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Uji Aktivitas Antijamur Nanopartikel Zink Oksida (ZnO) Ekstrak Kulit Jengkol terhadap Candida Albicans Ica Dwi Patricia; Vera Estefania Kaban; Astriani Natalia Br Ginting
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7539

Abstract

Natural materials are increasingly being used as sources of bioactive chemicals due to increased concerns about safety, sustainability, and environmental effect. Jengkol peel is one such natural material with potential because it contains various secondary metabolites compounds that have biological activity. On the other hand, Candida albicans fungal infections remain a health problem, while conventional antifungal options are limited and have the potential to cause side effects. Zinc oxide (ZnO) nanoparticles are known to have broad antimicrobial activity, and their synthesis can be carried out in an environmentally friendly manner through a green synthesis approach using natural materials. This study aims to test the antifungal activity of ZnO nanoparticles synthesized using jengkol peel extract against Candida albicans. The study was conducted experimentally. Antifungal activity was tested using the well diffusion method with various concentrations of ZnO nanoparticles. The results showed the formation of an inhibition zone around the well, indicating the antifungal activity of ZnO nanoparticles. The increase in ZnO nanoparticle concentration is directly proportional to the increase in inhibition zone diameter, with the highest inhibition of 14 mm categorized as moderate activity. This study proves that jengkol-based ZnO nanoparticles have the potential to be developed as an environmentally friendly alternative antifungal agent.
Perbandingan Pelarut Etanol dan Gliserin pada Ekstrak Etanol Buah Bit (Beta vulgaris L.) terhadap Pertumbuhan Bakteri Staphylococcus aureus Tiani Nduru; Astriani Natalia Br Ginting; Roy Indrianto Bangar
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 5 No. 1 (2026): Januari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v5i1.7167

Abstract

Infectious diseases caused by Staphylococcus aureus remain a significant health concern globally, with increasing antibiotic resistance necessitating alternative antimicrobial agents. Beetroot (Beta vulgaris L.) contains bioactive compounds with potential antibacterial properties. This study investigated the antibacterial activity of beetroot ethanol extract against Staphylococcus aureus and compared the effects of ethanol and aqueous solvents in the extraction process. Beetroot simplicia was prepared and characterized according to standard protocols. Extraction was performed using 70% ethanol maceration method, yielding 20.29% extract. Phytochemical screening and thin-layer chromatography identified secondary metabolites. Antibacterial activity was evaluated using the Kirby-Bauer disc diffusion method at concentrations of 5%, 10%, and 15%, both with and without glycerin addition. Simplicia characterization met quality standards with moisture content of 0.25%. TLC analysis revealed alkaloids, flavonoids, terpenoids, steroids, saponins, and tannins. Beetroot ethanol extract demonstrated concentration-dependent antibacterial activity with inhibition zones of 8.1±0.87 mm (5%), 10.2±0.71 mm (10%), and 13.9±0.79 mm (15%). Glycerin-supplemented extracts showed comparable activity. Beetroot ethanol extract exhibits significant antibacterial activity against Staphylococcus aureus, supporting its potential as a natural antimicrobial agent for pharmaceutical applications.