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PENGARUH PEMBERIAN EKSTRAK ALGA COKELAT (SARGASSUM POLYCYSTUM) DARI PERAIRAN PULAU NAIN TERHADAP GAMBARAN HISTOPATOLOGIK HEPAR TIKUS WISTAR (RATTUS NORVEGICUS) YANG DIBERI DIET TINGGI LEMAK Kiai Demak, Puspa Eldiaputri; Kairupan, Carla Felly; Wijaya, Nur Anindhita Kurniawaty
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.41823

Abstract

Penyakit hati berlemak non-alkohol/non-alcohol fatty liver disease (NAFLD) merupakan masalah kesehatan global yang semakin meningkat, terutama terkait dengan pola makan yang tinggi lemak dan kolesterol. Alga cokelat memiliki senyawa antioksidan yang berpotensi sebagai hepatoprotektor. Penelitian ini bertujuan untuk mengetahui pengaruh dari pemberian ekstrak alga cokelat (Sargassum polycystum) dari Perairan Pulau Nain terhadap gambaran histopatologik hepar tikus Wistar (Rattus norvegicus) yang diberikan diet tinggi lemak. Penelitian eksperimental ini menggunakan subjek 24 ekor tikus Wistar jantan yang terbagi dalam 4 kelompok. Kelompok A tidak diberi perlakuan selama 21 hari, kelompok B diberi perlakuan diet tinggi lemak 5 ml/ekor selama 21 hari, dan kelompok C dan D diberi perlakuan diet tinggi lemak masing-masing 5 ml/ekor dan ekstrak alga cokelat 450 mg/kgBB dan 900 mg/kgBB. Kelompok A menunjukkan gambaran histopatologik hepar tikus normal. Kelompok B terdapat banyak sel radang, nekrosis, steatosis mikrovesikuler dan sedikit steatosis makrovesikuler, dan fibrosis perisinusoid. Kelompok C menunjukkan sel hati yang teregenerasi, sedikit sel steatosis, sel radang dan fibrosis perisinusoid. Kelompok D terdapat sel radang dan sel steatosis yang lebih sedikit dari kelompok C serta terdapat fibrosis.  Pemberian ekstrak alga cokelat (Sargassum polycystum) mampu membantu proses regenerasi sel hepar dan mengurangi reaksi inflamasi pada hepar tikus Wistar yang diberikan diet tinggi lemak, dengan efek yang lebih baik terlihat pada hepar tikus Wistar yang diberi ekstrak alga cokelat dalam dosis yang lebih tinggi (900 mg/kgBB).
PENGARUH PEMBERIAN EKSTRAK DAUN CENGKEH (SYZYGIUM AROMATICUM) TERHADAP GAMBARAN HISTOPATOLOGIK HATI TIKUS WISTAR (RATTUS NORVEGICUS) YANG DIINDUKSI MINUMAN BERALKOHOL CAP TIKUS Janis, Ebenhard Ishak; Wijaya, Nur Anindhita Kurniawaty; Kairupan, Carla Felly
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.41826

Abstract

Penggunaan obat-obatan kortikosteroid dalam manajemen Alcoholic liver disease (ALD) memiliki efek samping yang serius. Daun cengkih (Syzygium aromaticum) mengandung senyawa fenolik dan eugenol yang tinggi yang berpotensi terhadap aktivitas antioksidan dapat melindungi jaringan parenkim hati dari kerusakan oksidatif akibat konsumsi minuman beralkohol. Tujuan penelitian ini untuk mengetahui pengaruh pemberian ekstrak daun cengkih terhadap gambaran histopatologik hati tikus wistar yang diinduksi minuman beralkohol cap tikus. Penelitian eksperimental ini menggunakan rancangan post test only control group design yang melibatkan subjek 27 ekor tikus wistar jantan yang dibagi menjadi tiga kelompok. Kelompok normal hanya diberi pakan standar AD2 dan aquadest, kelompok kontrol negatif diinduksi minuman beralkohol cap tikus 2,16 ml/hari, kelompok perlakuan diberikan ekstrak daun cengkih 100mg/kgBB kemudian dilanjutkan induksi minuman beralkohol cap tikus 2,16 ml/hari. Setelah itu hewan coba semuanya diterminasi pada hari kelima belas. Hasil penelitian menunjukkan adanya perubahan patologis jaringan parenkim hati berupa pembengkakkan sel, steatosis, nekrosis sel, dan infiltrasi sel radang pada tikus-tikus yang diinduksi cap tikus, baik yang diberi maupun yang tidak diberi ekstrak daun cengkih. Gambaran histopatologik hati tikus wistar tampak mirip pada kedua kelompok tersebut dan analisis statistik dengan uji Post hoc Dunn-Bonferroni mengindikasikan tidak terdapat perbedaan yang signifikan (p value = 1000). Sebagai kesimpulan, pemberian ekstrak daun cengkih (Syzygium aromaticum) tidak berpengaruh secara signifikan (p value = 1,000) terhadap gambaran histopatologik hati tikus wistar yang diinduksi minuman beralkohol cap tikus.
PELATIHAN PEMBUATAN SNACK BAR TEMPE DALAM UPAYA PENANGGULANGAN ANEMIA REMAJA PUTRI Lestari, Utami Sasmita; Angmalisang, Elvin Clara; Wijaya, Nur Anindhita Kurniawaty
Jurnal Abdi Insani Vol 11 No 4 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i4.2055

