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All Journal Jurnal Prima Medika Sains Buletin Kedokteran dan Kesehatan Prima
Lawrence, Christopher
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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The effect of moringa flower extract on kidney function in obese rats Meri, Meri; Lawrence, Christopher; Wilsen, Wilsen
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.3952

Abstract

This study aims to measure the effect of moringa flower extract administration on kidney function and histopathological features of the kidneys of obese male Wistar puith galir rats. This research is a type of experimental quantitative research using post-test only group design. This research was conducted at the Department of Pharmacy Pharmacology Laboratory, Faculty of Medicine, University of North Sumatra and Anatomical Pathology Laboratory, University of North Sumatra. Histopathology observation of kidney tissue was done by comparing the control and treatment groups. Changes observed will be the presence of fatty degeneration (vacuolization), necrosis and hydrophic degeneration. To obtain quantitative data, scoring was performed on each change found. The research data were tabulated and then the changes found were analyzed and presented descriptively. The research data were then analyzed with the help of SPSS version 25.0. The data normality test was analyzed with the Kolmogorov-Smirnov test approach (p> 0.05). To test the significance between test groups, one-way analysis of variance or One Way ANOVA technique was conducted at 95% confidence level (p < 0.05). Further analysis or test was conducted using Post Hoc Test with LSD technique. The results of the analysis showed that the administration of Moringa flower extract at a dose of 600 mg/KgBB was effective in improving kidney function in obese Wistar white rats. This improvement can be seen through the levels of ureum, creatinine, and histological structure of the kidneys that have improved. The results of histopathological observations of kidney tissue in treatment group 3, namely moringa flower extract at a dose of 600 mg/KgBB, experienced the most significant improvement and approached the control group compared to other groups.
The relationship between body mass index and blood sugar levels among menopausal women Manao, Oktoriadi; Lubis, Yolanda Eliza Putri; Nasution, Masdalena; Lawrence, Christopher; Pratomo, Fransiskus Aryo; Nardi, Leo
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.6352

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Decreased estrogen levels during menopause are often associated with various health problems, one of which is carbohydrate metabolism disorders characterized by changes in blood sugar levels. The purpose of this study was to analyze the relationship between body mass index (BMI) and blood sugar levels in menopausal women. This study is an analytic descriptive study with a cross-sectional design. The research sample involved all women aged 40-60 years who met the inclusion criteria. The results showed that most of the respondents (75%) were included in the late elderly category (age >56 years). Based on BMI, the majority of respondents (35%) were categorized as obesity I. Additionally, 51.7% of respondents had high blood glucose levels. Statistical analysis revealed a significant relationship between age status and blood glucose levels (p-value = 0.000). Similarly, there was a significant relationship between BMI and blood glucose levels (p-value = 0.026). These results indicate that age and obesity are factors associated with increased blood sugar levels in menopausal women.
Demographic characteristics and mortality of dengue fever in Medan City (2021-2024) Iqbal, Muhammad; Silalahi, Marlinang Isabella; Pane, Putri Yunita; Sibagariang, Eva Ellya; Munthe, Dewi Sartika; Nardi, Leo; Fransiskus, Antonius; Lawrence, Christopher; Ongko, Nicolas Xavier
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7350

Abstract

Dengue Hemorrhagic Fever (DHF) is a significant public health challenge in Indonesia, including the city of Medan. This study aimed to determine the prevalence, demographic distribution (by sex and age group), and mortality rates of DHF in Medan from 2021 to 2024. This study used secondary data from reports provided by the Medan City Health Office, which compiled information from all public health centers (Puskesmas) in the region. Analysis of the data revealed that the pediatric age group (5–14 years) was the most affected population. The distribution of cases showed a relatively balanced proportion between males and females. DHF mortality rates fluctuated annually, with a notable downward trend observed in 2024. These findings underscore the critical need to strengthen DHF prevention and control programs, with a specific focus on vulnerable age groups and high-incidence areas. This study is expected to serve as a foundational resource for public health policy planning and to enhance the capacity of primary healthcare services to effectively manage DHF cases.
Co-Authors Dewi Sartika Munthe Fransiskus, Antonius Manao, Oktoriadi Meri, Meri Muhammad Iqbal Nardi, Leo Nasution, Masdalena Ongko, Nicolas Xavier Pane, Putri Yunita Pratomo, Fransiskus Aryo Sibagariang, Eva Ellya Silalahi, Marlinang I. Wilsen Wilsen, Wilsen Yolanda Eliza Putri Lubis