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All Journal Indonesian Journal of Obstetrics & Gynecology Science Andalas obstetrics and gynecology journal Indonesian Journal of Cancer
Kemala Isnainiasih Mantilidewi
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Padjajaran-Dr. Hasan Sadikin General Hospital, Bandung
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Comparison of Chondroitin Sulfate-E Expression in Benign and Malignant Epithelial Type Ovarian Tumors Mantilidewi, Kemala Isnainiasih; A.W., Gatot Nyarumenteng; Kurniadi, Andi; Suardi, Dodi; Harsono, Ali Budi; Salima, Siti; A, Aditiyono; Hapsari, Kartika; Yantisetiasti, Anglita
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.861

Abstract

Objective: Ovarian cancer is the fifth leading cause of cancer-related death in women, due to late diagnosis and limited screening methods. Chondroitin Sulfate-E (CS-E) has shown potential as biomarkers. This study aims to evaluate CS-E expression in epithelial-type benign and malignant ovarian tumors and its potential as a biomarker using QuPath software.Methods: This observational analytic study used a cross-sectional design. Samples were selected based on histopathology of patients with epithelial-type benign and malignant ovarian tumors from surgeries in 2023. Immunohistochemistry using the GD3G7 antibody was performed to detect CS-E expression in tumor tissues preserved in paraffin blocks at Dr. Hasan Sadikin General Hospital Bandung. Expression was quantified using QuPath software. Statistical analysis used the Mann-Whitney and t-test. Result: No significant difference in CS-E expression was found between malignant and benign tumors (p = 0.492). Demographic factors (age, BMI, menopausal status, and parity) showed no significant differences between groups. Conclusion: CS-E expression has not yet demonstrated potential as a biomarker to distinguish between benign and malignant ovarian tumors.Perbandingan Ekspresi Chondroitin Sulfate-E pada Tumor Ovarium Jinak dan Ganas Tipe Epitel Abstrak Tujuan: Kanker ovarium merupakan penyebab kematian kelima terbanyak terkait kanker pada wanita yang disebabkan oleh keterlambatan diagnosis dan keterbatasan metode skrining. Chondroitin Sulfate-E (CS-E) menunjukkan potensi sebagai biomarker. Penelitian ini bertujuan mengevaluasi ekspresi CS-E pada tumor ovarium jinak dan ganas tipe epitelial serta menilai potensinya sebagai biomarker menggunakan perangkat lunak QuPath. Metode: Penelitian analitik observasional ini menggunakan desain potong lintang. Sampel dipilih berdasarkan hasil histopatologi pasien dengan tumor ovarium jinak dan ganas tipe epitelial dari operasi tahun 2023. Pemeriksaan imunohistokimia dengan antibodi GD3G7 dilakukan untuk mendeteksi ekspresi CS-E pada jaringan tumor yang diawetkan dalam blok parafin di RSUP Dr. Hasan Sadikin Bandung. Ekspresi dianalisis secara kuantitatif menggunakan perangkat lunak QuPath. Uji statistik yang digunakan adalah Mann-Whitney dan uji t. Hasil: Tidak ditemukan perbedaan bermakna dalam ekspresi CS-E antara tumor ganas dan jinak (p = 0,492). Faktor demografis (usia, indeks massa tubuh, status menopause, dan paritas) juga tidak menunjukkan perbedaan bermakna antar kelompok.Kesimpulan: Ekspresi CS-E belum menunjukkan potensi sebagai biomarker untuk membedakan antara tumor ovarium jinak dan ganas. Kata kunci: Biomarker, GD3G7, Glikosaminoglikan, Kanker Ovarium, Kondroitin sulfat 
Wound Dehiscence Following Obstetrics and Gynecology Surgeries: An Observational Study at a Tertiary Hospital in Bandung Mantilidewi, Kemala Isnainiasih; Firdaus, Nur’adilah; Kurniadi, Andi; Erfiandi, Febia; Kireina, Jessica; Natasya, Windy; Harsono, Ali Budi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.658

