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UJI EFEKTIVITAS EKSTRAK RIMPANG KUNYIT PUTIH (Curcuma zedoaria) TERHADAP PERTUMBUHAN JAMUR (Pityrosporum ovale) dan (Microsporum canis) Grandis, Lexandria; Chiuman, Linda; Wijaya, Linda Leonando; Indriani, Vidya; Lister, Gilbert
(Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Vol 5, No 1 (2020): JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat)
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37887/jimkesmas.v5i1.10516

Abstrak Kunyit putih memiliki kandungan minyak atsiri. Ketombe merupakan suatu keadaan abnormal yang muncul di lapisan kulit bagian terluar dan ditandai adanya peradangan serta gatal-gatal disekitar kulit kepala. Tujuan daripenelitian tersebut untuk mengetahui efektivitas antijamur ekstrak rimpang kunyit (Curcuma zedoaria) terhadappertumbuhan jamur Pityrosporum ovale dan Microsporum canis. Jenis penelitian adalah penelitian eksperimentallaboratorium dilanjutkan Posttest Only Group Design guna mengetahui efektivitas jamur ekstrak etanol rimpangkunyit putih (Curcuma zedoaria) pada pertumbuhan jamur Pityrosporum ovale dan Microsporum canis. Penelitian inimenggunakan metode difusi cakram dengan enam perlakuan yang terdiri dari kontrol negatif (aquadest), kontrolpositif untuk Pityrosporum ovale (miconazole), dan kontrol positif untuk Microsporum canis (itrakonazole) ekstrakrimpang kunyit putih konsentrasi 25%, 50%, 75%, dan 100%. Berdasarkan penelitian, ternyata ekstrak rimpang kunyitputih (Curcuma zedoaria) dapat menghambat pertumbuhan jamur Pityrosporum ovale dan Microsporum canis padakonsentrasi 25%, 50%, 75% dan 100%. Kata Kunci : Ekstrak rimpang kunyit putih (Curcuma zedoaria), antijamur, Pityrosporum ovale, Microsporum canis

Factors contributing to weight gain among students during the COVID-19 pandemic Marpaung, Jelentika; Marlinang, Putri; Siagian, Masryna; Bangun, Andreas Xaverio; Lister, Gilbert; Deseva, Frisca Gemmi; William, Andy
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6582

Weight gain among students during the COVID-19 pandemic was largely attributed to lifestyle changes, including diet, sleep patterns, decreased physical activity, and increased gadget use. This study aimed to identify the factors influencing weight gain in students at SMKN 10 Medan. A quantitative methodology was employed, utilizing a cross-sectional approach. The study population consisted of all students at SMKN 10 Medan, totaling 1,108 individuals. A sample of 294 students was selected using a random sampling technique. Data analysis was conducted using the chi-square test and logistic regression. The results indicated that all variables were significantly related to student weight gain during the COVID-19 pandemic, with p-values for physical activity (p=0.036), breakfast habits (p=0.042), snacking habits (p=0.001), sleep patterns (p=0.001), and gadget use (p=0.001). The most influential factors contributing to student weight gain were identified as snacking habits and sleep patterns, which exhibited the lowest significance values. It can be concluded that snacking habits and sleep patterns are the predominant factors associated with weight gain among students at SMKN 10 Medan during the COVID-19 pandemic.

Incidental detection of Tietze syndrome with costochondritis: A case report Lister, Gilbert; Soekardi, Adi; Icksan, Aziza Ghanie
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6815

Background: Tietze syndrome represents a rare and atypical source of anterior chest discomfort, distinguished by localized tenderness and non-suppurative swelling, typically centered around the 2nd or 3rd costal cartilages. Despite diligent investigation, the precise underlying causes of Tietze syndrome remain elusive. Case Report: We present a case of a 35 year old male patient with suspected Tietze syndrome with costochondritis. He came in with complaints of abdominal pain and frequent coughs. He has a history of ADPKD and thalassemia since age 12. Tietze syndrome was an incidental finding in this patient. A thorax scan showed multiple nodular and lobulated lesions in the medial mediastinum; additionally, an abnormal widening and flattening of the costochondral junction of the ribs bilaterally. The CT scan findings reveal notable deformities characterized by widened and irregularly shaped anterior rib masses spanning the 1st to the 4th ribs bilaterally. The USG scan of the thorax showed a hypogenic thickening of the costochondral junction with vascularization. Discussion: Tietze's syndrome presents a diagnostic challenge necessitating comprehensive imaging modalities for accurate diagnosis. Ultrasound imaging stands out as the primary approach, showcasing conspicuous soft tissue swelling indicative of the ongoing inflammatory process. While computed tomography often reveals subtle focal swellings or mild sclerosis in the affected joint. Conclusion: The clinical manifestations frequently encompass an abrupt onset of chest discomfort devoid of antecedent trauma, predominantly observed among younger cohorts with an otherwise clean bill of health. Ultrasound is an accurate and effective modality to diagnose Tietze syndrome. This disease is frequently associated with other comorbidities such as rheumetic and autoimmune disorders.

