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All Journal Farmaka Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) Science Midwifery Jurnal Abdimas Kartika Wijayakusuma Jurnal Kesehatan Bakti Tunas Husada
Putriyanti, Al-fira
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : science midwifery

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Preliminary study of blood pressure and arterial stiffness monitoring using the niva device (non-invasive vascular analyzer) Avianningsih, Reformia; Hasimun, Patonah; Jafar, Garnadi; Putriyanti, Al-fira; Zakaria, Hasballah
Science Midwifery Vol 13 No 6 (2026): February: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i6.2212

Abstract

Introduction: Measuring vascular parameters using the NIVA (Non-Invasive Vascular Analyzer) is an important step in assessing the health of blood vessels in the community, especially in groups at risk of hypertension. Objective: This study aims to describe the results of baseline blood pressure and vascular parameter examinations in respondents before further intervention. Methods: Respondents underwent an initial screening process including informed consent, anamnesis, and baseline blood pressure measurement. Results: The graph shows a balanced gender distribution and a dominance of the 31-40 and 41-50 age groups, which are age groups at high risk of experiencing increased arterial stiffness. The hand and foot blood pressure graphs show variations in systolic and diastolic values ​​​​in the mild to moderate hypertension range, indicating that the hemodynamic condition of the respondents is stable and safe for NIVA examination. NIVA measurements were performed by attaching a cuff to the upper arm and left ankle to obtain parameters such as baPWV, ABI, MAP, PP, and Vascular Age. Blood pressure variations in the baseline graph support accurate reading of vascular parameters, especially because there was no indication of peripheral stenosis based on the comparison of hand and foot blood pressure. The data recording and validation process was performed by comparing the measurement results to the baseline, which was consistent with the initial graph. Conclusion: The examination results indicate that the respondents' initial condition met the requirements for non-invasive vascular evaluation and provided a representative picture of blood vessel health status prior to clinical intervention.
Strategy for enhancing stability and bioavailability of active lipid ingredients through nanoparticle technology: Review Nurohman , Ikra; Putriyanti, Al-fira
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2288

Abstract

Background: Lipid-based active ingredients have high pharmacological potential, such as anti-inflammatory, antioxidant, and anticancer activities, but often face biopharmaceutical challenges such as low water solubility, poor chemical stability, and limited bioavailability. Objectives: This review article aims to analyze various nanoparticle technology-based formulation strategies to improve the stability and pharmacological activity of lipid active ingredients. Methods: A total of 31 scientific articles published between 2020 and 2025 were systematically analyzed to evaluate the types of lipid nanoparticle systems, production methods, the role of surfactants and additives, and their impact on stability and bioavailability. Commonly used systems include Solid Lipid Nanoparticles (SLN), Nanostructured Lipid Carriers (NLC), and nanoemulsions. Results: The results of the study indicate that encapsulation in a nano lipid matrix can protect the active ingredients from oxidative, photolytic, and enzymatic degradation and increase membrane solubility and permeability. Key factors for successful formulation include the selection of lipid type, production method, and the combination of surfactant and coating polymer. In addition to improving pharmacokinetic parameters, lipid nanoparticle systems also show potential for cost efficiency through dose reduction and increased therapeutic efficacy. Conclusions: Overall lipid nanoparticle technology is an effective, applicable and prospective approach in the development of modern pharmaceutical preparations based on lipophilic active ingredients.
Formulation and characterization of nanostructured lipid carriers of curcumin and their development in topical gel preparations for drug delivery systems Jafar, Garnadi; Choerrunisa, Choerrunisa; Sukmawati, Ika Kurnia; Putriyanti, Al-fira
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2339

Abstract

Curcumin is a bioactive compound derived from Curcuma longa with anti-inflammatory and antioxidant activities; however, its topical application is limited due to poor solubility and stability. The development of nanoparticle-based delivery systems such as Nanostructured Lipid Carriers (NLC) can enhance drug stability and skin penetration. This study aimed to formulate curcumin-loaded NLC, evaluate its physicochemical characteristics, and develop a gel dosage form based on the optimized NLC formulation. The research methods included preliminary solubility testing of curcumin in various lipid and surfactant components, compatibility analysis using Differential Scanning Calorimetry (DSC), formulation of five NLC formulations using hot homogenization and probe sonication methods, and characterization including particle size, polydispersity index, zeta potential, entrapment efficiency, and morphology using Transmission Electron Microscopy (TEM). The selected NLC formulation was subsequently incorporated into a gel system and evaluated for pH, viscosity, and spreadability. The results demonstrated that the curcumin NLC exhibited nanoscale particle size with relatively uniform distribution, stable zeta potential values, and high entrapment efficiency. TEM analysis confirmed spherical particle morphology. The NLC-based gel formulation showed acceptable physicochemical properties, including skin-compatible pH, suitable viscosity, and optimal spreadability. In conclusion, curcumin was successfully formulated into an NLC system and further developed into a topical gel formulation with promising physicochemical characteristics as a lipid-based drug delivery system.
Co-Authors Adinda, Deistha Avianningsih, Reformia Choerrunisa, Choerrunisa Garnadi Jafar, Garnadi Hasimun, Patonah Ilham Bintang, Muhamad Isvahanie, Salsha Rifa Jajang Japar Sodik Maulana, Mamay Mindiarto, Ahmad Bagus Mulki Irpani, Abdul Nurohman , Ikra Pratama, Reza Sofian, Ryan Soni Muhsinin Suhardiman, Aris Sukmawati, ika kurnia Yani Mulyani Zakaria, Hasballah