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All Journal The Indonesian Biomedical Journal Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Medik Veteriner Journal Of Widya Medika Junior Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Widya Medika
Sianty Dewi
Widya Mandala Surabaya Catholic University
Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Journal : Jurnal Widya Medika

 1 
A randomized controlled trial on the effectiveness and safety of tranexamic acid in decreasing blood loss in cesarean section Sianty Dewi
JURNAL WIDYA MEDIKA Vol. 2 No. 1 (2014)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v2i1.1647

Abstract

Background: WHO reported more than 100,000 maternal death due to obstetric hemorrhage annually, in other hand Cesarean Section (CS) is a common surgery done to save mother and child with one of the complications is hemorrhage. tranexamic acid (TXA) as antifibrinolytic might improve maternal outcome by decreasing blood loss in CS. Objectives:Determine effectiveness and safety of tranexamic acid in decreasing blood loss in cesarean section. Method:A prospective, double blinded, randomized controled study in Obstetrics and Gynecology Department of Southern Philippines Medical Center. The participants are 124 women underwent CS, 62 women given tranexamic acid after cord cut compared to 62 given placebo. Estimated blood loss, cardiac rate, systolic blood pressure before and after CS, events during CS and additional medicines. Hemoglobin and hematocrit was taken before and after CS, course in the ward, blood transfusion, adverse events, mortality and length of hospital stay were compared. Results: Socio demographic, clinical profile, events after interventions, need of additional medicines and complications are similar for both group (p-value>0.05). The cardiac rate after CS is significantly higher in TXA group (tranexamic:85.1±11.5 placebo:80.1±15. 6, p-value=0.0441), but still in normal range. Conclusion: Tranexamic acid is not recommended to be given routinely to reduce blood loss in CS, instead its more beneficence to abort severe bleeding hence its should be available during CS. There was no adverse events recorded in both treatment and placebo group showed safety of tranexamic acid.
EPIDEMIOLOGIC STUDY OF ENDOMETRIAL LESION CHARACTERISTICS BY AGE IN PATHOLOGY DIAGNOSTIC CENTER IN SURABAYA 2015-2017 Sianty Dewi; Imelda Theodora; Bernadette Dian Novita; Yulia Widyasari; Ricardo Gunadi; Maria Amelia Suhardi; Vincentius Diamantino Supit
JURNAL WIDYA MEDIKA Vol. 7 No. 1 (2021): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v7i1.3167

Abstract

Background: The etiology of endometrial lesions varies from benign to malignant. Early detection and management of malignancy give the best prognosis for the patient. While studies in America and Europe report a 3-5% risk of malignancy in women below 50 years and a significant increase up to 75-80% in postmenopausal, the availability of national epidemiologic data is limited, therefore the study is held.Method: A descriptive- retrospective study. Total sampling obtained from endometrial specimens in Pathology Diagnostic Center-Prof JH Lunardhi, Sp.PA(K) from 2015 to 2017, while gestation-related, inadequate sample, and incomplete report are excluded. Data analyzed by IBM SPSS 23.0 version. Result: Data of 560 samples, 90% from curettage, 8% hysterectomy, and 2% hysteroscopy. The majority belonged to the 40-49 age group (44.3%). Secretory phase endometrium is the most common finding in the age group of 20-29 years (26.9%). Proliferative phase endometrium is the most common finding. The highest incidence of endometrial hyperplasia occurred in the age group of 40-49 years, for both typical and non-atypical. Endometrial malignancy was found mostly in the 50-59 years (37.03%). Conclusion: The prevalence of endometrial lesions differed according to age groups, with physiological changes, endometritis, polyps, and hyperplasia were most common under 50 years old and the risk of malignancy increased 4.39 times (p.00) beyond 50 years old.
TELEMEDICINE AS AN OPTION FOR HEALTH SERVICE LIMITATIONS IN COVID-19 PANDEMIC ERA Bernadette Dian Novita; Sianty Dewi; Evelyn Ongkodjojo; Agatha Christi Palupi; Immanuel Michael; Paul L. Tahalele
JURNAL WIDYA MEDIKA Vol. 7 No. 2 (2021): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v7i2.3430

Abstract

Coronavirus disease 2019 (COVID-19) pandemic era provides a new habit in form of self-quarantine or physical distancing. The recommendation is to delay visits to health facilities if it is not in the emergency condition to slow down the spread of COVID-19 transmission. This study aims to develop a telemedicine system that integrates three main components, namely doctors, patients, and hospital management in Gotong Royong Hospital Surabaya to minimize the transmission of COVID-19 while still provides comprehensive health services. The development of telemedicine service is divided into 3 stages. In the first stage, emergency screening was carried out by developing Frequently Asked Questions (FAQs). The second stage was continued with prototype testing and the last part was improving the system to create a better referral system. Gotong Royong Hospital telemedicine has been active since June 2021, within 2 months, 45 patients are willing to use telemedicine services. The results showed that telemedicine was easily accepted by patients in internal medicine clinic services (p
HYPOGLYCEMIC, ANTI-INFLAMMATORY EFFECT OF PORANG (AMORPHOPHALLUS ONCHOPYLLUS) ON ALLOXAN-INDUCED DIABETIC RATS Young, Andre; Novita, Bernadette Dian; Ricardo, Evan; Dewi, I.G.A.P.D; Amadeo, Jovan; Dewi, Sianty; Tahalele, Paul
JURNAL WIDYA MEDIKA Vol. 9 No. 1 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i1.4173