Uji Efektivitas Ekstrak Umbi Bit (Beta vulgaris) Terhadap Kontrol Gula Darah dan Gambaran Histopatologi Pankreas Pada Tikus Diabetes Yang Diinduksi Aloksan Brahmana, Lisa Charolin Br; Angie, Evelyn; Lister, Gilbert
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 9 (2025): : JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i9.4886

Diabetes mellitus is a metabolic disease characterized by increased blood sugar levels due to the body's inability to process insulin. The disease can affect a variety of organs, including the eyes, kidneys, heart, and nervous system. This study aims to evaluate the effect of ethanol extract of beet tubers on the decrease in blood sugar levels and changes in the histopathology of the pancreas. Through a true experiment design with the pretest-postest group in aloxan-induced wistar rats, the animals were divided into six groups: the normal, negative control, positive control (metformin) groups, and three treatment groups with beet tuber extract at doses of 22.5 mg/kgBB, 45 mg/kgBB, and 90 mg/kgBB. Blood glucose levels were measured on days 0, 3, 6, 9, 12, and 14. Results showed a significant difference between day-0 and day-14 (P <0.05), but there was no significant difference between the positive control group and all treatment groups (P > 0.05). Histopathology shows beet tuber extract and metformin do not provide a significant difference to the pancreas. Beet tuber extract is effective as an antidiabetic in lowering blood sugar levels in aloxan-induced rats.

Factors contributing to weight gain among students during the COVID-19 pandemic Marpaung, Jelentika; Marlinang, Putri; Siagian, Masryna; Bangun, Andreas Xaverio; Lister, Gilbert; Deseva, Frisca Gemmi; William, Andy
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6582

Weight gain among students during the COVID-19 pandemic was largely attributed to lifestyle changes, including diet, sleep patterns, decreased physical activity, and increased gadget use. This study aimed to identify the factors influencing weight gain in students at SMKN 10 Medan. A quantitative methodology was employed, utilizing a cross-sectional approach. The study population consisted of all students at SMKN 10 Medan, totaling 1,108 individuals. A sample of 294 students was selected using a random sampling technique. Data analysis was conducted using the chi-square test and logistic regression. The results indicated that all variables were significantly related to student weight gain during the COVID-19 pandemic, with p-values for physical activity (p=0.036), breakfast habits (p=0.042), snacking habits (p=0.001), sleep patterns (p=0.001), and gadget use (p=0.001). The most influential factors contributing to student weight gain were identified as snacking habits and sleep patterns, which exhibited the lowest significance values. It can be concluded that snacking habits and sleep patterns are the predominant factors associated with weight gain among students at SMKN 10 Medan during the COVID-19 pandemic.

The Effect of Extra Virgin Olive Oil on Reducing Malondialdehyde Levels and Liver Histopathology in Male Rattus Norvegicus with Hypercholesterolemia Lister, Gilbert; Adinda, Adinda; Djohan, Djohan; Yuliansyah, Jeri
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3646

All living things age physiologically. Free radicals attack cells as they age, causing damage, disruption, and death. Free radicals oxidize and damage cell membrane lipids. The body needs optimum antioxidants during oxidative stress. This study hypothesizes EVOO can lower MDA and total cholesterol and repair liver histopathology in hypercholesterolemic Wistar male rats—this research with a pre-post-test control group experiment. The study found that the control group's MDA level was 0.14 ± 0.03 nmol/ml before treatment (pretest), while the group given standard meal for mice and distilled water/day/head for 14 days had a drop to 0.13 ± 0.10 nmol/ml. In treatment group 1, the average MDA level was 0.73 ± 0.03 nmol/ml before treatment, and after 14 days of high-fat, high-cholesterol meal without EVOO, the average MDA level was 0.73 ± 0.03 nmol/ml and dropped to 0.48 ± 0.10 nmol/ml. Treatment group 2 had an average MDA level of 0.22 ± 0.02 nmol/ml before treatment, but after receiving a high-fat, high-cholesterol diet and a 1cc dose of EVOO for 14 days, it decreased to 0.17 ± 0.02 nmol/ml. Before therapy, the mean MDA level in group 3 was 0.17 ± 0.02 nmol/mL. Giving mice a lot of fat and cholesterol and a two cc dose of EVOO for 14 days lowered their MDA levels to 0.08 ± 0.01 nmol/ml, ranging from 0.10 to 0.05. The research concluded that average MDA decreased significantly in treatment group 3 after mice were fed high-fat, high-cholesterol feed and given two ccs of EVOO.

