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All Journal Poltekita : Jurnal Ilmu Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Buletin Kedokteran dan Kesehatan Prima
Yuliansyah, Jeri
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Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Medicine & Pharmacology Nursing Public Health Other

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PENGARUH PERAWATAN LUKA SAYAT DENGAN MENGGUNAKAN KRIM EKSTRAK KULIT KAYU MANIS (CINNAMOMUM BURMANNII) TERHADAP KETEBALAN JARINGAN GRANULASI PADA TIKUS PUTIH JANTAN GALUR Lafonda, Kartini Anisa; Yuliansyah, Jeri; Amir, Dwi Fenny
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.41177

Abstract

Jaringan kulit mengandung berbagai sel dan matriks ekstraseluler (ECM). Keratinosit, melanosit, dan sel Langerhans terdapat di epidermis. Fibroblas adalah jenis sel utama di dermis. Penelitian ini bertujuan untuk menguji dan menganalisis efektivitas pemberian krim ekstrak kulit kayu manis (Cinnamomum burmannii) terhadap ketebalan jaringan granulasi pada tikus putih (Rattus norvegicus) jantan galur wistar yang mengalami luka sayat. Penelitian yang digunakan pada penelitian ini yaitu kuantitatif eksperimental dengan menggunakan desain true experiment atau eksperimental laboratorium. Penelitian eksperimen dilaksanakan dengan mengontrol semua variabel luar yang dapat mempengaruhi kegiatan eksperimen. Penelitian ini menggunakan post-test only control group design untuk mengetahui dan menganalisis efek pemberian ekstrak kulit kayu manis dalam mempercepat penyembuhan luka dan ketebalan jaringan granulasi pada tikus putih (Rattus norvegicus) galur wistar yang mengalami luka sayat. Berdasarkan uji fitokimia diketahui bahwa ekstrak kulit kayu manis mengandung saponin, alkaloid, steroid, dan flavonoid yang dapat digunakan sebagai antiinflamasi dan antioksidan yang potensial untuk mempercepat penyembuhan luka dan pembentukan jaringan granulasi. Perawatan luka sayat menggunakan krim ekstrak kulit kayu manis efektif dalam mempercepat penyembuhan luka sayat pada tikus putih (Rattus norvegicus) galur wistar dibandingkan dengan kelompok yang hanya diberikam krim basis. Kelompok yang diberi ekstrak kulit kayu manis memiliki rata-rata nilai persentase penyembuhan yang lebih besar dibanding kelompok kontrol. Peneliti menyimpulkan bahwa konsentrasi krim ekstrak kulit kayu manis yang paling efektif dalam penyembuhan luka sayat yaitu 4.5%. Penggunaan krim ekstrak kulit kayu manis dengan konsentrasi 4.5% memiliki rata-rata ketebalan jaringan granulasi yang lebih tinggi dibandingkan kelompok lainnya yaitu 238.85µm.
In-Vitro Antioxidant Activity of Eggplant (Epicarp Solanum Melongena L) Skin Extract on Aflatoxin-B1-Induced Rats Chintya Darma, Gladys; Ginting, Chrismis Novalinda; Chiuman, Linda; Yuliansyah, Jeri; Hasya, Muhammad Nawal
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 7 No 1 (2025)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v7i1.439

Abstract

Eggplant skin is the outer part of the eggplant fruit (Solanum Melongena L) which has therapeutic activities such as anti-inflammatory, anti-oxidant, anti-viral, anti-bacterial and anti-cancer. This study aims to evaluate the antioxidant potential of ethanol extract of eggplant skin through phytochemical analysis, antioxidant activity through ABTS and DPPH examination by assessing IC50, and its effect on oxidative stress-related enzymes in aflatoxin B1 (AFB1)-induced rats such as MDA, LPO-4HNE, and evaluating SOD levels in rat serum. The results showed that ethanol extract of eggplant peel has significant antioxidant activity in radical scavenging activity. The antioxidant activity of ethanol extract of eggplant skin in ABTS and DPPH methods showed IC50 values with strong antioxidant potential. In the In-Vivo test, aubergine skin ethanol extract showed a good protective effect against oxidative stress with decreased MDA and LPO-4HNE levels, and increased SOD activity in AFB1-induced rats. The optimal dose of aubergine skin ethanol extract in this study is the treatment with a dose of 600mg/kgBB, which gives the best results in reducing MDA and LPO-4HNE levels, and increasing SOD activity close to the neutral group.
The Effect of Extra Virgin Olive Oil on Reducing Malondialdehyde Levels and Liver Histopathology in Male Rattus Norvegicus with Hypercholesterolemia Lister, Gilbert; Adinda, Adinda; Djohan, Djohan; Yuliansyah, Jeri
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3646

