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All Journal Indonesian Journal of Obstetrics & Gynecology Science Andalas obstetrics and gynecology journal Indonesian Journal of Cancer
Kemala Isnainiasih Mantilidewi
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Padjajaran-Dr. Hasan Sadikin General Hospital, Bandung
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Comparison of Chondroitin Sulfate-E Expression in Benign and Malignant Epithelial Type Ovarian Tumors Mantilidewi, Kemala Isnainiasih; A.W., Gatot Nyarumenteng; Kurniadi, Andi; Suardi, Dodi; Harsono, Ali Budi; Salima, Siti; A, Aditiyono; Hapsari, Kartika; Yantisetiasti, Anglita
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.861

Abstract

Objective: Ovarian cancer is the fifth leading cause of cancer-related death in women, due to late diagnosis and limited screening methods. Chondroitin Sulfate-E (CS-E) has shown potential as biomarkers. This study aims to evaluate CS-E expression in epithelial-type benign and malignant ovarian tumors and its potential as a biomarker using QuPath software.Methods: This observational analytic study used a cross-sectional design. Samples were selected based on histopathology of patients with epithelial-type benign and malignant ovarian tumors from surgeries in 2023. Immunohistochemistry using the GD3G7 antibody was performed to detect CS-E expression in tumor tissues preserved in paraffin blocks at Dr. Hasan Sadikin General Hospital Bandung. Expression was quantified using QuPath software. Statistical analysis used the Mann-Whitney and t-test. Result: No significant difference in CS-E expression was found between malignant and benign tumors (p = 0.492). Demographic factors (age, BMI, menopausal status, and parity) showed no significant differences between groups. Conclusion: CS-E expression has not yet demonstrated potential as a biomarker to distinguish between benign and malignant ovarian tumors.Perbandingan Ekspresi Chondroitin Sulfate-E pada Tumor Ovarium Jinak dan Ganas Tipe Epitel Abstrak Tujuan: Kanker ovarium merupakan penyebab kematian kelima terbanyak terkait kanker pada wanita yang disebabkan oleh keterlambatan diagnosis dan keterbatasan metode skrining. Chondroitin Sulfate-E (CS-E) menunjukkan potensi sebagai biomarker. Penelitian ini bertujuan mengevaluasi ekspresi CS-E pada tumor ovarium jinak dan ganas tipe epitelial serta menilai potensinya sebagai biomarker menggunakan perangkat lunak QuPath. Metode: Penelitian analitik observasional ini menggunakan desain potong lintang. Sampel dipilih berdasarkan hasil histopatologi pasien dengan tumor ovarium jinak dan ganas tipe epitelial dari operasi tahun 2023. Pemeriksaan imunohistokimia dengan antibodi GD3G7 dilakukan untuk mendeteksi ekspresi CS-E pada jaringan tumor yang diawetkan dalam blok parafin di RSUP Dr. Hasan Sadikin Bandung. Ekspresi dianalisis secara kuantitatif menggunakan perangkat lunak QuPath. Uji statistik yang digunakan adalah Mann-Whitney dan uji t. Hasil: Tidak ditemukan perbedaan bermakna dalam ekspresi CS-E antara tumor ganas dan jinak (p = 0,492). Faktor demografis (usia, indeks massa tubuh, status menopause, dan paritas) juga tidak menunjukkan perbedaan bermakna antar kelompok.Kesimpulan: Ekspresi CS-E belum menunjukkan potensi sebagai biomarker untuk membedakan antara tumor ovarium jinak dan ganas. Kata kunci: Biomarker, GD3G7, Glikosaminoglikan, Kanker Ovarium, Kondroitin sulfat 
Co-Authors A, Aditiyono A.W., Gatot Nyarumenteng Aditya Rifandi Zaenudin Alamsyah Aziz Ali Budi Harsono Ali Budi Harsono Ali Budi Harsono Andi Kurniadi, Andi Andi Rinaldi Anglita Yantisetiasti Anita Deborah Anwar Ari Irawan Romulya Ari Irawan Romulya Balqis, Shalma Alaika Aurel Dodi Suardi Erfiandi, Febia Febia Erfiandi H Susiarno Hadi Susiarno Haifa Tuffahati Hanom Husni Syam HARSONO, ALI BUDI Harsono, Ali Budi Hartanto Bayuaji Jaeni Pringgowibowo Jessica Kireina Jessica Kireina Kartika Hapsari Maharani, Chintia Dewi Megantari, Salsa Bila Ritonga, Mulyanusa Amarullah Salima, Siti Siti Salima Steven Ridwan, Steven Syahrul Rauf Tita Husnita Madjid Tita Husnita Madjid Wibowo, Viko Duvadilan Windy Natasya Al Baihaqi Wiryawan Permadi Yudi Mulyana Hidayat Yuni Susanti Pratiwi, Yuni Susanti Zulvayanti Zulvayanti