Abstract

Introduction: Iles-iles / Porang is a tuber-producing plant that is commonly found in Indonesia. One of the most sought after content from Porang is Glucomannan. One of Porang’s health benefit is related to the effect of lowering blood glucose levels because it can prevent glucose absorption. These benefit is interesting to study because there has been no research linking the use of Porang to reduce inflammatory process in hyperglycmic conditions. Purpose: This study aims to analyze the anti-inflammatory, anti-oxidant and hypoglycemis effects of Glucomannan from Porang (Amorphophallus onchophyllus) extract in experimental animals. Method: The research design was a true experimental post-test only control group with random sampling to determine 5 white rats into the normal group, positive control group, negative control group and treatment 1, 2 and 3. The positive control group received Acarbose therapy thile the negative control group received carboxy-methyl-cellulose (CMC) therapy. This study used Porang extract (Amorphophallus onchophyllus) with concentrations of 200, 400 and 800 mg/Kg in hyperglycemic white rats that had been induced by Aloxan. The study was conducte for 50 days and then blood and serum samples were taken to assess the effect of hypoglycemia, anti-inflammatory and anti-oxidant using blood glucose, Malondialdehyde and C-reactiveprotein (CRP) measurement. Result and Discussion: The results showed no significant difference between the groups of rats receiving Porang extract and the positive and negative control groups. However, the MDA levels after 50 days of intervention between the negative control group and the therapy with doses of 200, 400 and 800 mg/Kg showed significant differences. Similarly found for blood glucose levels after intervention between negative control group and the 200 and 400 mg/Kg therapy group. This results may be caused by the type of Porang used, the form of the Porang and the concentration level of the Porang extract. Conclusion: Porang with the type of Amorphophallus onchophyllus can’t be used directly, but requires further processing to obtain the active substance Glucomannan.
PROTOCOL OPTIMIZATION OF RT-qPCR FOR NF-ΚB DETECTION IN CARDIAC TISSUE FROM HFHS-FED MICE Jaya, Ferdinand Wiliam; Novita, Bernadette Dian; Suwandito, Laurensius; Wijaya, Hendy; Tjahjono, Yudy; Hendrata, Adi Pramono; Dewi, Sianty; Wijaya, Sumi; Ervina, Martha; Kuncorojakti, Suryo
JURNAL WIDYA MEDIKA Vol. 12 No. 1 (2026): March
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v12i1.8196

Abstract

Accurate detection of gene expression in challenging tissues requires methodological optimization to ensure reproducibility. Cardiac tissue, with its low cell density and variable RNA yield, presents particular difficulties for RT‑qPCR analysis. This study aimed to refine NF‑κB detection in HFHS‑fed C57BL/6 mice by comparing a standard 2‑ΔΔCt approach with an optimized protocol incorporating individualized calibrators adjusted for RNA concentration. Six male mice were divided into standard-diet (STD) and high‑fat, high‑sucrose (HFHS) groups, and cardiac RNA was extracted after 8 weeks of feeding. While relative NF‑κB expression trends were higher in the HFHS group, differences were not statistically significant; however, the optimized method consistently reduced variability and improved measurement reliability compared to the generalized approach. These findings highlight the value of individualized calibration as a protocol refinement for RT‑qPCR, offering a more rational framework for gene expression analysis in heterogeneous or technically demanding tissue samples.
Co-Authors Agatha Christi Palupi Amadeo, Jovan Amalia, Nindya Bernadette Dian Novita Bernadette Dian Novita Budipramana, Vicky Sumarki Dewi, I.G.A.P.D Dian Putri, Maria Patricia Dyana Sarvasti Erwin, Ferdinand Evelyn Ongkodjojo Ferry, Ferry Ferry, Ferry Hendrata, Adi Pramono Hertanto, Maria Patricia Dian Icha, Icha Imelda Theodora Immanuel Michael Jaya, Ferdinand Wiliam Jong, FX Himawan Haryanto Khudrati, Wilson Christianto Kuncorojakti, Suryo Lucia Hendriati Malonda, Franklin Vincentius Maria Amelia Suhardi Martha Ervina Meredith, Jennifer Ni Putu Sudewi, Ni Putu Novita, Bernadette Dian Paul L Tahalele Putra, Brilliant Dwi Ricardo Gunadi Ricardo, Evan S.Pd. M Kes I Ketut Sudiana . Sandhy Prayudhana Soediono, Endang Isbandiati Soewangsa, Queency Amelia Sumi WIjaya, Sumi Suwandito, Laurensius Teguh Widodo Theodora, Imelda Tjahjono, Yudy Toynbee, Eddy Vincentius Diamantino Supit Wedharga, I Gede Putu Adhi Wijaya, Hendy Young, Andre Yulia Widyasari