Abstract

Anemia is the most common nutritional problem in the world. The increased need for iron in adolescents because they are in a period of growth makes adolescents very susceptible to anemia, especially in adolescent girls. Anemia can reduce fitness, productivity, learning ability, and cognitive abilities of adolescents. One effort that can be made to overcome anemia is providing tempe snack bar. Modifying tempe into tempe snack bars makes serving tempe more practical and preferred by adolescents. The purpose of this community service activity was to overcome the problem of anemia in adolescent girls by increasing the role of madrasah teachers through training in making tempe snack bars. The target of this service was madrasah teachers. The activity was carried out in the counseling stage, lectures and discussions about anemia and the benefits of tempe, especially in overcoming anemia in adolescent girls, followed by training in making tempe snack bars. The results of this community service activity hopely can be used as a solution to prevent and overcome anemia in adolescent girls. Providing motivation and awareness to adolescent girls to consume nutritious foods containing iron. This counseling activity is considered effective in changing the behavior of adolescent girls in preventing anemia. Keywords: anemia, tempe snack bar, adolescent, girls
ANALISIS HUBUNGAN FAKTOR RISIKO DAN DIAGNOSIS BERDASARKAN GAMBARAN HISTOPATOLOGI PADA PASIEN KANKER PAYUDARA DI RSUP PROF. DR. R. D. KANDOU MANADO Wijaya, Nur Anindhita Kurniawaty; Lampus, Harsali Fransiscus; Kepel, Billy Johnson; Bolang, Alexander Sam Leonard; Kaseke, Martha Marie; Salaki, Christina Leta
Jurnal Kesehatan Tambusai Vol. 5 No. 2 (2024): JUNI 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i2.30077

Abstract

Adapun tujuan dari penelitian ini adalah untuk menganalisis hubungan faktor risiko dan diagnosis berdasarkan gambaran histopatologi pada pasien kanker payudara di RSUP Prof. dr. R. D. Kandou Manado Tahun 2022-2023. Penelitian ini merupakan penelitian kuantitatif yang bersifat retrospektif analitik. Teknik pengambilan sampel adalah total sampling. Sampel penelitian sebanyak 375 pasien kanker payudara yang memiliki hasil histopatologi pada Electronic Medical Record (EMR). Teknik analisis statistik yang digunakan yaitu univariat, bivariat yaitu menggunakan Chi Square dan Fisher Exact Test serta multivariat yaitu regresi logistik berganda model prediksi.
Relationship between body mass index and postural balance and flexibility in adolescent girls Lestari, Utami Sasmita; Angmalisang, Elvin Clara; Wijaya, Nur Anindhita Kurniawaty; Wirawanti, Ika Wirya
Science Midwifery Vol 12 No 3 (2024): August: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i3.1644

Abstract

Adolescence is a transition period from childhood to adulthood which is marked by many changes. Adolescents generally have a sedentary lifestyle which causes an increase in body mass index. An increase in body mass index has a negative impact on postural balance and flexibility. Excessive fat in the body tends to change the location of the body's center of gravity and limit joint movement. This study aimed to determine the relationship between body mass index and postural balance and flexibility in adolescent girls. This research was a correlation study and used a cross sectional research design with a total of 35 young women. The parameters used to measure postural balance are the Y-balance test and flexibility is the sit-and-reach test. The data analysis used in this research is Pearson correlation analysis. The results showed that there was a significant relationship between body mass index and postural balance (p=0.001) and flexibility (p=0.001) and the level of closeness of the relationship between each variable was very strong (r=0.825). The higher the BMI, the lower the postural balance and flexibility.
Adverse Events Following Immunization (AEFI) in Nursing Science Program Sam Ratulangi University Students Based on the Type of COVID-19 Vaccine Ahmad, Musfirah; Natalia, Adriani; Wijaya, Nur Anindhita Kurniawaty
Indonesian Contemporary Nursing Journal (ICON Journal) Vol. 7 No. 2 (2023): Volume 7 No. 2 Februari 2023
Publisher : Faculty of Nursing, Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/icon.v7i2.23638

Abstract

Aims: The purpose of this study is to describe Adverse Events Following Immunization (AEFI) among Nursing Science Program Sam Ratulangi University students based on the type of Covid-19 vaccination that they received. Methods: This investigation was conducted using a descriptive retrospective study approach. Purposive sampling was utilized to choose the sample for this study, which included 183 undergraduate students in the Nursing Science Program Sam Ratulangi University. Results: After receiving the first dosage of the vaccination, Nursing Science Program Sam Ratulangi University students most frequently reported headache and muscle pain (30.4%), followed by pain and weakness in the injected arm (20.8%), and swelling at the injection site (26%). Additionally, there were students who received doses 1, 2, and 3 of the vaccination who did not exhibit any side effects. These students were 45 at dosage I, 73 at dose II, and 45 at dose III. At dose 1, the majority of Nursing Science Program Sam Ratulangi University students (73.2%) exhibited AEFI symptoms for less than a day, at doses II and III, 43.7% and 31.1%, respectively, reported experiencing symptoms for one to three days. Conclusion: Based on the research that has been done, it can be said that Nursing Science Program Sam Ratulangi University students only encounter mild AEFI symptoms. So it is hoped that the general public or students won't have to worry about the COVID 19 vaccine causing AEFI symptoms and can get vaccinated right away to strengthen their immunity against the virus.