Abstract

Introduction: Wound dehiscence is a severe postoperative complication that disrupts an abdominal wound closure which can be caused by endogenous or exogenous flora that infect a surgical wound. Many factors are responsible for surgical site infection in obstetric and gynecology patients considering all the basic standards are ideally maintained in tertiary care hospitals. To identify the characteristics of surgical wound dehiscence (SWD) patients who underwent obstetric and gynecological surgeries at Dr. Hasan Sadikin Hospital from 2021 to 2022.Methods: This study utilized a quantitative descriptive approach with a retrospective design. Results: A total of 43 subjects were included in the study and were divided into three groups based on their surgery type: obstetrics (n=11), gynecology (n=7), and gynecological oncology (n=25). The majority of SWD cases were associated with gynecological oncology surgeries. The patients were predominantly aged 18-65 years (88%), had superficial SWD (65%), normal BMI (37%), were non-smokers (67%), had a history of steroid medication usage (63%), received prophylactic antibiotics (63%), underwent elective surgery (58%), had laparotomy surgeries (100%), with a duration of ≥180 minutes (35%), and intraoperative bleeding of ≤1500 cc (63%). The surgical wounds were primarily classified as clean type (47%), and therapeutic antibiotics were administered to the majority of patients (74%).Conclusion: Most of our findings were consistent with existing theories. However, the discrepancies observed in some outcomes can serve as an evaluative tool to assess the adherence of current practices to established guidelines. It is crucial to consider the risk factors for SWD when developing preventive strategies.Dehisensi Luka Pascaoperasi Obstetri dan Ginekologi: Sebuah Studi Observasi di Rumah Sakit Tersier Di BandungAbstrakPendahuluan: Dehisensi luka pascaoperasi merupakan komplikasi serius yang dapat mengganggu penutupan luka di perut yang disebabkan oleh adanya flora bersumber secara endogen atau eksogen yang menginfeksi luka operasi. Banyak faktor yang berperan dalam infeksi daerah operasi walaupun sudah dilakukannya semua standar operasional yang selalu dipertahankan di rumah sakit perawatan tersier. Untuk mengetahui karakteristik pasien dehisensi luka pascaoperasi obstetri dan ginekologi di RSUP Dr. Hasan Sadikin.Metode: Penelitian ini merupakan penelitian deskriptif retrospektif yang menganalisis faktor praoperatif, intraoperatif, dan pascaoperatif dari subjek penelitian. Hasil: Pada studi ini, terdapat 43 subjek yang selanjutnya dikategorikan menjadi tiga kelompok berdasarkan jenis operasinya: obstetri (n=11), ginekologi (n=7), dan onkologi ginekologi (n=25). Sebagian besar kasus berhubungan dengan operasi onkologi ginekologi, berusia 18 - 65 tahun (88%), memiliki dehisensi luka superfisial (65%), indeks massa tubuh normal (37%), bukan perokok. (67%), memiliki riwayat penggunaan obat steroid (63%), menerima antibiotik profilaksis (63%), menjalani operasi elektif (58%), menjalani operasi melalui laparotomi (100%), dengan durasi ≥180 menit (35%), memiliki luka operasi tipe bersih (47%), mengalami perdarahan intraoperative ≤1500 cc (63%), dan mendapatkan antibiotik terapeutik (74%).Kesimpulan: Sebagian besar hasil studi didapatkan sesuai dengan teori yang telah ada. Kesenjangan yang ditemukan pada luaran studi dapat menjadi alat evaluasi untuk menilai ketaatan pada praktik yang dilakukan untuk kemudian dijadikan pedoman praktik. Penting juga untuk mempertimbangkan faktor risiko dari dehisensi luka pascaoperasi ketika akan mengembangkan strategi preventif.Kata kunci: dehisensi luka pasca operasi, faktor risiko, praoperasi, intraoperasi, pascaoperasi
Bacteriological Profile and Antibiotic Sensitivity Pattern of Surgical Site Infection Following Gynecologic Oncology Surgery at Hasan Sadikin General Hospital Mantilidewi, Kemala Isnainiasih; Harsono, Ali Budi; Kireina, Jessica; Pringgowibowo, Jaeni; Al Baihaqi, Windy Natasya
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 2 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.2.122-129.2022

Abstract

Introduction: Surgical site infection (SSI) is the most common complication of gynecologic oncology surgeries. Understanding the characteristics, bacteriological profile, and antibiotic sensitivity pattern of SSI patients can help guide patient’s management and reduce morbidity, mortality, and economic burden caused by SSI. The aim of this study is to describe the characteristics, bacteriological profile, and antibiotic sensitivity pattern of SSI patients following gynecologic oncology surgery at Hasan Sadikin General Hospital Bandung in 2021. Methods: This is a descriptive study that analyzed medical records of patients undergoing gynecologic oncology surgery at Hasan Sadikin Hospital Bandung from January to December 2021. Results: Out of 157 gynecologic oncology surgeries in 2021 that met the criteria, there were 11 incidences of SSI (7%). All SSI patients received postoperative antibiotics, with the most common type of antibiotic given being a combination of ceftriaxone and metronidazole. Ten out of the 11 specimens from SSI patients showed bacterial growth and a total of 17 bacterial isolates were found. Most specimens showed polymicrobial infection with the most common isolate being Escherichia coli Extended-Spectrum Beta-Lactamase (ESBL). Gram-positive bacteria in this study were most sensitive to Vancomycin, Tigecycline, and Gentamicin. Meanwhile, gram-negative bacteria were most sensitive to Ertapenem and Meropenem. Conclusion: Incidence of SSI following gynecologic oncology surgery at Hasan Sadikin General Hospital in 2021 is 7%. The most frequently found isolate was Escherichia coli ESBL. Gram-positive bacteria were most sensitive Vancomycin, Tigecycline, and Gentamicin; while gram-negative bacteria were most sensitive to Ertapenem and Meropenem.
Strategic Surgical Management of Complex Ovarian Masses During Second-Trimester Pregnancy: A Serial Case Report Homenta, Christian; Erfiandi, Febia; Mantilidewi, Kemala Isnainiasih
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.993

