is no significant difference, where in Long Beans the significance value is 0.795 (> 0.05). While in Mung Beans the significance value is 0.602 (> 0.05). The conclusion of this study is that there is no significant difference between each treatment, so that the various types of water in the treatment only as an initiator in the process of germination.
Effect of IBA Concentration on The Growth of Ramin Cuttings (Gonystylus bancanus (Mig.) Kurz) Decenly, Decenly; Simbolon, Samuel Grenkess Glovanus; Sunariyati, Siti; Anggoro, Rahayu Opi; Guevara, Krishna Ananka Reza
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8485

Abstract

Ramin (Gonystylus bancanus (Miq) Kurz) is a peat swamp plant with commercial value in both national and international markets. However, the existence of ramin is threatened with extinction, due to the imbalance between regrowth and utilization, making it increasingly difficult to obtain ramin seedlings naturally. One of the efforts to propagate ramin is by cuttings. This study aimed to determine the optimum concentration of IBA (Indole Butyric Acid) growth regulator used in supporting the growth of ramin cuttings. The research method used a Randomized Group Design (RGD) consisting of 4 treatments and 6 replicates. The treatment consisted of P0 (control/0 ppm), P1 (IBA concentration 1000 ppm), and P3 (IBA concentration 1500 ppm). The data were analyzed descriptively qualitatively. The results showed that the provision of IBA affects the growth of ramin cuttings. Based on the percentage of cuttings that successfully grew, P0 successfully grew by 50%, P1 successfully grew by 83.33%, P2 successfully grew by 100% and P3 successfully grew by 100%. The average number of shoots of ramin cuttings that successfully grew in the treatment of P0 amounted to 0, P1 treatment amounted to 1, then P2 amounted to 2, and the highest number of shoots was in the treatment of P3 with 3 shoots. It can be concluded that the concentration of IBA 2000 ppm gives the best results when compared to other concentrations based on the percentage of cuttings that managed to grow and the average number of shoots.
Co-Authors Anggoro, Rahayu Opi Citrariana, Shesanthi Dwijayanti, Rts. Sherly Fadia Khoirunnisa Sukowati Fandi Tuju Fauziah, Anisa Rahma Guevara, Krishna Ananka Reza Gunawan, Yohanes Edy Harianja, Henrigen Hermayantiningsih, Dwi Lauren Felia Ramai Muhammad Priyadi Putri, Alayya Adistia Reny Rosalina, Reny Rian Ka Praja Rizki Rachmad Saputra Sametri, Ni Wayan Septia Simbolon, Samuel Grenkess Glovanus Siti Sunariyati Suma, Joy Angel Aria Thathit Suprayogi Widhi Ayu Arwani Widya Krestina Yahya Febrianto