Abstract

All living things age physiologically. Free radicals attack cells as they age, causing damage, disruption, and death. Free radicals oxidize and damage cell membrane lipids. The body needs optimum antioxidants during oxidative stress. This study hypothesizes EVOO can lower MDA and total cholesterol and repair liver histopathology in hypercholesterolemic Wistar male rats—this research with a pre-post-test control group experiment. The study found that the control group's MDA level was 0.14 ± 0.03 nmol/ml before treatment (pretest), while the group given standard meal for mice and distilled water/day/head for 14 days had a drop to 0.13 ± 0.10 nmol/ml. In treatment group 1, the average MDA level was 0.73 ± 0.03 nmol/ml before treatment, and after 14 days of high-fat, high-cholesterol meal without EVOO, the average MDA level was 0.73 ± 0.03 nmol/ml and dropped to 0.48 ± 0.10 nmol/ml. Treatment group 2 had an average MDA level of 0.22 ± 0.02 nmol/ml before treatment, but after receiving a high-fat, high-cholesterol diet and a 1cc dose of EVOO for 14 days, it decreased to 0.17 ± 0.02 nmol/ml. Before therapy, the mean MDA level in group 3 was 0.17 ± 0.02 nmol/mL. Giving mice a lot of fat and cholesterol and a two cc dose of EVOO for 14 days lowered their MDA levels to 0.08 ± 0.01 nmol/ml, ranging from 0.10 to 0.05. The research concluded that average MDA decreased significantly in treatment group 3 after mice were fed high-fat, high-cholesterol feed and given two ccs of EVOO.
Breast cancer patients' quality of life during chemotherapy at Royal Prima General Hospital Saragih, Chanli; Lumbantobing, Christina J.R.E.; Chiuman, Linda; Sylvana, Dhini; Ibnu, Syahroni; Yuliansyah, Jeri; Iskandar, Ari Rahman
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.8049

Abstract

Background: Breast cancer is the most prevalent malignancy and a leading cause of cancer-related death among women worldwide. Chemotherapy, a primary treatment modality, often significantly impacts patient quality of life (QoL). This study aimed to analyze the QoL of breast cancer patients undergoing chemotherapy at Royal Prima General Hospital. Methods: We employed a descriptive-analytic cross-sectional design with a purposive sample of 51 patients. Data were collected using a respondent characteristics form and the validated Indonesian version of the WHOQOL-BREF instrument. Results: Results indicated the majority of respondents were aged 36-60 years (86.3%), married (100%), had a junior high school education (49%), and had a disease duration of 1-24 months (82.4%). Overall QoL for most patients was moderate (60.8%), followed by good (35.3%) and poor (3.9%). Cross-tabulation analysis revealed varied QoL distribution across age, marital status, education, disease duration, and cancer stage. Conclusion: We conclude that the QoL of breast cancer patients undergoing chemotherapy at Royal Prima General Hospital is predominantly at a moderate level, indicating a need for focused attention on psychosocial support, health education, and symptom management to holistically improve patient well-being during treatment.
Co-Authors Adinda Adinda Amir, Dwi Fenny Chintya Darma, Gladys Chiuman, Linda Djohan Djohan Ginting, Chrismis Novalinda Hasya, Muhammad Nawal Ibnu, Syahroni Iskandar, Ari Rahman Lafonda, Kartini Anisa Lister, Gilbert Lumbantobing, Christina J.R.E. Saragih, Chanli Sylvana, Dhini