Abstract

Introduction: Ovarian masses are found in about 1.5% – 5.7% of pregnancies, with suspicion of malignancy in 1% – 6% of cases. Large or complex adnexal masses can increase the risk of torsion, rupture, or malignant transformation. This report aims to highlight the importance of personalized surgical management of ovarian masses during pregnancy, particularly emphasizing the benefits of second-trimester intervention, and to explore the research question: Can elective adnexal surgery during the second trimester improve maternal and fetal outcomes in high-risk pregnancies? Case Report: Two pregnant patients with adnexal masses were evaluated clinically and radiologically. Decision-making was based on gestational age, mass characteristics, and maternal-fetal considerations. Both underwent surgical management in the second trimester, with histopathological confirmation obtained. Case 1: A 37-year-old G5P3A1 at 16 weeks’ gestation presented with a multilocular cystic mass (25×12×8 cm) in the right ovary. Salpingo-oophorectomy at 19 weeks revealed a benign non-papillary cyst. Case 2: A 24-year-old G3P2A0 at 23 weeks’ gestation had a complex adnexal mass (20×20×15 cm). Partial oophorectomy revealed sebaceous material, hair, and cartilage. Histopathology confirmed a mature cystic teratoma. The pregnancy progressed uneventfully, culminating in spontaneous vaginal delivery at term.Conclusion: This case report emphasizes the importance of prompt surgical intervention during the second trimester of pregnancy. It offers unique insights into the strategic management of complex ovarian masses, contributing valuable information to the limited literature and guiding clinical decision-making in similar cases. Abstrak Pendahuluan: Massa ovarium ditemukan pada sekira 1,5% – 5,7% kehamilan, dengan kecurigaan keganasan pada 1% – 6% kasus. Massa adneksa yang besar atau kompleks dapat menimbulkan risiko torsi, ruptur, atau transformasi ganas. Laporan ini bertujuan untuk menyoroti peran penatalaksanaan bedah individual pada massa ovarium selama kehamilan, khususnya dengan menekankan keuntungan intervensi pada trimester kedua, serta menjawab pertanyaan penelitian: Dapatkah pembedahan adneksa elektif pada trimester kedua mengoptimalkan luaran maternal dan janin pada kehamilan berisiko tinggi?Laporan Kasus: Dua pasien hamil dengan massa adneksa dievaluasi secara klinis dan radiologis. Pengambilan keputusan didasarkan pada usia kehamilan, karakteristik massa, dan pertimbangan maternal-janin. Keduanya menjalani penatalaksanaan bedah pada trimester kedua, dan konfirmasi histopatologi diperoleh. Kasus 1: Wanita 37 tahun G5P3A1 pada usia kehamilan 16 minggu dengan massa kistik multilokular (25×12×8 cm) pada ovarium kanan. Salpingo-ooforektomi pada usia kehamilan 19 minggu menunjukkan kista jinak non-papiler. Kasus 2: Wanita 24 tahun G3P2A0 pada usia kehamilan 23 minggu dengan massa adneksa kompleks (20×20×15 cm). Ooforektomi parsial menunjukkan adanya material sebaceous, rambut, dan kartilago. Histopatologi mengonfirmasi teratoma kistik matur. Kehamilan berlangsung tanpa komplikasi dan berakhir dengan persalinan spontan pervaginam aterm.Kesimpulan: Pembedahan adneksa elektif pada trimester kedua memberikan kondisi anatomi dan obstetri yang optimal, serta meminimalkan risiko teratogenik dan persalinan prematur. Dengan pendekatan individual, multidisipliner, dan berbasis bukti, strategi ini dapat memberikan luaran maternal dan neonatal yang baik pada kehamilan berisiko tinggi terpilih. 
Co-Authors A, Aditiyono A.W., Gatot Nyarumenteng Aditya Rifandi Zaenudin Al Baihaqi, Windy Natasya Alamsyah Aziz Ali Budi Harsono Ali Budi Harsono Ali Budi Harsono Andi Kurniadi, Andi Andi Rinaldi Anglita Yantisetiasti Anita Deborah Anwar Ari Irawan Romulya Ari Irawan Romulya Balqis, Shalma Alaika Aurel Dodi Suardi Erfiandi, Febia Febia Erfiandi Firdaus, Nur’adilah H Susiarno Hadi Susiarno Haifa Tuffahati Hanom Husni Syam Harsono, Ali Budi HARSONO, ALI BUDI Hartanto Bayuaji Homenta, Christian Jaeni Pringgowibowo Jessica Kireina Jessica Kireina Kartika Hapsari Kireina, Jessica Maharani, Chintia Dewi Megantari, Salsa Bila Natasya, Windy Pringgowibowo, Jaeni Ritonga, Mulyanusa Amarullah Salima, Siti Siti Salima Steven Ridwan, Steven Syahrul Rauf Tita Husnita Madjid Tita Husnita Madjid Wibowo, Viko Duvadilan Windy Natasya Al Baihaqi Wiryawan Permadi Yudi Mulyana Hidayat Yuni Susanti Pratiwi, Yuni Susanti Zulvayanti Zulvayanti