Uji Aktivitas Antibakteri Ekstrak Kulit Buah Pepaya Terhadap Diameter Zona Hambat Pertumbuhan Bakteri Escherichia Coli, Staphylococcus Aureus Dan Salmonella Typhimurium Halim, Vanessa; Lister, Gilbert; Angie , Evelyn
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 11 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i11.4998

Infeksi bakteri masih menjadi salah satu penyebab utama masalah kesehatan yang memerlukan penanganan serius. Resistensi bakteri terhadap antibiotik sintetis semakin meningkat sehingga mendorong penelitian terhadap sumber antibakteri alami, salah satunya kulit buah pepaya (Carica papaya L.) yang diketahui mengandung berbagai senyawa bioaktif. Penelitian ini bertujuan untuk menganalisis aktivitas antibakteri ekstrak kulit buah pepaya terhadap bakteri Escherichia coli, Staphylococcus aureus, dan Salmonella typhimurium berdasarkan diameter zona hambat pertumbuhan bakteri. Jenis penelitian ini yaitu eksperimental dengan design penelitian Post Test Only Control Group Design. Data dianalisis menggunakan uji normalitas, homogenitas, ANOVA satu arah, dan uji lanjut Tukey HSD. Hasil penelitian menunjukkan bahwa ekstrak kulit buah pepaya mengandung flavonoid, alkaloid, saponin, glikosida, serta steroid/terpenoid, sedangkan tanin tidak terdeteksi. Aktivitas antibakteri terlihat pada semua konsentrasi dengan peningkatan zona hambat seiring bertambahnya konsentrasi ekstrak. Zona hambat tertinggi pada E. coli (14,70 mm), diikuti oleh S. aureus (13,76 mm), dan S. typhimurium (11,66 mm). Hasil ANOVA menunjukkan adanya perbedaan yang signifikan antar kelompok perlakuan (p<0,05). Kesimpulan dari penelitian ini adalah ekstrak kulit buah pepaya memiliki potensi sebagai antibakteri alami, dengan efektivitas paling tinggi terhadap Escherichia coli dan konsentrasi 100% sebagai konsentrasi terbaik dalam menghambat pertumbuhan ketiga bakteri. Saran dari penelitian ini adalah perlu dilakukan isolasi senyawa aktif yang berperan dominan dalam aktivitas antibakteri kulit buah pepaya serta pengujian lebih lanjut terhadap bakteri lain, baik Gram positif maupun Gram negatif, untuk memperluas potensi penggunaannya dalam bidang kesehatan.

Antibacterial Activity Test of Gotu Kola Leaf Extract (Centella asiatica) Against Staphylococcus aureus Bacteria Isolated from Wounds of Diabetes Mellitus Patients Fioni; Heldayani, Debby; Lister, Gilbert; Tambunan, Andika Zayani
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6046

Staphylococcus aureus, a gram-positive bacterium, is the causative agent of diabetic foot. Traditional medicine using plants needs much further research, especially for wound healing in diabetes mellitus patients. This study is an experimental laboratory investigation on the efficacy of Gotu kola (Centella asiatica) leaf extract against wound-isolated Staphylococcus aureus. Gotu kola leaf extract (12.5%, 25%, 50%, 75%, and 100%), cefixime suspension (positive control), and sterile distilled water were tested. The results of the research showed the formation of an inhibitory zone from testing Gotu kola leaf extract against Staphylococcus aureus bacteria, where the average inhibitory zone was at concentrations of 12.5% (7.2 mm), 25% (11 mm), 50% (13.7 mm), 75% (14 .3 mm), and 100% (19.5 mm). The higher the concentration used, the larger the inhibition zone formed. Research shows that Gotu kola leaves' active substances inhibit energy formation, nucleic acid formation, cell membrane permeability, structure and function, and membrane protein lysis and damage.

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